Episoder
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Reza Shervin-Badv, a paediatric epileptologist and neurologist talks about the diverse care available for people in Iran, plus the common epilepsy stigma which is being challenged through education and advances in medical care.
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๐ Website & more about Reza: ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/reza-shervin-badv-iran-epilepsy-stigma
______________
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป https://www.epilepsysparks.com/glossary
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Find out about a new epilepsy discovery; how the microRNA-335 molecule impacts people with both Dravet Syndrome and Temporal Lobe Epilepsy, and what this could mean for research going forward! All with post-doc researcher Mona Heiland!
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๐ Website & more about Mona: ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/mona-heiland-newly-discovered-molecule-microrna-335
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Chapters ๐
00:00 Trailer & Intro
00:45 Meet Mona
01:07 Explaining Sodium Channel Epilepsies
06:03 Understanding MicroRNAs and Their Role in Epilepsy
07:47 Research Findings on MicroRNA-335 and Sodium Channels
10:01 Future Directions in Precision Therapies for Epilepsy
11:18 Conclusion & thanks
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป https://www.epilepsysparks.com/glossary
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๐ฒ Join me on social media!
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Manglende episoder?
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Physicist Sjoerd Vos shares his research in neuroimaging; aiming at decreasing language decline caused by temporal lobe resections!
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๐ Website & more about Sjoerd
https://www.torierobinson.com/epilepsy-sparks-insights/sjoerd-vos-physics-mri-temporal-lobe-epilepsy-resection-cognitive
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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Eduardo Pรฉrez Palma, a neurogenetics scientist and bioinformatician, discusses his work in neurogenetics and epilepsy research, emphasising the importance global collaboration in studying the epilepsies in different parts of the world! Eduardo also shares the upcoming Latin American Congress on Genetic Epilepsiesin Jan 2025; which aims to bring together experts from various fields to share knowledge and perspectives!
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๐ Website & more about Eduardo: ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/eduardo-perez-palma-neurogenetics-dee-latin-america
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Chapters ๐
- Intro to Eduardo
- The Value of Genetic Testing in Epilepsy
- Diversity and Representation in Genetic Research
- Understanding Developmental Epileptic Encephalopathies (DEEs)
- Contributing to Epilepsy Research
- Latin American Congress on Epileptsy Genetics
- Conclusion & thanks
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป https://www.epilepsysparks.com/glossary
------------------------------------------
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#genetics #neurogenetics #exomesequencing #epilepsy
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Learn of exciting research into a drug screening platform for personalised medicine for the epilepsies - through adult neurologist and researcher Patrick Kwan; head of the Kwan Lab! Patrick describes the process of extracting stem cells from blood, culturing them, and using them to develop new treatments for drug-resistant epilepsy. The conversation highlights the importance of collaboration and data sharing in epilepsy research.
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๐ Website & more about Patrick๐
https://www.torierobinson.com/epilepsy-sparks-insights/patrick-kwan-advances-stem-cell-research-epilepsy
-----------------------------------------
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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People with an epilepsy might be nervous about getting "gene therapy" - but in today's mini-episode, in part 2 of 2, epileptologist Josรฉ M Serratosa is asked if he would get gene therapy and why(!), explains the use of viral vectors for treating genetic epilepsies, where we are in preclinical development, what is next, and what is also holding us back!
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๐ Transcription & more about Josรฉ: ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/jose-m-serratosa-gene-therapies-viral-vectors
-----------------------------------------
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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#epilepsy #genetherapy #genetics #vectors #viralvectors #lafora
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What does the future for epilepsy treatments hold?! Epileptologist Josรฉ M Serratosa shares his predictions for epilepsy gene therapies; highlighting the importance of addressing all symptoms - including cognitive, motor, and psychiatric - as well as the seizures. Jose explains the role of viral vectors and how they may save people! This is part 1 of 2 with Josรฉ - in part 2, the conversation goes into the challenges of research clinical trials for these therapies; from basic, to pre-clinical, to clinical!
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๐ Transcription & more about Josรฉ: ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/jose-m-serratosa-future-epilepsy-gene-therapies
-----------------------------------------
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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#epilepsy #genetherapy #genetics #vectors #viralvectors #lafora
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Michael Sperling, a prof of neurology and director of the Jefferson Comprehensive Epilepsy Center, educates us on laser ablation therapy for epilepsy! He and Torie discuss the minimally invasive nature of the procedure, its advantages over traditional open surgery, and its efficacy in reducing seizures. They also touch on the suitability of the therapy for different age groups and types of epilepsy. The conversation highlights the precision and safety of laser ablation therapy and its potential to improve outcomes for patients.
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Michaelโs related papers ๐
https://www.researchgate.net/profile/Michael-Sperling-2
______________
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Who knows about Acute Symptomatic Seizures and how the babies and children experiencing them can be carefully weaned off of the anti-seizure medications they are on? Paediatric neurologist and epilepsy specialist Maria Gogou from University General Hospital of Alexandroupolis, Greece, explains more. Paediatric neurologist and epilepsy specialist Maria Gogou from University General Hospital of Alexandroupolis, Greece, explains more.
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๐ Website & more about Maria ๐
https://www.torierobinson.com/epilepsy-sparks-insights/maria-gogou-acute-symptomatic-seizures-weaning-babies-asms
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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Children may benefit from being weaned off of anti-seizure medications when they are on the ketogenic diet. Plus, find out how the ketogenic diet can significantly benefit children with epilepsy - even when it doesnโt control their seizures! Paediatric neurologist Maria Gogou discusses her work in managing rare and complex epilepsies in children.
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๐ Paper: โAntiseizure medication reduction and withdrawal in children with drug-resistant epilepsy after starting the ketogenic dietโ ๐
https://onlinelibrary.wiley.com/doi/full/10.1111/dmcn.15377
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๐ Website, transcription, & more about Maria ๐
https://www.torierobinson.com/epilepsy-sparks-insights/maria-gogou-staying-on-a-keto-diet-that-doesnt-work-dravet
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Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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David Henshall shares how information gathered when researching worms led to the discovery of microRNA, a far improved understanding of the epilepsies, and potential treatments - all explained in his new book (link below)! This is episode 2 of 2.
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Davidโs book ๐
https://www.amazon.co.uk/Fine-Tuning-Life-MicroRNAs-Genomes-Regulators/dp/1009466429/ref=sr_1_1
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๐ Website & more about David: ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/david-henshall-micro-rna-epilepsy
-----------------------------------------
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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#epilepsy #mrna #genetics #geneticepilepsy #DavidHenshall
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David Henshall discusses the role and importance the role of microRNAs in epilepsy; which act as master regulators of gene activity and help stabilise the gene pathway. He discusses the potential of RNA therapy in treating epilepsy and the challenges of delivering RNA molecules to the brain. Henshall's book, 'Fine Tuning Life: A Guide to MicroRNAs, Your Genome's Master Regulators,' explores the fascinating world of microRNAs and their impact on gene regulation.
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Davidโs book ๐
https://www.amazon.co.uk/Fine-Tuning-Life-MicroRNAs-Genomes-Regulators/dp/1009466429/ref=sr_1_1
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๐ Website & more about David: ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/david-henshall-fighting-epilepsy-with-micrornas
-----------------------------------------
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป
https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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#epilepsy #mrna #genetics #geneticepilepsy #DavidHenshall
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Epileptologist Eddie Chengo from Kenya discusses the stigma faced by people affected by epilepsy in Africa, explaining that around 75% of people with epilepsy in the region experience stigma and emphasising the importance of addressing this whilst implementing medical treatment. Eddie also shares the various initiatives and research projects his organisation is undertaking to raise awareness and challenge the stigma associated with epilepsy.
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๐ Eddie's papers ๐
https://www.researchgate.net/scientific-contributions/Eddie-Chengo-44151310
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๐ Website & more about Eddie ๐
https://www.torierobinson.com/epilepsy-sparks-insights/eddie-chengo-epilepsy-stigma-kenya
-----------------------------------------
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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#epilepsy #neurology #stigma #discrimination
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A mutation of a gene can lead to lack of absorption of glucose (our fuel) and cause epilepsy! Carla Marini, a paediatric neurologist and neuropsychiatrist tells us all about the rare epilepsy and metabolic disorder GLUT1 Deficiency Syndrome, emphasising the importance of early diagnosis, treatment using the ketogenic diet (which can help control seizures, improve cognitive function, and decrease the impacts of movement disorders). She also highlights the value of working closely with patient and family groups to understand the clinical manifestations and natural history of the disease. Carla shares an uplifting success story of a patient who has thrived with early intervention.
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Papers mentioned ๐
โGlucose Transporter 1 Deficiency as a Treatable Cause of Myoclonic Astatic Epilepsyโ:https://jamanetwork.com/journals/jamaneurology/fullarticle/1107863
โEarly onset absence epilepsy due to mutations in the glucose transporter GLUT1โ:https://www.researchgate.net/publication/26864996_Early_onset_absence_epilepsy_due_to_mutations_in_the_glucose_transporter_GLUT1
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๐ Website & more about Carla ๐
https://www.torierobinson.com/epilepsy-sparks-insights/carla-marini-glut1-disorder-metabolism-genetic
-----------------------------------------
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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Neuroscientist Nazanin Azarinejad Mohammadi discusses her research on epilepsy genetics, the clinical and functional characterisation of GABAA-receptor related disorders, and how mutations in the GABAA-receptor subunits can lead to epilepsy and morbidities. Nazanin also highlights the variability in symptoms among individuals with the same mutation and the need for further research to understand the factors that contribute to this variability. Plus, emphasised is the importance of genetic testing and personalised treatment for patients with these mutations.
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Paper: โClinical and functional characterization of GABAA-receptor related disorders: translating genetic diagnostics into personalized treatmentโ ๐
https://portal.findresearcher.sdu.dk/en/publications/clinical-and-functional-characterization-of-gabaa-receptor-relate
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๐ Website & more about Nazanin ๐
https://www.torierobinson.com/epilepsy-sparks-insights/nazanin-azarinejad-mohammadi-genetic-testing-personalised-treatment-GABA-receptors
-----------------------------------------
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
-----------------------------------------
๐ฒ Join me on social media!
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As well as preventing up to 100% of seizures in 20% of those with refractory focal epilepsy, Cenobamate may also (indirectly), positively impact mental health, cognitive function and reduce seizure propagation. Ricardo Morcos shares information on the titration of Cenobamate, how it is not suitable during pregnancy, and the importance of a 1:1 clinician-patient relationship. This is part 2 of 2.
Please note that this is not an endorsement of any particular anti-seizure medication (Cenobamate or any of the others mentioned) and any questions or ideas from a patient or carer must be brought up with oneโs neurologist/epileptologist.
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Spanish consensus on the management of concomitant anti-seizure medications when using Cenobamate in adults with drug-resistant focal seizures ๐
https://www.researchgate.net/publication/379572148_Spanish_consensus_on_the_management_of_concomitant_antiseizure_medications_when_using_cenobamate_in_adults_with_drug-resistant_focal_seizures
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๐ Website & more about Ricardo ๐
https://www.torierobinson.com/epilepsy-sparks-insights/ricardo-mocos-starting-cenobamate-cognition-pregnancy
-----------------------------------------
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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-
As well as preventing up to 100% of seizures in 20% of those with refractory focal epilepsy, Cenobamate may also (indirectly), positively impact mental health, cognitive function and reduce seizure propagation. Ricardo Morcos shares information on the titration of Cenobamate, pregnancy, and the importance of a 1:1 clinician-patient relationship. This is part 2 of 2.
Please note that this is not an endorsement of any particular anti-seizure medication (Cenobamate or any of the others mentioned) and any questions or ideas from a patient or carer must be brought up with oneโs neurologist/epileptologist.
------------------------------------------
Spanish consensus on the management of concomitant anti-seizure medications when using Cenobamate in adults with drug-resistant focal seizures
https://www.researchgate.net/publication/379572148_Spanish_consensus_on_the_management_of_concomitant_antiseizure_medications_when_using_cenobamate_in_adults_with_drug-resistant_focal_seizures
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๐ Website & more about Ricardo ๐
https://www.torierobinson.com/epilepsy-sparks-insights/ricardo-mocos-cenobamate-game-changer-for-epilepsy
-----------------------------------------
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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#cenobamate #focalepilepsy #partialseizures #epilepsy #RicardoMocos
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For the 11th World Brain Day, hear from co-chair and lead neurologist Tissa Wijeratne, who explains how so many of the brain disorders in nearly 4 billion people can be prevented, and how you can help this happen! Links to the free World Brain Day webinar, and more, are below.
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๐ง Listen to ESI on Spotify!๐
https://open.spotify.com/show/14rwL06qUowezZQGwpR7GW?si=dE4AEAsrQhqbeDc8dKM-dQ
Also on Apple Podcasts or anywhere else you listen!
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World Brain Day ๐
https://wfneurology.org/activities/news-events/wfn-news/2024-05-07-wfn-wbd
World Brain Day webinar ๐
https://us02web.zoom.us/webinar/register/WN_ayYclSOLRSKwriPFg7S5bg#/registration
World Brain Day content toolkit ๐
https://drive.google.com/drive/folders/1TD_CyerWAa_x65614G6UmWJ8WUBocGNz
World Health Organization Intersectoral Global Action Plan ๐
https://www.who.int/publications/i/item/9789240096356
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๐ Website & more about Tissa ๐
https://www.torierobinson.com/epilepsy-sparks-insights/tissa-wijeratne-world-brain-day-2024
-----------------------------------------
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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#WorldBrainDay #WBD2024 #BrainHealthandPrevention #TissaWijeratne
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People forget to bring up memory issues with their neurologistโฆbecause of their memory issues! Discover the potentials and limitations of neurosurgery and neuroplasticity with epileptologist Jon Kleen from UCSF medical Center.
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๐ Website & more about Jon: ๐
https://www.torierobinson.com/epilepsy-sparks-insights/jon-kleen-epilepsy-surgery-neuroplasticity-memory-cognition
-----------------------------------------
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐ https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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#cognition #memory #epilepsy #jonkleen
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Learn all about how people can have memory and other cognitive struggles as part of their epilepsy - in part 1 of 2 with epileptologist Jon Kleen from the UCSF Medical Center, USA! Jon speaks about his career focus, types of cognitive impairments, impacts on quality of life, and more.
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๐ Website & more about Jon: ๐๐ป
https://www.torierobinson.com/epilepsy-sparks-insights/jon-kleen-cognitive-impairments-epilepsy-research
-----------------------------------------
Donโt understand all the terms used? Check out the Epilepsy Sparks Glossary! ๐๐ป https://www.epilepsysparks.com/glossary
------------------------------------------
๐ฒ Join me on social media!
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#cognition #memory #epilepsy #jonkleen
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