Эпизоды
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For our third episode in our "Tools for Looking into the Brain" series, we are joined by Dr. Adil Khan, a neuroscientist and group leader at King's College London, to explore reading and writing patterns into the brain. We discuss the principles of two major tools used to examine and manipulate neural activity, namely two-photon microscopy and optogenetics, and explore how they have been applied to answering questions about the neural basis of flexible cognition and behaviour in the Khan lab.
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In today's episode, we are joined by Professor Tiago Branco, a Principal Investigator and Group Leader at the Sainsbury Wellcome Centre at UCL. The Branco lab studies how instinctive decisions are computed from sensory information, and from representations of the world built from experience. In this episode, we discuss what different sorts of approaches (top-down vs bottom-up) you can employ to study the neural basis of behaviour, and how computational models of behaviours can be created and used based on experimental data. Drawing on Professor Branco's extensive experience in the field of neuroscience, we delve into his research past and how it led him to pursue his current focus. We also explore how ethologically relevant naturalistic behaviours can be studied in a lab, and the paradigms that are utilised for this purpose in the context of instinctive defensive behaviours and responses to imminent threat.
You can find out more about the Branco Lab here: https://www.sainsburywellcome.org/web/groups/branco-labToday’s episode was made possible thanks to the support of the Sainsbury Wellcome Public Engagement fund. We would like to thank Sainsbury Welcome Centre (SWC) for the generous grant supporting Science Communication initiatives like these. https://www.sainsburywellcome.org/web/
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Пропущенные эпизоды?
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Today's episode is about fungi & lichen! We are joined by George Mears, a PhD student at Royal Holloway and Kew Gardens. Having carried out research on the evolutionary impact of the lichen lifestyle on the fungal genome during his Masters, George is currently in the LIDo iCASE PhD program, working under Professor Robin Williams to continue biological research into plant-derived products. In this episode, we discuss the ancient symbiotic relationships between plants and fungi and how lichens have impacted fungi evolution and vice versa.
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In today’s episode we are celebrating women’s day by discussing the current state of women’s reproductive healthcare and research, how much progress has been made and what still needs to be done. We are joined by Professor Sohier Elneil, a UCL Professor and Consultant specialising in Urogynaecology and Uroneurology.
Professor Elneil completed her PhD at the University of Cambridge in the physiology and pharmacology of sensory bladder dysfunction in women and now runs the neuromodulation programme for bladder and pelvic floor dysfunction at the National Hospital for Neurology and Neurosurgery. As well as actively teaching at University College London, the Royal College of Obstetricians and Gynaecologists.
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Welcome back to Neuroverse, this week we bring to you the second episode in our mini-series "Tools for Looking into the Brain", where we explore the diversity of experimental methods used to study the brain's structure and function. In this episode, we discuss the basic principles of fluorescence microscopy and how it can help us understand the brain. We explore how we can make cells of the brain fluorescent in the first place, and the different types of microscopes that are used to visualise and image this fluorescence, from widefield to confocal to 2-photon microscopes! We also discussed the advantages of each microscopy technique, and explored some examples of research studies that have taken advantage of them.
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Happy Valentines day! We hope today you celebrate love in all its shapes and forms.
It is also our Neuroverse 2 year anniversary! What better way to celebrate than to dive deep into Love's effect on the brain, from the neurobiology to the philosophy (Neuroverse style). We discuss how the initial phases of falling in Love activates the same biological pathways as acute stress, causing the classical symptoms of sleeplessness, shortness of breath and longing, as well as how long-term leave and heart-break is manifested in the brain. We also postulate about the epistemology of Love and if Plato was right about the idea of soulmates, based on the myth that Zeus separated four-armed and legged humans, cursed to forever search for their second halves. Or was it Fernando Pessoa that got its right when he said "We never love anyone. What we love is the idea we have of someone. It’s our own concept—our own selves—that we love."
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In today's episode we've answered some of your questions! Topics ranging from academic advice, lab and research environments, personal life choices and more. Tune in to find out the questions asked!
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In today's episode we are joined by Professor Carlos Ribeiro, who is based at the Champalimaud Research Institute in Lisbon. We discuss research in fruit flies (drosophila melanogaster) in the context of neuroscience and metabolism, the benefits of individual animal models in research, and how interdisciplinary approaches are key for the future of science. We also enquire into creativity and what it means to be creative in science, and much more!
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In today's episode, we delve into the complexities of sound. What is sound? Is it defined by what produces it or by what hears it? Is sound purely physical, or is it a construct of our minds? Is the perception of sound comparable to the perception of colour? We discuss these fascinating questions and more, and reflect on what sound means to us!
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In our final episode of 2023, we chat about another full year of Neuroverse- our highlights, favourite episodes, what we've most enjoyed learning about, what major questions and themes have arisen, and what we're excited for to come in 2024!Thank you so much for all your support in the past year.
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In today's episode we are joined by Pierre Glaser to discuss designing generative models. Pierre Glaser is a PhD student in Machine Learning at the Gatsby Computational Neuroscience Unit in UCL. He is working with Professor Arthur Gretton on advancing the methodology of flexible generative modelling. We discuss what generative models are (such as ChatGPT, Dall-E), what fitting a probabilistic model to a dataset entails, how physics and neuroscience are used in these models, and many more captivating topics!Today’s episode was made possible thanks to the support of the Sainsbury Wellcome Public Engagement fund. We would like to thank Sainsbury Welcome Centre (SWC) for the generous grant supporting Science Communication initiatives like these. https://www.sainsburywellcome.org/web/
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We are launching a new mini-series focusing on experimental methods to study the brain! How do we look at and listen to the activity of neurons, populations of neurons, and the whole brain? In this series, we will be exploring the multitude of techniques and recent advances in technologies to study the brain.
To kick of the series, in this episode we discuss patch-clamping, a type of electrophysiological technique that is used to measure the electrical activity and biophysical properties of individual neurons. Drawing on some of our personal experiences, we discuss the uses and challenges of patch-clamp, what we can discover from it, how different variations can offer different insights, and the future of patch-clamp. ---
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In this episode, we are joined by a special guest, Dr. Estella Newcombe, to discuss protein dysregulation in neurodegenerative disorders.
Estella is currently a Marie Sklodowska-Curie Fellow at the University of Copenhagen in the structural biology and NMR laboratory, researching intrinsically disordered proteins in the context of neurodegenerative disorders. Estella holds a Bachelor’s degree in Biotechnology and Chemistry from the University of Queensland and a PhD in Biochemistry and Molecular Biology from the University of Melbourne, where she studied the interactions and structures of proteins in Huntington’s disease. She subsequently worked as a postdoctoral fellow at the Queensland Brain Institute studying the structures of intrinsically disordered proteins. Based on her wide range of experience in the fields of structural protein biology and neuroscience, in this episode we discuss the value of studying human neurodegenerative disorders at the level of protein-protein interactions. We cover what intrinsically disordered proteins are, the relevance of structure-function relationships, and how environmental factors influence protein dysfunction in neurodegeneration.
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In today’s episode, Carolina and Clara discuss what beautiful science is, and what makes a beautiful experiment? We delve into aesthetics, what is good and beautiful in science, and highlight how these can influence bias in scientific experiments
---We hope you enjoy the episode! Please feel free to share with your friends and family, it means a lot to us🤍Neuroverse Websitehttps://neuroversepod.comPodcast directoryhttps://anchor.fm/neuroverse9 Support us! https://ko-fi.com/neuroverse Twitter: @neuroverse_podhttps://twitter.com/neuroverse_pod?s=21&t=KvAEuwGNKFQ9IPKlL7NTEg Instagram: @Neuroverse_pod https://instagram.com/neuroverse_pod?igshid=YmMyMTA2M2Y= Help us improve our podcast by giving us some feedback! https://forms.gle/PuEMC1BCWXdAqCRQA
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In this episode, we were joined by a special guest, Sydney Leaman, to discuss cellular identity and reprogramming cells in the brain. Sydney holds a BSc and MSc in human genetics as well as a medical degree and is currently completing his PhD in translational neurodevelopment at the MRC Centre for Neurodevelopmental Disorders in King's College London, where he works on reprogramming neuronal identity in the brain. We discuss the motivation behind reprogramming cells, the potential clinical applications for improving regenerative medicine, the challenges that the reprogramming field has faced, the future of reprogramming, and what cellular identity really means. Listen to find out more!
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This week, Carolina & Clara discuss the development of a novel technology- storing data in DNA. As the human population is producing an expontentially growing amount of data every day, it is easy to forget that all of this data also needs to be stored in a physical form. Currently, digital data is largely stored in exabyte centres, large warehouses that require millions of dollars and tons of electricity to maintain. Novel solutions relying on organic materials and biological technologies are therefore necessary for a sustainable approach to data storage. One growing method that is becoming increasingly possible is storing digital binary data in DNA, which is a natural data store that utilises its own unique genetic code. In this episode, we explore the possibility of DNA data storage, the limitations and challenges that need to be overcome, and the future of data.
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In today’s episode Carolina and Clara discuss biomimetic and bioinspired materials and the challenge with understanding the biological structure of natural materials to then create additional intelligent biological materials that allow us to bridge various challenges. But what about not only mimicking nature? What about creating ‘living’ materials that you can have a bi-directional flow of information? Well.. stay tuned to find out how some scientists where able to control cardiomyocytes (heart muscle cells) with light! Using nature as an inspiration to address problems in building materials for safer architecture that can withstand natural disasters from spider silk and resilin or materials such as chitosan that can change its solubility based on the pH of the environment can be crucial for drug deliver systems. ---
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This week, Carolina & Clara discuss the theory of Morphic Resonance. First proposed by Rupert Sheldrake in 1981, the theory of Morphic Resonance accounts for the laws of nature as being habits and a form of collective memory that accumulates across time, rather than ground truth upon which all of nature is built upon. In this episode, we discuss the validity of the theory, evaluate the empirical evidence that exists, and explore how it applies to different areas of knowledge and scales of existence. Listen to find out more!
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In today’s episode Carolina and Clara discuss stress, stressors and the impacts of chronic stress. Stress is a physiological response that aids us in situations of danger, however in our modern society we have created more abstract stressors which may lead to a chronic stress state. The cortisol cycle is a big player in this area. They also discuss mindfulness and other practices to help keep stress at bay!
This episode topic was picked by you guys! Do let us know what future topics you’d like to see us do next, you can do so by commenting on our social media.
We would also like to announce our new Neuroverse intro music! Kindly provided by TakT, two extremely talented science-artists. You can check out their other music and art-work here: (Music) https://open.spotify.com/artist/6R19JFl7psTx6wNMAMCQos?si=aj_wNBZAT-KIvCb0FthJjg
(Art) https://taktarts.com/about-us
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In this episode, Carolina & Clara discuss synapses in the brain. What are they? What is their function and importance? Where did they originate from? How are they different across evolutionarily distinct species? They also discuss how recent research in comb jellies has brought back to life an age-old debate between Santiago Ramon y Cajal and Camillo Golgi about the basis of communication in the brain.
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