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π Time Stamps:
0:00:00 β 0:00:50 β Introduction
0:00:50 β 0:05:32 β Why Paul Saladino Stopped The Carnivore Diet After 2 Years
0:05:32 β 0:08:41 β Is There Ever A Point Of Doing A Keto Diet?
0:08:41 β 0:11:21 β Why Paul Reached Out To Me To Do A Second Podcast After Seeing Me Speak With Peter Attia
0:11:21 β 0:17:36 β What Actually Causes Atherosclerosis? Paulβs Take On The Traditional Hypothesis
0:17:36 β 0:22:17 β Should We Ignore High LDL-C Or APOB?
0:22:17 β 0:25:05 β Paul Describes How Some Studies Suggest That Those With Higher HDL-C Levels May Be Less Likely To Get Atherosclerosis Despite Having High LDL-C Levels
0:25:05 β 0:25:26 β Paulβs Perspective On Why Many Doctors Arenβt Educating Their Patients About Metabolic Health
0:25:26 β 0:33:41 β "Ignore Nutrition Just Focus On Exercise"
0:33:41 β 0:37:55 β Sponsor: Eight Sleep
0:37:55 β 0:39:02 β The Most Important Lab Tests For Avoiding Atherosclerosis
0:39:02 β 0:42:53 β Is It Possible To Get Atherosclerosis If You Have A Fasting Insulin Of 3 uIU/mL Or Less
0:42:53 β 0:46:27 β Familial Hypercholesterolemia (FH) And Why Itβs A Phenotypic Diagnosis, Not A Genotypic Diagnosis
0:46:27 β 0:49:41 β What Happens When You Replace Saturated Fat With Linoleic Acid?
0:49:41 β 0:52:38 β How A Pure Carnivore Diet Affects Thyroid Metabolism
0:52:38 β 0:56:45 β Can Someone On A Keto Diet Long-Term Develop Atherosclerosis Despite Having A Low Fasting Insulin? Dave Feldmanβs Lean Mass Hyper-Responder Study
0:56:45 β 1:00:56 β How Paulβs Perspective Differs From Dave Feldman and Shawn Baker
β’ The Baseline Data From The LMHR Study Paul Mentioned: https://twitter.com/realDaveFeldman/status/1733387107610063195
1:00:56 β 1:03:55 β What Is APOB And LP(a)?
1:03:55 β 1:06:44 β Sponsor: Marek Health
1:06:44 β 1:10:21 β How Long It Takes For Plaque To Develop And Show On A CT Angiogram
1:10:21 β 1:13:46 β Why Paul Uses Proxy Biomarkers In Atherosclerosis Data Analysis To Discern Insulin Sensitivity
1:13:46 β 1:18:14 β Does Paul Think It Is Ever Justified To Take Lipid Lowering Medication To Avoid Atherosclerosis?
1:18:14 β 1:20:13 β How Should You Track If You Are Developing Atherosclerosis?
1:20:13 β 1:45:27 β Lipid Lowering Medication Risk-Reward Analysis. Will Lowering LDL-C Impair Quality Of Life, Regardless Of The Medication Used? Do Adolescents With Hypofunctioning PCSK9 And Very Low APOB Have Impaired Development Cognitively Or Structurally?
1:45:27 β 1:47:39 β If You Donβt Lower APOB But Want To Track Plaque Accumulation, Is The Dose Of Radiation From A CT Angiogram Concerning?
1:47:39 β 1:56:45 βWhy Certain Tribes Have Lower Rates Of Cardiovascular Disease Than The Average Person. Should Or Shouldnβt We Copy What Theyβre Doing?
1:56:45 β 2:16:17 β The Lowest Hanging Fruit For Avoiding Atherosclerosis And Evaluating Your Risk ββββββββββββ
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π For more content, check out my appearance on Peter Attia's podcast too from earlier this month: https://open.spotify.com/episode/4P4L9YNqE24DtqFfGnoVee?si=tDW3zOi3TDW-DiJWcKnWxg
π You can purchase Peter Attia's new book "Outlive" here: https://peterattiamd.com/outlive/
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Time Stamps:
00:00:00 - Peter Attiaβs new book βOutliveβ
00:02:26 - Who is Peter Attia? What is Medicine 3.0?
00:03:28 - Peter Attiaβs career. How did he become a doctor? And how did he evolve into his unique approach to preventative medicine?
00:07:54 - What do the acronyms in Peterβs Instagram bio stand for?
00:13:53 - The Four Horseman of Death (most will die from one of these)
00:22:46 - How to not die from atherosclerotic disease (the leading cause of death)
00:29:59 - The impact of smoking on atherosclerotic disease
00:30:36 - The impact of high blood pressure (hypertension) on atherosclerotic disease, how common it really is, and how to track it
00:32:32 - The accuracy of manual vs. automatic blood pressure cuffs
00:35:41 - The impact of APOB/all atherogenic particles (LDLβs, LP(a)βs, VLDLβs, and IDLβs) on atherosclerotic disease
00:40:57 - The minimum APOB level needed for adequate function
00:42:43 - PCSK-9 gene and its effect on LDL. How PCSK-9 inhibitors work to lower LDL
00:43:24 - APOB vs. APOA
00:44:56 - The most effective lipid managing dr*gs for preventing atherosclerosis
00:50:16 - Why Peter doesnβt see a reason why anybody should have an APOB over 60 mg/dL
00:52:15 - If Peter could go back in time knowing what he knows now and with modern pharmacology, at what age would he start lowering his APOB
00:55:04 - Arterial plaque accumulation starts as early as when you are a teenager. Calcification takes years to show up on a coronary CT calcium scan, but that does not mean plaque isnβt accumulating
00:57:12 - Should you screen for atherosclerosis before taking medication? If so, how?
01:01:06 - Why are carnivore diet zealots so dogmatic about cholesterol and atherosclerosis? What does the data show to date?
01:06:05 - If those with average genetics maintain a near perfect diet, exercise regimen and sleep hygiene, will many of those individuals still develop atherosclerosis? Even with perfect lifestyle factors, will those individuals still need to take lipid managing dr*gs if they want to essentially guarantee that plaque will never accumulate?
01:09:41 - How to lower blood pressure
01:13:25 - Sleep Apnea and the use of CPAP
01:16:49 - Cancer: Causes, Prevention, and Proactive Screening
01:35:53 - The devices and metrics Peter uses to track his sleep and recovery
01:41:50 - Resting heart rate, HRV, heart rate recovery, and how predictive they are of mortality
01:44:43 - Peter's full daily routine and diet
01:54:35 - Why Peter stopped fasting
01:57:12 - Bodybuilders abuse of T3, Clen, DNP, and other metabolic modulators
01:58:54 - Peter breaks down his 6000+ calorie diet, 6 hours of daily exercise, and the most absurd meals he ate to maintain his weight when he was younger
02:01:25 - How Peterβs kids eat. How strict should the diet be for your kids when it comes to food quality to maximize growth potential?
02:07:41 - Where is the best burger in Austin?
02:08:22 - What time Peter stops eating each night, and the hack he uses to prevent him from overeating
02:11:33 - Peter's non-negotiable nightly practices for maximizing sleep quality
02:12:31 - Why Peter has a Bat phone
02:14:29 - How to live in the moment and be happy. The vicious circle of financial success and/or accolades never being enough.
02:22:46 - How to decide if you should have kids
02:25:13 - Peterβs Top 10 Supplements and Top 10 Dr*gs
02:29:35 - Peter's personal supplement stack and dr*g protocol
02:42:26 - Homocysteine reduction protocol
02:44:11 - Vitamin B6 deficiency paradoxically caused by Pyridoxine Hydrochloride supplementation
02:46:00 - How safe is TRT for cardiovascular health? TRAVERSE clinical trial results
02:51:31 - Comparison of TRT administration methods. What Peter prefers for patients
02:52:40 - What podcasts and YouTube channels Peter likes to watch or listen to
02:55:09 - Formula 1
02:55:54 - AlphaTauri x Hugo Boss
02:56:21 - Daniel Ricciardo, Max Verstappen
02:59:33 - How Red Bull became such a dominant F1 team
03:01:35 - Sim racing
03:05:13 - How Peter got so interested in F1
03:06:33 - Peterβs dream car
03:06:50 - Ayrton Senna
03:08:25 - Outro-----------------------
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π‘ https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order
βοΈ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791
π§ͺ Blood Work: https://bit.ly/2wI3k9J
𧴠The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order
𧴠Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order
βοΈ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
𧴠The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order
π₯© The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): https://bit.ly/2JmpTGv
𧡠https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order
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Subscribe To The More Plates More Dates Podcast
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141
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β‘ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic infused energy drinks)
π‘ https://intelligent.shop/derek (Intelligent Shop - Gorilla Mind's Sister Company For Niche Products) discount code "MPMD" for 10% off your entire order
βοΈ My Preventive Medicine & HRT Clinic: https://bit.ly/373k791
π§ͺ Blood Work: http://bit.ly/2wI3k9J
𧴠The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | discount code "MPMD" for 10% off your entire order
𧴠Intelligent Minoxidil | The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | discount code "MPMD" for 10% off your entire order
βοΈ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2
𧴠The Skincare Products I Use: https://bit.ly/3pdS2DO - discount code "MPMD" for 10% off your entire order
π₯© The Best Newbie Friendly Diet For Muscle Growth (hits macros and micros): http://bit.ly/2JmpTGv
𧡠https://www.youngla.com/ (YoungLA Fitness & Lifestyle Clothing) discount code "MPMD" for 15% off your entire order
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Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR
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