Episodes
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Hi, This Week in Medicine, we will be discussing
First we will be discussing articles in New England Journal of Medicine
Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity
Continuation versus Interruption of Oral Anticoagulation during TAVI
Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A
CRISPR-Based Therapy for Hereditary Angioedema
Journal of American Medical Association
Health System, Community-Based, or Usual Dementia Care for Persons With Dementia and Caregivers
Palliative Care Program for Community-Dwelling Individuals With Dementia and Caregivers
The IN-PEACE Randomized Clinical Trial
Annals of Internal Medicine
The Association of Epstein–Barr Virus Donor and Recipient Serostatus With Outcomes After Kidney Transplantation
British Medical Journal
Frozen versus fresh embryo transfer in women with low prognosis for in vitro fertilisation treatment: pragmatic, multicentre, randomised controlled trial
Lancet
Coronary CT angiography-guided management of patients with stable chest pain: 10-year outcomes from the SCOT-HEART randomised controlled trial in Scotland
Journal of Clinical Oncology
Incidence of Medication-Related Osteonecrosis of the Jaw in Patients With Breast Cancer During a 20-Year Follow-Up: A Population-Based Multicenter Retrospective Study
journal of Hepatology
Patient-reported outcomes in chronic hepatitis delta: An exploratory analysis of the phase III MYR301 trial of bulevirtide
outcome following liver transplantation of patients with ACLF grade 3
Gastroenterology
Myosin Vb Traffics P-Glycoprotein to the Apical Membrane of Intestinal Epithelial Cells
Clinical Gastroenterology
Prevalence and Predictors of Follow-up Endoscopic Biopsy in Patients With Celiac Disease in the United States
Do Patients With NASH-related Cirrhosis Have Better Overall Survival Compared With Other Etiologies of Cirrhosis? A Population-based Study
Rheumatology
Associations of fire smoke and other pollutants with incident rheumatoid arthritis and rheumatoid arthritis‐associated interstitial lung disease
Circulation
Efficacy and Safety of Finerenone Across the Ejection Fraction Spectrum in Heart Failure With Mildly Reduced or Preserved Ejection Fraction: A Prespecified Analysis of the FINEARTS-HF Trial
Journals of the American College of Cardiology
Machine Learning-Based Prediction of Death and Hospitalization in Patients With Implantable Cardioverter Defibrillators
JAMA Cardiology
Artificial Intelligence–Enhanced Electrocardiography for Prediction of Incident Hypertension
Journal of Clinical Endocrinology & Metabolism
Causal Association Between BMI and Polycystic Ovarian Syndrome: Bidirectional 2-Sample Mendelian Randomization Study
Diabetes care
Glycemic and Psychosocial Outcomes of Advanced Hybrid Closed-Loop Therapy in Youth With High HbA1c: A Randomized Clinical Trial
Chest
Longitudinal Changes in Maximal Forced Inspiratory Flow and Clinical Outcomes in Patients With COPD
The American Journal of Respiratory and Critical Care Medicine
Toll-like Receptor 9 Inhibition Mitigates Fibroproliferative Responses in Translational Models of Pulmonary Fibrosis
Clinical Journal of American Society of Nephrology
Sodium-Glucose Cotransporter 2 Inhibitors and Kidney Outcomes across the Spectrum of Kidney Disease: A Systematic Review and Meta-Analysis
Cost-Effectiveness of Empagliflozin in CKD with or without Albuminuria
Kidney International reports
Randomized Trial Demonstrating No Translocation of Intact Intestinal Bacteria During Hemodialysis or Hemodiafiltration
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Hi, This Week in Medicine, we will be discussing
New England Journal of Medicine
Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer
A Randomized Trial of Drug Route in Out-of-Hospital Cardiac Arrest
Intraosseous or Intravenous Vascular Access for Out-of-Hospital Cardiac Arrest
Abelacimab versus Rivaroxaban in Patients with Atrial Fibrillation
Journal of American Medical Association
Transanal vs Laparoscopic Total Mesorectal Excision and 3-Year Disease-Free Survival in Rectal Cancer: The TaLaR Randomized Clinical Trial
Question Is transanal total mesorectal excision (TME) noninferior to laparoscopic Annals of Internal Medicine
Census Tract Rurality, Predominant Race and Ethnicity, and Distance to Lung Cancer Screening Facilities
Assessing the Risk for Falls in Older Adults After Initiating Gabapentin Versus Duloxetine
British Medical Journal
Dapagliflozin plus calorie restriction for remission of type 2 diabetes
Lancet
Transarterial chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study
Journal of Clinical Oncology
Efficacy and Safety of Roxadustat for Anemia in Patients Receiving Chemotherapy for Nonmyeloid Malignancies: A Randomized, Open-Label, Active-Controlled Phase III Study
journal of Hepatology
Induction of steatosis in primary human hepatocytes recapitulates key pathophysiological aspects of metabolic dysfunction-associated steatotic liver disease
Functional cure of hepatitis B in patients with cancer undergoing immune checkpoint inhibitor therapy
Gastroenterology
Glutamine Supplementation as a Novel Metabolic Therapeutic Strategy for LIG3-Dependent Chronic Intestinal Pseudo-Obstruction
Clinical Gastroenterology
Endoscopic Submucosal Dissection Criteria for Differentiated-type Early Gastric Cancer Are Applicable to Mixed-type Differentiated Predominant
Association Between Different Types of Physical Activity and Hepatic Steatosis and Liver Fibrosis: A Cross-Sectional Study Based on NHANES
Journal of Clinical Rheumatology
Preliminary Evaluation for the Development of a Scoring System to Predict Homozygous M694V Genotype in Familial Mediterranean Fever Patients: A Single-Center Study
Circulation
A Rare Noncoding Enhancer Variant in SCN5A Contributes to the High Prevalence of Brugada Syndrome in Thailand
Journals of the American College of Cardiology
Optimal Strategy for Complete Revascularization in ST-Segment Elevation Myocardial Infarction and Multivessel Disease: A Network Meta-Analysis
JAMA Cardiology
Cost-Effectiveness of a Polypill for Cardiovascular Disease Prevention in an Underserved Population
Journal of Clinical Endocrinology & Metabolism
Personalized Medicine in Acromegaly: The ACROFAST Study
Diabetes care
Diabetes Overtreatment and Hypoglycemia in Older Patients With Type 2 Diabetes on Insulin Therapy: Insights From the HYPOAGE Cohort Study
Chest
Neutrophil-Mediated Inflammatory Plasminogen Degradation, Rather Than High Plasminogen-Activator Inhibitor-1, May Underly Failures and Inefficiencies of Intrapleural Fibrinolysis
The American Journal of Respiratory and Critical Care Medicine
Lung Transcriptomics Link Emphysema to Barrier Dysfunction and Macrophage Subpopulations
Clinical Journal of American Society of Nephrology
Fracture in Association with Anticoagulant Therapy in Patients with CKD and Atrial Fibrillation
Albuminuria and Rapid Kidney Function Decline as Selection Criteria for Kidney Clinical Trials in Type 1 Diabetes Mellitus
Kidney International reports
Muscle Mass, Muscle Strength, and Health-Related Quality of Life in Kidney Transplant Recipients
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Missing episodes?
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Hi, This Week in Medicine, we will be discussing
New England Journal of Medicine
Transcatheter Aortic-Valve Replacement for Asymptomatic Severe Aortic Stenosis
APOL1 Bi- and Monoallelic Variants and Chronic Kidney Disease in West Africans
Fracture Prevention with Infrequent Zoledronate in Women 50 to 60 Years of Age
Survival with Trastuzumab Emtansine in Residual HER2-Positive Breast Cancer
Journal of American Medical Association
Intra-Arterial Tenecteplase Following Endovascular Reperfusion for Large Vessel Occlusion Acute Ischemic Stroke: The POST-TNK Randomized Clinical Trial
Intra-Arterial Urokinase After Endovascular Reperfusion for Acute Ischemic Stroke: The POST-UK Randomized Clinical Trial
Annals of Internal Medicine
Inequities in Distance to Lung Cancer Screening Programs
British Medical Journal
Time to nursing home admission and death in people with dementia
Lancet
Efficacy, safety, and target engagement of dazukibart, an IFNβ specific monoclonal antibody, in adults with dermatomyositis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial
Journal of Clinical Oncology
Association of Participation in Medicare's Oncology Care Model With Spending, Utilization, and Quality Outcomes Among Commercially Insured and Medicare Advantage Members
journal of Hepatology
Effect of pemvidutide, a GLP-1/glucagon dual receptor agonist, on MASLD: A randomized, double-blind, placebo-controlled study
Neuropilin-1 is a novel host factor modulating the entry of hepatitis B virus
Gastroenterology
Unveiling Cancer-Related Metaplastic Cells in Both Helicobacter pylori Infection and Autoimmune Gastritis
Clinical Gastroenterology
Satisfaction With and Adherence to Off-Label Corticosteroids in Adolescents and Adults With Eosinophilic Esophagitis: Results of a Web-Based Survey in the United States
Meta-Analysis of Endoscopic Full-Thickness Resection Versus Endoscopic Submucosal Dissection for Complex Colorectal Lesions
Rheumatology
Altered Protein Structures and Neoepitopes in Lupus Neutrophils From Dysregulated Splicing of Messenger RNA
Journal of Clinical Rheumatology
Nationwide Analysis of Variables Associated With Sarcoid Inpatient Mortality
Circulation
Sickle Trait and Alpha Thalassemia Increase NOS-Dependent Vasodilation of Human Arteries Through Disruption of Endothelial Hemoglobin-eNOS Interactions
Journals of the American College of Cardiology
Drug-Coated Balloon Angioplasty of the Side Branch During Provisional Stenting: The Multicenter Randomized DCB-BIF Trial
Aspirin and Hemocompatibility After LVAD Implantation in Patients With Atherosclerotic Vascular Disease
A Secondary Analysis From the ARIES-HM3 Randomized Clinical Trial
Journal of Clinical Endocrinology & Metabolism
Regional Adiposity and Insulin Sensitivity—Interactions With Menopause and HIV in Middle-Aged Black African Women
Diabetes care
Combination SGLT2 Inhibitor and Glucagon Receptor Antagonist Therapy in Type 1 Diabetes: A Randomized Clinical Trial
Here are the articles from Chest
Clinical Characteristics and Prognosis of Patients With Severe Pneumonia With Pneumocystis jirovecii Colonization
Here are the articles from The American Journal of Respiratory and Critical Care Medicine
Proteomic Risk Score of Increased Respiratory Susceptibility: A Multicohort Study.
Clinical Journal of American Society of Nephrology
Surrogate End Points in Apolipoprotein L1–Associated Kidney Disease: Evaluation in Three Cohorts
Medication Burden and Adverse Cardiovascular Events and Death in Patients Treated with Maintenance Hemodialysis: A Nationwide Cohort Study
Kidney International reports
Outcome of Patients Transplanted for C3 Glomerulopathy and Primary Immune Complex-Mediated Membranoproliferative Glomerulonephritis
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Hi, This Week in Medicine, we will be discussing
New England Journal of Medicine
Transcatheter Valve Replacement in Severe Tricuspid Regurgitation
Plozasiran for Managing Persistent Chylomicronemia and Pancreatitis Risk
Talquetamab plus Teclistamab in Relapsed or Refractory Multiple Myeloma
Clearance of Driver Mutations after Transplantation for Myelofibrosis
A Comparison of Peripherally Inserted Central Catheter Materials
Journal of American Medical Association
Changes in Patient Care Experience After Private Equity Acquisition of US Hospitals
Oral Glucose-Lowering Agents vs Insulin for Gestational Diabetes
Annals of Internal Medicine
Cardiovascular Safety and Fracture Prevention Effectiveness of Denosumab Versus Oral Bisphosphonates in Patients Receiving Dialysis
Assessing the Risk for Falls in Older Adults After Initiating Gabapentin Versus Duloxetine
British Medical Journal
Time to nursing home admission and death in people with dementia
Lancet
Induced pluripotent stem-cell-derived CD19-directed chimeric antigen receptor natural killer cells in B-cell lymphoma: a phase 1, first-in-human trial
Cancer Journal for Clinicians
Breast cancer statistics 2024
Journal of Clinical Oncology
Minimally Invasive Assessment of Peripheral Residual Disease During Maintenance or Observation in Transplant-Eligible Patients With Multiple Myeloma
journal of Hepatology
Effect of pemvidutide, a GLP-1/glucagon dual receptor agonist, on MASLD: A randomized, double-blind, placebo-controlled study
Induction of steatosis in primary human hepatocytes recapitulates key pathophysiological aspects of metabolic dysfunction-associated steatotic liver disease
Gastroenterology
Unveiling Cancer-Related Metaplastic Cells in Both Helicobacter pylori Infection and Autoimmune Gastritis
Clinical Gastroenterology
Satisfaction With and Adherence to Off-Label Corticosteroids in Adolescents and Adults With Eosinophilic Esophagitis: Results of a Web-Based Survey in the United States
Clinical Infectious Diseases
Epidemiology and Prognostic Factors Associated With Mold-Positive Blood Cultures: 10-Year Data From a French Prospective Surveillance Program (2012–2022)
Rheumatology
Frequency of Spondyloarthritis Symptoms Among U.S. Patients with Inflammatory Bowel Disease: A Cross‐sectional Multi‐Center Study
Circulation
Sickle Trait and Alpha Thalassemia Increase NOS-Dependent Vasodilation of Human Arteries Through Disruption of Endothelial Hemoglobin-eNOS Interactions
Journals of the American College of Cardiology
Drug-Coated Balloon Angioplasty of the Side Branch During Provisional Stenting: The Multicenter Randomized DCB-BIF Trial
JAMA Cardiology
Microaxial Flow Pump Hemodynamic and Metabolic Effects in Infarct-Related Cardiogenic ShockA Substudy of the DanGer Shock Randomized Clinical Trial
Journal of Clinical Endocrinology & Metabolism
Regional Adiposity and Insulin Sensitivity—Interactions With Menopause and HIV in Middle-Aged Black African Women
Diabetes care
Trends and Inequalities in Diabetes-Related Complications Among U.S. Adults, 2000–2020
Neurology
Patient-Relevant Digital-Motor Outcomes for Clinical Trials in Hereditary Spastic Paraplegia Type 7: A Multicenter PROSPAX Study
Chest
A 1-Year Weight Management Program for Difficult-to-Treat Asthma With Obesity
The American Journal of Respiratory and Critical Care Medicine
Association of Dose of Inhaled Corticosteroids and Frequency of Adverse Events
Clinical Journal of American Society of Nephrology
Impaired Incretin Homeostasis in Nondiabetic Moderate-to-Severe CKD
Kidney International reports
Outcome of Patients Transplanted for C3 Glomerulopathy and Primary Immune Complex-Mediated Membranoproliferative Glomerulonephritis
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Happy New year to all the listeners.
Thank you for listening in 2024 and hope to see you here weekly in 2025.
Hi, This Week in Medicine, we will be discussing
New England Journal of Medicine
Final, 10-Year Outcomes with Nivolumab plus Ipilimumab in Advanced Melanoma
Asundexian versus Apixaban in Patients with Atrial Fibrillation
Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy
Adjuvant Pembrolizumab versus Observation in Muscle-Invasive Urothelial Carcinoma
Journal of American Medical Association
Transcriptomic Profiles in Nasal Epithelium and Asthma Endotypes in Youth
Annals of Internal Medicine
Implementation of Billing for Patient Portal Messages as E-Visits in a Large Integrated Health System
British Medical Journal
Comparative effectiveness and safety of single inhaler triple therapies for chronic obstructive pulmonary disease
Lancet
Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies
Population-health impact of new drugs recommended by the National Institute for Health and Care Excellence in England during 2000–20: a retrospective analysis
journal of Hepatology
Metabolic phenotyping of patients with advanced chronic liver disease for better characterization of cirrhosis regression
Gastroenterology
Mucosal Single-Cell Profiling of Crohn’s-Like Disease of the Pouch Reveals Unique Pathogenesis and Therapeutic Targets
Clinical Infectious Diseases
Clinical characterisation and outcomes of human clade IIb mpox virus disease
Circulation
Multiplexed Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification
Journals of the American College of Cardiology
Using Electrocardiogram to Assess Diastolic Function and Prognosis in Mitral Regurgitation
AMA Cardiology
Artificial Intelligence–Enhanced Electrocardiography for Prediction of Incident Hypertension
Journal of Clinical Endocrinology & Metabolism
Regional Adiposity and Insulin Sensitivity—Interactions With Menopause and HIV in Middle-Aged Black African Women
Neurology
Patient-Relevant Digital-Motor Outcomes for Clinical Trials in Hereditary Spastic Paraplegia Type 7: A Multicenter PROSPAX Study
Chest
Exacerbation History and Risk of Myocardial Infarction and Pulmonary Embolism in COPD
Differential Association of COPD Subtypes With Cardiovascular Events and COPD Exacerbations
The American Journal of Respiratory and Critical Care Medicine
Pyrazinamide Safety, Efficacy, and Dosing for Treating Drug-Susceptible Pulmonary Tuberculosis: A Phase 3, Randomized Controlled Clinical Trial
Clinical Journal of American Society of Nephrology
Benefits and Harms of Coronary Revascularization in Non–Dialysis-Dependent Chronic Kidney Disease and Ischemic Heart Disease: A Systematic Review and Meta-Analysis
Kidney International reports
Projecting the Population Level Burden of CKD Progression According to Urine Albumin-to-Creatinine Ratio Categories
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Hi, This Week in Medicine, we will be discussing
New England Journal of Medicine
Ponsegromab for the Treatment of Cancer Cachexia
Levofloxacin for the Prevention of Multidrug-Resistant Tuberculosis in Vietnam
Ebola Outbreak Response in the DRC with rVSV-ZEBOV-GP Ring Vaccination
Twice-Yearly Depemokimab in Severe Asthma with an Eosinophilic Phenotype
Journal of American Medical Association
2024 Update of the RECOVER-Adult Long COVID Research Index
Annals of Internal Medicine
iImpaired Wnt/Planar Cell Polarity Signaling in Yellow Nail Syndrome
British Medical Journal
Christmas 2024: Age against the machine—susceptibility of large language models to cognitive impairment
Lancet
Global, regional, and national progress towards the 2030 global nutrition targets and forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2021
Journal of Clinical Oncology
Bladder-Preserving Trimodality Treatment for High-Grade T1 Bladder Cancer: Results From Phase II Protocol NRG Oncology/RTOG 0926
journal of Hepatology
Type-I interferon shapes peritoneal immunity in cirrhosis and drives caspase-5-mediated progranulin release upon infection
Gastroenterology
Spatially Resolved Niche and Tumor Microenvironmental Alterations in Gastric Cancer Peritoneal Metastases
Clinical Infectious Diseases
Impact of Intrapartum Azithromycin on the Carriage and Antibiotic Resistance of Escherichia coli and Klebsiella pneumoniae in Mothers and Their Newborns
Rheumatology
Achieving Medication‐Free Remission in Patients With Juvenile Dermatomyositis
Circulation
Therapeutic Effects of Heart Failure Medical Therapies on Standardized Kidney Outcomes: Comprehensive Individual Participant–Level Analysis of 6 Randomized Clinical Trials
Journals of the American College of Cardiology
Hypertensive Disorders of Pregnancy Increase the Risk for Myocardial Infarction: A Population-Based Study
Diabetes care
Risk of Infection in Older Adults With Type 2 Diabetes With Relaxed Glycemic Control
Chest
Occupational Exposure to Charcoal Smoke and Dust, a Major Risk Factor for COPD
Dexmedetomidine for Reducing Mortality in Patients With Septic Shock
The American Journal of Respiratory and Critical Care Medicine
Concordance and Prognostic Relevance of Different Definitions of Systemic Sclerosis Interstitial Lung Disease Progression
Clinical Journal of American Society of Nephrology
Impairment of Cardiovascular Functional Capacity in Mild-to-Moderate Kidney Dysfunction
Kidney International reports
Projecting the Population Level Burden of CKD Progression According to Urine Albumin-to-Creatinine Ratio Categories
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Hi, This Week in Medicine, we will be discussing
First we will be discussing articles in New England Journal of Medicine
Ponsegromab for the Treatment of Cancer Cachexia
Levofloxacin for the Prevention of Multidrug-Resistant Tuberculosis in Vietnam
Ebola Outbreak Response in the DRC with rVSV-ZEBOV-GP Ring Vaccination
Twice-Yearly Depemokimab in Severe Asthma with an Eosinophilic Phenotype
Journal of American Medical Association
2024 Update of the RECOVER-Adult Long COVID Research Index
Annals of Internal Medicine
Risk for Financial Precarity From Hospitalization: Implications for Targeting Financial Assistance in Medicare
Lancet
Efficacy and safety of mirikizumab in patients with moderately-to-severely active Crohn's disease: a phase 3, multicentre, randomised, double-blind, placebo-controlled and active-controlled, treat-through study
Journal of Clinical Oncology
Omission of Radiotherapy in Primary Mediastinal B-Cell Lymphoma: IELSG37 Trial Results
Gastroenterology
An Empirical Dietary Pattern Associated With the Gut Microbial Features in Relation to Colorectal Cancer Risk
Journal of Clinical Rheumatology
Evaluating Meaningful Changes in Patient‐Reported Outcome Measurement Information System–Fatigue Scores from Three Phase 3 Clinical Trials of Sarilumab for Patients With Rheumatoid Arthritis
Circulation
NT-proBNP and Cardiac Troponin I, but Not Cardiac Troponin T, Are Associated With 7-Year Changes in Cardiac Structure and Function in Older Adults: The ARIC Study
Journals of the American College of Cardiology
2-Fold More Cardiovascular Disease Events Decades Before Type 2 Diabetes Diagnosis: A Nationwide Registry Study
JAMA Cardiology
Amiodarone or Implantable Cardioverter-Defibrillator in Chagas CardiomyopathyThe CHAGASICS Randomized Clinical Trial
Diabetes care
Relationship of Plasma Apolipoprotein C-I Truncation With Risk of Diabetes in the Multi-Ethnic Study of Atherosclerosis and the Actos Now for the Prevention of Diabetes Study
Chest
Severity of Inhalation Injury and Risk of Nosocomial Pneumonia
Association of RBC Transfusion Thresholds and Outcomes in Medical Patients With Acute Respiratory Failure Supported With Extracorporeal Membrane Oxygenation
The American Journal of Respiratory and Critical Care Medicine
Association Between Baseline Driving Pressure and Mortality in Very Old Patients with Acute Respiratory Distress Syndrome
Clinical Journal of American Society of Nephrology
Breast and Prostate Cancer Screening by Life Expectancy in Patients with Kidney Failure on Dialysis
Kidney International reports
Pilot Trial of Hydroxychloroquine as Add-On Therapy in Patients With Membranous Nephropathy
Urine Protein-to-Creatinine Ratio Remains Informative Despite Nonsteady State Serum Creatinine During Acute Kidney Injury
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Hi, This Week in Medicine, we will be discussing
New England Journal of Medicine
PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation
Insulin Efsitora versus Degludec in Type 2 Diabetes without Previous Insulin Treatment
Bedaquiline Monotherapy for Multibacillary Leprosy
Obecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia
CRISPR-Cas9 Gene Editing with Nexiguran Ziclumeran for ATTR Cardiomyopathy
Journal of American Medical Association
Electronic Sepsis Screening Among Patients Admitted to Hospital Wards
Early Restrictive vs Liberal Oxygen for Trauma Patients: The TRAUMOX2 Randomized Clinical Trial
Annals of Internal Medicine
Development and Evaluation of a Comprehensive Prediction Model for Incident Coronary Heart Disease Using Genetic, Social, and Lifestyle–Psychological Factors: A Prospective Analysis of the UK Biobank
British Medical Journal
Contemporary menopausal hormone therapy and risk of cardiovascular disease: Swedish nationwide register based emulated target trial
Lancet
National-level and state-level prevalence of overweight and obesity among children, adolescents, and adults in the USA, 1990–2021, and forecasts up to 2050
Journal of Clinical Oncology
Clinical Outcomes and Histologic Findings of Patients With Hepatocellular Carcinoma With Durable Partial Response or Durable Stable Disease After Receiving Atezolizumab Plus Bevacizumab
Hepatology
Low-to-moderate alcohol consumption is associated with increased fibrosis in individuals with metabolic dysfunction-associated steatotic liver disease
Gastroenterology
Exon-Skipping–Based Subtyping of Colorectal Cancers
Rheumatology
Revisiting the Link Between HLA-DRB1 Alleles and Autoantibodies in Rheumatoid Arthritis: Association of non-Shared Epitope Alleles *09 and *15 With High Levels of Anti–Citrullinated Peptide/Protein Antibodies
Journal of Clinical Rheumatology
Periprosthetic Joint Infection in Patients With Inflammatory Arthritis: Optimal Tests to Differentiate From Flares
Circulation
Randomized Invitation to Systematic NT-proBNP and ECG Screening in 75-Year-Olds to Detect Atrial Fibrillation: STROKESTOP II
Journals of the American College of Cardiology
Hospitalization of Symptomatic Patients With Heart Failure and Moderate to Severe Functional Mitral Regurgitation Treated With MitraClip: Insights From RESHAPE-HF2
Endocrinology
Diabetes care
Initiation of Intermittently Scanned Continuous Glucose Monitoring Is Associated With Reduced Hospitalization for Acute Diabetes Events and Cardiovascular Complications in Adults With Type 1 Diabetes
Chest
Impact of Dyspnea on Adults With Respiratory Symptoms Without a Defined Diagnosis
Comparison of Early and Late Norepinephrine Administration in Patients With Septic Shock
The American Journal of Respiratory and Critical Care Medicine
Application of the European Respiratory Society/American Thoracic Society Spirometry Standards and Race-Neutral Equations in the COPDGene Study
Next we will be discussing articles In the field of Nephrology
Clinical Journal of American Society of Nephrology
Bioimpedance-Guided Fluid Removal in Continuous KRT: The VENUS Randomized Clinical Trial
Kidney International reports
Anti Phospholipase A2 Receptor 1 Antibodies and Membranous Nephropathy Recurrence After Kidney Transplantation
Combination Therapy With Rituximab and Low-Dose Cyclophosphamide and Prednisone in Membranous Nephropathy
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Hi, This Week in Medicine, we will be discussing
New England Journal of Medicine
Edoxaban Antithrombotic Therapy for Atrial Fibrillation and Stable Coronary Artery Disease
Inflammation, Cholesterol, Lipoprotein(a), and 30-Year Cardiovascular Outcomes in Women
Xalnesiran with or without an Immunomodulator in Chronic Hepatitis B
Trastuzumab Deruxtecan after Endocrine Therapy in Metastatic Breast Cancer
Prenatal cfDNA Sequencing and Incidental Detection of Maternal Cancer
Journal of American Medical Association
HepB-CpG vs HepB-Alum Vaccine in People With HIV and Prior Vaccine NonresponseQuestion Does vaccination with a hepatitis B vaccine with a cytosine phosphoguanine adjuvant (HepB-CpG vaccine) improve hepatitis B virus (HBV) seroprotection in people with HIV and nonresponse to prior hepatitis B vaccine?
Message Reminders to Improve Adherence to Chronic Cardiovascular Medications
Annals of Internal Medicine
A Framework for Considering the Value of Race and Ethnicity in Estimating Disease Risk
British Medical Journal
Chocolate intake and risk of type 2 diabetes: prospective cohort studies
Lancet
Balloon guide catheters for endovascular thrombectomy in patients with acute ischaemic stroke due to large-vessel occlusion in China (PROTECT-MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial
Journal of Clinical Oncology
Phase III KEYNOTE-789 Study of Pemetrexed and Platinum With or Without Pembrolizumab for Tyrosine Kinase Inhibitor‒Resistant, EGFR–Mutant, Metastatic Nonsquamous Non–Small Cell Lung Cancer
journal of Hepatology
Differing genetic variants associated with liver fat and their contrasting relationships with cardiovascular diseases and cancer
Gastroenterology
Atlas of Metastatic Gastric Cancer Links Ferroptosis to Disease Progression and Immunotherapy Response
Rheumatology
Axial Spondyloarthritis in Black Americans: An Observational Study From Five Centers in Shelby County, Tennessee
Journal of Clinical Rheumatology
Anticoagulant Treatment May Decrease the Relapse Rate of Pulmonary Arterial Involvement in Behçet’s Disease
Circulation
Restrictive Versus Liberal Transfusion in Patients With Type 1 or Type 2 Myocardial Infarction: A Prespecified Analysis of the MINT Trial
Journals of the American College of Cardiology
Major Bleeding and Mortality After Revascularization of Left Main Disease
Diabetes care
Clinical Prediction Models Combining Routine Clinical Measures Have High Accuracy in Identifying Youth-Onset Type 2 Diabetes Defined by Maintained Endogenous Insulin Secretion: The SEARCH for Diabetes in Youth Study
American Journal of Respiratory and Critical Care Medicine
Severity of Airflow Obstruction Based on FEV1/FVC Versus FEV1 Percent
Kidney International reports
Prognosis for Type 1 Diabetes with Diabetic Nephropathy between 2000 and 2020 - Changes in Kidney Function Decline Over Time and Development of Cardiovascular Disease, Kidney Failure, and Mortality
Evaluation of Race-Neutral Glomerular Filtration Rate Estimating Equations in an Indian Population
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Hi, This Week in Medicine, we will be discussing
New England Journal of Medicine
Overall Survival with Pembrolizumab in Early-Stage Triple-Negative Breast Cancer
Fractional Doses of Pneumococcal Conjugate Vaccine — A Noninferiority Trial
Nivolumab plus Ipilimumab in Microsatellite-Instability–High Metastatic Colorectal Cancer
Journal of American Medical Association
Association of Severe Maternal Morbidity With Subsequent Birth
Intravenous Lidocaine for Gut Function Recovery in Colonic Surgery
Transcatheter Edge-to-Edge Repair for Severe Isolated Tricuspid Regurgitation
The Tri.Fr Randomized Clinical Trial
Annals of Internal Medicine
Association of Work Control With Burnout and Career Intentions Among U.S. Physicians: A Multi-Institution Stud
British Medical Journal
Contemporary menopausal hormone therapy and risk of cardiovascular disease
Lancet
Balloon guide catheters for endovascular thrombectomy in patients with acute ischaemic stroke due to large-vessel occlusion in China (PROTECT-MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial
Cancer Journal for Clinicians
A phase 2 study of a brachyury-targeting vaccine in combination with radiation therapy for the treatment of advanced chordoma
Journal of Clinical Oncology
Prospective Study of Supplemental Screening With Contrast-Enhanced Mammography in Women With Elevated Risk of Breast Cancer: Results of the Prevalence Round
journal of Hepatology
Efficacy, tolerability and pharmacokinetics of survodutide, a glucagon/glucagon-like peptide-1 receptor dual agonist, in cirrhosis
Glutaryl-CoA dehydrogenase suppresses tumor progression and shapes an anti-tumor microenvironment in hepatocellular carcinoma
Gastroenterology
Gut Pathobiont–Derived Outer Membrane Vesicles Drive Liver Inflammation and Fibrosis in Primary Sclerosing Cholangitis–Associated Inflammatory Bowel Disease
Clinical Gastroenterology
Updated Reference Intervals for Alanine Aminotransferase in a Metabolically and Histologically Normal Population
Clinical Infectious Diseases
The Use of Long-term Antibiotics for Suppression of Bacterial Infections
Rheumatology
Implementing Patient Health Questionnaire Depression Screening in Inflammatory Arthritis Clinic
Journal of Clinical Rheumatology
Circulation
ErbB3 Governs Endothelial Dysfunction in Hypoxia-Induced Pulmonary Hypertension
Journals of the American College of Cardiology
Recaticimab Monotherapy for Nonfamilial Hypercholesterolemia and Mixed Hyperlipemia: The Phase 3 REMAIN-1 Randomized Trial
JAMA Cardiology
Routine Protamine Administration for Bleeding in Transcatheter Aortic Valve ImplantationThe ACE-PROTAVI Randomized Clinical Trial
Journal of Clinical Endocrinology & Metabolism
Obesity, Inflammation, and Clinical Outcomes in COVID-19: A Multicenter Prospective Cohort Study
Diabetes care
Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study
Neurology
SGLT2 Inhibitor Use and Risk of Dementia and Parkinson Disease Among Patients With Type 2 Diabetes
Chest
Rethinking Blood Eosinophils for Assessing Inhaled Corticosteroids Response in COPD
The American Journal of Respiratory and Critical Care Medicine
Preacinar Arterial Dilation Mediates Outcomes of Quantitative Interstitial Abnormalities in the COPDGene Study
Clinical Journal of American Society of Nephrology
Acute Myocardial Infarction and Chronic Kidney Disease: A Nationwide Cohort Study on Management and Outcomes from 2010 to 2022
Kidney International reports
Randomized Trial of Patiromer on Efficacy to Reduce Episodic Hyperkalemia in Patients with ESKD Treated With Hemodialysis
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in New England Journal of Medicine
Nationwide, Couple-Based Genetic Carrier Screening
Adjunctive Middle Meningeal Artery Embolization for Subdural Hematoma
Safety and Efficacy of Immunization with a Late-Liver-Stage Attenuated Malaria Parasite
Journal of American Medical Association
Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores
Zerlasiran—A Small-Interfering RNA Targeting Lipoprotein(a): A Phase 2 Randomized Clinical Trial
Annals of Internal Medicine
The Effect of Denosumab on Risk for Emergently Treated Hypocalcemia by Stage of Chronic Kidney Disease
British Medical Journal
Nurse and doctor turnover and patient outcomes in NHS acute trusts in England
Lancet
Induced pluripotent stem-cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human interventional study in Japan
Cancer Journal for Clinicians
Efficacy and safety of nivolumab monotherapy in patients with unresectable clear cell sarcoma and alveolar soft part sarcoma
Journal of Clinical Oncology
Trastuzumab Deruxtecan in Advanced Solid Tumors With Human Epidermal Growth Factor Receptor 2 Amplification Identified by Plasma Cell-Free DNA Testing: A Multicenter, Single-Arm, Phase II Basket Trial
Hepatology
Sodium taurocholate cotransporting polypeptide (NTCP) polymorphisms may influence HDV RNA load and early response to bulevirtide
Hepatic venous pressure gradient predicts risk of hepatic decompensation and liver-related mortality in patients with MASLD
Gastroenterology
Molecular Mechanisms Underlying Loss of Vascular and Epithelial Integrity in Irritable Bowel Syndrome
Clinical Gastroenterology
Prevalence and Determinants of Liver Disease in Relatives of Italian Patients With Advanced MASLD
Clinical Infectious Diseases
Prevalence, Clinical Severity, and Serotype Distribution of Pneumococcal Pneumonia Among Adults Hospitalized With Community-Acquired Pneumonia in Tennessee and Georgia, 2018–2022
Rheumatology
Circulating Adipokines and Response to Treatment in Patients With Early Rheumatoid Arthritis
Journal of Clinical Rheumatology
Prevalence and Clinical Implications of Autoantibodies in Juvenile Dermatomyositis: A Single-Center Experience From India
Circulation
Single-Cell RNA Sequencing Reveals Metabolic Stress-Dependent Activation of Cardiac Macrophages in a Model of Dyslipidemia-Induced Diastolic Dysfunction
Journals of the American College of Cardiology
Complete vs Culprit-Only Revascularization in Older Patients With Myocardial Infarction With or Without ST-Segment Elevation
JAMA Cardiology
Verinurad Plus Allopurinol for Heart Failure With Preserved Ejection FractionThe AMETHYST Randomized Clinical Trial
Journal of Clinical Endocrinology & Metabolism
Hemostatic Effects of Exercise-related Hypoglycemia in Male Persons With Type 1 Diabetes
Diabetes care
Trends in Racial and Ethnic Disparities in Early Glycemic Control Among Veterans Receiving Care in the Veterans Health Administration, 2008–2019
Neurology
Quantitative MRI Measures and Cognitive Function in People With Drug-Resistant Juvenile Myoclonic Epilepsy
Chest
Air Pollution Metabolomic Signatures and Chronic Respiratory Diseases Risk
A Longitudinal Study
The American Journal of Respiratory and Critical Care Medicine
Lung-Protective Mechanical Ventilation in Patients with Severe Acute Brain Injury: A Multicenter Randomized Clinical Trial (PROLABI)
Clinical Journal of American Society of Nephrology
Physical Function and Mortality in Older Adults with Chronic Kidney Disease
Kidney International reports
Associations of Urine Epidermal Growth Factor With Kidney and Cardiovascular Outcomes in Individuals With CKD in SPRINT
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New England Journal of Medicine
Perioperative Durvalumab with Neoadjuvant Chemotherapy in Operable Bladder Cancer
Transcatheter Repair versus Mitral-Valve Surgery for Secondary Mitral Regurgitation
Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation
Preoperative Chemoradiotherapy for Resectable Gastric Cancer
Journal of American Medical Association
Symptom Screening Linked to Care Pathways for Pediatric Patients With Cancer: A Randomized Clinical Trial
Tenofovir and Hepatitis B Virus Transmission During Pregnancy
Symptom Screening Linked to Care Pathways for Pediatric Patients With Cancer
Annals of Internal Medicine
Association Between False-Positive Results and Return to Screening Mammography in the Breast Cancer Surveillance Consortium Cohort
British Medical Journal
SGLT-2 inhibitors and mortality among patients with heart failure with reduced ejection fraction
Malnutrition in infants aged 6-23 months in China’s poorest rural counties from 2016 to 2021
Lancet
Genetic sequencing analysis of monkeypox virus clade I in Republic of the Congo: a cross-sectional, descriptive study
Cancer Journal for Clinicians
Comparison of infection risk between enzalutamide and abiraterone in patients with prostate cancer
Journal of Clinical Oncology
Stockholm3 in a Multiethnic Cohort for Prostate Cancer Detection (SEPTA): A Prospective Multicentered Trial
Hepatology
CRISPR-Cas13b-mediated suppression of HBV replication and protein expression
Epigenetic scars in regulatory T cells are retained after successful treatment of chronic hepatitis C with direct-acting antivirals
Gastroenterology
The Global Incident Gastrointestinal Cancers Attributable to Suboptimal Diets From 1990 to 2018
Clinical Gastroenterology
The Efficacy of Real-time Computer-aided Detection of Colonic Neoplasia in Community Practice: A Pragmatic Randomized Controlled Trial
Clinical Infectious Diseases
Preventing New Gram-negative Resistance Through Beta-lactam De-escalation in Hospitalized Patients With Sepsis: A Retrospective Cohort Study
Rheumatology
Gout Flare Burden in the United States: A Multiyear Cross‐Sectional Survey Study
Journal of Clinical Rheumatology
Development and Validation of Nosocomial Bacterial Infection Prediction Models for Patients With Systemic Lupus Erythematosus
Circulation
Complete Versus Culprit-Only Revascularization in Older Patients With ST-Segment–Elevation Myocardial Infarction: An Individual Patient Meta-Analysis
Journals of the American College of Cardiology
Comprehensive Proteomic Profiling of Human Myocardium Reveals Signaling Pathways Dysregulated in Hypertrophic Cardiomyopathy
JAMA Cardiology
Prehospital Pulse-Dose Glucocorticoid in ST-Segment Elevation Myocardial InfarctionThe PULSE-MI Randomized Clinical Trial
Journal of Clinical Endocrinology & Metabolism
Medullary Thyroid Cancer: Single Institute Experience Over 3 Decades and Risk Factors for Recurrence
Diabetes care
Development of a Core Outcome Set for Studies Assessing Interventions for Diabetes-Related Foot Ulceration
Neurology
Identification of Genetic Loci Associated With Intracerebral Hemorrhage Using a Multitrait Analysis Approach
Chest
Sex Differences After Treatment With Ivacaftor in People With Cystic Fibrosis
The American Journal of Respiratory and Critical Care Medicine
Low-Dose Morphine Does Not Cause Sleepiness in Chronic Obstructive Pulmonary Disease: A Secondary Analysis of a Randomized Clinical Trial
Clinical Journal of American Society of Nephrology
Association between Chronic Kidney Disease-Mineral and Bone Disorder Biomarkers and Symptom Burden in Older Patients with Advanced Chronic Kidney Disease: Results from the EQUAL Study
Kidney International reports
IMPACT CKD: Holistic Disease Model Projecting 10-Year Population Burdens
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New England Journal of Medicine
Invasive Treatment Strategy for Older Patients with Myocardial Infarction
Randomized Trial of Very Early Medication Abortion
Neoadjuvant Nivolumab and Ipilimumab in Resectable Stage III Melanoma
Final Results for Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma
Journal of American Medical Association
Postmarketing Surveillance of Inferior Vena Cava Filters Among US Medicare Beneficiaries
The SAFE-IVC Study
A Digital Health Behavior Intervention to Prevent Childhood Obesity
The Greenlight Plus Randomized Clinical Trial
Annals of Internal Medicine
Ensuring Safe Practice by Late Career Physicians: Institutional Policies and Implementation Experiences
British Medical Journal
SGLT-2 inhibitors and mortality among patients with heart failure with reduced ejection fraction
Lancet
Optimal timing of anticoagulation after acute ischaemic stroke with atrial fibrillation (OPTIMAS): a multicentre, blinded-endpoint, phase 4, randomised controlled trial
Cancer Journal for Clinicians
Epidemiology, treatment patterns, and clinical outcomes in de novo oligometastatic hormone-sensitive prostate cancer
Journal of Clinical Oncology
Addition of Metastasis-Directed Therapy to Systemic Therapy for Oligometastatic Pancreatic Ductal Adenocarcinoma (EXTEND): A Multicenter, Randomized Phase II Trial
journal of Hepatology
Diagnostic performance of non-invasive tests in patients with MetALD in a health check-up cohort
Histological improvements following energy restriction and exercise: The role of insulin resistance in resolution of MASH
Gastroenterology
Gluten-Dependent Activation of CD4+ T Cells by MHC Class II–Expressing Epithelium
Clinical Gastroenterology
Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial
Clinical Infectious Diseases
Successful Treatment of Carbapenem-Resistant Acinetobacter baumannii Meningitis With Sulbactam-Durlobactam
Rheumatology
Comprehensive Enteroviral Serology Links Infection and Anti‐Melanoma Differentiation‐Associated Protein 5 Dermatomyositis
Journal of Clinical Rheumatology
Factors Associated With Successful Withdrawal of Biologic Agents in Children With Colchicine-Resistant Familial Mediterranean Fever
Circulation
Contemporary Outcomes and Trends for the Transseptal Mitral Valve-in-Valve Procedure Using Balloon Expandable Transcatheter Valves in the United States
Journals of the American College of Cardiology
Reaffirmation of Mechanistic Proteomic Signatures Accompanying SGLT2 Inhibition in Patients With Heart Failure: A Validation Cohort of the EMPEROR Program
Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure
Journal of Clinical Endocrinology & Metabolism
Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas
Diabetes care
Health Care Utilization and Costs Associated With Empagliflozin in Older Adults With Type 2 Diabetes
Neurology
Frequency and Longitudinal Course of Behavioral and Neuropsychiatric Symptoms in Participants With Genetic Frontotemporal Dementia
Chest
Primary Ciliary Dyskinesia in Adult Bronchiectasis
American Journal of Respiratory and Critical Care Medicine
Discovery and Validation of a Volatile Signature of Eosinophilic Airway Inflammation in Asthma
Clinical Journal of American Society of Nephrology
Urine Output and Acute Kidney Injury in Neonates/Younger Children: A Prospective Study of Cardiac Surgery Patients with Indwelling Urinary Catheters
Large Discordance between Creatinine-Based and Cystatin C–Based eGFRs is Associated with Falls, Hospitalizations, and Death in Older Adults
Kidney International reports
Systematic Review of Individual Patient Data COVID-19 Infection and Vaccination–Associated Thrombotic Microangiopathy
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New England Journal of Medicine
Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis
Inavolisib-Based Therapy in PIK3CA-Mutated Advanced Breast Cancer
Isatuximab, Bortezomib, Lenalidomide, and Dexamethasone for Multiple Myeloma
Total Hip Replacement or Resistance Training for Severe Hip Osteoarthritis
from Journal of American Medical Association
Early Intervention in Patients With Asymptomatic Severe Aortic Stenosis and Myocardial Fibrosis
The EVOLVED Randomized Clinical Trial
Annals of Internal Medicine
Projected Impact and Cost-Effectiveness of Novel Molecular Blood-Based or Stool-Based Screening Tests for Colorectal Cancer
Comparative Effectiveness and Safety of Atorvastatin Versus Rosuvastatin: A Multi-database Cohort Study
British Medical Journal
Comparative effectiveness of sodium-glucose cotransporter-2 inhibitors for recurrent nephrolithiasis among patients with pre-existing nephrolithiasis or gout: target trial emulation studies
Lancet
The effect of tranexamic acid on postpartum bleeding in women with moderate and severe anaemia (WOMAN-2): an international, randomised, double-blind, placebo-controlled trial
Journal of Clinical Oncology
Randomized Phase II Trial of Immunotherapy-Based Total Neoadjuvant Therapy for Proficient Mismatch Repair or Microsatellite Stable Locally Advanced Rectal Cancer (TORCH)
journal of Hepatology
Histological improvements following energy restriction and exercise: The role of insulin resistance in resolution of MASH
Gastroenterology
A Single-Cell Atlas of the Murine Pancreatic Ductal Tree Identifies Novel Cell Populations With Potential Implications in Pancreas Regeneration and Exocrine Pathogenesis
Fazirsiran for Adults With Alpha-1 Antitrypsin Deficiency Liver Disease: A Phase 2 Placebo Controlled Trial (SEQUOIA)
Clinical Infectious Diseases
Evidence-Informed Provision of Doxycycline Post-Exposure Prophylaxis for Prevention of Bacterial Sexually Transmitted Infections
Abstract
Rheumatology
Implementing Patient Health Questionnaire Depression Screening in Inflammatory Arthritis Clinic: Insights From a Quality Improvement Project at a Tertiary Rheumatology Center
Circulation
RNA Helicase DDX5 Maintains Cardiac Function by Regulating CamkIIδ Alternative Splicing
Journals of the American College of Cardiology
Urinary Metal Levels and Coronary Artery Calcification: Longitudinal Evidence in the Multi-Ethnic Study of Atherosclerosis
JAMA Cardiology
Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure
Journal of Clinical Endocrinology & Metabolism
Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas
Diabetes care
Sitting Time and Its Interaction With Physical Activity in Relation to All-Cause and Heart Disease Mortality in U.S. Adults With Diabetes
The American Journal of Respiratory and Critical Care Medicine
The Effect of Positive End-Expiratory Pressure on Pulmonary Vascular Resistance Depends on Lung Recruitability in Patients with Acute Respiratory Distress Syndrome
Rationale: A U-shaped relationship should exist between lung volume and Kidney International reports
Prospective Trial on the Pharmacokinetics of Clopidogrel in Hemodialysis Patients
A Survey on End-of-Life Contemplation Among Patients on Dialysis
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New England Journal of Medicine
Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction
Amivantamab plus Lazertinib in Previously Untreated EGFR-Mutated Advanced NSCLC
Collagenase Injection versus Limited Fasciectomy for Dupuytren’s Contracture
Journal of American Medical Association
Dialysis Facility Staffing Ratios and Kidney Transplant Access Among Adolescents and Young Adults
Expanded Newborn Screening Using Genome Sequencing for Early Actionable Conditions
Annals of Internal Medicine
Colorectal Cancer Screening Completion and Yield in Patients Aged 45 to 50 Years: An Observational Study
British Medical Journal
Association of holidays and the day of the week with suicide risk: multicounty, two stage, time series study
Lancet
Induction chemotherapy followed by standard chemoradiotherapy versus standard chemoradiotherapy alone in patients with locally advanced cervical cancer (GCIG INTERLACE): an international, multicentre, randomised phase 3 trial
Journal of Clinical Oncology
Social Characteristics and Adherence to Adjuvant Endocrine Therapy in Premenopausal Women With Breast Cancer
journal of Hepatology
Diagnostic performance of non-invasive tests in patients with MetALD in a health check-up cohort
Gastroenterology
Effect of Brain-Gut Behavioral Treatments on Abdominal Pain in Irritable Bowel Syndrome: Systematic Review and Network Meta-Analysis
Targeting 5-Hydroxytryptamine Receptor 1A in the Portal Vein to Decrease Portal Hypertension
Clinical Gastroenterology
Vonoprazan is Efficacious for Treatment of Heartburn in Non-erosive Reflux Disease: A Randomized Trial
Clinical Infectious Diseases
Comparative safety of different antibiotic regimens for the treatment of outpatient community-acquired pneumonia among otherwise healthy adults
Journal of Clinical Rheumatology
Factors Associated With Successful Withdrawal of Biologic Agents in Children With Colchicine-Resistant Familial Mediterranean Fever
Circulation
Novel Long Noncoding RNA HEAT4 Affects Monocyte Subtypes, Reducing Inflammation and Promoting Vascular Healing
Journals of the American College of Cardiology
Heart Failure Risk Assessment Using Biomarkers in Patients With Atrial Fibrillation: Analysis From COMBINE-AF
Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure
Journal of Clinical Endocrinology & Metabolism
Obesity, Inflammation, and Clinical Outcomes in COVID-19: A Multicenter Prospective Cohort Study
Diabetes care
Empowering Hospitalized Patients With Diabetes: Implementation of a Hospital-wide CGM Policy With EHR-Integrated Validation for Dosing Insulin
Use of Financial Incentives to Promote Adolescent Type 1 Diabetes Self-management: A Pilot Randomized Controlled Trial
Neurology
Frequency and Longitudinal Course of Behavioral and Neuropsychiatric Symptoms in Participants With Genetic Frontotemporal Dementia
Chest
Characteristics of Adults With Severe Asthma in Childhood
A 60-Year Follow-Up Study
The American Journal of Respiratory and Critical Care Medicine
Genetically Predicted Body Mass Index and Mortality in Chronic Obstructive Pulmonary Disease
Clinical Journal of American Society of Nephrology
Urine Output and Acute Kidney Injury in Neonates/Younger Children: A Prospective Study of Cardiac Surgery Patients with Indwelling Urinary Catheters
Kidney International reports
Elevated Ambient Temperature Associated With Increased Cardiovascular Disease–Risk Among Patients on Hemodialysis
Lower Parathyroid Hormone Levels are Associated With Reduced Fracture Risk in Japanese Patients on Hemodialysis
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New England Journal of Medicine
Nivolumab+AVD in Advanced-Stage Classic Hodgkin’s Lymphoma
Safety of Kidney Transplantation from Donors with HIV
A Modular Communicative Leadless Pacing–Defibrillator System
Phase 3 Trial of Stereotactic Body Radiotherapy in Localized Prostate Cancer
Journal of American Medical Association
Testing and Evaluation of Health Care Applications of Large Language Models
A Systematic Review
Annals of Internal Medicine
School Mask Mandates and COVID-19: The Challenge of Using Difference-in-Differences Analysis of Observational Data to Estimate the Effectiveness of a Public Health Intervention
British Medical Journal
Paternal metformin use and risk of congenital malformations in offspring in Norway and Taiwan: population based, cross national cohort study
Progress of nations in the organisation of, and structures for, kidney care delivery between 2019 and 2023: cross sectional survey in 148 countries
Lancet
Reductions in recurrence in women with early breast cancer entering clinical trials between 1990 and 2009: a pooled analysis of 155 746 women in 151 trials
Journal of Clinical Oncology
Human Leukocyte Antigen Mismatching and Survival in Contemporary Hematopoietic Cell Transplantation for Hematologic Malignancies
journal of Hepatology
Diagnostic performance of non-invasive tests in patients with MetALD in a health check-up cohort
Gastroenterology
Subcutaneous Infliximab (CT-P13 SC) as Maintenance Therapy for Inflammatory Bowel Disease: Two Randomized Phase 3 Trials (LIBERTY)
Prognostic Factors for Early Recurrence After Resection of Pancreatic Cancer: A Systematic Review and Meta-Analysis
Clinical Infectious Diseases
Successful Treatment of Carbapenem-Resistant Acinetobacter baumannii Meningitis With Sulbactam-Durlobactam
Rheumatology
Leveraging Habits to Improve Adherence to Gout Medications: A Qualitative Study
Journal of Clinical Rheumatology
Development and Validation of Nosocomial Bacterial Infection Prediction Models for Patients With Systemic Lupus Erythematosus
Circulation
Neurofilament Light Chain and Risk of Stroke in Patients With Atrial Fibrillation
Journals of the American College of Cardiology
Bivalirudin vs Heparin Anticoagulation in STEMI: Confirmation of the BRIGHT-4 Results
JAMA Cardiology
Leadless Ultrasound-Based Cardiac Resynchronization System in Heart Failure
Journal of Clinical Endocrinology & Metabolism
Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas
Diabetes care
Discrepancy Between Genetically Predicted and Observed BMI Predicts Incident Type 2 Diabetes
Associations of High BMI and Excessive Gestational Weight Gain With Pregnancy Outcomes in Women With Type 1 Diabetes
Neurology
Association of Polygenic Risk Score With Lifetime Risk of Developing Multiple Sclerosis in a Population-Based Birth-Year Cohort
Chest
Characteristics of Adults With Severe Asthma in Childhood
The American Journal of Respiratory and Critical Care Medicine
Impact of Using Pre- and Postbronchodilator Spirometry Reference Values in a Chinese Population
Clinical Journal of American Society of Nephrology
Urine Output and Acute Kidney Injury in Neonates/Younger Children: A Prospective Study of Cardiac Surgery Patients with Indwelling Urinary Catheters
Kidney International reports
Imlifidase in Highly Sensitized Kidney Transplant Recipients With a Positive Crossmatch Against a Deceased Donor
Losing Much More Than a Transplant: A Qualitative Study of Kidney Transplant Recipients’ Experiences of Graft Failure
-
New England Journal of Medicine
Beta-Blocker Interruption or Continuation after Myocardial Infarction
Hematologic Cancer after Gene Therapy for Cerebral Adrenoleukodystrophy
Lentiviral Gene Therapy for Cerebral Adrenoleukodystrophy
Durvalumab after Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer
Journal of American Medical Association
Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial
Extracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery: The SIRAKI02 Randomized Clinical Trial
Annals of Internal Medicine
Pain Reduction With Oral Methotrexate in Knee Osteoarthritis
British Medical Journal
Rainfall events and daily mortality across 645 global locations
Lancet
Tivozanib plus nivolumab versus tivozanib monotherapy in patients with renal cell carcinoma following an immune checkpoint inhibitor: results of the phase 3 TiNivo-2 Study
Effects of oral sepiapterin on blood Phe concentration in a broad range of patients with phenylketonuria (APHENITY): results of an international, phase 3, randomised, double-blind, placebo-controlled trial
Journal of Clinical Oncology
Post-Transplant Cyclophosphamide–Based Graft-Versus-Host Disease Prophylaxis Attenuates Disparity in Outcomes Between Use of Matched or Mismatched Unrelated Donors
Gastroenterology
WNT Oncogenic Transcription Requires MYC Suppression of Lysosomal Activity and EPCAM Stabilization in Gastric Tumors
Organoids for Functional Precision Medicine in Advanced Pancreatic Cancer
Journal of Clinical Rheumatology
Factors Associated With Successful Withdrawal of Biologic Agents in Children With Colchicine-Resistant Familial Mediterranean Fever
Circulation
Relationship of Subendocardial Perfusion to Myocardial Injury, Cardiac Structure, and Clinical Outcomes Among Patients With Hypertension
Journals of the American College of Cardiology
Minimum National Prevalence of Diagnosed Atrial Fibrillation Inferred From California Acute Care Facilities
Diabetes care
Hemoglobin A1c Genetics and Disparities in Risk of Diabetic Retinopathy in Individuals of Genetically Inferred African American/African British and European Ancestries
Comprehensive Multiple Risk Factor Control in Type 2 Diabetes to Mitigate Heart Failure Risk: Insights From a Prospective Cohort Study
The American Journal of Respiratory and Critical Care Medicine
Exploring Definitions and Predictors of Severe Asthma Clinical Remission after Biologic Treatment in Adults
Kidney International reports
Clinical Outcomes of a Novel Multidisciplinary Care Program in Advanced Kidney Disease (PEAK)
Bringing a Systems Approach to Living Donor Kidney Transplantation
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New England Journal of Medicine
Twice-Yearly Lenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women
Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity
Standard or Extended Lymphadenectomy for Muscle-Invasive Bladder Cancer
Journal of American Medical Association
Screening for Helicobacter pylori to Prevent Gastric Cancer
Assessment of Antitachycardia Pacing in Primary Prevention Patients
The APPRAISE ATP Randomized Clinical Trial
Annals of Internal Medicine
Time-Restricted Eating in Adults With Metabolic Syndrome: A Randomized Controlled Trial
British Medical Journal
Model of integrated mental health video consultations for people with depression or anxiety in primary care
Lancet
Global burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050
journal of Hepatology
Prospective validation of the EASL management algorithm for acute kidney injury in cirrhosis
Gastroenterology
Comparison of Vonoprazan Versus Intravenous Proton Pump Inhibitor for Prevention of High-Risk Peptic Ulcers Rebleeding After Successful Endoscopic Hemostasis: A Multicenter Randomized Noninferiority Trial
Clinical Gastroenterology
Representation of Racial Minorities in the United States Colonoscopy Surveillance Interval Guidelines
Clinical Infectious Diseases
Make Modern Microbiology Matter More in the 2023 European Society of Cardiology Guidelines for the Management of Infective Endocarditis
HIV, HIV-Specific Factors, and Myocardial Disease in Women
Arthritis and Rheumatology
Expanded CD8+CD38+ T Cell Population in Patients With Systemic Lupus Erythematosus Is Linked to Increased Infection Rates: A Prospective Study
Circulation
Race and Sex Differences in the Association of Bystander CPR for Cardiac Arrest
Journals of the American College of Cardiology
Anticoagulation Alone vs Anticoagulation Plus Aspirin or DAPT Following Left Atrial Appendage Occlusion
JAMA Cardiology
Rare and Common Genetic Variation Underlying Atrial Fibrillation Risk
Journal of Clinical Endocrinology & Metabolism
Contralateral Suppression in Adrenal Venous Sampling Predicts Clinical and Biochemical Outcome in Primary Aldosteronism
Diabetes care
Long-term Neurobehavioral and Metabolic Outcomes in Offspring of Mothers With Diabetes During Pregnancy: A Large, Population-Based Cohort Study in Ontario, Canada
Neurology
Public Views on Whether the Use of Pharmaceutical Neuroenhancements Should Be Allowed
Chest
Barriers and Facilitators of Surrogates Providing Consent for Critically Ill Patients in Clinical Trials
\
The American Journal of Respiratory and Critical Care Medicine
Biological Age, Chronological Age, and Survival in Pulmonary Fibrosis: A Causal Mediation Analysis
Clinical Journal of American Society of Nephrology
A National Survey of Pregnancy and Parenthood among Nephrology Trainees: A Focus on Nephrology Fellowship
Kidney International reports
APOL1 High-Risk Genotype is Not Associated With New or Worsening of Proteinuria or Kidney Function Decline Following COVID-19 Vaccination
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New England Journal of Medicine
Results after Four Years of Screening for Prostate Cancer with PSA and MRI
Ziresovir in Hospitalized Infants with Respiratory Syncytial Virus Infection
Gene Therapy with Fidanacogene Elaparvovec in Adults with Hemophilia B
Journal of American Medical Association
Fever Prevention in Patients With Acute Vascular Brain Injury: The INTREPID Randomized Clinical Trial
Thrombectomy for Stroke With Large Infarct on Noncontrast CT
The TESLA Randomized Clinical Trial
Annals of Internal Medicine
Severe Maternal and Neonatal Morbidity Among Gestational Carriers: A Cohort Study
British Medical Journal
Model of integrated mental health video consultations for people with depression or anxiety in primary care
Lancet
Mineralocorticoid receptor antagonists in heart failure: an individual patient level meta-analysis
journal of Hepatology
B-cell characteristics define HCV reinfection outcome
Gastroenterology
Gut Microbiota-Derived Butyrate Induces Epigenetic and Metabolic Reprogramming in Myeloid-Derived Suppressor Cells to Alleviate Primary Biliary Cholangitis
Clinical Gastroenterology
Efficacy and Safety of Vedolizumab and Tumor Necrosis Factor Inhibitors in the Treatment of Steroid-refractory Microscopic Colitis: A Systematic Review and Meta-analysis
Clinical Infectious Diseases
Drivers of Geographic Patterns in Outpatient Antibiotic Prescribing in the United States
Nosocomial Infections in Adults Receiving Extracorporeal Membrane Oxygenation: A Review for Infectious Diseases Clinicians
sparent reporting of practices at individual facilities in future clinical trials.
Arthritis and Rheumatology
Prevalence and Risk of Immunostimulatory Herbal Supplement Treatment Among Autoimmune Dermatology Patients
Cardiology
Mineralocorticoid Receptor Antagonism Prevents Aortic Plaque Progression and Reduces Left Ventricular Mass and Fibrosis in Patients With Type 2 Diabetes and Chronic Kidney Disease: The MAGMA Trial
Journals of the American College of Cardiology
Antithrombotic Strategies in Atrial Fibrillation After ACS and/or PCI: A 4-Way Comparison From AUGUSTUS
JAMA Cardiology
Plasma Proteomics of Exercise Blood Pressure and Incident Hypertension
Journal of Clinical Endocrinology & Metabolism
The Spectrum of Dysregulated Aldosterone Production: An International Human Physiology Study
] Diabetes care
Effectiveness of Multilevel and Multidomain Interventions to Improve Glycemic Control in U.S. Racial and Ethnic Minority Populations: A Systematic Review and Meta-analysis
Neurology
Graded Multidimensional Clinical and Radiologic Variation in Patients With Alzheimer Disease and Posterior Cortical Atrophy
Chest
Changes in Spirometry Interpretative Strategies
The American Journal of Respiratory and Critical Care Medicine
Physiologic Effects of Extracorporeal Membrane Oxygenation in Patients with Severe Acute Respiratory Distress Syndrome
Clinical Journal of American Society of Nephrology
A Six-Year Follow-Up of Bloodstream Infections in Hemodialysis Facilities in the United States, National Healthcare Safety Network, 2020
Kidney International reports
Global aHUS Registry Analysis of Patients Switching to Ravulizumab From Eculizumab
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First we will be discussing articles in New England Journal of Medicine
Long-Term Oxygen Therapy for 24 or 15 Hours per Day in Severe Hypoxemia
Community-Based Cluster-Randomized Trial to Reduce Opioid Overdose Deaths
Axatilimab in Recurrent or Refractory Chronic Graft-versus-Host Disease
Pomalidomide for Epistaxis in Hereditary Hemorrhagic Telangiectasia
Journal of American Medical Association
Risk Stratification in Nonischemic Dilated Cardiomyopathy Using CMR Imaging
Malaria Rapid Tests, Febrile Illness Management, and Child Mortality Across Sub-Saharan African Countries
Annals of Internal Medicine
Factors Associated With Recurrent Pediatric Firearm Injury: A 10-Year Retrospective Cohort Analysis
Class I Recalls of Cardiovascular Devices Between 2013 and 2022: A Cross-Sectional Analysis
British Medical Journal
Cumulative live birth rate of a blastocyst versus cleavage stage embryo transfer policy during in vitro fertilisation in women with a good prognosis
Lancet
Temporary mechanical circulatory support in infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials with 6-month follow-up
Gastroenterology
Resolution of Acinar Dedifferentiation Regulates Tissue Remodeling in
Clinical Gastroenterology
Symptom Outcomes of Celiac Disease in Those on a Gluten-free Diet
Clinical Infectious Diseases
Changes in the Appropriateness of US Outpatient Antibiotic Prescribing After the COVID-19 Outbreak
The Value of Outpatient Parenteral Antimicrobial Therapy: Better Care in 27 Minutes
Arthritis and Rheumatology
Returning Incidental Research Findings from FDG PET/CT to Participants
Circulation
Induction of DEPP1 by HIF Mediates Multiple Hallmarks of Ischemic Cardiomyopathy
Journals of the American College of Cardiology
Triglyceride Levels, Alirocumab Treatment, and Cardiovascular Outcomes After an Acute Coronary Syndrome
JAMA Cardiology
Postpartum Ambulatory Blood Pressure Patterns Following New-Onset Hypertensive Disorders of Pregnancy
Journal of Clinical Endocrinology & Metabolism
An Open-label Phase 2 Study of Eneboparatide, a Novel PTH Receptor 1 Agonist, in Hypoparathyroidism
Diabetes care
Association Between Accelerometer-Measured Irregular Sleep Duration and Type 2 Diabetes Risk: A Prospective Cohort Study in the UK Biobank
Neurology
Pathologic Substrates of Structural Brain Network Resilience and Topology in Parkinson Disease Decedents
Chest
Effect of Corticosteroids on Long-Term Humoral and Memory T-Cell Responses in Follow-Up Visit of Hospitalized Patients With COVID-19
The American Journal of Respiratory and Critical Care Medicine
Potential Diaphragm Muscle Weakness-related Dyspnea Persists 2 Years after COVID-19 and Could Be Improved by Inspiratory Muscle Training: Results of an Observational and an Interventional Clinical Trial
Clinical Journal of American Society of Nephrology
Lower-Dosage Acute Peritoneal Dialysis versus Acute Intermittent Hemodialysis in Acute Kidney Injury: A Randomized Controlled Trial
Kidney International reports
Phase 1b/2a Study Assessing the Safety and Efficacy of Felzartamab in Anti-Phospholipase A2 Receptor Autoantibody–Positive Primary Membranous Nephropathy
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