Episoder
-
In this week's episode, we explore the quest for a therapy that not only alleviates symptoms of osteoarthritis but also addresses the underlying disease process. Host Professor David Hunter is joined by Chris Knight and Dr Sandeep Basnet from Formation Bio to discuss the complexities and breakthroughs in developing disease-modifying osteoarthritis drugs (DMOADs).
They dive into the challenges of clinical trials, the high stakes of drug development, and the promising future of AI in revolutionising this field.
Tune in to learn how close we are to seeing these game-changing therapies become a reality and what it could mean for millions living with osteoarthritis.
RESOURCES
Formation Bio: https://www.formation.bio/
CONNECT WITH US
Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]Hosted on Acast. See acast.com/privacy for more information.
-
This week on Joint Action, we explore the potential of natural ingredients in relieving knee osteoarthritis pain. We start with a short introduction to the ATLAS study, a clinical trial by Professor David Hunter and a team of researchers at The University of Sydney. The ATLAS study is testing a groundbreaking supplement combining curcumin, boswellia serrata extract, and more. Can this blend offer pain relief for people with knee osteoarthritis? To learn more or be part of the study, visit: www.osteoarthritisresearch.com.au/atlas-study-overview
To help unravel the complexities of supplements and complementary medicines for osteoarthritis, we welcome Dr. Joanna Harnett, a Senior Lecturer at the University of Sydney's School of Pharmacy. Dr. Harnett discusses the most commonly used supplements for osteoarthritis, the evidence supporting their use, and important safety considerations. She also provides practical advice on selecting the right complementary medicine and emphasizes the importance of consulting healthcare providers.
Whether you're curious about natural supplements or looking for guidance on managing osteoarthritis, this episode offers valuable insights to help you make informed decisions.
RESOURCES
ATLAS study: www.osteoarthritisresearch.com.au/atlas-study-overviewJournal articles
Which supplements can I recommend to my osteoarthritis patients?Dietary supplements for treating osteoarthritis: a systematic review and meta-analysisManaging Dietary Supplements and Complementary Medicines in OsteoarthritisCONNECT WITH US
Twitter: @ProfDavidHunter @jointactionorgEmail: [email protected]: www.jointaction.info/podcastHosted on Acast. See acast.com/privacy for more information.
-
Manglende episoder?
-
In this episode of the Joint Action podcast, we explore how injuries to the ACL (anterior cruciate ligament) in the knee can lead to osteoarthritis, especially in young people aged 15-25. Did you know that up to 20% of people who develop knee osteoarthritis do so because of a past injury? ACL injuries are a major culprit, and their impact can be life-changing.
We chat with Dr Andrew Ross, a physiotherapist and researcher, and Associate Prof Chris Schilling, a health economist, about how we can prevent these injuries in the first place. They share insights from recent studies showing that national injury prevention programs could save millions in healthcare costs, improve quality of life, and keep more people active in sports for longer.
We also discuss the challenges of getting these programs off the ground and why they’re so crucial - not just for individual athletes but for society as a whole. If you’re interested in how we can better protect our knees and prevent osteoarthritis, this episode is a must-listen!
RESOURCES
Previous episodes
Knee injury and osteoarthritis with Tim HewettIs osteoarthritis preventable? with Dr Jackie WhittakerPrograms
Perform+FIFA 11+ ProgramGLAD AustraliaPapers
The economics of a national anterior cruciate ligament injury prevention program for amateur football players: a Markov model analysisThe time is right to do more to reduce ACL injuriesCONNECT WITH US
Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]Hosted on Acast. See acast.com/privacy for more information.
-
On this week's episode of the Joint Action podcast, we dive into a critical aspect of osteoarthritis care: pain management. Dr Stefan Ivanavicius and Dr Sarah Kennedy join us to unravel why pain remains an unmet need in osteoarthritis. They shed light on the complexity of pain, influenced by biological, psychological, and social factors. We explore different pain types and why current treatments fall short, highlighting the need for personalised care.
We'll also take you through the journey of drug development, from preclinical to clinical trials, revealing why it takes years and billions of dollars to bring a new pain management drug to market.
Tune in as we discuss innovations on the horizon, the hope for targeted treatments, and the collaborative efforts driving advancements in osteoarthritis care. Whether you're living with osteoarthritis or interested in the science behind pain management, this episode is packed with insights and optimism for the future.
RESOURCES
Previous episodes
New insights into osteoarthritis pain with Prof Nidhi SofatWhere does osteoarthritis pain come from ? with Prof Anne-Marie MalfaitCONNECT WITH US
Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]Hosted on Acast. See acast.com/privacy for more information.
-
In this episode, we dive into the often overlooked world of younger adults living with osteoarthritis. Associate Professor Anthony Perruccio joins us to explore why people develop osteoarthritis and the unique challenges faced by younger individuals with the disease. We discuss key risk factors such as age, sex, weight, genetics, prior joint injuries, and muscle strength.
Associate Professor Perruccio also sheds light on the delayed diagnosis in younger adults and the severe impact on their overall and mental health, life satisfaction, and the likelihood of having other chronic conditions. We examine how current diagnostic methodologies might be contributing to these delays and what needs to change.
This conversation highlights the importance of recognising osteoarthritis in younger populations and encourages proactive management and participation in research to improve outcomes. Tune in to learn more about the hidden struggles and how we can better support younger individuals with osteoarthritis.
RESOURCES
Journal articles
Old Before Their Time? The Impact of Osteoarthritis on Younger Adults - PubMed (nih.gov)CONNECT WITH US
Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]Hosted on Acast. See acast.com/privacy for more information.
-
In this week's episode, we explore how knee osteoarthritis affects the way people walk. Experts Dr. Kathryn Bacon and Associate Professor Deepak Kumar from Boston University explain that osteoarthritis impacts everyone differently, but common changes include walking slower, taking fewer steps per minute, and experiencing more muscle activity and pressure on certain parts of the knee. Join them as they reveal findings from one of their recent major studies, in which 2,500 participants wore sensors to track their walking patterns. Interestingly, the data from the study showed that changes in walking speed, step length, and symmetry can be linked to worsening pain and knee function over time.
Importantly, we also discuss how this research can help doctors understand osteoarthritis better and develop new ways to monitor and treat it, using simple sensors to track walking patterns in everyday life.
Tune in to learn more about how osteoarthritis impacts walking and the implications for future research and treatment.
RESOURCES
Journal articles
Gait Alterations and Association With Worsening Knee Pain and Physical Function: A Machine Learning Approach With Wearable Sensors in the Multicenter Osteoarthritis Study - PubMed (nih.gov)Website
www.osteoarthritisclinicalresearchgroup.com.auCONNECT WITH US
Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]Hosted on Acast. See acast.com/privacy for more information.
-
Join us on this week's episode as we delve into the complexities of osteoarthritis pain with Professor Nidhi Sofat. In this episode, we explore the sources of pain in osteoarthritis, from cartilage damage to synovitis and bone marrow lesions. Professor Sofat discusses groundbreaking research on the role of nerves and blood vessels in pain, the significance of bone and synovium in joint health, and the latest findings on gene expression and inflammation. We also cover the different types of pain - nociceptive, inflammatory, nociplastic, and neuropathic - and what this means for treatment. Whether you're a clinician, researcher, or someone affected by osteoarthritis, this episode offers valuable insights into understanding and managing this common yet complex condition.
Nidhi Sofat is a Professor of Rheumatology at St George's, University of London, where she studies what causes pain and inflammation in diseases that affect muscles and joints. Her research takes a hands-on approach, bridging the gap between lab experiments and real-world medical applications.
Tune in for an enlightening conversation on the future of osteoarthritis research and discover how her team's innovative approaches may pave the way for future treatments in osteoarthritis.
RESOURCES
Journal article:
Can we achieve pain stratification in musculoskeletal conditions? Implications for clinical practicePrevious episodes:
Why does my knee hurt with Dr. Jason McDougallWhere does osteoarthritis pain come from ? with Prof Anne-Marie MalfaitCONNECT WITH US
Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]Hosted on Acast. See acast.com/privacy for more information.
-
Join this week’s conversation with Dr Sam Bunzli which explores how health professionals can better understand and support people with osteoarthritis by moving beyond checklists and truly listening to their stories. We'll debunk common misconceptions about osteoarthritis, such as the belief that pain always means joint damage or that imaging is always necessary and provide evidence-based corrections.
We’ll also discuss the importance of culturally safe care and share resources for improving clinician communication. Finally, we’ll look at how empowering communication and providing the right information, skills, and resources can help individuals manage their osteoarthritis effectively.
Dr Sam Bunzli is a Senior Research Fellow in Physiotherapy who holds a conjoint position between the School of Health Sciences and Social Work at Griffith University and the Physiotherapy Department at the Royal Brisbane and Women’s Hospital, Queensland Australia.
In her program of osteoarthritis research, Dr Bunzli engages the voices of people with lived experience, their carers, and clinicians to advance person-centred communication and inform the design and implementation of interventions that meet their needs and preferences.
Tune in for valuable insights and practical advice on living well with osteoarthritis.
RESOURCES
The Osteoarthritis Health Professional Training ManualClinical Yarning: www.clinicalyarning.orgStaying Strong with Osteoarthritis: www.stayingstrongwitharthritis.org.auJournal of Orthopaedic and Sports Physiotherapy (JOSPT):Broken Machines or Active Bodies?
Part 1. Ways of Talking About Health and Why It Matters
Part 2: How People Talk About Osteoarthritis and Why Clinicians Need to Change the Conversation
Part 3: Five Recommendations to Shift the Way Clinicians Communicate With People Who Are Seeking Care for Osteoarthritis
CONNECT WITH US
Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]Hosted on Acast. See acast.com/privacy for more information.
-
Metabolism plays an important role in our day to day lives. Our metabolism changes over time as we age, with conditions such as osteoarthritis and in people who are above a healthy weight. The study of the small molecules chemicals in biological samples or the study of metabolomics is an emerging field in research. On this week's episode of Joint Action, we are joined by Ron June and Hope Welhaven to discuss the role of the metabolome in osteoarthritis.
Dr Ron June is a Professor and bioengineer based at Montana State University, USA. His research interests include osteoarthritis and biomechanics. He also recently founded a company, OpenBioWorks, seeking to provide commercial metabolomic profiling services.
Dr Hope Welhaven’s research focusses on investigating the metabolism of musculoskeletal tissues during times of health and disease, such as osteoarthritis. She uses mass spectrometry-based techniques including metabolomics and imaging to identify and examine metabolic mechanisms involved in disease progression.
RESOURCES
Journal articles
· The metabolome of individuals with knee osteoarthritis is influenced by 18-months of an exercise and weight loss intervention and sex: the IDEA trial
CONNECT WITH US
Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]Hosted on Acast. See acast.com/privacy for more information.
-
Learn more about what happens during the history taking and physical examination components of getting your osteoarthritis diagnosed.
RESOURCES
The Osteoarthritis Health Professional Training ManualMSK Physical Examination of the KneeMSK Physical Examination of the HipMSK Physical Examination of the HandCONNECT WITH US
Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]Hosted on Acast. See acast.com/privacy for more information.
-
On this week's episode of Joint Action, we are joined by Dr Bryan Tan to discuss how mental health can contribute to the experience of living with osteoarthritis.
Dr Bryan Tan is an Orthopaedic Surgeon-Scientist in Singapore. He has experience practicing both locally and overseas having done several fellowships internationally including US and New Zealand. His research focuses on health service research, implementation science, population health and taking a biopsychosocial perspective in musculoskeletal health. He has a strong interest in administration, policy making and public health and applies a public health, system lens to musculoskeletal problems and currently sits on several health cluster-wide and national committees looking to deliver new models of care for musculoskeletal health.
RESOURCES
Journal articles
CORR Insights®: What Are the Underlying Mental Health Constructs Associated With Level of Capability in People With Knee and Hip Osteoarthritis?A Qualitative Study of Psychosocial Factors in Patients With Knee Osteoarthritis: Insights Learned From an Asian Population.Adaptation and validation of the chronic illness-related shame scale among patients with knee osteoarthritis in Singapore. Discordance between self-reported and performance-based physical function in patients who have knee osteoarthritis: Associations with pain intensity and negative affect.A cross sectional study exploring the relationship of self-reported physical activity with function, kinesiophobia, self-efficacy and quality of life in an Asian population seeking care for knee osteoarthritis.Singapore KneE osTeoarthritis CoHort (SKETCH): protocol for a multi-centre prospective cohort study. Complex Lifestyle and Psychological Intervention in Knee Osteoarthritis: Scoping Review of Randomized Controlled Trials.CONNECT WITH US
Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]Hosted on Acast. See acast.com/privacy for more information.
-
On this week's episode of Joint Action, we delve into the world of osteoarthritis management through the lens of mobile applications. Professor James Bilzon joins us to discuss how mobile apps are transforming osteoarthritis care, including the features, benefits and future potential of these innovative tools to empower individuals to take control of their osteoarthritis journey. James is a professor of Human and Applied Physiology with specific expertise in rehabilitation medicine at the University of Bath, UK.
RESOURCES
Journal articles
Influence of the intelligent knee osteoarthritis lifestyle app (iKOALA) on knee joint painDevelopment of the intelligent knee osteoarthritis lifestyle app: a person-based approachCONNECT WITH US
Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]: www.jointaction.info/podcastHosted on Acast. See acast.com/privacy for more information.
-
On today’s episode of Joint Action, we are joined by Dr James Linklater OAM to discuss the use and misuse of imaging in the context of knee osteoarthritis. James is a radiologist and CEO of Castlereagh Imaging. He has particular skills in all aspects of musculoskeletal imaging and intervention and has ongoing research interests in imaging osteoarthritis and imaging of ACL reconstructions.
CONNECT WITH US
Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]: www.jointaction.info/podcastHosted on Acast. See acast.com/privacy for more information.
-
On today’s episode of Joint Action, we are joined by Professor Jasvinder Singh to discuss disparities in total joint replacement, including disparities in who receives surgery and in surgical outcomes.
Jasvinder Singh, MD, MPH, is Professor of Medicine and Epidemiology and holds the Musculoskeletal Outcomes Research Endowed Professor of Medicine. He has served as Director of the Rheumatology Research at the Birmingham VA Medical Center since 2009.
RESOURCES
Does the money matter? Disparities in total joint replacement outcomes by incomeCONNECT WITH US
Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]: www.jointaction.info/podcastHosted on Acast. See acast.com/privacy for more information.
-
On today’s episode of Joint Action, we are joined by Professor Toby Smith to discuss core outcome sets in osteoarthritis trials. Toby is Professor of Clinical Trials at the Warwick Clinical Trials Unit, University of Warwick. His current research areas include exploring the rehabilitation of people after hip and knee surgery, trauma, and persistent pain.
RESOURCES
Journal articles
Adoption of core outcome sets in osteoarthritis clinical trials: Still a long way to goThe OMERACT-OARSI Core Domain Set for Measurement in Clinical Trials of Hip and/or Knee OsteoarthritisUptake of the OMERACT-OARSI Hip and Knee Osteoarthritis Core Outcome Set: Review of Randomized Controlled Trials from 1997 to 2017Website
OMERACTCONNECT WITH US
Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]: www.jointaction.info/podcastHosted on Acast. See acast.com/privacy for more information.
-
On this week's episode of Joint Action, we are joined by Dr Lauren King. Lauren is a rheumatologist and clinician scientist at St. Michael’s Hospital and Assistant Professor in the Department of Medicine at the University of Toronto. Her clinical research program combines epidemiology and implementation science, with the goal of identifying gaps in care and developing evidence-informed solutions to improve care and outcomes for people living rheumatic and musculoskeletal diseases, with a particular focus on osteoarthritis.
RESOURCES
“You don't put it down to arthritis”: A qualitative study of the first symptoms recalled by individuals with knee osteoarthritisCONNECT WITH US
Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]: www.jointaction.info/podcastIf you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review!
Hosted on Acast. See acast.com/privacy for more information.
-
On this week's episode of Joint Action, we are joined by Dr Matlock Jeffries. Matlock is a rheumatologist and clinical associate professor of medicine at the University of Oklahoma Health Sciences Centre. His research interests include the microbiome in osteoarthritis and his research lab was the first to identify a microbiome within human and mouse cartilage which changes as patients develop osteoarthritis.
RESOURCES
OA susceptibility in mice is partially mediated by the gut microbiome, is transferrable via microbiome transplantation and is associated with immunophenotype changesThe Microbiome in Osteoarthritis: a Narrative Review of Recent Human and Animal Model LiteratureCONNECT WITH US
Twitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]: www.jointaction.info/podcastIf you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review!
Hosted on Acast. See acast.com/privacy for more information.
-
Dr Kosaku Aoyagi is a physical therapist and Assistant Professor based at the University of Texas at El Paso and the Director of Pain Research in Mechanism-based Physical Therapy. His expertise is in pain and central pain mechanism in osteoarthritis. On this week's episode of Joint Action, we discuss the use of opioids for osteoarthritis, opioid induced hyperalgesia and much more.
RESOURCES
Mediating Effect of Pain Sensitization on the Paradoxical Relation of Taking Opioids to Pain Severity in Knee Osteoarthritis: The Multicenter Osteoarthritis StudyCONNECT WITH KOSAKU
Laboratory websiteLinkedInTwitter/XInstagramCONNECT WITH US
Twitter: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: [email protected]: www.jointaction.info/podcastIf you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review!
Hosted on Acast. See acast.com/privacy for more information.
-
On today’s episode of Joint Action, we discuss common misconceptions about osteoarthritis and how we can improve knowledge and build helpful beliefs. We are joined by Dr Ben Darlow. Ben is an Associate Professor at the University of Otago Wellington and Musculoskeletal Physiotherapy Specialist based in Wellington, New Zealand.
RESOURCES
Living with osteoarthritis is a balancing act: an exploration of patients' beliefs about knee painThe osteoarthritis knowledge scaleCONNECT WITH US
Twitter: @ProfDavidHunter @jointactionorgEmail: [email protected]: www.jointaction.info/podcastIf you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review!
Hosted on Acast. See acast.com/privacy for more information.
-
On the final episode for 2023, we answer some listener questions. Best wishes for the end of 2023 and Happy Holidays!
CONNECT WITH US
Twitter: @ProfDavidHunter @jointactionorgEmail: [email protected]: www.jointaction.info/podcastIf you enjoyed this episode, don't forget to subscribe to learn more about osteoarthritis from the world's leading experts! And please let us know what you thought by leaving us a review!
Hosted on Acast. See acast.com/privacy for more information.
- Vis mere
