Episodes
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What if death isn’t inevitable but a solvable problem? This episode explores how biohacking is reshaping our understanding of mortality, legacy, and the limits of human performance. You’ll learn why some of today’s top thinkers are treating longevity as both a science and a spiritual movement, and how this shift affects your brain, your mitochondria, and your entire approach to life.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with philosopher and best-selling author Dr. Stephen Cave, Director of the Institute for Technology and Humanity at the University of Cambridge. With decades of expertise studying death, immortality, and ethics, Dr. Cave brings a rare depth of insight into how our desire to live longer intersects with neuroplasticity, supplements, and even nootropics.
Together, they unpack the four universal immortality narratives, the dangers of mind uploading, and why AI might become humanity’s next god or destroyer. You’ll discover how legacy, ego, functional medicine, and even fasting and ketosis play into our fear of death. The conversation also dives into the deeper psychological and societal consequences of radical life extension, and what happens when biohacking crosses into belief.
This episode is a must-listen for anyone serious about hacking longevity, brain optimization, metabolism, and building a future where living to 180 isn’t science fiction. You’ll also hear surprising thoughts on Danger Coffee, RFK, sleep optimization, and how to approach mortality using the Smarter Not Harder mindset.
You’ll Learn:
• Why all technology is a form of life extension
• How ego and boredom threaten longevity more than disease
• The real dangers of digital immortality and uploading consciousness
• Why procrastination could be the enemy of eternal life
• How to balance transhumanist tech with human values
• The surprising connection between cold therapy, supplements, and meaning
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing.
SPONSORS:
Puori | Head to http://puori.com/dave for 20% off, including subscriptions.
Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.
Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Stephen's Website: https://www.ith.cam.ac.uk/staff/stephen-cave
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:09 Intro
• 01:39 Life Extension Challenges
• 02:05 Boredom and Mental Health
• 04:28 Immortality vs. Enlightenment
• 06:21 Death’s Role in Civilization
• 09:06 Life Stages and Aging
• 10:41 Global Immortality Narratives
• 15:50 Personal Takes on Immortality
• 20:46 Biohacking and Longevity
• 28:43 Transhumanism Today
• 31:00 Techno-Utopianism and Happiness
• 32:20 Wealth and Fulfillment
• 32:54 Purpose and Meaning
• 34:00 Legacy and Death
• 36:33 Near-Death and Mortality
• 37:52 Time and Procrastination
• 42:00 AI and Human Future
• 45:56 Ethics of Life Extension
• 50:35 Autonomy and Mortality
• 52:35 Dangerous Ideas in Longevity
• 55:53 Advice for the Young
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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You feel stiff, tired, or older than you should—and this episode shows you how to reverse it. Learn how to fix joint pain, restore youthful movement, and upgrade your longevity by hacking the hidden causes of early aging like mitochondrial dysfunction, leaky gut, and chronic inflammation.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Dr. Gregory Kelly, SVP of Product Development at Qualia Life and a leading authority on functional medicine, nootropics, and anti-aging science. Dr. Kelly is a naturopathic physician, author of Shape Shift, former editor of Alternative Medicine Review, and a university instructor who’s published over 30 peer-reviewed papers and contributed to the Textbook of Natural Medicine. His deep expertise spans cellular regeneration, sleep optimization, metabolism, and the chronobiology of performance.
They reveal why most joint pain has nothing to do with age, why your cartilage and synovial fluid become insulin resistant, and how biohacking your gut can dramatically improve joint function and brain optimization. You’ll discover how neuroplasticity, metabolism, sleep, and mobility are all tied to your ability to stay pain-free and high performing. Dr. Kelly also breaks down the science behind unconventional joint-support compounds like tamarind seed extract, eggshell membrane, L-carnitine, and senolytics.
You’ll Learn:
• Why joint pain is often a metabolic and mitochondrial issue, not aging
• How zombie cells and gut toxins silently destroy your cartilage
• What to take instead of glucosamine to actually rebuild your joints
• Why most joint supplements fail and what new research says to use instead
• How to enhance mobility using functional medicine and cutting-edge ingredients
• How movement, inflammation, and brain health are deeply connected
• Tools for real recovery without burnout using the smarter not harder method
This channel explores how ketosis, fasting, cold therapy, and smarter not harder strategies affect movement, inflammation, and longevity. Dave also shares how Danger Coffee and his own supplement routines helped him reverse years of joint damage—and how you can do the same without drugs or surgery.
This is essential listening for anyone serious about biohacking, human performance, and outsmarting the aging process at any age.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Qualia’s Website: www.qualialife.com/asprey15
• Qualia's Instagram: https://www.instagram.com/qualialife/?hl=en
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:07 Joint Pain vs. Aging
• 04:46 Gut-Joint Connection
• 06:33 Diet’s Impact on Joints
• 10:14 Smarter Joint Supplements
• 19:15 Senescent Cells and Pain
• 22:47 Collagen Breakdown
• 24:21 Tamarind and Turmeric Benefits
• 26:34 Inflammation Fixes
• 29:39 Mobility and Movement
• 38:26 Sleep and Joint Recovery
• 42:52 Can You Reverse Joint Damage?
• 44:48 Final Takeaways
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Missing episodes?
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93% of people are metabolically unhealthy, and it’s not because they’re lazy or eating too much fat. It’s because their bodies forgot how to burn fat at all. This episode gives you a complete roadmap to reboot your metabolism, escape the sugar-burning trap, and reignite your fat-burning engine for good.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Ben Azadi, functional health expert, best-selling author of Metabolic Freedom, and one of today’s most trusted voices in the ketogenic and fasting space. After reversing his own obesity through biohacking and functional medicine, Ben has helped millions unlock metabolic flexibility and master human performance through smarter-not-harder strategies.
They explore how high insulin, not fat or salt, drives most chronic disease, and why your doctor probably isn’t testing for it. You’ll learn the truth about seed oils, fructose, and blood sugar spikes, and why most people using continuous glucose monitors are still missing the real metabolic threat.
You’ll also discover how to:
• Switch out of sugar-burning mode and back into fat-burning ketosis
• Use fasting, cold therapy, and sleep optimization to repair mitochondrial damage
• Fix hidden nutrient deficiencies with the right supplements, potassium, and electrolytes
• Build real metabolic resilience with Danger Coffee, functional medicine, and nootropics
• Avoid the trap of endless keto or carnivore and learn how to cycle your way to true metabolic freedom
• Understand why low HRV, high insulin, and sleep debt crush longevity, energy, and brain optimization
• Decode how neuroplasticity, emotional regulation, and resilience all connect to metabolism
This is your science-backed guide to transforming your energy, losing stubborn fat, and becoming metabolically unstoppable.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
SPONSORS:
- BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino.
- IGNITON | Save 10% at https://endlss.io/sl/igniton/daveasprey.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Ben’s New Book - Metabolic Freedom: A 30-Day Guide to Restore Your Metabolism, Heal Hormones & Burn Fat: https://www.amazon.com/Metabolic-Freedom-Restore-Metabolism-Hormones/dp/1401994369
• Ben’s Instagram: https://www.instagram.com/thebenazadi/?hl=en
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:04 Intro
• 02:42 Insulin Explained
• 06:00 Salt vs. Potassium
• 08:10 Uric Acid & Fructose
• 12:56 Health Trolls
• 18:14 Seed Oil Truth
• 24:24 Cooking Oil Breakdown
• 31:08 Carnivore & Flexibility
• 34:57 Gut Test Insights
• 36:09 Cholesterol Panel
• 36:43 LMHR Explained
• 37:39 Inflammation Markers
• 40:25 Managing Autoimmunity
• 42:07 Gut Bacteria & Fiber
• 46:55 Fasting for Gut Health
• 48:03 Saturated Fat & Gut
• 49:34 Oxalates & Diet
• 57:32 Metabolic Efficiency
• 01:03:08 Hormesis & Stress
• 01:08:21 Final Takeaways
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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You’re working out, eating clean, and still not getting the results you want. This episode reveals the real reason your fitness isn’t translating to the summer body you’re chasing and what to do instead.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with performance-driven entrepreneur and former Army Ranger Nick Bare, founder of Bare Performance Nutrition and the Go One More movement. With over a decade of experience in human performance, endurance, and mindset training, Nick has built a cult-like following by pushing the limits of physical and mental resilience without burning out.
In this episode, you’ll learn why consistency beats intensity, how to spot the traps of overtraining, and how to train smarter by understanding mitochondria function, recovery science, and sleep optimization. Dave and Nick go deep on longevity tactics, cold therapy, neurohacking rituals, and why emotional regulation is the missing link in high performance.
They also break down elite strategies for entrepreneurial stress, parenting under pressure, and how to balance ambition with recovery using tools from biohacking, self-quantification, and functional medicine. You’ll get practical insights into how Upgrade Labs, Danger Coffee, and the principles behind Smarter Not Harder can dramatically boost your energy and focus.
Whether you’re an endurance athlete, a sleep-deprived parent, or a business builder trying to avoid burnout, this conversation gives you the blueprint for sustainable energy, powerful willpower, and next-level fitness that actually works.
You’ll Learn:
• The true cost of overtraining and how to avoid it
• How to create “sprints” in life without sacrificing long-term performance
• Tactical upgrades for training, sleep, fasting, and emotional recovery
• What most people get wrong about motivation and discipline
• How to use nootropics, cold therapy, and fasting to accelerate growth
• Why fear of mediocrity can be fuel if used correctly
• How testosterone, cortisol, and dopamine affect parenting, performance, and purpose
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
SPONSORS:
- Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order
-Active Skin Repair | Visit http://activeskinrepair.com/ to learn more and use code DAVE to get 20% off your order.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Nick’s Website – https://www.nickbare.com/
• Nick’s Instagram: https://www.instagram.com/nickbarefitness/?hl=en
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 00:55 Intro
• 02:59 Longevity & health
• 07:51 Endurance vs recovery
• 20:23 Focus & boundaries
• 23:16 Pain & recovery
• 24:48 Dopamine & motivation
• 25:48 Breath work & states
• 28:24 Endurance as meditation
• 30:44 Curiosity & fear
• 32:22 Purposeful suffering
• 33:33 Vision quests
• 40:18 Nervous system switching
• 45:59 Decision-making
• 47:59 Final thoughts
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Your everyday habits might be accelerating aging, and this episode reveals what to do instead. You’ll learn how specific plants trigger powerful longevity pathways and how to eliminate the hidden toxins disrupting your hormones, brain, mitochondria, and overall health. This is a masterclass in biohacking from two experts who’ve spent decades researching how to upgrade the human body.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey is joined by Darin Olien, environmental health expert, bestselling author of Fatal Conveniences, and co-host of the Netflix series Down to Earth with Zac Efron. Darin has traveled the globe uncovering forgotten plant compounds, investigated the most overlooked environmental toxins, and now works with leading scientists and governments to bring these breakthroughs into functional medicine and human performance.
Together, they break down:
• How rare plant compounds like osmotin support adiponectin and mitochondrial repair
• Why PFAS, synthetic fragrances, and EMFs are sabotaging your biology
• How environmental toxins contribute to hormone disruption and infertility
• What makes tap water so dangerous and how to fix it with simple filtration
• Why microplastics and heavy metals are harder to avoid than ever
• The role of habit design, detox protocols, and indoor air quality in biohacking longevity
• Why removing toxins first leads to better results in fasting, ketosis, nootropics, and cold therapy
This episode delivers practical tools for building resilience, improving detox capacity, and navigating the modern world with awareness. You’ll also get insights into the systems that have failed to protect public health and how personal action can create collective change.
If you’re interested in senolytics, sleep optimization, neurohacking, and smarter ways to upgrade your environment, you’ll find those topics explored in depth throughout this channel.
Whether you’re detoxing from hidden toxins or optimizing with Danger Coffee, this conversation aligns with the core principles of Smarter Not Harder and the mission of Upgrade Labs.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
SPONSORS:
-OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY.
-Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.
-Apollo Neuro | To get an Apollo wearable, go to https://apolloneuro.com/Dave and save 15%.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Darin’s Website – https://superlife.com/
• Darin’s Instagram: https://www.instagram.com/darinolien/
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:10 Intro
• 02:14 Meet Darin Olien
• 04:26 Wildfires and Pollution
• 07:13 PFAS and Everyday Toxins
• 12:37 Corporate and Regulatory Failure
• 26:36 Synthetic Fragrances
• 36:12 Water and Air Filtration
• 36:53 Indoor Air Quality
• 38:33 Building Healthy Habits
• 40:05 Essential Oils and Hormones
• 41:54 Tofu, Tempeh, and Estrogen
• 46:34 Adiponectin and Biohacking
• 47:04 Osmotin for Longevity
• 49:48 Stem Cells and Repair
• 53:57 Communicating Science
• 01:04:12 Nutrition and the Microbiome
• 01:06:14 Final Thoughts
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Your anti-aging skincare routine might be secretly aging you faster. In this episode, you’ll uncover how trending skincare products including vitamin C serums, harsh exfoliants, and blue light therapies can damage your skin’s mitochondria, accelerate senescence, and trigger systemic inflammation. You’ll learn how to reverse this damage, support cellular repair, and choose smarter formulations that work with your biology for long-term skin and brain health.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Amitay Eshel, a pioneer in biohacking skincare and founder of Young Goose. With expertise in regenerative aesthetics and advanced bioactive formulations, Amitay is leading the charge in applying longevity science, epigenetics, and senolytics to skincare. His work helps high performers integrate topical nootropics, mitochondrial support, and neurohacking principles directly into their daily routine through the skin.
You’ll explore how skin aging connects to brain inflammation, how leaky skin barriers affect immune health, and why most anti-aging trends are outdated or biologically disruptive.
The Human Upgrade unpacks how red-light therapy, ketosis, cold therapy, fasting, and self-quantification tools can be leveraged to enhance skin function from the inside out. This is a masterclass in smarter not harder skincare, rooted in cellular optimization and performance longevity.
This episode is essential listening for anyone serious about biohacking, human performance, skincare longevity, mitochondria, Upgrade Labs-style recovery, and science-backed beauty routines.
You’ll learn:
• Which anti-aging skincare trends actually age you faster
• How mitochondria and senescent cells influence visible aging and inflammation
• What role neurohacking and the skin-brain connection play in longevity
• How to repair the skin barrier and reduce oxidative stress naturally
• The best red light, cold therapy, and fasting tools to reverse skin aging
• How to use skin as a self-quantification tool for overall health
• Why smarter skincare equals better cognitive and biological performance
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
SPONSORS:
-OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY.
-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.
-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Young Goose Website – https://www.younggoose.com/ and use code “Dave10” at checkout to get a discount!
• Young Goose Instagram: https://www.instagram.com/young_goose_skincare/?hl=en
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 – Trailer
• 00:52 – Intro
• 01:27 – Anti-Aging Mistakes
• 05:20 – Skin Recovery Science
• 07:44 – NAD & Mitochondria
• 08:52 – Autophagy Compounds
• 12:06 – Sleep & Topicals
• 18:36 – Overtraining Effects
• 21:07 – Vitamin C & Antioxidants
• 28:48 – Breakthrough Formulations
• 35:50 – Tallow vs. MCT
• 36:11 – Sun & Longevity
• 37:28 – Red Light Therapy
• 40:12 – UV Light Benefits
• 42:18 – Advanced Skincare Tech
• 48:48 – NAD Topicals
• 01:00:05 – Building Your Routine
• 01:07:39 – Final Takeaways
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Most supplements don’t work, and this episode reveals why. You’ll learn how to stop wasting money on “expensive pee,” how to spot marketing lies on labels, and which ingredients actually move the needle for energy, focus, and longevity.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Jeff Boyd, founder of MTE and a leader in the new wave of performance supplements. With a background in data-driven wellness and a decade of experience optimizing human performance without caffeine or sugar, Jeff breaks down the science of nootropics, adaptogens, and smart nutrient stacking. His work focuses on self-quantification, nervous system regulation, and sustainable energy for founders, athletes, and high performers.
Together, they explore why 85% of supplements are designed to fail, how to activate mitochondria for real results, and what it means to biohack your biology smarter, not harder. This isn’t just about supplements. It’s about reclaiming your energy, upgrading your brain, and aligning your stack with how your body actually works. You’ll also hear how fasting, sleep optimization, and even subtle neurohacking protocols support long-term resilience and better decision-making.
You’ll Learn:
• The real reason most supplements don’t absorb and how to fix it
• How to build a caffeine-free stack that fuels energy, mood, and clarity
• The latest in adaptogens, nootropics, and functional medicine
• How to align your supplement timing with circadian biology and ketosis
• Why “clean labels” often mean nothing
• How emotional regulation and neurotransmitters shape performance
• Tools for self-quantification and supplement personalization
This is essential listening for anyone serious about biohacking, longevity, smarter supplementation, mitochondrial health, sleep optimization, emotional resilience, and conscious human performance.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks questions no one else dares and brings you real tools to become more resilient, aware, and high performing.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• MTE website – www.getmte.com
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:13 Saffron Benefits
• 02:26 Medicinal Herbs
• 04:12 Supplement Formulation
• 13:16 Theanine & GABA
• 20:06 Adaptogens & Performance
• 23:23 Stress & Muscle Growth
• 24:03 Parenting & Energy
• 27:47 Nervous System for Kids
• 35:15 Sleep for Families
• 36:41 Wrap-Up & Offers
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Psychedelic therapy is on the verge of reshaping mental health, trauma healing, and human consciousness. This episode reveals what’s really happening behind the scenes at the FDA, inside pharmaceutical companies, and within the global movement to legalize MDMA-assisted therapy.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Rick Doblin, PhD, the legendary founder of MAPS and one of the most influential figures in psychedelic science. With nearly 40 years leading clinical research on MDMA, psilocybin, and trauma healing, Rick brings unmatched insight into how these compounds are transforming functional medicine, emotional resilience, and neuroplasticity.
They break down the regulatory battle over MDMA therapy, the clash between pharmaceutical profit and public benefit, and the urgent need to combine pharmacology with therapy for real results. You’ll also learn how psychedelics impact neurohacking, epigenetics, and the default mode network—and why the next frontier of self-transformation may be couples therapy with MDMA.
This episode offers critical knowledge for anyone serious about biohacking, trauma release, mental performance, and accessing deeper states of healing. This podcast channel dives into the intersections of psychedelics with fasting, ketosis, cold therapy, and self-quantification—and how altered states can unlock more energy, better relationships, and lasting change.
You’ll Learn:
• Why separating therapy from psychedelics is the most dangerous path forward
• How MAPS evolved into a public benefit pharma company—and what went wrong
• The real story behind the FDA’s rejection of MDMA therapy in 2024
• How MDMA affects neuroplasticity, mitochondria, and trauma recovery
• Why group therapy and couples therapy are the future of psychedelic healing
• The dangers of overusing ketamine—and how it’s being exploited by profit-driven clinics
• What the Psychedelic Science 2025 conference will reveal about the future of medicine, spirituality, and consciousness hacking
• How psychedelics could reverse epigenetic trauma passed down through generations
• The role of default mode network suppression in spiritual experiences and trauma resolution
• Why the war on drugs was never about safety—and what a post-drug-war world might look like
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, neurohacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
SPONSORS:
- Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off
- ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Psychedelic Science Conference 2025 Website – https://www.psychedelicscience.org/
• Rick’s Website: https://maps.org/
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 02:00 Intro
• 03:43 Rise of Psychedelic Pharma
• 05:00 Therapy vs. Profit
• 06:44 Neurofeedback + Psychedelics
• 08:28 Origins of Drug Laws
• 14:06 MDMA Safety + Usage
• 16:32 Psychedelics in Therapy + Meditation
• 25:18 Psychedelic Hierarchy for New Users
• 26:51 Psychedelic Churches + Culture
• 28:58 Ayahuasca: Spiritual Insights
• 30:24 MDMA and Federal Policy
• 31:09 Inside the FDA Decision
• 32:52 Therapeutic Promise of Psychedelics
• 34:43 Psychedelics + Spirituality
• 37:37 Neuroscience of Psychedelics
• 40:12 Epigenetics + Generational Trauma
• 43:50 War on Drugs Revisited
• 46:37 Future of Legalization
• 49:55 MDMA for Couples
• 51:29 Group Therapy with Psychedelics
• 52:26 Psychedelic Science 2025 Preview
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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You’ve been told to eat clean, but what if your “healthy” foods are wrecking your gut, crushing your hormones, and aging you faster? This episode exposes the nutrient-depleted truth behind modern diets, soil erosion, and why regenerative farming might be the key to reversing chronic disease, boosting mitochondria, and rebuilding your biology from the ground up.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Dr. Josh Axe, a trusted pioneer in functional medicine, bestselling author, and co-founder of Ancient Nutrition. Dr. Axe bridges the gap between biblical farming, ancestral nutrition, and modern science to explain how your food and even your supplements may be harming your human performance, digestion, and brain health. With clinical insights, personal stories, and science-backed tools, he shares what to eat instead if you want real longevity, energy, and healing.
They dig into the collapse of soil nutrients, how monocropping damages the microbiome, and why organic food standards may be outdated. You’ll learn how regenerative agriculture rebuilds the earth and your gut, and why biohacking starts with dirt, not pills. Plus, they explore the hormonal chaos caused by seed oils, plastics, blue light, sleep disruption, and even birth control, especially in relation to testosterone loss in men and women.
This episode also touches on biblical nutrition, fasting cycles, natural nootropics, testosterone-supporting peptides, the dangers of synthetic vitamins, and the future of real-time self-quantification. From poop-powered farming to smarter sourcing, it’s a wild ride into how food, faith, and farming affect every part of your biology.
This is essential listening for anyone serious about biohacking, neurohacking, longevity, Upgrade Labs, Danger Coffee, Smarter Not Harder, and understanding the real root of disease and dysfunction.
You’ll Learn:
• Why regenerative farming beats “organic” for health and the planet
• How depleted soil is linked to hormone imbalances and chronic disease
• What birth control is doing to testosterone, fertility, and mitochondrial health
• Why your supplements may just be “expensive pee”
• The truth about biblical farming and why dirt still matters
• How to support testosterone naturally with diet, peptides, and habits
• Why sleep optimization, mineral balance, and circadian alignment are key for healing
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
SPONSORS:
- BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off.
- Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Josh Axe’s Website – https://thehealthinstitute.com/
• Josh Axe’s Instagram: https://www.instagram.com/drjoshaxe/?hl=en
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 00:52 Intro
• 01:01 From Medicine to Farming
• 02:21 Regenerative Farming
• 03:36 Fixing Modern Agriculture
• 05:43 Biblical Farming Meets Modern Science
• 08:23 The Truth About Organic Food
• 12:41 What’s Causing the Testosterone Crash
• 18:07 Hormonal Birth Control
• 27:37 New Hormone Replacement
• 29:58 The Future of Health Tracking
• 32:00 What Is Biblical Farming?
• 33:38 Biblical Principles of Nutrition
• 33:55 Foods Most Mentioned in the Bible
• 35:17 Pork, Parasites, and Dietary Laws
• 37:29 Chinese Medicine’s View on Pork
• 39:36 Did the Flood Shorten Human Lifespan?
• 42:26 Biodynamic Farming and Spirituality
• 54:27 Fatherhood and Words That Heal
• 56:21 What Josh Feeds His Kids
• 01:03:41 Mental Health, Faith, and Healing
• 01:05:36 Final Thoughts
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Your brain is under constant assault from devices you use every day. This episode reveals the hidden effects of 5G on brain function, cognitive performance, and nervous system stress, along with the science-backed method that neutralizes the damage.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Philipp Samor von Holtzendorff-Fehling, founder of Quantum Upgrade and a former VP at T-Mobile, to explore groundbreaking EEG research that shows how EMF exposure disrupts brainwaves in real time. Philipp shares how new tools are changing the way we approach biohacking, human performance, and energy medicine, and why even hardcore skeptics are paying attention.
They break down double-blind studies, ATP production, and real-world EMF mitigation techniques that support brain health, mitochondrial resilience, and recovery. You’ll hear why professional athletes, clinicians, and even animals are benefiting from non-invasive approaches once dismissed as fringe, and how to evaluate what actually works in your own biology.
This conversation is essential for anyone focused on biohacking, self-quantification, neurohacking, longevity, functional medicine, Upgrade Labs protocols, and protecting the brain in a wireless world. Whether you’re optimizing your nervous system, improving sleep, or just trying to stay sharp in a high-EMF environment, this episode gives you a toolset to reclaim your state.
You’ll learn:
• What EEG brain scans reveal after just 30 minutes of 5G exposure
• Why ATP production increases in certain energetic fields
• How energy fields influence brainwaves, stress, and performance
• The connection between EMFs, mitochondrial function, and resilience
• Why placebo doesn’t explain these results and what that means for self-tracking
• How to use energetic tools alongside Danger Coffee, cold therapy, fasting, and nootropics
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing.
SPONSORS:
- Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.
- Calroy | Head to https://calroy.com/dave for an exclusive discount.
Resources:
• Quantum Upgrade Website – Go to https://quantumupgrade.io/Dave for a free trial.
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Quantum Upgrade Instagram: https://www.instagram.com/quantumupgrade.io/?hl=en
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 00:54 Intro
• 01:18 Resistance to Energy Work
• 03:25 Inner Intuition
• 04:22 Science vs Experience
• 09:12 Quantum Effects on Body
• 13:43 Biohacking for Pets
• 15:43 EMFs & Quantum Upgrade
• 23:39 Explaining Quantum Tech
• 27:58 Understanding Frequencies
• 28:53 Scientific Proof & Use
• 31:07 Brain Support Tools
• 32:28 Ethics & Consent
• 34:09 EMF Defense & Biofield
• 39:07 Meditation & Altered States
• 46:59 Performance Optimization
• 48:02 Science Catching Up
• 50:39 Free Trial & How to Try
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Most people think 10,000 steps a day is the gold standard for health, but it’s outdated, inefficient, and often damaging. In this episode, you’ll discover a smarter, faster way to walk for longevity, fat burning, and total body resilience.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Mark Sisson, bestselling author, primal health pioneer, and founder of Primal Kitchen. With over 40 years at the forefront of fitness and ancestral health, Mark has helped millions rethink everything they thought they knew about cardio, running, metabolism, and movement. He was one of the first to challenge the chronic cardio myth, helped popularize ketosis and fat-adapted performance, and now returns with a new message: walking right, not more, is one of the most powerful biohacks for human performance and aging.
They dive into the Japanese walking interval method that outperforms 10,000 steps, and explore the critical link between foot health, barefoot shoes, and the brain-body connection. Mark also shares why he trains just 20 minutes a week, why too much saturated fat might backfire, and why performance should never come at the cost of your mitochondria. You’ll learn how to build muscle and endurance with less effort, how to reverse foot dysfunction with every step, and how to age with strength, intuition, and freedom.
This episode hits hard on biohacking, functional movement, longevity, self-quantification, and the real science of walking smarter, not longer. It’s also packed with insights on ketosis, nootropics, sleep optimization, and why perfectionism ruins health gains.
If you’re serious about Smarter Not Harder strategies, tuning into your body, and reclaiming your natural performance potential, don’t miss this one.
You’ll learn:
• Why zone 1 walking beats zone 2 training for longevity
• How foot dysfunction leads to systemic breakdown
• The hidden brain-glute-big toe connection no one talks about
• Why Mark no longer runs or eats ribeyes
• The minimum effective dose for strength, mobility, and fat burn
• Why perfectionism in wellness is toxic and what to do instead
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
**Go to www.peluva.com and use code ‘DAVE’ for 15% off **
SPONSORS:
- LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE.
-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Mark’s Website – www.peluva.com
• Mark's Instagram: https://www.instagram.com/wearpeluva/?hl=en
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 – Trailer
• 00:43 – Intro
• 01:13 – Mark’s entrepreneurial journey
• 04:53 – The rise of health blogging
• 05:40 – Why cardio might be hurting you
• 17:53 – Foot health and performance
• 20:54 – Barefoot and minimalist footwear
• 33:30 – Launching PVA Shoes
• 42:59 – Diet’s role in foot recovery
• 43:38 – Why comfort matters in footwear
• 44:12 – Personal footwear hacks
• 45:03 – Building a footwear brand
• 46:21 – Fashion vs function in foot health
• 49:17 – Simple foot strengthening tools
• 52:35 – What history reveals about shoes
• 58:47 – Walking and brain optimization
• 01:06:41 – Protein, aging, and nutrition
• 01:19:50 – Longevity and biohacking wins
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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This episode dives into the brutal, mind-altering experience of spending 60 days alone in Antarctica, and how extreme suffering became a catalyst for spiritual awakening, peak performance, and deep inner peace.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with elite adventurer, Marine Corps veteran, and Fearvana founder Akshay Nanavati, who dragged a 420lb sled solo across Antarctica in a brutal test of endurance, fasting, and spiritual transformation. Akshay shares how he used suffering as a tool to transmute PTSD, expand consciousness, and awaken what he calls the “paradox of oneness”—where discomfort unlocks the deepest joy.
Together, they explore how cold therapy, isolation, and extreme hardship reshape dopamine, mitochondria, neurochemistry, and the stories we tell ourselves. Akshay’s journey through darkness retreats, trauma healing, and polar expeditions opens a raw and unfiltered look at self-quantification, mental resilience, and human performance at the edge.
This episode will challenge your assumptions about comfort, suffering, and what it means to live fully awake. Whether you’re optimizing for longevity, exploring consciousness, or breaking free from invisible scripts, this conversation blends science, spirituality, and hardcore biohacking with moments of unexpected humor and wisdom.
You’ll Learn:
• How intentional pain resets your dopamine response and boosts performance
• Why Akshay chose fasting and cold exposure over nootropics and psychedelics
• How darkness retreats and solitude sharpen consciousness and intuition
• The neuroscience behind pain, trauma, and transformation
• Why true freedom lies in facing discomfort—not avoiding it
• How to find God in suffering and create meaning from chaos
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
SPONSORS:
- Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.
- IGNITON | Go to https://www.igniton.com/
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Akshay’s Website – https://fearvana.com/
• Akshay’s Instagram: https://www.instagram.com/fearvana/
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 – Trailer
• 00:58 – Intro
• 01:55 – Meeting His Wife Through Intuition
• 06:28 – Pain, Dopamine & Neurohacking
• 15:19 – The Paradox of Oneness
• 21:20 – Darkness Retreats & Mysticism
• 34:39 – Constructing Reality
• 38:32 – Consciousness & Perception
• 39:18 – Polar Travel: Mental & Physical Strain
• 40:22 – Calculated Risk vs. Suffering
• 43:40 – Trauma as Fuel
• 56:26 – Solitude & Self-Reflection
• 01:05:45 – Embracing Fear & Building Courage
• 01:09:29 – Death, Meaning & Bliss
• 01:12:53 – Final Reflections on Purpose
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
-
This episode reveals how one simple breath pattern can rewire your nervous system, regulate stress in seconds, and become your most powerful tool for human performance and longevity.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Aaron Alexander, a world-renowned human performance coach, manual therapist, and creator of The Align Method. Aaron has worked with elite athletes, high-level entrepreneurs, and celebrity performers to transform the way they move, breathe, and live in their bodies. He merges structural alignment, functional medicine, emotional awareness, and deep nervous system science to help people get unstuck, physically and emotionally.
Together, they explore the science and strategy behind breathwork, vagal tone, posture, and fascia, revealing how the body stores trauma, how breath shifts brain states, and how physical misalignment can sabotage mental clarity, energy, and even mitochondrial function. They also dive into why mouth taping, tongue posture, nitric oxide, and movement patterns are foundational to sleep optimization, cold therapy adaptation, and long-term vitality.
You’ll learn how to regulate your state in 10 seconds or less, how to shift from sympathetic overdrive to parasympathetic calm, and how to use tools like humming, OMing, and deep exhales to control your biology in real time. This is a tactical, science-rich, emotionally grounded guide to neurohacking from the inside out.
If you care about biohacking, functional medicine, sleep optimization, or want to feel stronger, calmer, and more in control—this episode is essential.
You’ll also hear how Aaron:
• Uses breath patterns to hack the nervous system and improve strength, mood, and cognition
• Teaches mouth taping and facial alignment for deeper sleep and recovery
• Connects trauma, honesty, and physical tension through a somatic lens
• Guides clients through cold therapy, touch, and movement to recalibrate resilience
• Applies fascia science and polyvagal theory to elite performance and everyday health
This is essential listening for anyone exploring Smarter Not Harder protocols, high-level biohacking, and the connection between movement, mitochondria, and mind control.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing.
SPONSORS:
- Sunlighten | Go to https://www.sunlighten.com/dave/ and enter code DAVE at checkout to save up to $1,400.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Aaron’s Website – www.alignpodcast.com
• Aaron's Instagram: https://www.instagram.com/aaronalexander/
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:39 Intro: Walking, lifestyle design, and longevity
• 05:38 Breathwork to shift state and boost energy
• 21:16 Honesty, alignment, and nervous system health
• 29:35 Safety, regulation, and somatic awareness
• 30:43 Touch as therapy and connection
• 31:53 Pheromones and subconscious signaling
• 35:00 Breath as a tool for emotional control
• 39:33 Growth through relationships and repair
• 43:03 Nature’s role in healing and performance
• 47:25 Tongue posture, eye movement, and fascia
• 56:32 Final thoughts on presence and physical truth
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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This episode reveals the ancient health protocols Western medicine forgot, and how they are now being used to heal stress, rewire the nervous system, and radically improve human performance.
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Host Dave Asprey sits down with Mona Sharma, a renowned Ayurvedic practitioner, celebrity wellness expert, and functional medicine advocate who grew up in a Canadian ashram. Mona combines ancient Vedic practices with cutting-edge science to help her clients, including Will Smith and other high-profile figures, achieve high performance, emotional resilience, and deep-rooted healing. She translates the 5,000-year-old system of Ayurveda into practical strategies anyone can use to optimize health in today’s chaotic world.
Together, they explore how Ayurvedic biohacking techniques like breathwork, circadian alignment, detoxification, and herbal medicine are now being validated by data in neuroscience, mitochondrial biology, and functional medicine. They also dive into trauma, stress rewiring, nervous system resilience, and how to build your own modern “ashram” for healing and longevity.
You’ll learn how to shift from hypervigilance into calm, how to optimize vagal tone, and how ancient practices like tongue scraping and ghee detox intersect with modern tools like cold therapy, nootropics, sleep optimization, and self-quantification.
If you care about biohacking, neurohacking, longevity, or want to understand how emotional states shape mitochondrial function, this episode is packed with grounded insight and powerful takeaways. It offers a masterclass in approaching health through both spiritual and systems biology perspectives, while avoiding burnout and noise.
You’ll also hear how Mona:
• Reversed her own heart condition after failed surgeries and medication
• Guides high-stress clients using Ayurvedic principles and modern lab testing
• Connects vagal nerve stimulation, breathwork, and emotional detox for lasting nervous system regulation
• Uses personalized nutrition, pulse reading, and lifestyle upgrades to treat the root cause
• Brings ancient healing into modern wellness spaces like Upgrade Labs
This is essential listening for anyone exploring Smarter Not Harder protocols, blending functional medicine with high-level biohacking, and finding sustainable ways to enhance vitality without relying on pharmaceuticals or performance fads.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing.
SPONSORS:
-Calroy | Head to https://calroy.com/dave for an exclusive discount.
-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Mona’s Website – https://www.monasharma.com/
• Mona’s Instagram: https://www.instagram.com/monasharma/?hl=en
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 00:54 Intro
• 01:44 Mona’s Personal Healing Journey
• 03:42 What Ayurveda Really Is
• 07:15 Breathwork and Daily Rituals
• 09:41 Where Western Medicine Falls Short
• 13:27 Ancient Tools That Still Work
• 22:02 Nervous System as the Healing Key
• 31:50 Rewiring Through Visualization
• 32:59 Transformations with Celebrity Clients
• 33:31 Stress in the Public Eye
• 34:18 Finding Core Values and Alignment
• 35:48 Home Detox, Real Impact
• 37:52 Blending Body and Spirit
• 48:52 Understanding Your Dosha
• 54:02 Applying Ayurveda Today
• 58:34 Final Thoughts and Takeaways
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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You’re being programmed, and it’s more subtle and pervasive than you think. From invisible influence to psychological manipulation, this episode shows you how to recognize when your thoughts aren’t really yours.
Host Dave Asprey uncovers the hidden science of mind control with Harvard historian Rebecca Lemov. She is a professor of the History of Science at Harvard University and one of the world’s leading experts on psychological manipulation, surveillance science, government experimentation, and Cold War brainwashing programs. Her groundbreaking research into MK Ultra, behavioral psychology, and reeducation campaigns reveals exactly how external forces hijack your thoughts, emotions, and decisions, without you knowing.
They break down how mind control evolved from CIA-funded brain implants and LSD experiments into today’s algorithmic persuasion, trauma-based manipulation, and tech-driven influence. This episode gives you practical tools to defend your thoughts, upgrade your awareness, and reclaim your mental sovereignty.
This is essential listening for anyone serious about biohacking, mindfulness, longevity, mental performance, self-awareness, hacking the nervous system, emotional control, and high-performance mindset training.
You’ll Learn:
• How the CIA used MK Ultra, psychedelics, hypnosis, and implants to test behavior control
• What mind control looks like in modern media, social platforms, and persuasive technology
• How unresolved trauma and emotional blind spots leave you vulnerable to manipulation
• The connection between neurohacking, mindset, and mental autonomy
• How to recognize when you are running someone else’s code
• The best psychological tools to build resilience and conscious awareness
• How to build a “mental firewall” with meditation, breathwork, and attention training
Watch this episode on YouTube for the full video experience:
https://www.youtube.com/@DaveAspreyBPR
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.
Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing.
SPONSORS:
-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.
-Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.
-OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Rebecca’s New Book – The Instability of Truth: https://wwnorton.com/books/9781324075264
• Rebecca's Website: https://rebeccalemov.com/
• Rebecca’s Instagram: https://www.instagram.com/rebeccalemov/?hl=en
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:01 Intro
• 01:49 Mind Control at Harvard
• 02:54 Hypnosis and Mental Programming
• 04:48 Morning Routines and Meditation
• 06:02 AI Companions and Digital Influence
• 11:17 MK Ultra and Government Experiments
• 20:25 Archives and the War on Truth
• 24:49 Marketing and Manipulation
• 27:22 Chilling CIA Mind Control Stories
• 33:59 Meditation and God Encounters
• 34:40 Biohacking Origins
• 35:15 Building Mental Resilience
• 36:11 Compassion as Control
• 37:54 Escaping Modern Programming
• 39:57 Free Will vs. Influence
• 46:03 Therapy and Suggestion
• 49:25 SEER Training and Torture Simulation
• 01:03:27 One-Pointed Focus
• 01:06:46 Final Reflections
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Your brain runs slow when it’s running on the wrong fuel.
In this episode of The Human Upgrade, Dave Asprey sits down with Geoffrey Woo, Stanford-trained computer scientist and founder of Ketone-IQ, to reveal the high-performance brain fuel once reserved for Special Forces and elite athletes.
Discover how ketones helped operators in combat zones sharpen focus, recover faster, and boost reaction speed by up to 30%. Learn why glucose falls short, how to hack your mitochondria for better cognition, and what it takes to unlock rapid-fire thinking on demand.
This is brain energy for people who want to win, at life, work, and everything in between. Whether you’re fasting, flying, or facing real pressure, ketones flip the switch.
You’ll Learn:
• Why ketones beat glucose for focus, speed, and mental clarity
• How Special Forces use ketones to recover brain function under stress
• The truth about esters, salts, and the new wave of ketone diols
• How ketones support faster thinking, emotional control, and clean energy
• What makes Ketone-IQ different, and how Dave stacks it for peak performance
• The best ways to combine ketones with fasting, workouts, and meditation
• Why your metabolism controls your mood, reaction time, and resilience
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Ketone-IQ Website – https://ketone.com/pages/dave-asprey?utm_source=partners&utm_medium=referral&utm_campaign=DAVE
• Geoffrey's Website: https://www.geoffreywoo.com/
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 – Trailer
• 02:00 – Intro
• 02:12 – Ketosis & brain performance
• 02:53 – Geoffrey’s background
• 03:52 – Ketone supplement evolution
• 04:41 – What makes Ketone-IQ different
• 07:18 – Manufacturing breakthroughs
• 13:53 – Entrepreneur mindset
• 18:58 – Future of biohacking
• 45:59 – Why classics still matter
• 46:23 – Cultural decline
• 47:04 – Decentralization
• 48:25 – Info overload & mental clarity
• 49:38 – Ketones & consciousness
• 57:49 – Religion & belief systems
• 01:03:32 – Key biohacking biomarkers
• 01:12:47 – Brain data & future upgrades
• 01:26:34 – Listener offer
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Your cells are starving. Not for food—but for oxygen.
In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Jason Sonners, world-renowned hyperbaric expert and regenerative medicine pioneer, to reveal how controlled oxygen under pressure is becoming one of the most powerful tools in anti-aging and performance science.
You’ll learn how hyperbaric oxygen therapy (HBOT) triggers stem cell activation, rewires your epigenome, boosts mitochondrial energy, and reverses biological aging—if you use it the right way. Jason shares breakthrough findings from his latest PhD research comparing low- and high-pressure chambers, with surprising results on inflammation, telomeres, cognitive performance, and recovery speed.
This is next-gen longevity—measurable, stackable, and customizable. From sleep upgrades and HRV boosts to stacking HBOT with fasting, methylene blue, or red light, this episode dives into what it takes to oxygenate your biology at the deepest level.
You’ll Learn:
• How hyperbaric oxygen therapy (HBOT) triggers stem cell regeneration and cellular repair
• Why mild-pressure chambers may be more powerful than you think
• What HBOT does to inflammation, brain fog, and biological aging markers
• How to stack HBOT with fasting, red light, and methylene blue for amplified results
• What Dr. Sonners’ PhD research reveals about oxygen pressure and genetic expression
• The truth about oxygen toxicity—and how to avoid the common mistakes
• How elite performers use HBOT for brain optimization, recovery, and resilience
** Get 30% of yourr tickets to the Biohacking conference by going to https://biohackingconference.com/2025 and use code ‘OXYHEALTH’ **
Thank you to our sponsors!
-Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order.
-Timeline | Head to https://www.timeline.com/dave to get 10% off your first order.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Jason's Website – www.hbotusa.com
• OxyHealth Website: https://www.oxyhealth.com/
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 Trailer
• 01:59 Intro
• 03:14 New research on aging and oxygen
• 05:39 Mild vs. hard-shell chambers
• 13:05 HBOT for longevity and stem cells
• 16:43 How to optimize your sessions
• 22:35 Best therapies to stack with HBOT
• 25:40 Oxygen delivery and safety
• 26:43 Altitude and chamber effects
• 30:01 Key benefits of hyperbaric therapy
• 34:22 Supplement synergy and timing
• 37:25 Pressure and oxygenation findings
• 39:27 Medical vs. welding oxygen
• 44:57 Safety myths and toxicity risks
• 47:39 Future of biohacking with oxygen
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Your brain has a gear you’ve never touched. Psychedelics can shift you into it.
In this episode of The Human Upgrade, Dave Asprey uncovers how high-performance psychedelic mushrooms help you access flow states, rewire your brain, and enhance clarity, energy, and emotional resilience. This is next-level biohacking rooted in real science.
You will learn how to use psychedelics with intention. When to microdose. When to go deep. How to stack them with nootropics for even stronger results. Dave breaks down the latest research on psilocybin, brain plasticity, trauma release, and how to turn ancient compounds into modern performance tools.
What You Will Learn in This Episode:
• How psychedelic shrooms unlock flow, focus, and creative power
• Why psilocybin boosts neuroplasticity, mood, and emotional healing
• Microdosing vs. full-dose: what works, when, and how
• How to stack psychedelics with nootropics and other biohacks
• The newest research on brain optimization and long-term benefits
• How to use psychedelics safely, strategically, and for real results
• Why shrooms may be the strongest mental upgrade in your toolkit
Thank you to our sponsors!
-Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial.
-fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Matt’s Website – https://mattzemon.com/
• Matt's Instagram - https://www.instagram.com/matt.zemon/
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
• 00:00 – Trailer
• 01:00 – Intro
• 06:01 – Personal Psychedelic Journeys
• 07:39 – Psychedelics and Self-Discovery
• 11:59 – Safe Use and Smart Navigation
• 29:09 – Psychedelics and Society
• 36:40 – Building Trust in the Process
• 37:14 – Facing Inner Fear
• 37:38 – Choice and Healing
• 37:51 – Diet and Conscious Decisions
• 38:55 – Judgment and Relationships
• 39:29 – Spirituality and Psychedelics
• 40:07 – The Entheogenic Reformation
• 41:29 – Past Lives and Expanded States
• 43:44 – Where Science Meets Spirituality
• 49:59 – Gratitude and Compassion in Healing
• 01:01:47 – The Power of Apologies
• 01:04:56 – Psychedelics in Therapy
• 01:08:57 – Final Thoughts on Psychedelics and Culture
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Low testosterone is sabotaging your health, motivation, and longevity. Diet alone will not fix it.
In this episode of The Human Upgrade, Dave Asprey sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to expose the truth about testosterone decline in both men and women. They break down why testosterone is crashing worldwide, why natural fixes almost always fail, and how the latest science finally makes testosterone therapy safer, simpler, and more effective than ever before.
You will discover why testosterone is essential for dopamine, brain function, sleep, muscle, libido, and mitochondrial health. Fixing your levels can reverse fatigue, brain fog, poor motivation, and slow aging itself.
Shalin reveals how new oral testosterone technology (Kyzatrex®) overcomes the dangers of old therapies and restores natural hormone rhythms without needles, creams, or dangerous side effects.
What You Will Learn in This Episode:
• Why testosterone matters for men and women at every age
• The real causes of the global testosterone crash
• Why diet, sleep, and exercise cannot fully fix low testosterone
• How testosterone drives dopamine, motivation, and longevity
• The breakthrough that makes oral testosterone safe and effective
• How Kyzatrex® lowers SHBG and boosts free testosterone naturally
• Why maintaining youthful testosterone levels protects brain, muscle, libido, and lifespan
• How to safely use testosterone therapy without suppressing fertility or causing side effects
** Visit livethrive.co/asprey to get a discount on your first month's supply! **
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Purchase Kyzatrex® – https://livethrive.co/?utm_campaign=11813552-Asprey
• Shalin’s Instagram - https://www.instagram.com/themetabolicceo/
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
00:00 Trailer
00:52 Introduction
01:29 Global Decline in Testosterone Levels
02:27 Symptoms of Low Testosterone
03:48 Personal Journey with Testosterone Therapy
05:06 The Role of Testosterone in Overall Health
06:18 Testosterone Levels in Men and Women
08:48 Challenges and Innovations in Testosterone Delivery
16:25 The Importance of Circadian Rhythm in Testosterone Therapy
19:19 The Future of Testosterone Therapy
32:00 Investment and Development in Testosterone Therapy
34:57 Introduction to FDA and Hormone Replacement
35:31 FDA’s Impact on Women’s Health
36:10 Testosterone and Cardiovascular Risk
39:05 Testosterone and Depression
40:30 Testosterone Testing and Misconceptions
44:58 The Testosterone Project and Female Hormone Therapy
47:51 Testosterone’s Role in Longevity and Health
55:37 Cost and Accessibility of Testosterone Therapy
01:04:03 Conclusion and Final Thoughts
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Your environment is rewiring your hormones, fertility, and long-term health without your consent.
In this episode of The Human Upgrade, Dave Asprey sits down with Dr. Aly Cohen, board-certified rheumatologist, integrative medicine specialist, and environmental health educator. Together they expose how common toxins in plastics, pesticides, drinking water, personal care products, and food packaging are hijacking your biology.
Dr. Cohen explains how daily chemical exposures contribute to autoimmune disease, thyroid dysfunction, hormone imbalance, infertility, obesity, cancer, and accelerated aging. You will learn how to identify hidden endocrine disruptors, spot surprising sources of microplastics and PFAS (“forever chemicals”), and apply science-backed detox strategies to protect your hormones, fertility, metabolism, and longevity.
What You’ll Learn in This Episode:
• How chemicals in household, cleaning, and beauty products disrupt hormones
• The link between environmental toxins, autoimmune disease, thyroid issues, and infertility
• Hidden sources of microplastics and PFAS chemicals and how to eliminate them
• Affordable, practical steps to detox your home, water, and personal care routine
• Dr. Cohen’s top biohacks to protect fertility, balance hormones, and build toxin resilience
THANK YOU TO OUR SPONSORS!
-BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off.
-ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order.
Resources:
• Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
• Aly’s Website – https://thesmarthuman.com/
• Aly's Website - https://alycohenmd.com/
• Aly’s New Book – Detoxify: https://alycohenmd.com/books
• 2025 Biohacking Conference: https://biohackingconference.com/2025
• Danger Coffee: https://dangercoffee.com
• Dave Asprey’s Website: https://daveasprey.com
• Dave Asprey’s Linktree: https://linktr.ee/daveasprey
• Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com
• Own an Upgrade Labs: https://ownanupgradelabs.com
• Upgrade Labs: https://upgradelabs.com
• 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com
Timestamps:
00:00 Trailer
02:01 Introduction
02:15 Rheumatism and Rheumatology
03:36 Autoimmune Diseases and Toxins
04:17 Chemical Impact on Health
04:49 Personal Health Journey
06:15 Microplastics and Immune Disruption
08:21 Resilience and Lifestyle Changes
21:45 Nutritional Deficiencies
26:48 Lab Results and Assessments
34:40 Detoxification and Resilience
41:14 Personal Journey Continued
42:22 Clean Drinking Water
44:20 Travel Hacks for Water
46:15 Hotel Room Detox Tips
50:06 EPA Water Standards
53:06 Restaurant Toxins and Home Safety
55:36 Top Toxic Household Items
01:08:31 Synthetic Materials Impact
01:13:30 Final Thoughts and Book
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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