Episodes

  • 00:21:43

    Financial Transactions – Frank Holmes, HIVE Blockchain Technologies Ltd. – Blockchain, Bitcoin, and The Changing Financial Landscape

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    Frank Holmes, Interim Executive Chairman of HIVE Blockchain Technologies Ltd.’s board of directors, provides an analysis of blockchain, bitcoin, and the future of finance. Holmes is a seasoned investor and financial strategist. Throughout his illustrious career, he has helmed many financial entities, and is currently the chief executive and chief investment officer at U.S. Global Investors, a forward-thinking mutual fund and asset management firm. 


    Holmes talks about his background in finance. As a young analyst, he transitioned into corporate finance and pushed forward until he took his first company public. He became well known in the gold funds market and eventually discovered bitcoin and that was the beginning of his passion for the new currency. His excitement over the processing of these transactions led him to launch a company in the space.


    Holmes’ passion for emerging financial markets is perfectly matched to his current role directing the board of directors at HIVE Blockchain Technologies Ltd., and he is leading the company forward evidenced by their significant innovation in the market. HIVE is a growth-oriented, TSX.V-listed company that has built a bridge from the blockchain sector to traditional capital markets. HIVE’s team seeks to create significant long-term shareholder value. HIVE has formed a solid partnership with Genesis Mining Ltd. to create the next wave of blockchain infrastructure. 


    HIVE even owns the actual GPU-based digital currency mining facilities in Iceland and Sweden that produce these new digital currencies like Ethereum. Holmes discusses HIVE’s place in the market as a proxy, and he explains the interconnectedness of HIVE to the market, in terms of flow. He discusses the enthusiasm globally for blockchain, and he outlines the arrival of the JP Morgan coin that is backed by US dollars. Holmes goes on to explain regulations and speculation as they relate to investor interests. And he talks about the benefits of cash trades in the market and the future of emerging financial markets. Holmes discusses the mobile gaming industry and the astronomical revenue that is pushing that industry. Wrapping up, Holmes discusses volatility in the markets and how to steer in the right direction to financial stability as technology changes everything in our world.


    Holmes is a regular keynote speaker at various international investment conferences and his popular “Frank Talk” CEO blog is one of the most read in the financial industry.

  • 00:23:19

    Gamifying Stroke Rehabilitation for Better Outcomes—Dr. John W. Krakauer—Johns Hopkins University School of Medicine, Department of Neurology

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    Human beings enjoy a level of dexterity superior to most other species by virtue of what’s called the corticospinal tract, which is a projection that reaches from the motor cortex in the brain, down to the brain stem and spinal cord,  and connects directly to the muscles. As beneficial as this special pathway in humans can be, it comes at a cost: even a small amount of damage can have devastating results. When someone suffers from a stroke, it is this pathway that gets damaged and leads to many possible symptoms, including weakness, loss of dexterity, clumsiness, and the inability to isolate joint movements. The key to the best recovery from stroke is very early, very intense rehab, but it can be challenging to motivate people into maintaining such intense work.

    Dr. John W. Krakauer works in the Brain, Learning, Animation, and Movement (BLAM) Lab at Johns Hopkins University School of Medicine, where he’s not only studying the differences between movement in health and movement in disease, but also exploring and testing ways of engaging post-stroke patients in the intense rehab routines necessary in order to help them regain as much movement and control over their bodies as possible. He explains how important it is to create emotionally gratifying and motivating experiences for people early on in their recovery in order to engage them in ways that will best amplify the abilities they do have—the abilities they did not lose as a result of stroke. The same idea applies to all types of neurological diseases and injuries, including traumatic brain injury, Parkinson’s disease, cerebellar ataxia, and multiple sclerosis.

    At the BLAM lab, they are developing interactive, exciting, and engaging games specifically geared toward patients with neurodegenerative issues, encouraging them to perform miles’ worth of movement without even noticing it. They are also working on forming cohorts of people who have suffered from stroke and who could benefit from working together in multi-player games. The idea is that this would build a sense of competition, thereby making it easier for people to sustain the level of rehabilitative intensity needed. Furthermore, by isolating problems with particular  body parts to particular characters in games, each individual’s specific problem area could be addressed in the most effective way possible. Interested in learning more? Tune in for all the details and visit www.blam-lab.org.



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  • 00:23:36

    The Smartest Motorcycle Helmet in the World—Jeremy Lu—Jarvish

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    If you’ve ever ridden a motorcycle, you might understand all too well the drawbacks of the helmet—it makes it hard to see, hard to hear, and feels very insulating. The team at Jarvish set out to improve this while keeping safety as their top priority. They’ve used traditional motorcycle helmets as their starting point, adding a high-resolution front camera for greater visibility in foggy or rainy weather, a sensor and alert system for detecting accidents and contacting an ambulance and next of kin, biosensors to detect the rider’s heart rate and other vitals which may indicate an impending medical emergency, and a crystal-clear sound system. The team at Jarvish has trained their AI to analyze videos and identify objects or vehicles obscured from the rider’s line of sight, as well as remove raindrops from videos and penetrate foggy conditions. All of this data is then analyzed and sent back to the rider warning them of dangers on the road ahead. It’s the world’s first truly smart motorcycle helmet, and it has the ability to save lives.


    Jeremy Lu is the CEO of Jarvish and he joins the podcast to discuss all the details of this technology, how they are allowing for comfort customization of their helmets, what’s in store for them over the next year, and how their technology could be implemented in all types of helmets—bicycle, industrial, police, military, and even space helmets.


    Previous press kit with most of the content, and below is the most updated crowdfunding prices and new updates: 


    - a NASA iTech Finalist (2019) 

    - Partnering with Qualcomm for its X-AR helmet.

    - JARVISH Tron Electric Helmet: 

    The brand just launched an awesome helmet design for the X and X-AR range. The JARVISH Tron Electric Helmet with LED strips, will certainly make riders stand out on the road. Current backers have the option to upgrade their pledges to this design. The LED light could be controlled by voice command or app. 

    - secured over $420K in funding on Kickstarter and have continued their funding on Indiegogo.


    -Discounted prices on Indiegogo campaign:

     

    JARVISH X - USD 499 

    JARVISH X-AR - USD 1099

    JARVISH Tron X USD 599

    JARVISH Tron X-AR USD 1199


    The X-AR and X models have been designed with a range of technology integrations, such as voice control, noise cancellation, built-in memory to give riders a safer, more enjoyable on-road experience. The X-AR also includes an AR-powered head-up display (HUD) for riders who prefer visual instructions. 


    Press play for more information, reach out with questions via jeremy@jarvish.com, and visit <a href="http://www.jarvish.com">www.jarvish.com</a>. 

  • 00:26:41

    The World’s First Electronic Completions Recorder for the Fracking Industry—Brett Chell—Cold Bore Technology

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    “If you don’t track it you can’t improve it… and you can’t pay enough people to go through the data fast enough to get a handle on it…but every other industry in the world…has switched over to sensors that drive software…which produces ten times the results you could ever get out of humans in the blink of an eye,” says Brett Chell, founder of Cold Bore Technology. 


    The company began as a manufacturer of drilling tools, and it was through that line of work that the team at Cold Bore Technology made a realization which would completely change the focus of their efforts: frack locations were missing the operating systems and IOT software that drilling locations—and really every industry in the world—rely upon for efficient, accurate data collection and operations.


    Instead, they’ve been relying upon the manual collection of data with the use of notebooks and Excel sheets—an inefficient method with tons of room for errors which could end up costing hundreds of thousands of dollars.


    Fracking operations are complex and involve several service companies acting independently but simultaneously; this creates a constant flow of important data which must be accurately captured and organized in order for mistakes and inefficiencies to be identified and corrected.


    Cold Bore Technology is offering a solution that will allow for exactly this. Despite being just a small to mid-sized company, they are now working with some of the largest oil companies in the world, delivering a sensor-based software solution and level of automation never before seen in the field.


    The results? Greater operational visibility, the ability to identify important and costly errors that would otherwise continue to happen, less expensive and more efficient operations, and the ability to move data through businesses seamlessly and without anyone touching it.


    Learn more by visiting coldboretechnology.com

  • 00:19:37

    Alexa-Integrated Smart Pillow Designed to Improve Your Sleep—Kevin Houston—REM-Fit

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    Kevin Houston is head of execution at REM-Fit, a company that was founded about five years ago with the goal of harnessing the power of technology to improve one of the most important aspects of life: sleep. At REM-Fit, sleep is considered the most important factor in recovery, whether you’re recovering from a stressful day at work or an intense workout. The team at REM-Fit is passionate about sleep, and for the past several years they’ve poured that passion into the design, development, and continual improvement of a product which actively participates in your sleep: the ZEEQ smart pillow.


    It’s Alexa-integrated and able to connect with other smart devices in your home, which means it can get your coffee brewing before you wake up, draw the shades back when you need to get up, change the humidity in your environment based on your sleep patterns, and heat your bathroom floor just a few minutes before you need to get ready for your day. The pillow is wrapped in a unique textile that’s antimicrobial-resistant, moisture-wicking, and cool to the touch. Perhaps the most popular feature is its ability to stream music, white noise, guided meditations, or whatever else it is you might want to hear in your own private ecosystem. With a compartment located on both the top and bottom of the pillow, you decide how much filling you want and where you want it—a feature which truly makes it infinitely adjustable.


    The team at REM-Fit takes a personal approach with every customer and wants to hear feedback, whether it’s good or bad. They are constantly looking for ways to improve their product and working on the release of a new mattress line in the fall of 2019. 


    Interested in learning how to get a ZEEQ pillow for yourself? Visit <a href="http://remfit.com">remfit.com</a>

  • 00:26:13

    The Fabulous Life of Plants – Dennis van der Wiel, Co-founder at Polariks – Advancing Technology That Can Detect Problems With Plant Health and Help Agricultural Farmers Manage Their Crops

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    Dennis van der Wiel, co-founder at Polariks (polariks.com/en/home), provides an overview of their groundbreaking technology that can help farmers assess their agriculture and improve their production. 


    Polariks is all about precision agriculture and remote sensing. Polariks has developed a precision agriculture analysis method that is directly based on Hyperspectral Imaging. Their innovative technology enables better harvest planning with increased efficiency in resources, as well as early detection of diseases. And, importantly, it significantly reduces overall inspection costs.


    Dennis discusses the premise of his company, Polariks, that uses reflected light to determine properties. By using their technique of light they can determine whether a plant is sick or healthy, which ultimately helps farmers to make better decisions. Dennis explains how their technology can be integrated with drone and aerial tech to make the assessments regarding agriculture.


    From strawberries to grapes, Dennis discusses how their robotic and stationary systems-implemented technology can help improve agriculture and prevent outbreaks. He states that humans can easily detect coloring and other issues that could be indicative of a plant’s ailing health, but the real test comes from looking deeper, beyond what the naked eye can reveal. He outlines the infrared analysis that can assess photosynthetic activity.


    The tech guru explains some of the overall goals that Polariks has in the works. He talks about the differences between outside farming and greenhouse growing. He states that greenhouses promote very homogeneous qualities and plant disease can spread quickly in a greenhouse environment. He explains that two plants side by side may both appear green and healthy, but one could already be well into a deep stage of sickness. 


    This is why the Polariks technology is so useful, because the Polariks technology can identify problems with plant health several weeks before even the most trained human eye can. He explains the advanced principles of their technology and how it generates much more information that can be utilized to understand plant health.


    Dennis discusses modern farming techniques and he talks about the importance of regular monitoring over time, in regard to plant disease or plant health conditions, including the effects of drought. Finally, the farming technology expert provides some thoughts on predictive modeling and other advances that Polariks expects to promote as they develop their innovative technology and platform further.

  • 00:33:58

    Dental Education – John Tucker, DMD, Founder of Tucker Educational Excellence LLC – Sleep Apnea and Dental Sleep Medicine

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    John Tucker, DMD, founder of Tucker Educational Excellence LLC (tuckereducationalexcellence.com), discusses sleep apnea and treatment.


    Tucker is an experienced medical professional who has treated many patients over his long career, as well as educated countless dentists on dental sleep medicine. Tucker Educational Excellence provides intensive educational programs that focus on the successful implementation of dental sleep medicine practices within the dental industry. Tucker is a respected dentist and Diplomate of The American Board of Dental Sleep Medicine.


    Tucker explains that dental sleep medicine focuses on treating patients who have obstructive sleep apnea and are intolerant of their traditional CPAP therapy. Tucker describes CPAP, which stands for Continuous Positive Airway Pressure, as a vacuum cleaner in reverse. 


    CPAP provides a continuous flow of airway pressure to your throat to keep your airway open during sleep, which is generally successful as a means to treat the spontaneous pauses in your breath that are so often connected with sleep apnea. 


    Tucker describes their process for diagnosing, which must come from a board certified sleep physician. He discusses home sleep testing, which is becoming more and more popular as it offers users the opportunity to stay within the comfort of their own home and bed.


    Tucker talks about his experiences as a child, watching his father have snoring problems and extended periods without breathing. Tucker states that remarkably, some people they have seen, go up to a minute and a half without breathing when they are experiencing sleep apnea. 


    The sleep expert talks about strategies to prevent various diseases; and he stresses the importance of early intervention, accessible care that is cost effective, and the family members need to be engaged. He talks about the costs of untreated sleep apnea, and the correlation with diabetes, sexual dysfunction, stroke, and GERD. 


    Tucker states that 1 out of 4 Americans are undiagnosed. Tucker goes on to explain his practice and how they discover airway issues. He explains how they look into the mouth and search for what he refers to as a high-vaulted palate, as well as tongue issues, and gum issues.


    Tucker Educational Excellence offers intensive learning experiences for all levels of knowledge. Their courses cover basic dental sleep medicine implementation, individualized onsite programs, as well as guided learning experiences working directly with Tucker for extended periods.

  • 00:58:19

    Biological Beginnings – Luis P. Villarreal, Professor Emeritus, Department of Molecular Biology and Biochemistry, University of California, Irvine – The Viruses In Our World

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    Luis P. Villarreal, Professor Emeritus, Department of Molecular Biology and Biochemistry, School of Biological Sciences at the University of California, Irvine, discusses his thoughts on viruses, life, and the changes that motivate evolution.


    Is it possible to be passionate about viruses? The answer is yes. As a scientist who is constantly experimenting, with an unquenchable thirst for knowledge, Luis Villarreal is definitely passionate about understanding viruses, indeed, especially with regard to viruses that linger either in the genomes or epigenomes of their host. For over 20 years, Villarreal has centralized his study on the overall role of virus evolution on life. And Villarreal states that viruses have had a significant and profound influence on the origin and evolution of life.


    Villarreal talks about his early years in science and the classes and information that truly sparked his desire to learn more, and how it organically led him to his life’s work. He details his study of negative-strand RNA viruses, viruses that resemble rabies and ebola—highly pathogenic. He recounts his observation of regulatory RNA that had dramatic consequences, which was the beginning of his true curiosity about viruses. He delves into his study of rearrangements of the genome by various types of retroviruses. He describes how retroviruses actually work together to create the placental network. He questions why this would happen, and surmises that in order for a mother or host to create life, they must take in a foreign biological entity, the embryo, and suppress its natural immune rejection, feed it, and host it for its lifespan, which requires a significant amount of change. Villarreal states that the virus footprint is literally all over all of these functions. 


    The biology expert provides an overview of cellular DNA and the many jobs that DNA can fulfill. He explains how RNA and DNA react with each other and outlines their complicated network, although he states that there is much work to be done still to understand the complexity. He discusses his thoughts on human evolution and recounts stories that relate, such as endogenization of the koalas in Australia. He explains that a particular virus that was within these koalas was becoming part of them, and thus their ability to deal with the virus in their immune systems was being changed in real time. He compares this example to human development over time and discusses theories about viruses as they relate to humans, discussing the details of modification as it pertains to viruses and survival. 


    His discussion of viruses and biology continues as he summarizes his thoughts on the human species and the many elements that relate to evolution and brain function, etc. On a lighter note, Villarreal muses about some Hollywood versions of viral mutations and provides his thoughts on Hollywood’s interpretation of real science turned into fiction for the movies we enjoy. He goes on to explain the astronomic scale of viruses in our environment, discussing the ocean extensively, and the microbiome. 

  • 00:23:01

    Sleep Rockin’– Mark Russell, Founder of Rocking Bed – Sleep and Motion, the Science Behind It and the Potential for Great Sleep

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    Mark Russell, founder of Rocking Bed (rockingbed.com), talks extensively about sleep quality, and their rocking bed that is causing a stir in the good sleep industry.


    Russell is a self-described career entrepreneur, and his curiosity for creation has led him on an interesting journey in business. From small business to tree service, computers to marketing, with a little software design, advertising and sales thrown in, Russell has really done it all. In this interesting podcast, Russell talks about his exciting creation, Rocking Bed, the better way to fall asleep.


    Russell discusses the bed that will literally allow you to sleep like a baby again, as it gently rocks you to sleep. Russell recounts his early experiences as a child, trying to sleep in the family car on long road trips. He talks about a cruise he went on in 2004 that literally rocked his world. As he describes, he was truly amazed by the quality of sleep he got due to the cruise vessel’s gentle rocking motion. After the cruise he was driven to find a way to create this experience in his own home, and after much study and research, Rocking Bed was born.


    The sleep entrepreneur discusses various studies on movement and sleep, and explains that some studies are backing what he already knew to be true—that motion helps with sleep. As he states, the rocking motion of their product is so subtle that most people who try out their product at demo/trade shows think the rocking stops when they close their eyes, and then open their eyes quickly to discover that it’s still rocking. Russell recounts some of the stories he has heard from people regarding sleep and the rocking bed, and he talks about the immense potential for special needs children who need to be rocked to even fall asleep.


    He talks about the mechanics of the bed, its movement, and the potential for helping those who have trouble falling asleep. And Russell explains some of the product tweaks that they are working on to try to keep quality high but lower the price point. Ultimately, it is Russell’s hope that they can launch the bed to a larger audience as they grow their business, and help everyone… find a way to better sleep.

  • 00:37:18

    Exploring the Neurobiology of Sleep—Dr. John Peever—University of Toronto Department of Cell and Systems Biology, Canadian Sleep Society

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    “Even Aristotle, over 2,000 years ago, remarked on the benefits of sleep…there’s no doubt that it’s beneficial, but we are trying to understand the specific benefits and how those benefits are occurring,” says Dr. John Peever, professor at the University of Toronto Department of Cell & Systems Biology and Vice President of research at the Canadian Sleep Society. 


    It’s easy to identify the benefits of a good night’s sleep—we wake feeling more refreshed and alert, and we stay more focused and productive throughout the day—but it’s a lot harder to identify how exactly those benefits occur. Part of the investigation into this question involves understanding the neurobiology of sleep, which means understanding how different parts of the brain cause different behaviors relating to sleep.


    The work being done in Dr. Peever’s lab is focused on the study of rapid eye movement sleep, commonly referred to as REM or dreaming sleep. Specifically, Dr. Peever and his team are trying to determine what part of the brain is responsible for pushing us into REM sleep, what occurs once we are experiencing REM sleep, the underlying mechanism of REM sleep behavior disorder, and why parts of brain that cause REM are so vulnerable to degenerative processes, such as those that underlie Parkinson’s disease.


    Dr. Peever offers an exciting and informative conversation that touches on a range of other topics, including sleep’s potential to repair DNA damage, genetic predispositions for being a night owl versus an early bird, and the importance of understanding the true nature of narcolepsy. Tune in for all the details and learn more by visiting www.peeverlab.com.

  • 00:36:40

    The Lexicon of Life – John Hands, Author of Cosmosapiens:Human Evolution from the Origin of the Universe – Asking the Big Questions Regarding the Origin of Life

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    John Hands, a British author who received his scholarly training as a scientist, discusses his thoughts on the origin of life in the universe.


    Hands’ book, Cosmosapiens: Human Evolution from the Origin of the Universe, is a crash course of sorts that bridges the gap between cosmology and neuroscience and hits a lot of points in between. In Cosmosapiens, Hands provides his theories on how humans evolved to be such a dominating force on Earth. It delves into current themes of study such as cosmic inflation, dark energy, and neurogenetic determinism. It examines various fields of study such as string theory and often challenges the general consensus in multiple areas of science from cosmology to biology, and even neuroscience.


    Hands talks about his curiosity regarding various matters of science. He recounts how it was the passing of his wife that caused him to take an introspective look, as he began to ask big questions related to our existence on Earth, such as “what are we,” and “where do we come from,” and “why do we exist.” He explains how society has sought answers to these and other questions from the supernatural, and also from science. As a curious scientist, he was dissatisfied with the current literature on these complex subjects and decided to dig deeper on his own. He states that the specialization of science has perhaps prevented us from seeing the bigger picture as a whole. He embarked on a journey of discovery on his quest to get to the beginning of it all. He talks about some widely accepted theories in science, such as the big bang theory, that have been clearly contradicted by observation evidence. He delves into a discussion of dark matter and dark energy and explains how decades of research has failed to provide answers or evidence of what that is, leaving no scientific explanation whatsoever. He discusses the obvious fallacies in Darwinism and expounds upon the details that pertain to them. 


    The scientific author explains the collaborative process that produces life and change. Continuing, Hands expounds further on his conclusion that humans are unique as a species. He states that it is actually reflected consciousness that makes humans unique. As neural complexity increased, human consciousness was created. Hands state, “We are the only species that not only knows but knows it knows.” Hands deliver an overview of ancient philosophies and other theories that make an effort to explain the origin of life. Hands talks about how it is important to admit when we do not know the answers, and though he has answered many questions about life in his book, there is so much we do not know. 


    Hands talks about interesting feedback he has received from his readers, including validation of his theories from some of the world’s leading scientists and philosophers. And he talks about his plans for future works in the subjects of science.

  • 00:34:15

    Amid a Major Evolutionary Transition—Michael Garfield—Future Fossils Podcast, Santa Fe Institute

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    Michael Garfield is a paleontologist, futurist, evolutionary theorist, multimedia artist, and public speaker currently on the trail of a new unifying theory to explain major evolutionary transitions. In particular, he’s looking at the one he says humans are experiencing today, amidst unprecedented extinctions and innovation and rapid change—an environment that’s actually creating discomfort for many. He refers to the current major evolutionary transition as a conceptual one, whereby the human is seen not as separate from its environment or the systems around it, but embedded within its many layers. In his view, everything from single-celled organisms to the solar system itself can be seen as different layers of a single metabolic process; humans exist somewhere in between, as thinking organisms navigating their environment like any other.


    He draws attention to the effect of technological advances and third-world development on the ecosystem within which we live, comments on the way in which AI and augmented reality will continue to impact evolutionary change, and challenges us to rethink the nature of our existence and perceived realities. 


    Check out michaelgarfield.net to learn more about Garfield’s theories and thought processes, and follow him on Twitter and Instagram.

  • 00:23:34

    Wisdom Tooth Removal Replacing the Industry Standard with an Opioid-Free Surgical and Post-Op Solution—Dr. James Babiuk—The Wisdom Tooth Doc

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    It’s a procedure most people end up needing, and one that almost everyone dreads: wisdom tooth removal. But aside from the puffy cheeks and pain and misery that follow, there’s one other drawback that accompanies the standard protocol and actually threatens lives: the use of highly addictive narcotics for surgical and post-op pain management.


    Dr. James Babiuk has been a practicing oral surgeon in Chicago for about 25 years now, and over time he’s noticed a marked increase in the number of people who have become reliant upon heavy-duty and highly addictive narcotics for pain management. He's seen first-hand how something as benign as a shoulder injury or back pain can result in long-term use of heavy narcotics for pain management and eventual addiction. As he began digging deeper into research regarding opioid use in the medical field, he learned that most people’s first exposure to narcotics is during and after wisdom tooth removal; this compelled him to take action.


    Dr. Babiuk set out to alter his technique in a way that would allow him to perform wisdom tooth extractions without the use of IV narcotics and without having to prescribe narcotics for post-op pain management. This might initially sound impossible, but Dr. Babiuk has made it a reality—one that's proving to be incredibly effective. Rather than follow the standard protocol which is to expect and alleviate the pain associated with wisdom tooth removal, Dr. Babiuk’s approach focuses on reducing the cause of the pain, which is simply inflammation.


    He joins the podcast to discuss all of this and more, including the need for medical providers to receive narcotic education and the long-term goals for his practice. 


    For more information, reach out via email at info@wisdomteethjoliet.com, visit <a href="http://wisdomteethjoliet.com">wisdomteethjoliet.com</a>, or call 815-254-1560.

  • 00:26:38

    Master of the Tickets – Micah Hollingworth, Co-founder and CEO of BROADWai – High Tech Ticketing, Using Technology to Simplify the Ticketing Industry

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    Micah Hollingworth, co-founder and CEO of BROADWai (broadw.ai), delivers an overview of the current state of special event ticketing and the technology that drives it.


    Hollingworth is a seasoned entrepreneur with over two decades of experience in creating, operating, and marketing live events. His innovative entrepreneurial skills include strategic planning, fundraising, and execution. And with an intensive fascination for all things technology it was inevitable that Hollingworth would launch another great tech-oriented business such as BROADWai.


    Hollingworth talks about the many and varied interests that led him to launch BROADWai, along with co-founder, Jon Scott. He describes his entrepreneurial spirit as a child and the love for live theater he developed that led him to his current career. Moving to NYC about 25 years ago set the stage for his total immersion in the theater world.


    The technology guru discusses the many challenges that people face when trying to purchase tickets for events. He states that difficulty in purchasing or reserving tickets for live events can often discourage ticket buyers, and providers may lose them to other events when the experience is arduous. Hollingworth explains how their technology platform works, and how it provides a smooth, efficient process for ticket buyers.  


    BROADWai’s technology solutions assist customers with their total experience, helping them to navigate and effortlessly plan. The platform offers a valuable exchange between the guests and the Broadway community, a customized experience in one simple, single digital transaction that incorporates everything, from ticketing to parking, as well as preshow and postshow needs to provide real-time information regarding theater policies and so much more. Hollingworth discusses their integration with other ticketing partners, and the events that they currently support. Hollingworth expounds upon the future of ticketing. He states that voice-enabled devices will be a part of their future because the voice-enabled tech market is exploding. And he talks about their voice clients that will be launching later in the year. Regarding their platform, BROADWai’s AI/ML abilities continue to evolve during each conversation and with every question asked. Their innovative platform will set the bar high for competitors as BROADWai accelerates to the edge of technology and continually integrates the latest and greatest, in order to deliver a totally frictionless experience to the user.

  • 00:49:59

    Understanding Biological Meaning, Biological Versus Artificial Intelligence, and Evolutionary Agency—Victoria N. Alexander—Dactyl Foundation, Author of The Biologist's Mistress

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    “In biosemiotics, we say that the human ability to interpret signs—which is the ability to think really, to think creatively and adaptively and learn new things—didn’t just emerge with animals; rudimentary sign reading emerged in the simplest forms of life with single-celled organisms,” says Victoria Alexander, biosemiotician, Director of Dactyl Foundation, Fulbright specialist, and author of The Biologist's Mistress: Rethinking Self-Organization in Art, Literature, and Nature.


    What’s biosemiotics, you ask? Alexander explains biosemiotics as the study of sign use in biological systems, where signs can be almost anything in the environment—a word, a pictogram, a smell, a sound, or a chemical gradient. Signs are intelligence; we can train a computer to read signs, but can we train a computer to interpret signs that depend on the context within which they exist? 


    Answering this question is one aspect of the investigation into the differences between biological and artificial intelligence, which is what Alexander’s work is currently focused on. She explains that biological cells don’t just react to the chemistry around them, but interpret and respond to it. 


    She goes on to explain how this underlies a system of interpretation that's related to random change in a way that’s changing the direction of evolution. In this way, Alexander argues that it is within the organism that evolutionary agency is found and explained, rather than in the mechanisms of randomness and competition.


    Alexander offers an exciting and informative conversation that touches on a variety of topics, including metabolic pathways, the association of properties and the placebo effect, the idea that dysfunctional semiotic habits are the cause of some syndromes and conditions, cell differentiation, self-organization in nature, and butterfly wing pattern development. Press play to hear the full conversation.

  • 00:35:40

    Drug Discovery – Ilan Morad, PhD, Founder and CEO of Accelerated Evolution Biotechnologies Ltd. – How Advanced Biopharmaceutical Technology Is Making Great Strides Toward Treating Diseases

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    Ilan Morad, Ph.D., founder, and CEO of Accelerated Evolution Biotechnologies Ltd. (aebi-bio.com) discusses drug discovery and development on the cellular level.


    Morad has been fascinated with biology most of his life and began practicing molecular biology and biochemistry in 1984. He is a noted expert in gene cloning, protein engineering, purification, and characterization, as well as drug discovery and development. Morad’s company, Accelerated Evolution Biotechnologies Ltd. (AEBI) is a development-stage biopharmaceutical company primarily engaged in the discovery and development of various therapeutic peptides and has developed an innovative combinatorial biology screening platform technology.


    Morad discusses the origin of his company, AEBI. He details their groundbreaking screening platform and explains how it works. Their platform provides functional leads to extremely difficult targets, not merely those that best bind with the target.

    AEBI’s novel technology that goes by the name, SoAP, allows them to develop drugs for many illnesses, among them cancer, and Morad expects to completely transform the drug discovery R&D phase by seriously reducing the attrition rate of any new drug candidates.


    As Morad explains, peptides are microproteins. He elaborates on these and other building blocks and where they are produced and how. He discusses how they make large numbers of synthetic peptides and how they isolate them for research and development. Further, he expounds upon the roles of various peptides within the body. He discusses drug resistance, side effects of drugs, and cancer treatment. Digging deeper, he explains the properties of cancer and how the disease reacts to certain treatment, drugs, etc. Morad relates some of his thoughts on drug successes, such as the drug cocktail that has solved the problem of HIV for many patients. And as he states, drug cocktails are a possibility for other diseases. He details how cancer cells work and explains the related probabilities. 


    The biology expert continues his discussion of cancer and peptides. He explains how toxic peptides can be utilized to poison cells and kill them very efficiently. This strategy shows great promise for future treatment. And he explains how immune systems work and how they recognize molecules, giving special attention to how cancer cells are targeted. Wrapping up, Morad talks about the expectations for his company and the areas they are expecting to make strides in as they move into the future. Finally, Morad talks about upcoming clinical trials and his expectations for the new cocktails and peptides. 

  • 00:42:50

    Self-Experiments and the Power of Data: When Medical Systems Fail to Diagnose—Damien Blenkinsopp— The Quantified Body Podcast, Ketosource.co

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    In his early twenties, Damien Blenkinsopp lived a nomadic lifestyle, rolling with life’s punches and going in whatever direction it seemed to take him. But when it took him to Thailand, it presented something which would change him forever: a mysterious illness that would leave him intermittently bed-bound and battling symptom after symptom for years on end. No matter how many specialists he visited, he couldn’t get an answer as to what was going on with his body. Not many of us have found ourselves in such a position, but the prospect terrifyingly begs the question: where would we turn for help?


    Forced to answer this question for himself, Blenkinsopp embarked on a journey filled with research, self-experimentation, and conversation with any and every scientist or layperson who might provide some insight. Along this journey, Blenkinsopp created The Quantified Body, a podcast that he used as a tool for collecting information and anecdotal evidence. 


    Having tried countless avenues of potential relief, Blenkinsopp can attest to his personal success with two things: the ketogenic diet and the fasting diet. He has since founded Ketosource, a website dedicated to providing others with the information and insight he’s learned throughout his journey, which continues to this day.


    Blenkinsopp has a one-of-a-kind story that is simultaneously inspiring and intriguing, informative and enlightening. Press play to hear all the details, including his advice on navigating medical systems that fail to provide diagnoses, the fasting mimicking diet, and how to take back control of your health by harnessing the power of data. For resources, check out his podcast and visit ketosource.co.

  • 00:39:09

    Medical Crisis – Jack Rubinstein, Associate Professor of Medicine, University of Cincinnati – An Interesting Look at the Many Challenges and Problems in Today’s Medical and Pharmaceutical Industries

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    Jack Rubinstein, Associate Professor of Medicine, University of Cincinnati discusses his medical thriller, The Perfect Dose, and how it relates to real-world problems in the healthcare industry.


    Dr. Rubinstein is affiliated with multiple hospitals in the greater Cincinnati area, including Cincinnati Veterans Affairs Medical Center and University of Cincinnati Medical Center. Dr. Rubinstein talks about his book, The Perfect Dose, which is a medical thriller that highlights corruption within the healthcare system, and those who threaten scientific progress. He outlines his reasons for writing the book, specifically mentioning that he thought a fictional thriller with interesting characters and story would establish a stage for societal dialogue regarding the very real, demonstrable problems within the American healthcare system. He discusses the case of Martin Shkreli, the much-maligned, now imprisoned American businessman and former hedge fund manager who sent shockwaves across the country when he raised drug prices thousands of percent. He uses Shkreli as an example of the constant battle in the industry—helping the most people possible versus helping shareholders of pharmaceutical companies make large profits. Dr. Rubinstein points out that many drugs are funded by the government agency, National Institutes of Health (NIH), which funds academia that conducts much of the research that leads to new drug development. Then drugs are often licensed to pharmaceutical companies who may charge a very high price for the drug as they sell it back to taxpayers, the very people who funded the drugs in the first place.


    Dr. Rubinstein discusses many of the drugs and medical issues in his spectrum of study. He studies select drugs that have had success in specific areas of medicine and through his research has repurposed some of them for cardiovascular issues such as heart failure. He delves further into the off-label uses of many prescription drugs. Further, he expounds upon how his book highlights many issues in the American system versus other countries outside of the US. Dr. Rubinstein talks about his experiences caring for other doctors and their family members. He speaks extensively about what makes a doctor a good doctor, and the systems and standardized treatments that play a part in reputation.

  • 00:41:32

    Thyroid Health and A Life Well-Lived – Dr. Christianson, Naturopathic Medical Doctor – Improving the Thyroid, Adrenal Issues, and the Path to Better Health

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    Dr. Alan Christianson is one of America’s revered naturopathic physicians and the bestselling author of several books, including The Metabolism Reset Diet, the celebrated book that teaches its readers how to repair the liver, stop storing fat and lose weight naturally. Dr. Christianson, or Dr. C as many of his patients call him, provides an interesting overview of the many factors that influence good health.


    Dr. Christianson is a naturopathic medical doctor, a specialist in natural endocrinology who focuses on thyroid disorders. He is extremely passionate about bringing life-changing medical information to his patients and the general public alike. Specifically, he discusses the power of diet and how it can absolutely affect your body’s hormones. An understanding of these issues provides insight into the many interrelated issues of diet, weight, and hormone balance. 


    The naturopathic physician talks about the personal journey that led him to his career path. Afflicted with cerebral palsy and seizures, abysmal coordination, and the onset of obesity, Dr. Christianson had many medical and physical struggles as a child. His struggles pushed him to learn more and shift his lifestyle, which led to a new physical life and career path as well. He talks about eating well, and being active, and discusses the studies in medical school that he found particularly intriguing, such as thyroid and adrenal problems. Hormones, endocrinology, and the connection points between lifestyle and health are the basis of his intensive study. 


    Dr. Christianson goes deep into an analysis of thyroid issues and explains the many problems that people can and do experience regularly. He talks about compounded thyroid medicines, and Dr. C discusses T3 in detail. As he states, T3 is a thyroid hormone that is often overlooked in basic lab work. And measuring T3 is critically important for understanding the complete functionality of the thyroid. He talks about the many medical issues that patients struggle with and how his doctors diagnose and treat the myriad of complex thyroid issues. 


    Dr. C underscores the importance of optimizing blood levels and taking a serious look at everything that patients are putting in their bodies, even down to the vitamins that they are taking, some of which could even block thyroid function for those being treated. From circadian rhythms to diet, hormones, and the importance of iodine, there are many impacting factors that will definitely influence health, and Dr. Christianson seeks to spread this important knowledge to everyone, to improve lives and health.

  • 00:21:15

    Increasing the Accessibility and Convenience of Healthier Food Options via Gene Editing—Ryan Rapp—Pairwise

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    The power of gene editing is putting nutritious, convenient produce in the hands of people who otherwise might not have access to it. Ryan Rapp is the head of product discovery at Pairwise, a company whose mission is to utilize gene editing technology to explore collaborations focused on gene editing in the production of real crops, such as cotton, corn, and soybeans, as well as the accessibility of healthy produce options for consumers. Still, in the exploratory phase, the team at Pairwise is looking into how to help plants make the transition to the lab, which tools in the gene editing process are most efficient and effective for their goals, and how to overcome the challenges presented.


    Rather than trying to breed new crops, the team at Pairwise has been focused on improving those that already exist in order to bring spectacular options to consumers. There are many products out there that hold great potential but suffer from one or more hang-ups—perhaps it’s the taste, the convenience, or the production system. Regardless of what it is, the team at Pairwise is dedicated to fixing it and maximizing consumer satisfaction.


    Rapp provides a few examples of real-world results of the type of work they’re aiming to accomplish, discusses how the production of ‘baby’ carrots has significantly increased the general consumption of carrots, explains what drives their work, and what makes a plant a good food source for human food production. 


    Interested in hearing more? Press play and check out their website at <a href="http://pairwise.com">pairwise.com</a>.