Episoder
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Keywords:
insulin sensitivity, metformin, blood sugar management, dietary approaches, microbiome, GLP-1 agonists, functional medicine, probiotics, metabolic health, clinical signs
Summary:
Episode 3 part 1 covers general metabolic health as it relates to pharmaceuticals, the microbiome and nutrition. My guest is Dr. Alex Nataros, a family doctor practicing in Port Hardy, BC.
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References:
Weight Gain Drugs
https://pmc.ncbi.nlm.nih.gov/articles/PMC6109660/
Weight loss drugs
https://mobile.fpnotebook.com/Endo/Pharm/MdctnsAsctdWthUntntnlWghtLs.htm
Insulin Sensitivity Drugs
Giglio RV, Papanas N, Rizvi AA, Ciaccio M, Patti AM, Ilias I, Pantea Stoian A, Sahebkar A, Janez A, Rizzo M. An Update on the Current and Emerging Use of Thiazolidinediones for Type 2 Diabetes. Medicina. 2022; 58(10):1475. https://doi.org/10.3390/medicina58101475
Laurindo LF, Barbalho SM, Guiguer EL, da Silva Soares de Souza M, de Souza GA, Fidalgo TM, Araújo AC, de Souza Gonzaga HF, de Bortoli Teixeira D, de Oliveira Silva Ullmann T, et al. GLP-1a: Going beyond Traditional Use. International Journal of Molecular Sciences. 2022; 23(2):739. https://doi.org/10.3390/ijms23020739
https://doi.org/10.1016/j.redox.2020.101517 (Mechanisms of Action of metformin in type 2 diabetes: effects on mitochondria and leukocyte endothelium interactions.
Microbiome and obesity:
https://doi.org/10.1016/j.biopha.2022.112678
Sohail MU, Althani A, Anwar H, Rizzi R, Marei HE. Role of the Gastrointestinal Tract Microbiome in the Pathophysiology of Diabetes Mellitus. J Diabetes Res. 2017;2017:9631435. doi:10.1155/2017/9631435
HMF Metabolic:
Michael DR, Jack AA, Masetti G, et al. A randomised controlled study shows supplementation of overweight and obese adults with lactobacilli and bifidobacteria reduces bodyweight and improves well-being. Sci Rep. 2020;10(1):4183. Published 2020 Mar 6. doi:10.1038/s41598-020-60991-7
UltraFlora Control:
Stenman LK, Lehtinen MJ, Meland N, et al. Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin, in Overweight and Obese Adults-Randomized Controlled Trial. EBioMedicine. 2016;13:190-200. doi:10.1016/j.ebiom.2016.10.036
Super intense study on personalized nutrition published in cell that I talked too long about :)
Zeevi D, Korem T, Zmora N, et al. Personalized Nutrition by Prediction of Glycemic Responses. Cell. 2015;163(5):1079-1094. doi:10.1016/j.cell.2015.11.001
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References from Shelley:
- UpToDate as referenced summer 2025
- RxFiles 2023 edition
- Bristol Stool Chart
- probioticchart.ca
- Why you should be careful with psyllium husk fiber supplement. YouTube:
https://youtu.be/mPHXldh4_H4?si=wtAMhpP2QDCxPlr6
- Cascara Sagrada withdrawal in USA https://www.fda.gov/about-fda/fda-history-exhibits/drug-therapeutics-regulation-us#
- Phenothalein withdrawal from market
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/phenolphthalein#
- Bisacodyl
Neurogastroenterol Motil. 2021 Mar 9;33(10):e14123. doi: 10.1111/nmo.14123
Bisacodyl: A review of pharmacology and clinical evidence to guide use in clinical practice in patients with constipation
Maura Corsetti 1,2,, Sabine Landes 3, Robert Lange 4
PMCID: PMC8596401 PMID: 33751780
https://pmc.ncbi.nlm.nih.gov/articles/PMC8596401/
- Stimulant laxatives
First published online June 16, 2024
Review article: do stimulant laxatives damage the gut? A critical analysis of current knowledge
Peter Whorwell https://orcid.org/0000-0002-5220-8474 [email protected].uk, Robert Lange, and Carmelo Scarpignato
https://doi.org/10.1177/17562848241249664
- Rhubarb
https://pmc.ncbi.nlm.nih.gov/articles/PMC8321582/#
- Demulcents
https://www.sciencedirect.com/topics/neuroscience/demulcent#
References from Kim:Lexicomp drug information for: podophyllum, wheat dextrin, phenolpthalein, polyethylene glycol 3350
https://time.com/archive/6617019/medicine-cut-out-the-liver/
Pharmacology, toxicology, clinical efficacy, and adverse effects of calcium polycarbophil, an enteral hydrosorptive agent. PMID: 6765389Hosted on Acast. See acast.com/privacy for more information.
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Manglende episoder?
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On this episode of the Rings A Bell Pharmacy Podcast I welcome on Cheen-Young Liu. A bright star from U of T's PharmD program, she schools me on contraception!
References from Cheen-Young:
· CPS (Compendium of Pharmaceuticals and Specialties) - Contraception
· Up To Date (I can't remember which specific pages I used, I viewed a lot but didn't necessarily use all of them)
· Class notes from Dr. Thomas Brown
· HC Monograph - TARO-MEDROXYPROGESTERONE INJECTION (https://pdf.hres.ca/dpd_pm/00080310.PDF)
· HC Monograph - Evra patch (https://pdf.hres.ca/dpd_pm/00077976.PDF)
HC Monograph - NuvaRing (https://pdf.hres.ca/dpd_pm/00077755.PDF)
· BC College of Pharmacists Conscientious Objection (https://www.bcpharmacists.org/faq/how-does-conscientious-objection-work-pharmacy-practice)
References from Kim:
· Bone mineral density and Depo-Provera mechanism: Article Titled Estrogen Supplementation with Depot Medroxyprogesterone found at: https://www.aafp.org/pubs/afp/issues/2005/1015/p1602.html
· Mirena as emergency contraception: This changed my practice article found at https://thischangedmypractice.com/iud-for-emergency-contraception/
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What is the deal anyway?
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