Episodes
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Status Epilepticus: Part II
Special Guest: Jason Vilar, PharmD, BCCCP @TheBrainPharmD
03:40 – Definitions/Terminology
14:30 – Landmark status epilepticus (SE) literature
21:30 – Emergent ASM SE pharmacotherapy
26:00 – DDI management/TDM
33:55 – Refractory status epilepticus (RSE) treatment
48:15 – Medication safety considerations and weaning
58:00 – EEGs for PharmD’s
68:10 – Inhaled anesthetics
74:30 – Studies on the horizon/take-home points
Reference List: https://pharmacytodose.com/wp-content/uploads/2024/08/status-epilepticus-part-ii-references.pdf
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Literature Review Series
April 2024
Special Guests: Katherine Kessel, PharmD
Ming May Zhang, PharmD, BCPS
04:05 – RCT’s
21:28 – Reviews/Prospective observational
35:25 – Guidelines/Post-hoc
43:00 – Retrospective/ SRMA
64:54 – PharmD-featured/Sweet Emotion
2024 Award Nomination Ballot: https://forms.gle/HG1ytSHjrcRCW3SA9
Reference List: https://pharmacytodose.com/wp-content/uploads/2024/08/april-2024-lrs-references.pdf
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Trial of the Week: PARAMEDIC2
Special Guest: Scott Benken, PharmD, MHPE, FCCP, FCCM, BCPS
06:20 – C4 conference preview
12:50 – PARAMEDIC2 trial of the week
C4 conference registration link: https://c4conference.uic.edu/
Reference list: https://pharmacytodose.com/wp-content/uploads/2024/08/paramedic2-tow-references.pdf
2024 Pharmacy to Dose Award nominations: https://forms.gle/BTgirsv8uoFj7Rux5
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Literature Review Series
March 2024
02:40 – RCT’s
13:20 – Prospective observational/Post-hoc
20:30 – Reviews & SR/MA
27:05 – Retrospective
32:00 – PharmD-featured/Sweet Emotion
2024 Award nomination ballot: https://forms.gle/HG1ytSHjrcRCW3SA9
Reference list: https://pharmacytodose.com/wp-content/uploads/2024/08/march-2024-lrs-references.pdf
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Literature Review Series
February 2024
Special Guests: Taylor Law, PharmD
Meaghan Rettele, PharmD
08:05 – RCT’s
30:00 – Prospective observational studies/Guidelines
50:10 – Post-hoc/Reviews
58:55 – Retrospective
75:20 – PharmD-featured/Sweet emotion
2024 Award Nomination Ballot: https://forms.gle/HG1ytSHjrcRCW3SA9
Reference List: https://pharmacytodose.com/wp-content/uploads/2024/08/feb-2024-lrs-references.pdf
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Trial of the Week: ROSE
Special Guest: Christina Rose, PharmD, BCCCP, FCCM @CRosePharmD
05:40 – Pathophysiology/ACURASYS trial
13:45 – ROSE trial discussion
38:40 – Current role of NMBA in ARDS
Reference list: https://pharmacytodose.com/wp-content/uploads/2024/07/rose-tow-references.pdf
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HRS-AKI & Terlipressin
Special Guest: Stephanie Bass, PharmD, FCCP, BCPS, BCCCP
05:45 – HRS and HRS-AKI diagnosis
17:00 – Albumin and volume status
23:55 – Terlipressin/vasoconstrictor treatment
52:00 – Medication safety considerations
Reference List: https://pharmacytodose.com/wp-content/uploads/2024/07/hrsaki-terlipressin-references.pdf
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Rapid Reaction: BLING III
Special Guest: Jason Roberts, BPharm, PhD, FSHP
05:10 – BLING research background
17:30 – BLING III methodology/results
53:50 – Practical application/future directions
Reference List: https://pharmacytodose.com/wp-content/uploads/2024/07/bling-iii-rapid-reaction-references.pdf
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ANNEXa-I Deep Dive Part II
Special Guests: Scott Dietrich, PharmD, BCCCP
Brian Gilbert, PharmD, MBA, BCCCP, FCCM, FNCS
Todd Miano, PharmD, PhD, FCCM
03:13 – Safety/thrombotic findings
21:50 – Questions that remain
26:50 – Practical considerations
41:40 – P&T elevator pitch
Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/annexai-deep-dive-part-ii-references.pdf
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ANNEXa-I Deep Dive Part I
Special Guests: Scott Dietrich, PharmD, BCCCP
Brian Gilbert, PharmD, MBA, BCCCP, FCCM, FNCS
Todd Miano, PharmD, PhD, FCCM
05:40 – Brief ANNEXa-I study overview
20:40 –Primary composite outcome
26:40 – Anti-FXa levels
30:45 – Statistics/methodology questions
Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/annexai-deep-dive-part-i-references.pdf
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Literature Review Series
January 2024
Special Guests: Haley Torr, PharmD
Nick Tran, PharmD
06:55 – Featured Articles
32:55 – PAD-IS articles
37:10 – Cardiology articles
46:00 – Heme articles
51:40 – Potpourri articles
60:05 – Pharmacist-featured articles
67:30 – Sweet Emotion articles
Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/jan-2024-lrs-references.pdf
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Trial of the Week: PROWESS-SHOCK
Special Guest: Paul Szumita, PharmD, FCCM, FASHP, BCCCP, BCPS @paulszumita
03:30 – Background studies/Setting the scene
30:25 – PROWESS-SHOCK discussion/Where are we now
Paul Szumita joins to highlight a June Trial of the Week “Drotrecogin alfa (activated) in adults with septic shock” published in the New England Journal of Medicine in 2012.
To fully understand the discussion regarding drotrecogin alfa, Paul and I review the mechanism of action and its proposed action in the treatment of sepsis. Then we review earlier studies and the controversy behind the FDA approval process. Finally, we go into detail on what Clinical Pharmacists were tasked with doing at the time based on treatment protocols or hospital restrictions.
Then we dive into the Trial of the Week, discussing the study design and results. What was the mood in ICUs and Pharmacy Departments after this publication? How much did our sepsis care improve from PROWESS to PROWESS-SHOCK? What lessons did we learn with the Xigris FDA approval process? Is there a patient population that could still benefit from drotrecogin alfa treatment? Plus, trial fun facts, issues with calculating APACHE II scores, and so much more.
Reference list: https://pharmacytodose.com/wp-content/uploads/2024/06/prowess-shock-trial-of-the-week-references.pdf
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Literature Review Series
2023 Year-In-Review
Special Guests: Jacquelyn Crawford, PharmD @jacuronium
Kathleen Hartman, PharmD @HartKate8
04:30 – Neurology
11:05 – Cardiology
18:50 – Cardiac Arrest
26:30 – Pulmonary
35:00 – Sepsis
44:05 – Endocrine/Renal
52:30 – Trauma
61:05 – Infectious Diseases
Reference List: https://pharmacytodose.com/wp-content/uploads/2024/06/yir-2023-lrs-references.pdf
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Trial of the Week: Ketamine for EM Agitation
Special Guest: Justin Lin, PharmD, BCPS, BCCCP @jjlinpharmd
Justin Lin joins to review the May Trial of the Week “Efficacy of ketamine for initial control of acute agitation in the emergency department: a randomized study” published in the American Journal of Emergency Medicine in 2021.
We set the scene by discussing how this research idea started, review the classic agitation presentation at his institution, and highlight evidence comparing pharmacotherapy treatment options prior to this study. Then we dive into the Trial of the Week, discussing the study design and results. What was the biggest pushback from providers or the IRB? Any unique education strategies? Would results stay the same with increased IV push administration? What would the comparator arm be if this study was replicated today? Plus, the most challenging part of this project, Justin’s favorite agent, and so much more.
Reference list: https://pharmacytodose.com/wp-content/uploads/2024/05/ketamine-for-em-agitation-trial-of-the-week-references.pdf
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Sanford Guide Q&A
Special Guest: Doug Black, PharmD
04:40 – Doug’s background/Sanford guide introduction
14:20 – Print v. digital guide/included content
34:35 – Tables/tools highlights
41:55 – Doug’s favorites/conclusions
Sanford Guide Website: https://web.sanfordguide.com/
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Code ICH
Special Guest: Gabe Fontaine, PharmD, MBA, BCPS, BCCCP, FNCS, FCCM @gabe_fontaine
04:00 – Code ICH and history of ICU bundled care
15:15 – BP control
22:50 – Hemostasis
33:15 – Challenges & future directions
Reference List: https://pharmacytodose.com/wp-content/uploads/2024/05/code-ich-references.pdf
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Trial of the Week: MENDS2
Special Guest: John Devlin, PharmD, BCCCP, MCCM, FCCP @devlinpharmd
03:20 – PADIS background and research introduction
35:25 – MENDS2 discussion
John Devlin joins to review the May Trial of the Week “Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis” the MENDS2 study, published in NEJM in 2021.
We set the scene by discussing how John developed an interest with PADIS research, discussing PK/PD sedative properties and considerations, landmark trials prior to MENDS2, and how much background work is required for a large RCT.
Then we dive into the MENDS2 trial itself. Any significant findings? Biggest methodologic differences from MENDS2 and previous studies? Most challenging process of blinding? Any potential safety concerns? How to avoid unblinding study patients (and why that’s so important)? Plus, trial fun facts, seeing your name in a NEJM research article, applying MENDS2 findings into daily practice, and so much more.
Reference list: https://pharmacytodose.com/wp-content/uploads/2024/05/mends2-trial-of-the-week-references.pdf
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Rapid Reaction: ANNEXA-I
02:35 – Study design/results
18:30 – Considerations/questions
Reference List: https://pharmacytodose.files.wordpress.com/2024/05/annexa-i-references.pdf
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Trial of the Week: DESIRE & In-Flight Medical Emergencies References
Special Guests: Jim Miller, PharmD, BCCCP @millerjtm
Michael Liu, PharmD, MBA, BCCCP, BCNSP, BCPS
04:05 – DESIRE trial
31:15 – In-flight medical emergencies
The episode starts off with special guest, Jim Miller, helping review the DESIRE study as a Trial of the Week.
We set the scene reviewing dexmedetomidine pharmacokinetic advantages and landmark dexmedetomidine research. Then we highlight the DESIRE trial itself discussing the study methodology and results. What was considered usual care with regards to sedation? What is the external validity in this trial? What was the effect of changing the primary outcome measure mid-study? Are there anti-inflammatory properties with dexmedetomidine? What did Jim’s novel research show? What would Jim and I want for sedation if mechanically ventilated? And much more.
Then the episode closes with Michael Liu highlighting his experience assisting with an in-flight medical emergency.
We review his AJHP article describing his experience. Was this his first time in this situation? Biggest difference between in-hospital and out-of-hospital emergency response? What advice would he give others? And so much more.
Reference list: https://pharmacytodose.files.wordpress.com/2024/05/desire-trial-of-the-week-references.pdf
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December 2023 Literature Review Series
Special Guests: Jenna Self, PharmD
Hannah Millard, PharmD
04:30 – Featured Articles
38:45 – Cardiology
49:30 – Potpourri
53:20 – Sepsis
60:00 – PharmD
65:00 – Sweet Emotion
Reference List: https://pharmacytodose.com/wp-content/uploads/2024/05/december-2023-lrs-references.pdf
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