Episoder
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Radiolab: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------
How much does knowledge cost? While that sounds like an abstract question, the answer is surprisingly specific: $3,096,988,440.00. That’s how much the business of publishing scientific and academic research is worth.
This is the story of one woman’s battle against a global network of academic journals that underlie published scientific research. In 2011, Alexandra Elbakyan had just moved home to Kazakhstan after a disappointing few years trying to study neuroscience in the United States when she landed on an internet forum where a bunch of scientists were all looking for the same thing: access to academic journal articles that were behind paywalls. That’s the moment the very simple, but enormously powerful, website called Sci Hub was born.
The site holds over 88 million articles and serves up about a million downloads to people in practically every country on the globe. We travel to Kazakhstan to meet the mysterious woman behind it all and to find out what it takes to make everything we know about anything available to anyone anywhere, for free.
Special thanks to Vrindra Bhandari, Balázs Bodó, Stephen Buranyi, Ian Graber-Stiehl, Joel Joseph, Noorain Khalifa, Aparajita Lath, Steve McLaughlin, Marcia McNutt, Randy Scheckman Tanmay Singh, Deborah Harkness, Joe Karaganis, Lawrence Lessig, Glyn Moody, and Steven Press.Episode Credits:
Reported by - Eli Cohen
Reporting help from - Karishma Mehrotra, Emily Krumberger and Norihelys Ramos
Produced by Simon Adler
with help from - Eli Cohen
Original music and sound designed by - Simon Adler
Mixing by - Jeremy Bloom
Edited by - Alex NeasonOur newsletter comes out every Wednesday. It includes short essays, recommendations, and details about other ways to interact with the show. Sign up (https://radiolab.org/newsletter)!
Radiolab is supported by listeners like you. Support Radiolab by becoming a member of The Lab (https://members.radiolab.org/) today.
Radiolab is on YouTube! Catch up with new episodes and hear classics from our archive. Plus, find other cool things we did in the past — like miniseries, music videos, short films and animations, behind-the-scenes features, Radiolab live shows, and more. Take a look, explore and subscribe!
Follow our show on Instagram, Twitter and Facebook @radiolab, and share your thoughts with us by emailing [email protected].
Leadership support for Radiolab’s science programming is provided by the Gordon and Betty Moore Foundation, Science Sandbox, a Simons Foundation Initiative, and the John Templeton Foundation. Foundational support for Radiolab was provided by the Alfred P. Sloan Foundation.
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Modern Wisdom: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------
Alex Hormozi is a founder, investor and an author.
Alex's Twitter has been one of my favourite sources of great insights over the last year. Today we get to go through some of my favourite lessons from him about life, human behaviour, psychology, business and resilience. This is really good.
Expect to learn how your ego is keeping you poor, why you never need to care about what anyone else thinks of you, why having a life that sucks is actually a blessing, whether most easy opportunities are just distractions, how to conquer your tiny impulses, why you are built to deal with things being hard, how to beat anyone who ever copies you and much more...
Sponsors:
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Extra Stuff:
Follow Alex on Twitter - https://twitter.com/AlexHormozi
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Get my free Reading List of 100 books to read before you die → https://chriswillx.com/books/
To support me on Patreon (thank you): https://www.patreon.com/modernwisdom
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Get in touch.
Instagram: https://www.instagram.com/chriswillx
Twitter: https://www.twitter.com/chriswillx
YouTube: https://www.youtube.com/modernwisdompodcast
Email: https://chriswillx.com/contact/
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Manglende episoder?
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Infinite Loops: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------
This week, we’re delighted to welcome Ed Latimore back for his second Infinite Loops appearance.
Ed’s Twitter
Ed is a best-selling author, former professional heavyweight boxer, competitive chess player, Physics graduate, father, and husband. He joins us to discuss stoicism, progress & pain, demonstrating authenticity, being liked vs. being respected, and a whole lot more.
Important Links:
Ed’s website
Ed’s Substack
Ed’s first Infinite Loops appearance
Show Notes:
New child; new house; new book
How Ed’s new book has developed
Humor and progress
Understanding addiction
Being liked vs being respected
“Stoicism found me”
Is progress possible without pain?
“Humans are very bad at the future”
Demonstrating authenticity
Being cast as a father figure
What’s next for Ed
Ed’s three step process for self-improvement
“I don't think any situation has ever gotten worse because someone has good manners.”
Books Mentioned:
The Founders: The Story of PayPal and the Entrepreneurs who Shaped Silicon Valley; by Jimmy Soni
The Art of Learning: An Inner Journey to Optimal Performance; by Josh Waitzkin
Can't Hurt Me: Master Your Mind and Defy the Odds; by David Goggins
The Subtle Art of Not Giving a F*ck: A Counterintuitive Approach to Living a Good Life; by Mark Manson -
Pod of Jake: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------
Keith is the CEO & Co-Founder of OpenStore and a General Partner at Founders Fund. He is an experienced technology executive and entrepreneur, a prolific investor, and a self-described contrarian. Keith previously served as a General Partner at Khosla Ventures. Before that, he was COO at Square and served in influential roles at LinkedIn. He also co-founded Opendoor. Keith began his career in technology as a senior executive at PayPal. He has since invested early in many great companies including YouTube, Airbnb, Palantir, DoorDash, Stripe, Quora, Yammer, Affirm, Eventbrite, and many others. He also served as a Board Member from inception to IPO at Yelp and Xoom. Follow Keith on Twitter @rabois.
[0:00] - OpenStore's early momentum and fundraising strategy
[5:35] - How an decentralized department store could unlock eCommerce growth
[12:33] - Introducing OpenStore Drive and why it is great for Shopify store owners
[16:49] - OpenStore's horizontal approach and why Keith believes it is best
[18:41] - OpenStore’s business acquisition strategy and thoughtful process design
[24:09] - How learnings from OpenStore’s initial acquisitions have led to improvements
[28:56] - Why OpenStore’s business is resilient in various macroeconomic environments
[35:06] - Acquisition offers and accept rates as metrics and countermetrics at OpenStore
[38:45] - Introducing Gumdrop which matches long-tail influencers to long-tail SKUs
[41:40] - The advantages of aggregation that benefit OpenStore’s business model
[45:19] - Building a great company culture; finding & developing undiscovered talent
[51:11] - The most high-leverage activities Keith allocates time to as OpenStore's CEO
homeofjake.com
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The Underworld Podcast✓Claim: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------The biggest drug cartel in the world isn't Mexican, or Colombian. It's Asian. Buried deep in the Burmese jungle are networks of cutting edge meth labs, guarded by rebels and run by kingpins so powerful they make El Chapo look like a corner boy. In 2019, Underworld cohost Sean Williams went looking for one of the billion dollar meth labs spending months on the Mekong, in lawless casinos and hunting a drug industry bigger than any other on earth...and now he's a dad!Learn more about your ad choices. Visit megaphone.fm/adchoices
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HBR IdeaCast✓Claim: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------How do you solve the world's toughest problems? Or find the next big thing in tech? Lots organizations fail to explore and take big bets on new ideas because they can't tolerate the mess of experimentation and the fear of failure. At X, Alphabet's dedicated innovation factory, they don't have that problem, and Astro Teller, Captain of Moonshots at X, can explain why. Undertaking projects on everything from rural communication to ocean health to machine learning, he and his teams operate with different creative mindsets and decision-making principles than many of us. He spoke with host Alison Beard at HBR at 100: Future of Business live virtual conference.
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Econtalk: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------
Photographer, author, and visionary Kevin Kelly talks about his book Excellent Advice for Living with EconTalk's Russ Roberts. His advice includes how to have a deep conversation, why it's better to control time than money--and whether, in the end, we should give advice in the first place. Other topics of discussion include the right object of our aspirations, the reason for optimism when it comes to technology, and why Kelly is not worried about AI.
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Starting Greatness with Mike Maples: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------Startup founders dealt with uncertainty, stress and trauma in the wake of the run on Silicon Valley Bank, but the most important lessons from this crisis never showed up in social media. In this lesson of greatness, Mike Maples, Jr of FLOODGATE calls on the actions of a variety of founders who showed incredible courage and competence to showcase three crucial lessons for founders for how to deal with another potential crisis: Scenario planning, financial agility, and crisis communication.Check out the new Pattern Breakers Blog at patternbreakers.substack.comfor even more Pattern Breaking content from Mike.
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Artificial Intelligence Podcast: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------Sam Altman is the CEO of OpenAI, the company behind GPT-4, ChatGPT, DALL-E, Codex, and many other state-of-the-art AI technologies. Please support this podcast by checking out our sponsors:- NetSuite: http://netsuite.com/lex to get free product tour- SimpliSafe: https://simplisafe.com/lex- ExpressVPN: https://expressvpn.com/lexpod to get 3 months freeEPISODE LINKS:Sam's Twitter: https://twitter.com/samaOpenAI's Twitter: https://twitter.com/OpenAIOpenAI's Website: https://openai.comGPT-4 Website: https://openai.com/research/gpt-4PODCAST INFO:Podcast website: https://lexfridman.com/podcastApple Podcasts: https://apple.co/2lwqZIrSpotify: https://spoti.fi/2nEwCF8RSS: https://lexfridman.com/feed/podcast/YouTube Full Episodes: https://youtube.com/lexfridmanYouTube Clips: https://youtube.com/lexclipsSUPPORT & CONNECT:- Check out the sponsors above, it's the best way to support this podcast- Support on Patreon: https://www.patreon.com/lexfridman- Twitter: https://twitter.com/lexfridman- Instagram: https://www.instagram.com/lexfridman- LinkedIn: https://www.linkedin.com/in/lexfridman- Facebook: https://www.facebook.com/lexfridman- Medium: https://medium.com/@lexfridmanOUTLINE:Here's the timestamps for the episode. On some podcast players you should be able to click the timestamp to jump to that time.(00:00) - Introduction(08:41) - GPT-4(20:06) - Political bias(27:07) - AI safety(47:47) - Neural network size(51:40) - AGI(1:13:09) - Fear(1:15:18) - Competition(1:17:38) - From non-profit to capped-profit(1:20:58) - Power(1:26:11) - Elon Musk(1:34:37) - Political pressure(1:52:51) - Truth and misinformation(2:05:13) - Microsoft(2:09:13) - SVB bank collapse(2:14:04) - Anthropomorphism(2:18:07) - Future applications(2:21:59) - Advice for young people(2:24:37) - Meaning of life
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My First Million: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------Episode 436: In a special Friday episode, Shaan Puri (@ShaanVP) gives a special masterclass on his pitch deck that has raised millions from investors. Go to the MFM YouTube channel to see examples.Want to see more MFM? Subscribe to the MFM YouTube channel here.SHAAN'S NEW DAILY NEWSLETTER --> shaanpuri.com-----Links:* shaanpuri.com/deck* Do you love MFM and want to see Sam and Shaan's smiling faces? Subscribe to our Youtube channel.------Show Notes:(01:35) - Title(05:41) - Data/personal story(07:30) - Future vision(10:30) - Hero metric(14:15) - Track record(16:30) - Sweeten the pot-----Past guests on My First Million include Rob Dyrdek, Hasan Minhaj, Balaji Srinivasan, Jake Paul, Dr. Andrew Huberman, Gary Vee, Lance Armstrong, Sophia Amoruso, Ariel Helwani, Ramit Sethi, Stanley Druckenmiller, Peter Diamandis, Dharmesh Shah, Brian Halligan, Marc Lore, Jason Calacanis, Andrew Wilkinson, Julian Shapiro, Kat Cole, Codie Sanchez, Nader Al-Naji, Steph Smith, Trung Phan, Nick Huber, Anthony Pompliano, Ben Askren, Ramon Van Meer, Brianne Kimmel, Andrew Gazdecki, Scott Belsky, Moiz Ali, Dan Held, Elaine Zelby, Michael Saylor, Ryan Begelman, Jack Butcher, Reed Duchscher, Tai Lopez, Harley Finkelstein, Alexa von Tobel, Noah Kagan, Nick Bare, Greg Isenberg, James Altucher, Randy Hetrick and more.-----Additional episodes you might enjoy:• #224 Rob Dyrdek - How Tracking Every Second of His Life Took Rob Drydek from 0 to $405M in Exits• #209 Gary Vaynerchuk - Why NFTS Are the Future• #178 Balaji Srinivasan - Balaji on How to Fix the Media, Cloud Cities & Crypto* #169 - How One Man Started 5, Billion Dollar Companies, Dan Gilbert's Empire, & Talking With Warren Buffett• #218 - Why You Should Take a Think Week Like Bill Gates• Dave Portnoy vs The World, Extreme Body Monitoring, The Future of Apparel Retail, "How Much is Anthony Pompliano Worth?", and More• How Mr Beast Got 100M Views in Less Than 4 Days, The $25M Chrome Extension, and More
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Knowledge Project: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------Visionary technology and business leader Nathan Myhrvold just might be the most interesting person in the world, and in this episode of The Knowledge Project he dives deep into some of the most pressing questions facing our world today. Where will technology take us in the future? Should we trust artificial intelligence? Where have we gone wrong in protecting our planet? How do we reverse the effects of what we’ve already done? Myhrvold answers all these and much, much more. Myhrvold is a prominent scientist, technologist, inventor, author, and food photographer, and the former Chief Technology Officer at Microsoft. He’s also the co-founder of patent portfolio developer Intellectual Ventures, the principal author of the culinary book Modernist Cuisine: The Art and Science of Cooking, part of a team that won first place at the World Barbecue Championships, and he completed his postdoctoral fellowship under legendary theoretical physicist Stephen Hawking.
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Nudge - Marketing Science Simplified✓Claim: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------Ever worried about someone stealing your phone at the beach? Well, there’s one thing you can do to make your phone 4x safer. It involves using a psychology-inspired principle to change behaviour. On this show, you’ll learn what it is, and why it’s important to marketers. Today, Nancy Harhut and I will cover five more marketing principles. Plus, I’ll share my real-world experiments to reveal which principles work, and which don’t. Try HubSpot for free: https://hubspot.sjv.io/jWq4k6Consistency experiment: https://bit.ly/3sABZTUInput bias experiment: https://bit.ly/3sEPFgCFraming experiment: https://bit.ly/3TMKgA2Information gap experiment: https://bit.ly/3DiGasAAuthority bias experiment: https://bit.ly/3sF0G1ANancy’s book: https://amzn.to/3DZTl23Sign up for the Nudge Newsletter: https://www.nudgepodcast.com/mailing-listTake my marketing course: https://science-of-marketing.teachable.com/
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Uncommon with Chance Lunceford✓Claim: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------
Brian Roemmele is in contention for the most interesting man on the internet.
That's why I invited him on the podcast. I wanted to discuss his work, his thoughts and philosophy and his propensity for finding fascinating content not found anywhere else.
What I got was three hours of unmitigated fascination.
Brian was ready to rock-n-roll. His heart and mind opened up and delivered such a lucid and thought-provoking monologue that I was little inclined to say anything.
So, I didn't, really.
I just let him say what he needed to say.
The result was one of the most interesting, coherent and salient testimonies I've ever had the good fortune to witness.
Grab a notebook, clear your mind and buckle up. This is a wild ride.
I'll bring Brian back on sometime relatively soon, but in the mean time, find him here:
Twitter: https://twitter.com/BrianRoemmele
Website: http://voicefirst.expert/
Quora: https://www.quora.com/profile/Brian-Roemmele
--- Support this podcast: https://podcasters.spotify.com/pod/show/logocentrifugal/support -
My First Million: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------In a special episode of My First Million, Shaan (@ShaanVP) talks about the nine things he learned from Emmett Shear - CEO of Twitch - who resigned today.Want to see more MFM? Subscribe to the MFM YouTube channel here.SHAAN'S NEW DAILY NEWSLETTER --> shaanpuri.com-----Past guests on My First Million include Rob Dyrdek, Hasan Minhaj, Balaji Srinivasan, Jake Paul, Dr. Andrew Huberman, Gary Vee, Lance Armstrong, Sophia Amoruso, Ariel Helwani, Ramit Sethi, Stanley Druckenmiller, Peter Diamandis, Dharmesh Shah, Brian Halligan, Marc Lore, Jason Calacanis, Andrew Wilkinson, Julian Shapiro, Kat Cole, Codie Sanchez, Nader Al-Naji, Steph Smith, Trung Phan, Nick Huber, Anthony Pompliano, Ben Askren, Ramon Van Meer, Brianne Kimmel, Andrew Gazdecki, Scott Belsky, Moiz Ali, Dan Held, Elaine Zelby, Michael Saylor, Ryan Begelman, Jack Butcher, Reed Duchscher, Tai Lopez, Harley Finkelstein, Alexa von Tobel, Noah Kagan, Nick Bare, Greg Isenberg, James Altucher, Randy Hetrick and more.-----Additional episodes you might enjoy:• #224 Rob Dyrdek - How Tracking Every Second of His Life Took Rob Drydek from 0 to $405M in Exits• #209 Gary Vaynerchuk - Why NFTS Are the Future• #178 Balaji Srinivasan - Balaji on How to Fix the Media, Cloud Cities & Crypto* #169 - How One Man Started 5, Billion Dollar Companies, Dan Gilbert's Empire, & Talking With Warren Buffett• #218 - Why You Should Take a Think Week Like Bill Gates• Dave Portnoy vs The World, Extreme Body Monitoring, The Future of Apparel Retail, "How Much is Anthony Pompliano Worth?", and More• How Mr Beast Got 100M Views in Less Than 4 Days, The $25M Chrome Extension, and More
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What Got You There with Sean DeLaney: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------
Kyle Kowalski is the Funder of Sloww.co (one of my favorite websites for synthesized knowledge + wisdom!)
Kyle is an ex-marketing executive turned corporate dropout and solopreneur who found and created his life purpose after an existential crisis. In one sentence, his purpose is synthesizing lifelong learning that catalyzes human development (LFG!!!). In a nutshell, Kyle is learning why and how to live and publicly sharing what he learns along the way at Sloww.co. Thinking is his passion—but he's not a professor, philosopher, psychologist, sociologist, anthropologist, scientist, or guru. He's an interdisciplinary dot connector across all those humans and many more. Kyle does all the homework—researching, curating, reading, note-taking, summarizing, synthesizing, writing, creating, and sharing. You get all the highlights—so you spend less time on all those things and more time learning, practicing, and mastering. About Sloww: Sloww shares the art of living with students of life. Sloww currently has a Premium membership with 1,000+ global members, a weekly email newsletter with 10,000+ subscribers, a social media following of 30,000+, and a website with 60,000+ monthly visitors (5,000,000+ lifetime pageviews). Kyle's 10 Most Life Changing Ideas Ikigai 2.0 Guidebook Watch on YouTube About Host Sean DeLaney: For the last 15 years Sean DeLaney has been working at the intersection of elite performance, entrepreneurship and personal development. As an executive life coach, former professional athlete, entrepreneur, investor and podcast host Sean has been helping people discover their untapped potential and live their best life.He has been an advisor to INC. fastest growing companies, has interviewed billionaire business titans and personally coached CEO’s and executives. Interested in having Sean coach you? CLICK HERE
I’ve studied hundreds of the world’s must successful people and compiled:13 Insights from the World’s Most Successful People – Click Here to get access
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You Unleashed is an online personal development course created by Sean DeLaney after spending years working with and interviewing high achievers.The online course that helps you ‘Unleash your potential’!
You Unleashed teaches you the MINDSETS, ROUTINES and BEHAVIORS you need to unleash your potential and discover what you’re capable of.
You know you’re capable of more and want to bring out that untapped potential inside of you.
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Learning Leader Show: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------
Text Hawk to 66866 to become part of "Mindful Monday." Join 10's of thousands of your fellow learning leaders and receive a carefully curated email from me each Monday morning to help you start your week off right...
Full show notes at www.LearningLeader.com
Twitter/IG: @RyanHawk12 https://twitter.com/RyanHawk12
David Lieberman, Ph.D., is a renowned psychotherapist and the author of eleven books, including the New York Times bestsellers Get Anyone to Do Anything and Never Be Lied to Again. He has trained personnel in the U.S.
Ralph Waldo Emerson wrote: “People do not seem to realize that their opinion of the world is also a confession of character.” A person looks at the world as a reflection of themselves. If they see the world as corrupt, they feel on some level that they are corrupt. If they see honest working people, that is frequently how they see themselves. “How someone treats you is a reflection of their own emotional health and says everything about them and nothing about you.” Speaking negatively behind someone’s back orients you to look for the negative in others. Wouldn’t we rather spend time with people who seek the greatness in others? “The less emotionally healthy a person is, the more they denigrate the world to accommodate their own insecurities.” Knowledge is not power. Knowledge is a tool. How it is wielded makes all of the difference. Real power is the responsible application of knowledge. Word usage: Let’s take the example of giving a compliment. A woman who believes what she’s saying is more likely to use a personal pronoun. For instance, “I really liked your presentation.” However, a person offering insincere flattery might say, “Nice presentation,” or “Looks like you did a lot of research.” In the second case, she has removed herself from the equation. The Art of reading the bluff - When a person is bluffing, they are managing others’ impressions to convey the “right” effect and serve a personal agenda. Conversely, the authentic person is not interested in how they come across because they are unconcerned with their image. “People who bluff habitually overcompensate, so you can uncover a bluff instantly by noticing how someone tries to appear.” Relationships: Whenever David speaks to couples, he's always on the lookout when the word we is conspicuously absent from the conversation. We are attracted to positivity. It reflects humility. "Humility connects you to the ownership of mistakes." Humility can recognize a weakness in self. The difference between a sociopath and a psychopath: A sociopath has no conscious. They are very dangerous. A psychopath's wiring is off. They were born that way. Life and career advice: Find a passion that contributes to the world. Don't get too caught up in image or ego. "You can be anything. you're good at. as long as they're hiring." -- Chris Rock -
Invest Like the Best: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------
My guest this week is Trae Stephens. Trae is a partner at Founders Fund and co-founder and Executive Chairman of Anduril. Trae’s philosophy can be boiled down to finding good quests, which has led him to investing in businesses that work closely with the government on societally important issues. Clearly, that extends to co-founding Anduril and I would highly recommend listening to my Business Breakdowns episode on Anduril if you haven’t already. In this conversation, we discuss the importance of lobbyists, why the high-tech defense firms of the past became stale, and how he hunts for disagreeableness in founders. Please enjoy my conversation with Trae Stephens.
For the full show notes, transcript, and links to mentioned content, check out the episode page here.
Listen to Founders Podcast
Founders Episode 136 - Estee Lauder
Founders Episode 288 - Ralph Lauren
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Invest Like the Best is a property of Colossus, LLC. For more episodes of Invest Like the Best, visit joincolossus.com/episodes.
Past guests include Tobi Lutke, Kevin Systrom, Mike Krieger, John Collison, Kat Cole, Marc Andreessen, Matthew Ball, Bill Gurley, Anu Hariharan, Ben Thompson, and many more.
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Follow us on Twitter: @patrick_oshag | @JoinColossus
Show Notes
[00:03:17] - [First question] - Why Trae thinks most high-margin businesses are bad for society
[00:04:28] - What would he change to impact energy technology most if he were in charge
[00:06:18] - His investing focus on dynamism and mission-driven tech companies
[00:09:42] - Analyzing why relatively few people strive to make society-level advancements
[00:11:35] - What he’s done as a parent to enable his kids to develop passions
[00:12:41] - The most noteworthy adventures in his career
[00:14:41] - Founding Anduril and what it taught him about the tech industry
[00:18:40] - The cutting-edge of defense technologies today
[00:21:29] - What Shyam Sankar of Palantir taught him about defense tech
[00:23:34] - Why some of the biggest defense tech companies have stopped innovating
[00:28:29] - What he and Anduril have learned about sales and scaling in the public sector
[00:32:12] - Where lobbyists and decision makers play in to defense tech business models
[00:35:22] - His take on Peter Thiel’s notion that competition should be avoided
[00:38:24] - The importance of being psychologically disagreeable when building a start-up
[00:39:54] - The origin story that stands out the most from companies he has interviewed
[00:41:12] - How he developed an investor mindset on his unorthodox path to the venture world
[00:43:57] - What he has learned from playing supporting roles and aligning with great leaders
[00:46:11] - Important but uncommon lessons about entrepreneurship
[00:48:21] - Venture investing lessons he’s learned from Lauren Gross
[00:50:00] - His first VR project and aspirations for the future of VR
[00:54:50] - The role of religion and spirituality in his business philosophies
[00:59:13] - Why he tries to capitalize on morality as opposed to sin
[01:03:57] - The kindest thing anyone has ever done for him
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Drive with Dr. Peter Attia: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------
View the Show Notes Page for This Episode
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In this “Ask Me Anything” (AMA) episode, Peter focuses the discussion on two topics getting a lot of attention recently. He first dives deep into GLP-1 agonists, most notably semaglutide and tirzepatide, which originally came to market as diabetes drugs but are now being studied and prescribed for weight loss. He walks through the data and compares the effectiveness of the two drugs, the side effects, and perhaps more importantly, his reservations around wide use of these drugs and who he would consider to be a candidate for them. Next, Peter discusses how metformin, another drug originally brought to market for diabetes management, gained popularity as a potential longevity drug even for non-diabetics. Peter gives his take on this possibility and reviews data from a more recent study investigating the question of whether metformin should be used for general “geroprotection.”
If you’re not a subscriber and are listening on a podcast player, you’ll only be able to hear a preview of the AMA. If you’re a subscriber, you can now listen to this full episode on your private RSS feed or our website at the AMA #45 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits here.
We discuss:
The hype around semaglutide, tirzepatide, and other GLP-1 agonists for weight loss [2:30]; Overview of GLP-1 agonists and why these drugs are getting so much attention [6:15]; Defining the term “geroprotective” [13:30]; Semaglutide: background, brand names, indications, and more [15:15]; Tirzepatide: background, brand names, indications, and more [19:15]; How semaglutide and tirzepatide compare in their efficacy in terms of weight loss and other metabolic health metrics [23:45]; Data showing sustained weight loss and improved metabolic metrics with after more than a year of using semaglutide and tirzepatide [29:00]; What happens to body weight when a patient discontinues the medication? [34:45]; Noteworthy side effects of GLP-1 agonists and similar classes of drugs [40:45]; Increased resting heart rate and other concerning trends in patients using GLP-1 agonists [45:15]; Changes in body composition (body fat and lean muscle) in patients on GLP-1 agonists [50:45]; Possible reasons for the loss of lean muscle mass and tips for protecting lean mass [59:00]; GLP-1 agonists and thyroid cancer [1:01:30]; Who might be a candidate for GLP-1 agonists? [1:03:45]; The large financial cost of this class of drugs [1:08:30]; Metformin as a geroprotective drug: origin of the idea that metformin could be a longevity agent even for non-diabetic patients [1:11:30]; A 2022 study on metformin sheds more light on the question of whether metformin should be used for “geroprotection” in non-diabetics [1:21:00]; Peter’s current approach with metformin for his patients [1:25:15]; and More.Connect With Peter on Twitter, Instagram, Facebook and YouTube
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A16z Podcast: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------
With every new technology, some jobs are lost while others are gained. People often focus on the former, but in this episode we chose to highlight the latter – a highly creative role that emerges alongside AI: the prompt engineer.
Until AI can close the loop of its own, each tool still requires a set of prompts. Just like a composer feeds an instrument the notes to play, a prompt engineer feeds an AI a map of what to produce. And if we know anything from music it’s that composing great music takes great skill!
In this episode we explore the emerging importance of prompting with Guy Parsons, the early learnings of how to do it effectively, and where this field might be going.
Will the prompt engineer be more like the highly sought after DevOps engineer, or a proficiency like Excel that you find on every resume? Listen in to hear Guy’s take.
Interested in the prompt competition? Email us at [email protected].
Resources:
DALL-E 2 Prompt Book: https://dallery.gallery/the-dalle-2-prompt-book/
Find Guy on Twitter: https://twitter.com/GuyP
Guy’s combining image experiment: https://twitter.com/GuyP/status/1612880405207580672
Guy’s amorphous prompt experiment: https://twitter.com/GuyP/status/1608475973300948993
Guy’s space duck: https://twitter.com/GuyP/status/1601342688225525761
Prompt base: https://promptbase.com/
Lexica: https://lexica.art/
Topics Covered:
0:00 - Introduction
01:49 - DALL-E 2 Prompt Book
05:29 - Parallel skills
06:51 - 80/20 prompting
10:16 - New ways of prompting
13:44 - Pulling the AI slot machine
18:09 - Comparing models
21:04 - Requested features
26:34 - Learning with AI
27:58 - Practical use cases
32:08 - A top 1% prompt engineer
36:17 - The most popular images
Stay Updated:
Find us on Twitter: https://twitter.com/a16z
Find us on LinkedIn: https://www.linkedin.com/company/a16z
Subscribe on your favorite podcast app: https://a16z.simplecast.com/
Follow our host: https://twitter.com/stephsmithio
Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. For more details please see a16z.com/disclosures.
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Art of Manliness: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday---------
In your journey towards becoming stronger, fitter, and healthier, there often comes a point where you wonder if taking some supplements will help your progress along. But what fitness supplements are actually effective and worth investing in?
Here to answer that question is Layne Norton, a powerlifter and doctor of nutritional science who has a passion for debunking health-related myths and promoting evidence-based recommendations. He’s also, full disclosure, the owner of a supplement company himself. But I don’t have any financial connection to Layne’s company and we keep this conversation neutral and high-level. In our conversation, Layne argues that there are three top-tier research-backed supplements to consider — whey protein, creatine, and caffeine — and we unpack how to use each of them for optimal results. We discuss whether plant proteins are sufficient for building muscle, whether it’s true that creatine causes bloating, acne, and hair loss, how to best time your caffeine intake to energize your workouts, and much more. At the end of our conversation, Layne shares some additional supplements that seem promising for enhancing your health and fitness.
Resources Related to the EpisodeLayne’s previous appearance on the AoM podcast: Episode #475 — How to Lose Weight, and Keep It Off ForeverLayne’s supplement company: Outwork NutritionAoM Article: A Primer On Muscle-Building Supplements — Which Work and Which Don’t?AoM Article: Creatine — A Primer on Its Benefits and UseAoM Article: How to Use Caffeine to Optimize Your WorkoutsAoM Article: Chugging Your Protein — It’s Whey Easier Than You ThinkAoM Podcast #285: The Real Science of Nutrition and SupplementsConnect With Layne NortonLayne on InstagramLayne‘s website - Vis mere
