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CAR T cells are genetically engineered to express a receptor that recognizes and kills tumor cells. CAR T-cell products are now FDA approved for 6 hematologic malignancies. Author Jennifer N. Brudno, MD, National Cancer Institute, joins JAMA Deputy Editor Mary McGrae McDermott, MD, to discuss "CAR T Cells and T-Cell Therapies for Cancer: A Translational Science Review.”
CAR T Cells and T-Cell Therapies for Cancer Translational Science Reviews—A New JAMA Review
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Peptic ulcer disease affects approximately 1% of the population in the US, and H pylori is a common cause of peptic ulcer disease. Author Nimish Vakil, MD, a gastroenterologist from the University of Wisconsin, Madison, discusses current evidence regarding diagnosis and treatment of peptic ulcer disease with JAMA Deputy Editor Mary McGrae McDermott, MD.
Peptic Ulcer Disease
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High prescription costs are a major barrier to the optimal treatment of many health conditions. Prescribers need tools to help patients find the lowest drug costs. Author Hussain S. Lalani, MD, MPH, MSc, of Brigham and Women's Hospital and Harvard Medical School joins JAMA Senior Editor Anne R. Cappola, MD, ScM, to discuss "Strategies to Help Patients Navigate High Prescription Drug Costs."
Strategies to Help Patients Navigate High Prescription Drug Costs Strategies to Help Patients Afford Their Medicines in the US
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Even though highly effective medications are currently available to prevent HIV, there are about 1.3 million new infections worldwide each year. Monica Gandhi, MD, MPH, of the University of California San Francisco joins JAMA Senior Editor Karen E. Lasser, MD, MPH, to discuss preexposure prophylaxis (PrEP) for HIV.
Preexposure Prophylaxis (PrEP) for HIV What Is Doxycycline Postexposure Prophylaxis?
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In July 2023, the US Food and Drug Administration (FDA) approved Opill, a daily progestin-only oral contraceptive for over-the-counter sale to people of all ages. Daniel Grossman, MD, discusses this and more with JAMA Associate Editor Melissa A. Simon, MD, MPH.
Over-the-Counter Oral Contraceptives Over-the-Counter Oral Contraceptive Pills Over-the-Counter Progestin-Only Oral Contraceptives
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Selection of hemodialysis or peritoneal dialysis and timing of dialysis initiation are influenced by patient symptoms, laboratory trajectories, patient preferences, and therapy cost and availability; shared decision-making is key. Jennifer E. Flythe, MD, MPH, from the University of North Carolina, discusses dialysis for chronic kidney failure with JAMA Deputy Editor Kristin L. Walter, MD, MS.
Dialysis for Chronic Kidney Failure
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Chronic spontaneous urticaria affects approximately 1% of the general population worldwide, impairs patients’ quality of life, and is associated with multiple comorbidities. Pavel Kolkhir, MD, discusses the current evidence on the epidemiology, pathophysiology, diagnosis, and treatment of chronic spontaneous urticaria with JAMA Senior Editor Karen E. Lasser, MD, MPH.
Chronic Spontaneous Urticaria
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Community-acquired pneumonia is associated with approximately 740 000 hospitalizations and 41 000 deaths in the US annually. JAMA Review authors Scott A. Flanders, MD, and Valerie M. Vaughn, MD, MSc, discuss diagnosis and treatment of community-acquired pneumonia with JAMA Deputy Editor Mary McGrae McDermott, MD.
Community-Acquired Pneumonia
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Infestations by ectoparasites such as scabies, bedbugs, and body lice are common. Diagnosis requires history, including social drivers of health such as living environment, and physical examination. Author Aileen Y. Chang, MD, of UCSF, joins JAMA Senior Editor Karen Lasser, MD, to discuss Scabies, Bedbug, and Body Lice Infestations: A Narrative Review.
Scabies, Bedbug, and Body Lice Infestations
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Pericarditis accounts for up to 5% of emergency department visits for nonischemic chest pain in North America and Western Europe. JAMA Review author Paul C. Cremer, MD, MS, discusses the recommended treatments for acute pericarditis and more with JAMA Associate Editor David L. Simel, MD, MHS.
Diagnosis, Risk Stratification, and Treatment of Pericarditis
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JAMA Editor in Chief Kirsten Bibbins-Domingo reviews 4 JAMA trials presented at this year’s European Society of Cardiology (ESC) Congress on antihypertensive continuation before elective surgery, potassium supplementation after cardiac surgery, pulmonary vein isolation for symptomatic atrial fibrillation, and a triple-drug combination pill for resistant hypertension in Africa.
Correction: an earlier version of this podcast contained an error in the conclusion of the TIGHT K trial summary, which has been updated.
Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery Low-Dose Triple-Pill vs Standard-Care Protocols for Hypertension Treatment in Nigeria Is a Low-Dose Triple-Drug Combination Pill Protocol the Answer for Hypertension Control in Sub-Saharan Africa? Potassium Supplementation and Prevention of Atrial Fibrillation After Cardiac Surgery Pulmonary Vein Isolation vs Sham Intervention in Symptomatic Atrial Fibrillation
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Renal cell carcinoma has an estimated lifetime prevalence of 2.3% for men and 1.3% for women in the US. Affected patients in early stages can have >94% cancer-specific survival. Author William Y. Kim, MD, of the University of North Carolina joins JAMA Associate Editor David L. Simel, MD, MHS, to discuss the epidemiology, clinical presentation, pathophysiology, and management of renal cell carcinoma.
Renal Cell Carcinoma
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Interview with Esa M. Davis, MD, MPH, USPSTF member and coauthor of Screening and Supplementation for Iron Deficiency and Iron Deficiency Anemia During Pregnancy: US Preventive Services Task Force Recommendation Statement. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS.
Screening and Supplementation for Iron Deficiency and Iron Deficiency Anemia During Pregnancy Screening and Supplementation for Iron Deficiency and Iron Deficiency Anemia During Pregnancy Anemic Data for Preventive Screening and Supplementation to Address Iron Deficiency Anemia in Pregnancy Screening for Iron Deficiency and Iron Deficiency Anemia During Pregnancy Iron Deficiency and Iron Deficiency Anemia During Pregnancy—Opportunities to Optimize Perinatal Health and Health Equity
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Genital herpes is a common sexually transmitted infection that is caused by HSV-1 or HSV-2 and may result in ulcers, neonatal herpes infection, and increased risk of HIV acquisition. Author Christine Johnston, MD, University of Washington, discusses herpes infection and more with JAMA Deputy Editor Preeti Malani, MD, MSJ.
Genital Herpes
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Direct oral anticoagulants (DOACs) are commonly used to treat patients with atrial fibrillation and venous thromboembolism. Author James D. Douketis, MD, from McMaster University discusses with JAMA Deputy Editor Kristin L. Walter, MD, MS, the management of DOACs in patients undergoing an elective or emergency surgery or procedure.
Perioperative Management of Patients Taking Direct Oral Anticoagulants
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About 20% of adolescents in the US are living with obesity. Author Aaron S. Kelly, PhD, of the University of Minnesota Medical School joins JAMA Senior Editor Karen E. Lasser, MD, MPH, to discuss Obesity in Adolescents: A Review.
Obesity in Adolescents
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Exertional heat illness at its extreme may cause heat stroke and altered mental status (confusion, delirium, stupor, or unconsciousness), which can result in organ failure and death. Author Francis G. O’Connor, MD, MPH, discusses heat-related illness in athletes, including risk factors, prevention, symptoms, and management, with JAMA Associate Editor David Simel, MD, MHS. Current NWS Forecast
Heat-Related Illness in Athletes
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New weight-loss drugs have transformed care for people with obesity. In this Clinical Reviews podcast, Robert F. Kushner, MD, MS, of Northwestern University Feinberg School of Medicine joins JAMA Deputy Editor Mary McGrae McDermott, MD, to discuss prescribing these drugs to improve health outcomes and minimize adverse effects in people with obesity.
Medications for Obesity
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Medical practice accounts for 8% of carbon emissions in the US. Author Wendy Levinson, MD, discusses simple changes that clinicians can make to reduce adverse effects of health care on the climate and the environment with JAMA Deputy Editor Mary McGrae McDermott, MD.
Medical Practice and the Climate Crisis How Can Operating Rooms Be Greener?
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Essential tremor is a common movement disorder. Author Binit B. Shah, MD, of the University of Virginia joins JAMA Deputy Editor Christopher C. Muth, MD, to discuss the diagnostic evaluation and treatment of essential tremor, including pharmacological, nonpharmacological, and surgical treatments.
Essential Tremor
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