Episodes
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Dr Glenn McConell chats with Associate Professor Lykke Sylow from The University of Copenhagen. She is a rising star in exercise metabolism and in particular the effect of exercise on cancer. This is the second podcast episode on exercise and cancer (See Professor Kathryn Schmitz episode #9).
Remarkably she said that if you are a non-smoker your biggest risk of getting cancer is inactivity. Not clear if this is independent of obesity etc. Can associated with a reduction of insulin sensitivity and also cachexia (with the loss of muscle mass is very important). The cancer itself may cause insulin resistance. Exercise can reduce the likelihood of getting cancer, improve the prognosis during cancer treatment and reduce the likely of getting cancer again. There is even evidence that exercise can improve the effectiveness of chemotherapy and reduce the extent of metastasis. Really remarkable stuff. A lot more research is needed to clarify these things. X: @lykkesylow
0:00. Introduction
2:40. Lykke is a rising star
3:59. Cancer and exercise overview
6:09. Wasting of muscle mass with cancer
7:00. Evidence that exercise reduces the risk of getting cancer
11:40. Inactivity / obesity and cancer
13:03. Glucose metabolism and cancer
15:20. Cancer cachexia
19:05. The cancer itself may cause insulin resistance
22:55. Cancer cachexia/ loss of muscle mass
29:30. When loss weight tend to lose muscle
30:30. Mechanisms of cancer cachexia
33:20. Pre cancer muscle mass/strength and survival
35:50. With cancer insulin resistance may come before cachexia
40:07. What do different cancers have different effects?
41:48. Exercise can improve tolerance to cancer treatment/fatigue
46:20. Does exercise reverse the insulin sensitivity with cancer
46:30. Exercise increases muscle glucose use during and after exercise
52:10. Exercise during chemotherapy treatment
54:55. What kind/type of exercise are we talking about?
1:01:20. Mechanisms/AMPK
1:03:25. Exercise reduces fatigue in cancer
1:04:13. Exercise may improve the effectiveness of chemotherapy
1:06:25. Exercise may reduce metastasis of cancer
1:08:30. Sex differences, cancer and exercise
1:12:20. Age, cancer and exercise
1:15:15. Availability of exercise in oncology departments
1:18:50. Diet vs exercise in cancer treatment
1:19:50. Strength vs endurance training with cancer
1:21:22. Takeaway messages
1:26:23. Outro
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Dr Glenn McConell chats with Professor Paul D. Thompson who is Chief of Cardiology, Emeritus at Hartford Hospital, Hartford, CT and Professor of Medicine, Emeritus at the University of Connecticut. He has published over 500 peer reviewed journal articles, was a past President of the American College of sports medicine (ACSM) and was a impressively fast marathon runner. This is the third of a series of podcast episodes on sport cardiology (See Professor Benjamin Levine and Associate Professor Andre La Gerche’s episodes). We covered a lot of ground. There is a greater prevalence of atrial fibrillation in athletes (is it due to larger hearts?). We discussed possible reasons why coronary artery calcium/calcification is higher in athletes. He recommends 8000 steps done vigorously per day. Exercise is very important for your health. What exercise to do depends on your goals and health status. See time stamps further much more. We discuss his free substack called 500 rules of cardiology.
0:00. Introduction
2:40. Previous IE podcast episodes on sports cardiology
5:30. Worked with ex physiol legend David Costill
8:00. Ex physiol legend Bengt Saltin
9:00. More than 500 publications, importance of collaboration
10:45. Can exercise have negative effects on the heart?
13:00. More atrial fibrillation in athletes (due to larger hearts?)
20:30. Genetics and exercise
25:15. Was excellent marathoner
27:30. Exercise and right ventricle “fatigue”
32:00. Genetics, exercise and longevity
34:10. Cut off points/prevalence of increased risk of atrial fibrillation
36:26. Atrial fibrillation, blood thinners and strokes
39:30. Daily aspirin and heart risk
42:42. Why coronary artery calcium/calcification (CAC) higher in athletes?
48:40. Sex differences
51:03. Less heart beats per day in endurance athletes
53:40. Athletes, higher CAC and cardiovascular events
56:15. Exercise reduces cardiovascular events
58:30. Almost never restricts exercise in patients
1:00:20. Rationale to train hard
1:02:30. Most bang for your buck if less fit to start with
1:05:30. Cadence and turbulence in artery
1:09:30. Better athletes have more heart issues
1:11:40. Exercise intensity and coronary calcification
1:13:55. Walking and the heart
1:18:00. Fit handle operations/illnesses better
1:20:17. Statins and muscle pain /cholesterol
1:24:15. Medications vs lifestyle in diabetes
1:26:32. Metformin and exercise adaptations
1:27:15. Sudden death during exercise
1:29:25. Coronary narrowing and heart attacks
1:31:45. Best athletes have larger aortas
1:35:20. Intermittent fasting /ketosis
1:38:45. Exercise intensity and heart adaptations
1:39:40. Pay attention to symptoms
1:41:55. Broke his hip in a bike accident, cycles now
1:43:25. Exercise training early in life /epigenetics
1:47:05. Drugs and exercise performance
1:49:20. Environmental factors: eg walking to school
1:51:52. Cardiac sex differences re exercise
1:54:05. Wise advice
1:58:45. Be mindful of the media’s take on exercise
2:00:25. Takeaway messages
2:02:12. His free substack 500 rules of cardiology
2:02:59. OutroInside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Missing episodes?
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Dr Glenn McConell chats with Professor Bryan Heiderscheit from the University of Wisconsin in USA. He is an expert on running injuries. This is the third of a series of podcast episodes on running injuries (See Professor Irene Davis’s and Associate Professor Rasmus Østergaard Nielsen’s episodes). Bryan focuses on overstriding and how increasing the stride rate can reduce overstriding and therefore running injuries. The importance of making gradual changes in all aspects. Different kinds of running injuries when land on the forefoot vs the heel. He thinks the type of shoes (minimalist vs cushioned etc) doesn’t make much difference to running injury rates etc. If bouncing up and down when running then may be overstriding which can result in injury. Some people bounce more but don’t overstride, some people overstride but don’t bounce and some do both. Bryan likes to try altering the stride rate/cadence to reduce over striding in an attempt to reduce bouncing and therefore, hopefully, running injuries. Bryan and the previous running. We also discussed causes of hamstring injuries during sprinting. A very interesting chat that brought together not only his research but also the previous two episodes on running injuries.
0:00. Introduction
3:16. Similarities/differences re the 3 interviews on running injuries
8:36. How Bryan got into running injury research
10:53. Running injuries when land on the forefoot vs heel
17:02. Specificity: function vs capacity
20:08. Do cushioned shoes increases injuries?
26:04. Injury rates /injury risks
28:45. Accumulation of strides, resilience, loads
31:30. The centre of mass movement during running (bounce)
34:20. Changing gait to alter centre of mass movement
36:50. Overstriding re centre of mass
40:20. Overstriding and eccentric load on the knee
41:15. Cadence/step rate to alter overstriding/bounce
45:38. Speed of runner and how land when running
47:13. Loading rate and injuries
49:08. Some overstride but don’t bounce and vice versa
50:42. Experience of runner and overstriding
52:40. Elite runners and extent of overstriding
55:26. Gait retraining and injury rates
57:14. Step rate increase when land on forefoot
1:00:01. Other causes of running injuries
1:00:50. Need shoes to control pronation?
1:03:26. Causes of hamstring injuries during sprinting
1:06:43. Bone density reduction after bone injury
1:08:25. When ready to return after ACL reconstruction?
1:10:00. Takeaway messages
1:11:49. Outro
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Dr Glenn McConell chats with Associate Professor Rasmus Østergaard Nielsen from Aarhus University who is an expert on the affect of training load and shoes on running-related injuries. This is the second of a series of podcast episodes on running injuries (See Prof Irene Davis’s episode).
Rasmus went from an overweight gamer to an injured runner to a exercise researcher! His research focuses on injury prevention, especially the importance of training load. Need to make slow changes. Seems don’t need motion control shoes for those with “excess pronation”. His main point is that one needs to give the body enough time to adapt or the likelihood of injury is increased. So don’t suddenly change things. This includes speed, distance, shoes, terrain etc. How gradual is gradual though? There tend to be different injuries from running long vs running fast (and when returning to running one should consider the cause of the original injury). What do in leisure time affects the total load. Shoes and running injuries. Very interesting stuff.
0:00. Introduction
3:05. Rasmus focuses on injury prevention
4:50. The importance of training load with injuries
8:10. Went from overweight gamer to runner to exercise researcher
15:12. “Excessive pronation” doesn’t increase injuries
20:20. If it ain’t broke, don’t fix it.
21:38. Injury rates
23:50. Don’t suddenly change things
25:00. Should increase 5-10% a week?
26:35. Injury from one session vs more chronic effects
30:20. Running speed, distance and load
32:40. Stride length and stride rate
36:00. Gradual changes are very important
40:08. Different injuries when run long vs fast
43:02. Don’t do too much too soon (change shoes, different terrain etc)
48:45. Generally the body can adapt if give it time
50:40. Might be good to have different shoes if used to them
53:50. How gradual is gradual though?
59:20. What do in leisure time affects the total load
1:02:27. Rearfoot vs forefoot strike and injuries
1:07:08. Evolution and running shoes, fan of minimalist shoes?
1:10:35. Training load needs to be considered in injury research
1:16:43. Quantifying load per stride etc
1:21:00. Recovery from injury (plantar fasciitis)
1:24:02. Shoes and running injuries
1:27:05. “Super shoes” and injury risk
1:28:48. Recovery from achilles tendon recovery
1:31:32. Running and knee osteoarthritis
1:33:53. Strength training and running injuries
1:39:00. Aging, stretching and running injuries
1:42:37. Sex differences and running injuries
1:44:23. Takeaway messages
1:46:26. Outro
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Dr Glenn McConell chats with Professor Irene Davis from the University of South Florida who is a top running injuries researcher and the current president of the American College of Sports Medicine. She makes the argument that we were born to run and have evolved to land on the ball of the foot during running and this reduces impact load compared with landing on the heel. Modern running shoes tend to increase the likelihood of landing on one’s heel. She is a fan of minimalist shoes, which tend to result in landing on the forefoot not the heel. She also believes that neutral shoes are best rather than the commonly advised shoes that attempt to minimize pronation. In addition, she also believes that if one has stubborn injuries and have tried other rehabilitation retraining your running gait may be helpful. Not a huge fan of orthotics. I was actually blown away by the chat and very motivated by it. Really fun stuff. Twitter: @IreneSDavis0:00. Introduction to podcast/Irene Davis3:05. How Irene got into exercise research6:43. Running injuries took off when started running shoes13:30. Variability of loading results in less injuries18:50. Rear foot landers have weak calves19:54. Born to run22:00. Calves vs tibialis anterior/shin splints23:00. Running boom and padded running shoes27:00. Landing on the ball of the foot reduces impact load32:15. Cushioned shoes tended to cause heel landing33:40. Tarahumara Mexican tribe use minimalist type shoes35:30. Tibial shock when running on different surfaces36:55. Running barefoot and with minimalist shoes40:45. Training in cushioned shoes then racing in flats42:40. The recent more efficient plated shoes46:55. Flared shoes and greater pronation49:40. Should change running gait?53:50. Retraining running gait1:02:18. Should change to minimalist shoes to land on ball of foot?1:06:40. Should use orthotics?1:10:10. Preparing to run with minimalist shoes1:18:50. This is, however, controversial1:28:32. Microtears in muscle/stress fractures1:30:06. Warming up, stretching, ice useful?1:35:10. Body weight and injuries1:36:47. Can anyone run?1:39:00. Q angle and leg length running injuries1:42:00. Taping the patellar tendon1:42:45. What % should increase running per week?1:43:55. Listen to your body1:45:00. Irene: her running and injuries etc1:50:00. Not a fan of super shoes1:52:17. Need to minimize pronation?1:53:48. Retraining gait1:56:07. Sex differences1:57:00. Age1:58:35. Her prestigious role as President of ACSM2:02:02. Takeaway messages2:03:10. Never too late to change to minimalist shoes2:03:55. OutroInside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: [email protected] to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218Not medical advice
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Dr Glenn McConell chats with Dr David Martin. David has a remarkable and varied background starting off as a research scientist at the Australian Institute Sport and then National Sports Science Coordinator at Cycling Australia. He then became Director, Performance Research and Development at the Philadelphia 76ers. He is currently Chief Scientist, Director of Performance at Apeiron Life, San Francisco where he works to improve the healthspan of high net worth individuals. He is also an Adjunct Professor at the Australian Catholic University. We talked about all of this with a focus on the importance of belief systems in sports performance, how placebo effects are real, the use of placebos/belief effects in sports etc. A really interesting chat. I learned a lot. Twitter: davidtmartin
0:00. Introduction to podcast and David Martin
3:20. Testing Lance Armstrong and Cadel Evans
8:00. Thermoregulation, Heat susceptibility
9:10. Derek Clayton
10:35. Amy Gillett Foundation
11:40. Physiological attributes vs belief for exercise performance
18:05. Cycling selection camps based on combat selection
23:00. Belief effect
25:20. Placebo effect of altitude training
33:25. Does EPO (Erythropoietin) have its own effects on perf etc?
38:00. Placebo effects on pain and depression etc
42:00. The “I went to Harvard” /credentials etc effect
45:05. Lying to win and Belief vs evidence
47:05. How handle if mismatch between belief and evidence
53:20. Real physiological effects of placebos
1:01:40. How much of perf effect of CHO ingestion is belief effect
1:03:10. Believable vs well informed people in sports team
1:05:40. Importance of belief in the coach
1:09:40. Physiological needs of the specific sport
1:13:40. David and the Philadelphia 76ers
1:19:00. NBA and trust/protection/managing
1:23:53. His ideas and finishing up at the Philadelphia 76ers
1:26:20. Regretted not going fully into academia?
1:28:22. Rather fight 1000 x 1lb chickens or 1 x 1000 lb chicken?
1:30:24. Balancing S&C needs and the coaches needs
1:32:55. Reducing injuries in team sports
1:34:55. Importance of pre-season conditioning
1:35:40. Balance of winning vs how much money can make
1:38:40. Lower body strength in NBA vs track cyclists
1:41:18. Improving healthspans of high net worth individuals
1:53:10. A focus on healthspan rather than lifespan
1:58:55. Evidence base re supplements
2:03:45. Miss the adrenaline of working with athletes?
2:05:12. Outro
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Dr Glenn McConell chats with Professor Mark Haykowsky from the University of Alberta, Canada and remarkable heart transplant recipients Dwight Kroening, Edmonton, Alberta, Canada and Elmar Sprink, Cologne, Germany. Dwight was very fit before a heart defect resulted in his heart transplantation (HT) way back in 1986. Elmar was an endurance athlete who suffered a series of cardiac arrests before his HT 12 years ago. They have undertaken Ironman triathlons and more. Both had VO2 maxes in the high 50s! (ml/kg/min). They embody the importance of exercise. Really motivating stuff, incredible. I loved this chat with these three remarkable people. Twitter: @mhaykows0:00. Introduction5:40. How Mark got into this area of research8:40. History of heart transplantation (HT)10:00. The age of the heart donors/recipients11:15. The transplanted heart doesn’t perform as well15:45. Reinnervation of the heart16:45. Heart rate during exercise after HT18:55. Dwight before the HT26:00. Matching donor/ recipient30:00. Time from donor death until HT32:20. Matching/rejection/immunosuppression35:10. Elmar before HT46:35. Elmar’s resting lactate was 11mmol/l52:20. Time from diagnosis to transplant54:00. Vascular and skeletal muscle impacts56:00. Dwight’s heart donor58:05. Dwight belief in exercise after HT1:04:15. Importance of being fit before HT1:05:25. Dwight’s VO2 max1:06:30. Very high O2 extractions1:07:25. Dwight motivated Mark to exercise!1:10:50. Elmar’s exercise journey after HT1:13:15. Delay in heart rate increases during exercise1:15:10. Triathlon 1 yr, Ironman 2 yrs after HT1:18:00. Cape Epic in South Africa1:20:00. Elmar better than before heart issues!1:23:20. They can hold the same HR for hours that most HT recipients can hold for 1 min1:25:40. Most HT recipients don’t ex train1:27:30. Muscle issues after transplant1:30:00. World transplant games1:32:10. Doctor loved being wrong about exercise1:33:10. HT recipients and HR delay1:35:10. These guys push the importance of exercise!1:38:30. Max HR with age after HT 1:39:50. Reinnervation after HT1:42:40. Heart stiffer after HT1:44:02. Ex training and cardiac output/left ventricle adaptations1:47:10. Most adaptations to training in HT are peripheral1:49:20. These 2 the fittest HR recipients ever1:51:18. Exercise the key to longevity1:52:24. Dwight feels poorly when doesn’t exercise1:53:20. Go back to old new normal/legacy effect1:55:10. Their prognosis1:57:10. Dwight: More to life than the physical2:02:10. Takeaway messages2:07:10. They are much more than only HT recipients2:10:32. OutroInside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Dr Glenn McConell chats with Associate Professor Chris Fry from the University of Kentucky, USA. Joint injury causes muscle weakness and atrophy (reductions in muscle size) due to the the inactivity but also separately due to the injury itself. Substances are released from muscle to help repair the joint/bone. Prehab is important before surgery. There can be residual effects long after joint injury. We also discussed hypertrophy and aging and the importance of having a lot of muscle capillaries as age to obtain the optimum response to resistance training. Lots more. We had a really great chat. Chris has a very pleasant manner. I enjoyed it a lot. Twitter: @ChrisFryPhD
0:00. Introduction and welcome
3:09. How Chris got into exercise research
6:10. ACL injuries and muscle wasting /weakness
9:05. Joint injuries and the risk of arthritis
10:05. The effects of the inactivity vs the injury itself
13:55. Protein synthesis vs breakdown after an ACL injury
19:30. Why in evolutionary sense does joint injury result in muscle atrophy
22:50. What are the signals to cause muscle atrophy
24:00. Myostatin release after joint injury
26:55. Acute vs chronic injury
28:15. Other joint injuries to joints (other than ACL)
29:25. Atrophy in different muscle fibre types
31:15. Best way to prepare for surgery after an injury
34:05. How quickly start rehab after surgery
35:45. Are there residual effects long after joint injury?
39:55. Bone vs joint injury
43:30. Muscle reactive oxygen species/ mitochondria after injury
46:05. Aerobic capacity of muscle still reduced after rehab
47:05. Should take anti inflammatories after injury?
49:20. Vitamin D and muscle injury
52:15. Does joint injury affect muscle in the non injuried limb?
54:45. What can do to slow atrophy after injury?
55:55. Does muscle size and strength go hand in hand after injury
57:15. Time since injury/trauma and surgery
58:55. Sex difference and joint injury
1:00:20. Age and joint injuries
1:01:10. Hypertrophy and aging
1:02:05. Aging: inactivity vs training response
1:03:00. More capillaries in muscle increases response to resistance training
1:05:00. Aerobic pre conditioning can help with hypertrophy
1:08:30. Anabolic resistance and aging
1:12:25. Connective tissue and training responses with aging
1:15:20. Satellite cells and muscle growth
1:17:45. Takeaway messages
1:19:01. OutroInside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Dr Glenn McConell chats with Assistant Professor Kevin Murach who is a rising star from the University of Arkansas, USA. Kevin is an expert on muscle, muscle growth, adaptation to exercise training, “muscle memory”, the regulation of muscle growth and muscle memory and the effect of aging etc. Muscle memory definitely seems real (especially in slow muscle fibers). Looks like epigenetics involved more than changes to muscle fibers nuclei. But more work needs to be done, especially in humans. We had a really great chat. I enjoyed it a lot. A very smart chap. Twitter: @KevinMurachPhD
0:00. Introduction and welcome
2:16. How Kevin got into exercise research
6:53. What is “muscle memory”.
9:15. Human evidence of muscle memory
13:58. Mice models to investigate resistance training
19:30. Training, detraining and retraining
20:35. Comparing rodents and human re their different lifespans
22:30. Evidence for muscle memory in mice after ex training
31:05. Mouse model that has both endurance and strength effects
33:25. Voluntary wheel running: matching the training
35:45. 10% greater hypertrophy with retraining
39:25. Mice slow postural muscles didn’t detrain!
44:45. Mechanisms: epigenetics
49:50. Muscle nuclei and exercise training/muscle memory
1:02:00. Muscle memory and epigenetics in the nuclei
1:05:40. MicroRNA and muscle memory
1:07:30. Epigenetics
1:08:35. Exercise training and each bout of exercise
1:11:20. MicroRNA and muscle memory
1:16:20. Balance of protein synthesis and breakdown
1:20:20. Muscle memory: Endurance vs resistance training
1:21:35. Time course of muscle memory
1:23:55. How much training need to get muscle memory
1:25:18. Specificity of ex training muscle memory
1:26:40. Nature and nuture
1:27:25. Dutch famine and epigenetics
1:28:18. Age and muscle memory
1:29:38. Biological sex and muscle memory
1:30:40. Common misconceptions: use it or lose it
1:31:38. Identical twins
1:32:25. Don’t need to go hard or go home.
1:33:05. Research experts vs influencers etc
1:37:15. Takeaway messages
1:39:44. Do health benefits have a memory too?
1:41:45. Outro
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Dr Glenn McConell chats with Dr Nicola Guess from Oxford University, England and Professor Jonathan Little from the University of British Columbia, Canada. Nicola is a dietitian researcher with many years of expertise including the importance or otherwise of glucose “spikes” or excursions and the pros and cons of continuous glucose monitor use. Jonathan is an expert on exercise metabolism who is coming onto the podcast for the second time after speaking previously about keto diets and exercise. A major point is the difference between having chronically elevated blood glucose levels such as in diabetes (pathology) versus having normal increases in glucose ("spikes") in response to a meal. Also increases in glucose before and during very intense exercise is normal physiology and not a concern. There was also a clear message that the use of continuous glucose monitors (CGMs) have both pros and cons and that need to be considered. A very interesting chat. Twitter: @DrJonLittle
0:00. Introduction and welcome
3:20. What are glucose “spikes”/excursions
4:45. Hyperglycemia in diabetes is very different to “spikes”
6:20. Glucose spikes in type 2 diabetes
7:19. Why is chronically elevated glucose a problem?
12:20. Confusion about glucose levels 2hrs after a meal
15:29. Underlying insulin resistance the problem not spikes
19:08. Fasting glucose and insulin measures
21:10. Meal tests and oral glucose tolerance tests
24:55. Be careful not to make the underlying pathology worse
26:15. Keto diets: T2D, weight loss, exercise
32:10. Glucose even in diabetes is not as important as we think
35:00. Are CGMs useful?
38:30. Too much focus on glucose than more important things
41:00. CGMs very important for people with T1D
42:05. CGMs and anxiety
43:25. CGMs and higher cholesterol
44:00. Misunderstanding of pre-diabetes re CGMs
46:00. Metabolic flexibility
47:40. “Nervous normals”
49:42. Is how loses weight important?
53:41. What about CGMs in type 1 diabetes?
54:15. CGMs, diabetes, diet, behaviour change and exercise
57:40. Glucose metabolism during exercise
59:55. Exercise and insulin sensitivity
1:02:15. Effect of exercise on glucose spikes from a meal
1:04:10. Intense exercise can increase blood glucose levels
1:07:10. Normal to have elevated glucose after intense exercise
1:09:50. Influencers misinterpreting data re glucose spikes etc
1:12:10. Misunderstanding glucose cut offs
1:13:10. Takeaway messages etc
1:14:00. Weight loss diet strategies
1:17:50. Amino acids and insulin secretion
1:24:40. Should everyone use CGMs?
1:26:30. Keep it simple re diet and exercise
1:27:40. Outro
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Dr Glenn McConell chats with Associate Professor from the University of Wisconsin-Madison, USA. Jill is an expert on the brain and exercise. We discussed the effect of acute (one bout) and chronic physical activity/ exercise on cognitive function, brain blood flow (BBF), dementia/Alzheimer’s disease risk and progression etc. A very interesting chat. Twitter: @Barnes_Lab
0:00. Introduction and welcome
2:01. How Jill got into exercise research
4:25. Studying with Hiro O. Tanaka
6:00. Researching with Michael Joyner
7:45. How measure brain blood flow (BBF)
10:00. Blood vessels that supply the brain and blood flow
19:16. What would look at if had unlimited funding?
20:32. BBF vs glucose use in the brain
21:30. Regional blood flow in the brain
22:40. Does BBF increase during exercise?
24:40. Blood pressure and regulation of brain blood flow
29:00. Effect of exercise intensity in BBF
32:25. Hypnosis/anticipatory rises in BBF
34:30. BBF distribution has not been examined much during exercise
37:00. Cognitive tests and BBF
38:00. Why does BBF decrease during very intense exercise?
41:00. Central fatigue and BBF
42:30. Exercise training and BBF
45:00. BBF and cognitive function
46:20. How quickly does BBF increase with exercise?
47:25. Fitness and BBF at rest
49:55. Cognition and exercise/lifestyle
51:44. Exercjse intensity and the brain
53:10. Resistance training and cognitive function
55:07. Exercise and brain endothelial function
57:10. Exercise and the risk of stroke
59:35. Exercise and the risk of dementia/Alzheimers disease
1:02:14. Exercise and mental health
1:03:45. Diet and BBF/brain health
1:06:15. Sex differences in BBF
1:12:57. Age and BBF
1:15:20. Fitness/strength and cognition etc
1:16:10. Erythropoietin, hemoglobin and cognitive function.
1:18:48. Exercise and myokines, BDNF, exosomes
1:21:10. Neurogenesis and exercise
1:22:20. Exercise, cognition and hypertension/diabetes
1:25:00. Prevention of Alzheimer’s disease/dementia
1:27:00. Exercise intensity and mode of exercise
1:29:55. BBF during resistance exercise
1:31:20. Controversies in the field
1:34:52. Keep things simple re exercise
1:37:00. Takeaway messages
1:39:57. Outro
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Dr Glenn McConell chats with Professor Margie Davenport from the University of Alberta, Canada. She is an expert on exercise and pregnancy. We discussed the effect of pregnancy on the health (including pre-eclampsia and gestational diabetes) and exercise performance of the mother and on the health of the fetus during pregnancy and the offspring after pregnancy. It became very clear that there needs to be more focus on the beneficial effects of exercise before and during pregnancy on both the mother and the fetus/offspring. A very interesting chat. Twitter: @ExercisePreg
0:00. Introduction
2:09. How Margie went from top athlete to exercise researcher
6:15. History of thinking on exercise and pregnancy
8:49. What intensity of exercise should do during pregnancy?
12:28. Fetal heart rate during mothers exercise
14:10. HIIT exercise during pregnancy
15:55. Monitoring the baby during exercise research
19:50. Contraindications for exercise during pregnancy
20:38. Different types of exercise
21:49. Effect of the initial fitness of the mother
24:15. Heavy lifting during pregnancy
29:00. Effect of exercise on placenta blood flow
30:03. Animal studies: effect of exercise on the fetus
33:25. Health outcomes better when exercise during pregnancy
35:45. Reduced pre-eclampsia when exercise during pregnancy
44:25. Effect of exercise during pregnancy in elite athletes
45:40. Exercise during pregnancy and offspring health
49:07. Effect of pregnancy trimester/stage on exercise
52:40. Contraindications for exercise during pregnancy
55:05. Speaking with health care provider
57:13. Miscarriage levels during the first trimester and exercise
1:01:26. Individualized approach to exercise during pregnancy
1:03:15. Relaxin and pregnancy
1:04:20. Exercise during pregnancy and birth weight
1:06:15. Gestational diabetes and exercise
1:10:05. Exercise reduces gestational diabetes
1:11:55. Exercise before pregnancy vs during vs both
1:15:10. Exercise during pregnancy and mental health
1:19:05. Athletes and returning to sport after pregnancy
1:25:35. “Pregnancy advantage” from childbirth?
1:29:05. Diet during pregnancy and sport
1:32:09. Effect of the age of the mother
1:34:30. Research controversies in the field
1:36:50. Insufficient research in women/pregnancy
1:38:39. Misinformation in the area on social media etc
1:41:50. Takeaway messages etc
1:45:48. Outro
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Dr Glenn McConell chats with Professor Darren Candow from the University of Regina. Saskatchewan, Canada. He is an expert on creatine (Cr) and the effects of creatine supplementation on resistance exercise and other exercise. He is also examining the role of creatine in bone metabolism and cognitive function.
Get greater increases in strength than muscle mass when supplement with Cr during resistance training. Vegetarians/vegans have lower muscle but not lower brain Cr. Need to exercise to get benefits of Cr on muscle. Lots more. A very interesting chat. Twitter: @darrencandow
0:00. Introduction
1:40. How Darren got into exercise research
4:15. The early pioneers of creatine and other exercise research
7:30. What is creatine (Cr) and where get it from?
9:30. Do people need Cr and other supplements?
11:50. Effects of Cr supplementation on muscle Cr
14:10. Cr vs creatine phosphate (ATP and H+ buffering)
20:12. How Cr/creatine phosphate effects exercise performance
23:30. Cr supplementation and resistance training
26:30. Vegetarians/vegans and Cr
28:15. Aging and Cr
29:40. Mechanisms that Cr effects exercise performance
33:44. Does Cr increase strength/muscle more if control volume?
40:10. Pre print means not reviewed/published
42:15. Cr causes cell swelling but need exercise
43:40. Use it or lose it
45:10. Cr suppl: how much?
50:40. Cr transporter and muscle creatine levels
52:40. Does age or biological sex affect Cr levels?
54:30. What % increase with Cr suppl during resistance training
55:40. Dissociation of muscle mass and strength
1:00:15. Cr suppl has no effect on fat mass
1:01:15. Cr suppl timing/anti-inflammatory effects
1:05:15. Keep it simple and food first
1:06:45. Top sprinters, vegetarians/vegan and Cr
1:09:00. Time for Cr to decrease after stop Cr suppl
1:10:10. Side effects of Cr suppl?
1:12:00. Sarcopenia, resistance training and Cr
1:14:40. Bone and Cr suppl
1:20:12. The brain and Cr suppl
1:27:00. If brain is compromised Cr suppl may be beneficial
1:28:55. Who can Cr suppl benefit
1:31:50. Do untrained vegetarians/vegans need Cr suppl?
1:35:50. Need to exercise for Cr suppl to have any effect
1:40:10. Caffeine and creatine may interfere with eachother
1:43:40. Can put Cr suppl in coffee?
1:44:12. CHO (insulin) and protein can increases Cr uptake
1:45:19. Volume of resistance training and Cr suppl
1:46:10. Depression and creatine
1:47:08. Surprises with Cr research
1:48:15. Controversies in the field
1:51:15. Need to be careful with info on social media
1:53:42. Takeaway messages
1:54:46. Outro
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Dr Glenn McConell chats with Associate Professor Nisha Charkoudian from the US Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA. She is an expert on the effects of extreme environments on exercise capacity. We talked about dehydration, electrolytes, effects of humid vs dry environments etc. We also discussed the importance of considering sex as a biological variable. This included including both sexes in studies even if underpowered to examine both. We then discussed the importance of conducting more studies on thermoregulation and blood pressure with aging. A very interesting chat.
0:00. Introduction
3:45. What is the definition of extreme environments?
5:05. Who gets the hottest/has the most issues with heat?
9:00. Effects of humid vs dry environments and hydration
12:05. Should drink until urine is clear before a race?
16:10. Should people worry about electrolytes?
20:44. Sex as a biological variable. Women not more fragile etc
23:30. Sex differences in heat acclimation
25:20. No difference in risk of heat stroke between the sexes
25:50. If no difference then just study one sex?
27:38. Need to include women even if small sample
32:34. Even if underpowered it’s ok to include both sexes
40:20. Gender vs sex, binary vs non binary etc
42:00. Women and blood flow/blood pressure/heat etc
49:05. Body surface area and heat/cold
52:01. Progesterone and body core temperature
54:25. Aging and thermogerulation
57:35. Takeaway messages
1:00:44. Outro
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Dr Glenn McConell chats with Associate Professor from the University of Copenhagen, Denmark. He is an expert on the effect of beta2-agonist asthma bronchodilator medications (like Ventolin) on muscle and exercise performance. We talked about what is asthma/exercise induced bronchoconstriction, can you train your lungs?, the increased prevalence of asthma in endurance athletes, can asthma limit aerobic capacity, what are beta2-agonists?, acute and chronic effects of beta2-agonists on muscle mass, sprinting, strength and endurance, side effects of beta2-agonists and negative effects of beta2 agonists on endurance exercise. Beta2-agonists should only be used for asthma treatment. A very interesting chat. Twitter: @morten_hostrup.
0:00. Introduction
2:12. Morten’s very good excuse for postponing coming on
5:15. What is asthma?
6:50. Lungs in endurance athletes vs general population
1:11:15. Increased asthma in endurance athletes
13:58. Why more asthma in endurance athletes?
17:20. Asthmatic athletes can be very successful
19:50. VO2 max etc not effected by asthma
24:18. Beta2-agonists can have negative effects on VO2 max
26:30. Sympathetic/parasympathetic nervous systems
29:06. What are Beta2-agonists and what do they do?
31:30. Inhaled medications can get into the blood
32:40. Different beta2-agonists
35:23. Legitimate and illegitimate use of beta2-agonists
40:30. Up to 90% of some cohorts take beta2-agonists
42:30. Legal limits of beta2-agonists use
43:40. Acute effects on muscle mass/ sprinting
49:02. Mechanisms of effect on muscle
53:13. How limit misuse?
56:39. Chronic effects on muscle
1:02:50. Hypertrophy from chronic beta2-agonists
1:06:15. Prevalence of use in body builders
1:07:40. Combined use of drugs in body builders
1:10:00. Effect of combining with corticosteroids
1:16:30. Normal doses have small effects on muscle
1:17:10. Side effects
1:21:00. Mechanisms of chronic beta2-agonists on muscle
1:23:30. Muscle mass and insulin sensitivity
1:27:22. Potency vs anabolic steroids etc
1:29:35. Competition with beta blockers
1:31:55. Cycling on and off beta2-agonists?
1:32:35. Effects during exercise
1:37:04. Anti-diabetic effects?
1:38:15. Maintains muscle mass during weight loss
1:39:30. Alzheimer’s and Parkinson’s disease
1:40:55. Sex differences
1:42:40. Age effects
1:43:40. Does exercise training affect beta2 receptors?
1:44:45. Negative effects on endurance exercise
1:47:02. Increase muscle mass but not so much strength
1:50:20. Controversies in the field
1:52:30. Some claim beta2 agonists have no systemic effects
1:58:00. Takeaway messages
1:59:28. OutroInside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Dr Glenn McConell chats with Professor Luc van Loon from Maastricht University, The Netherlands. He is an expert with a wealth of knowledge on the role of physical activity/exercise and nutrition on muscle adaptation. A lot of his research focuses on protein and protein synthesis. He applies these studies to young healthy individuals, the aged and also has conducted important experiments on people in ICU. He makes it clear that most people, especially athletes, get enough protein in their diet so do not need to take supplements. Are there really non responders to exercise training? Anabolic resistance with aging is due to inactivity. Lots more. A very interesting chat.0:00. Introduction2:09. How Luc got into exercise research6:30. Moving into protein metabolism8:05. Using tracers to determine exercise metabolism11:40. How much protein do we need?16:35. Protein rich foods after exercise17:00. Generally don’t need supplements.18:20. Food vs supplements19:35. Effects of lower protein intakes23:50. Protein turnover in some organs higher than muscle28:00. Optimal protein intake/additional protein31:00. Athletes eat more so likely don’t need extra protein34:00. Exercise increases protein uptake for up to 48hr38:40. Increased protein synthesis doesn’t necessarily mean increased muscle mass42:37. Protein needs of strength vs endurance athletes44:45. “Protein supplementation” just means above normal diet49:30. Misunderstanding of research findings re translation50:43. Need consistent exercise to adapt56:43. Plant vs animal proteins: not a big issue1:03:40. We are recycling a lot of protein each day1:05:33. Exercise stimulus and individual variations of adaptations1:07:50. Are there really non responders to exercise training?1:11:09. Re-sensitizing muscle by changing the stimulus1:12:42. Anabolic resistance with age (due to inactivity?)1:16:50. Muscle loss with aging largely episodes of bed rest etc1:20:17. Electrical stimulation prevents muscle loss in ICU1:25:06. Normal response to resistance training with aging1:34:22. Protein use during exercise1:36:16. Protein synthesis occurs during exercise1:40:00. Protein requirements when injuries/in bed1:41:40. Does collagen supplementation have benefits?1:45:20. What further studies would Luc like to do?1:46:10. Personalized diet and exercise prescription1:47:09. Sex differences, men and women studies etc1:49:22. Takeaway messages1:50:28. What’s most important, diet or physical activity?1:51:55. OutroInside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).Connect with Inside Exercise and Glenn McConell at:Twitter: @Inside_exercise and @GlennMcConell1Instagram: insideexerciseFacebook: Glenn McConellLinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460ResearchGate: Glenn McConellEmail: [email protected] to Inside exercise:Spotify: shorturl.at/tyGHLApple Podcasts: shorturl.at/oFQRUYouTube: https://www.youtube.com/@insideexerciseAnchor: https://anchor.fm/insideexerciseGoogle Podcasts: shorturl.at/bfhHIAnchor: https://anchor.fm/insideexercisePodcast Addict: https://podcastaddict.com/podcast/4025218Not medical advice
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Dr Glenn McConell chats with Professor Michael Kjær from the Department of Clinical Medicine, Bispebjerg Hospital, the University of Copenhagen, Denmark. He is an expert on tendons and exercise. We chatted about muscle vs musculotendinous junction vs tendon, what structures get injured and why, tendon injuries: mechanisms, prevention, treatment, acute vs chronic/overuse tendon injuries, best to rest or exercise injured tendons?, whether diet, supplements or medicine can assist recovery from tendon injuries etc. We also discussed his earlier work on glucose metabolism during exercise. A very interesting chat.
0:00. Introduction
2:05. How Michael got into exercise research
5:54. His glucose metabolism during exercise work
11:20. Redundancy in physiology, animal vs human work
13:45. His muscle work and movement into injury research etc
16:20. His move into connective tissue/tendon research
21:30. Taking a risk to move fields/finding collaborations
23:30. Muscle vs musculotendinous junction vs tendon
28:00. Why get muscle/tendon injuries
31:45. Tendon stretches as muscle shortens
33:05. Age and body weight effects on injury
34:15. Interface between muscle and tendon
37:10. Tendon overuse injuries
41:40. What determines if injury occurs in muscle vs tendon
44:20. Why tendon can feel better once warms up
46:45. Water accumulation vs structural changes
48:00. No evidence that exercising painful tendon increases rupture
50:00. Development and turnover of tendons/circadian rhythm
52:08. Blood vessels and flow in tendons at rest/during exercise
55:00. Strength training and tendon size
56:20. Best not to rest if injured tendon
57:45. Need controlled loading of tendon to recover
1:00:00. Supplements/surgery for tendon recovery?
1:01:00. Can a tendon biopsy activate tendon repair?
1:02:40. 3 x 10 reps per week may be enough
1:04:50. Don’t need to focus on eccentric phase
1:06:35. Need good shoes etc to reduce injury?
1:09:00. What is a tendonopathy?
1:10:00. RICE, anti inflammatories and cortisol shots etc?
1:13:01. Collagen etc supplements and tendons
1:15:10. Prevention of tendon injuries
1:17:40. Signs of tendon injury
1:20:20. Does warm up/ stretching reduce injury?
1:23:18. Can a tendon torn off the bone recover without surgery?
1:24:10. Age and tendon stiffness: inactivity vs age
1:25:50. Fast twitch fibers and injuries
1:27:35. Type 2 diabetes and tendon problems
1:28:35. Can predict tendon injuries?
1:29:18. Do tendons secrete molecules during exercise?
1:30:00. Circadian rhythm, sleep and tendons
1:32:17. Takeaway messages
1:33:28. Outro
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Dr Glenn McConell chats with Professor Sue Bodine from the Oklahoma Medical Research
Foundation, Oklahoma, USA. She is an expert on muscle, in particular muscle atrophy with inactivity/aging. We chatted about how with age muscle size is reduced and this is associated with a reduction in muscle fiber size and also a loss of fast muscle fibers. Resistance training (and perhaps intense endurance exercise) can attenuate the rate of muscle atrophy. We discussed how much muscle atrophy is due to age per se and how much is due to inactivity. Anabolic resistance, protein synthesis, the importance of strength for balance etc. A very interesting chat.
0:00. Introduction + how Sue got into exercise research
5:25. What determines muscle strength
7:20. What age do we start losing muscle mass and strength?
8:40. Muscle atrophy and loss of fast muscle fibers
13:10. Can exercise training reduce the loss of fast fibers with age?
17:50. How muscle of muscle atrophy with age in inactivity?
19:20. Anabolic resistance with age
20:40. A role of hormones in muscle atrophy with age?
22:30. Protein synthesis and turnover in muscle with aging
26:46. How much exercise is needed to attenuate muscle atrophy?
30:30. Aging vs inactivity vs immobilizing vs bed rest etc
33:30. Importance of exercise after bed rest/immobilization
37:27. Upper body atrophy in runners/cyclist etc
39:55. Intense endurance exercise and slow muscle fiber size
43:00. Need to actually work out not just turn up
44:42. Exercise prescription with aging
47:05. Balance with age/inactivity
48:45. Diet and muscle atrophy
50:00. Need a stimulus (ex training) not eating more protein
54:52. Disease processes and muscle atrophy
58:10. Mechanisms playing a role in muscle atrophy/hypertrophy
1:08:53. Don’t need to break down muscle to build muscle
1:10:40. Determining muscle quality/specific tension
13:02. Are slow fibers really weaker than fast fibers?
1:17:22. Takeaway messages
1:18:53. Can very old people still get stronger/hypertrophy?
1:19:50. Do females really hypertrophy less?
1:22:00. Outro
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Dr Glenn McConell chats with Professor Shona Halson from the Australian Catholic University, Melbourne, Australia. We chatted about how much sleep athletes need compared with how much sleep they actually get. Night sleep vs naps vs total sleep in athletes vs non athletes. The importance of consistency of sleep. Caffeine, sleep and exercise performance. Is overtraining actually a lot less common than believed? Ice baths may reduce hypertrophy with resistance training but improve team sports/endurance. Effects of compression garments on recovery. The effects of mental fatigue on exercise performance. A very interesting chat. Twitter: @ShonaHalson
0:00. Introduction + how Shona got into sports/exercise research
3:45. Defining what we mean by recovery and fatigue
5:40. How much sleep do athletes need/get?
11:30. If athletes extend their sleep they do better
13:05. Athletes night sleep vs total sleep per day (naps)
15:10. Physical load vs mental load and sleep
16:45. Sleep quality/architecture
20:15. Is one night of reduced sleep a problem?
21:15. Lack of sleep and perception of effort
22:20. Importance of sleep consistency/regularity
28:55. Does a lack of sleep reduce performance
29:56. Best to prioritize sleep or exercise?
34:27. Caffeine and sleep studies (hard to control)
39:15. Caffeine: responders and non responders etc
41:30. Genetics and sleep/can one sleep too much?
43:12. Intensified training vs overreaching vs overtraining
52:52. Ice baths/contrast baths, adaptations and recovery
1:03:00. Water, hydrostatic pressure and blood flow
1:05:25. Inflammation, anti-inflammatories and ice
1:07:30. Physical fatigue vs mental fatigue
1:11:00. Mental fatigue and exercise performance
1:13:40. Are wearables useful for gauging recovery?
1:16:24. Listening to your body
1:17:50. Compression garments and recovery
1:21:05. Menstrual cycling and sleep
1:22:30. Takeaway messages
1:23:30. Placebo effects
1:24:49. Outro (9 seconds)Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice -
Dr Glenn McConell chats with Assoc Prof Andre La Gerche a world leading Sports Cardiologist from St Vincent’s Institute of Medical Research, Melbourne, Australia. Acute exercise for long periods at a high intensity can result in abnormal right ventricle function. In addition, years of long, hard exercise training is associated with increased coronary artery calcium (CAC) levels and atrial fibrillation (AF). Despite this, Andre is a huge advocate of exercise across the population and generally even in these individuals. The evidence is that exercise training increase healthspan and reduces mortality rates despite some of these changes. A very important, interesting chat. Twitter: @ALaGerche
0:00. Introduction + how Andre got into sports/exercise research
5:30. Andre’s excellent marathon running
7:32. Is exercise good for the heart?
10:50. Media fear around ex and the heart
13:45. Increased CAC and heart attack risk
17:00. Exercise protective even if increased CAC
18:56. Andre hasn’t had a CAC scan
22:28. Plague build up in the coronary arteries
23:50. Some people never have coronary issues
24:50. Genetics and the heart
26:55. Jim Fixx: died running
27:40. How can exercise increase CAC?
32:00. Get into exercise slowly
33:30. Coronary “hot plagues” and heart attacks
35:30. Exercise before a heart operation
36:45. Exercise training increases hearts reserve with age
37:33. 1969 marathon WR holder Derek Clayton: still amazing heart
43:15. AF more common in endurance athletes
45:43. Female endurance athletes have increased AF
47:55. Generally if in doubt, keep exercising
50:43. Women have relatively more stable hearts
52:50. Cardiac screening of athletes
55:55. Ventricular arrhythmias: continue sport or not?
59:50. It's hard to estimate heart attack risk
1:01:58. Right ventricle after long hard races
1:08:10. Rare ventricular tachycardia in professional athletes
1:11:34. The importance of seeing a sports cardiologist
1:14:40. Big vs enormous hearts in top endurance athletes
1:18:10. Genetics and the heart
1:19:25. EPO, anabolic steroids, very hard training and the heart
1:24:20. Resistance training, anabolic steroids and the heart
1:28:15. Best exercise to do for the heart and health
1:29:50. What’s the cutoff of ex for increased AF?
1:33:50. Blood indicators of heart damage/recovery
1:36:45. Right ventricle “fatigue” and recovery
1:40:50. Heart failure/heart reserve and exercise (sex differences)
1:44:00. Don't assume sudden death in athletes drug related
1:45:45. Negative cardiac effects of the Covid19 vaccine in some people
1:50:12. Takeaway messages
1:52:38. Outro (9 seconds)
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: [email protected]
Subscribe to Inside exercise:
Spotify: shorturl.at/tyGHL
Apple Podcasts: shorturl.at/oFQRU
YouTube: https://www.youtube.com/@insideexercise
Anchor: https://anchor.fm/insideexercise
Google Podcasts: shorturl.at/bfhHI
Anchor: https://anchor.fm/insideexercise
Podcast Addict: https://podcastaddict.com/podcast/4025218
Not medical advice - Show more
