Episodes
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The idea that we can live however we want and then rely on a magic treatment for cognitive issues is unrealistic and dangerous. The reality is that our daily choices profoundly impact our brain’s future, and once cognitive decline begins, there is no clear-cut pharmaceutical solution.
I had the pleasure of speaking with Dr. Dale Bredesen, whose book The Ageless Brain is an incredible resource for protecting brain health. He has pioneered a comprehensive approach to preventing and even reversing cognitive decline. This book offers a powerful blueprint not only for sharpening your mind but also for building resilience against neurodegenerative diseases.
In The Ageless Brain, Dr. Bredesen distills decades of research into actionable steps. He explores key lifestyle factors—nutrition, sleep, exercise, stress management, and supplementation—that influence cognitive performance and long-term brain resilience. What’s exciting is his proactive, personalized approach. Rather than waiting for symptoms to appear, Dr. Bredesen shows us how to build a brain that resists aging from the start.
Today, we’ll unpack some of the most impactful strategies from his book, discuss major breakthroughs in neuroscience, and explore how we can all take charge of our cognitive health. If you’ve ever wondered what it takes to maintain lifelong clarity and vitality, you won’t want to miss this conversation.
Dale Bredesen, MD, is an internationally recognized neurologist specializing in neurodegenerative diseases. He is the Senior Director of Precision Brain Health at Pacific Neuroscience Institute® and the Chief Scientific Officer at Apollo Health.
Guided by his belief that Alzheimer’s is not just preventable but reversible, Dr. Bredesen’s groundbreaking research has helped explain the biological mechanisms behind memory loss. His decades of study have led to new treatment approaches, including the ReCODE Protocol™—also known as the Bredesen Protocol—a strategy designed to prevent, slow, and even reverse cognitive decline associated with Alzheimer’s, dementia, and mild cognitive impairment.
Timestamps:
0:00 Introduction to Guest2:48 Phase 3 Trial Upcoming
10:11 Alzheimer’s: Different Triggers, Different Outcomes
13:11 Could Brushing Your Teeth Save Your Brain? (Oral Microbiome & Alzheimer’s
18:45 The 3 Major Players in Brain Health
22:24 How to Make Sure You Never Get Dementia
22:33 Blood Markers for Alzheimer’s: What Your Tests Reveal
28:10 Diabetes and Alzheimer’s: The Hidden Connection
34:18 The #1 Contributor to Cognitive Decline: Insulin Resistance
39:54 How to Match Your Brainspan to Your Lifespan
40:31 Top Supplements for Brain Health
43:15 The Power of Nitric Oxide for Your Brain
48:07 Leaky Gut & Cognitive Decline
54:15 Metformin & Brain Longevity
57:31 Why Do More Men Than Women Get Parkinson’s
1:05:24 ADHD & Alzheimer’s: The Fruit Fly Discovery ("Alzflymers")
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Dale Bredesen, M.D., is an expert in neurodegenerative diseases such as Alzheimer’s. He is a graduate of Caltech and received his MD from Duke University Medical Center. His career includes serving as Chief Resident in Neurology at UCSF, working as an NIH Postdoctoral Fellow, and holding faculty positions at UCSF, UCLA, and UC San Diego. He was the director of the Program on Aging at the Burnham Institute and the founding President and CEO of the Buck Institute. His work has led to a new therapeutic approach for treating Alzheimer’s. He is the author of The End of Alzheimer’s: The First Program to Prevent and Reverse Cognitive Decline.
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Yes, we need stress in our lives! Staying in our comfort zone may be doing us more harm than good. That’s probably surprising to hear from me having spoken about the importance of reducing stress over the years. But, nonetheless, a level of stress that is not overly damaging, and that may actually have positive benefits.
Today we are going to learn much more about that will be looking at the book, The Stress Paradox with Dr. Sharon Horesh Bergquist. We're going to learn about the"Stress dilemma" that we face, how stress enhances, cellular resilience, how our life compares to the lives of our ancestors in terms of the physical stresses that we endure. We will explore how stressing ourselves in relation to the times that we eat, our physical exercise, and even explore how sleep or lack of sleep, may affect us in negative and even perhaps positive ways. All in all, we"re learning these days how we want to do our best to leverage the value of being out of our comfort zone but also recognizing our
boundaries.
00:00 Introduction
02:00 Welcoming Sharon and Introducing The Stress Paradox
06:33 Sleep is Critical
07:12 Good Stress (HIIT) vs. Bad Stress (Financial Hardship)
09:50 Hormetic Stress? Current Environment vs. Ancestors' Stress Levels
13:20 Stress Responses Stored in Phytochemicals and our Evolutionary Relationship with Plants
19:01 10,000 DNA Injuries Any Given Day, 7 Per Minute
22:03 The Biggest Factor Related to Longevity
26:01 Relationship with Decreased Risk of Alzheimer’s & The Role of Myokines
30:17 Microglia Cells Can Share Mitochondria (Before & After)
35:13 Heat Exposure Mimics the Benefits of Exercise
38:01 Key Strategies for Longevity and Vitality
45:32 Personalized Health Strategies for Optimal Performance
50:25: The Cortisol Spike and Why It is Necessary
58:20 Why You Need Non-negotiables In Your Physiology
50:20 Conclusion
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Sharon Horesh Bergquist, MD, is an award-winning physician, innovative healthcare leader, and visionary researcher renowned for spearheading a science-based approach to applying lifestyle as medicine. She has helped lead numerous clinical trials, including the Emory Healthy Aging Study and the NIH funded Emory Healthy Brain Study. Dr. Bergquist is widely published in peer-reviewed journals and has contributed to over 200 news
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We all want to live a stress-free life. But as it turns out, this may not necessarily be in our best interest having a low level of stress of various types turns out to be good for our physiology and can even help us recover from illness. When stress is implemented in this way, it is termed, other words, the upside of low-grade stress. That stress can be exercise, immersion ourselves in cold or hot temperatures, time restricted eating, or even various forms of light exposure all of which we will explore on my podcast today, which is an interview with my good friend, Jeff Krasno. His new book, Good Stress, that he wrote along with his wife Schuyler Grant
He is the CEO and founder of Commune Media, a masterclass platform for well-being that features renowned authors and teachers. He hosts the Commune podcast, which has over 520 episodes and generates more than 750,000 monthly downloads, featuring interviews with luminaries such as Deepak Chopra, Marianne Williamson, Matthew McConaughey, and Gabor Maté. Additionally, Jeff writes a weekly "Commusing" essay exploring well-being, spirituality, and culture, distributed to an email list of over one million subscribers.
Prior to founding Commune Media, Jeff co-created Wanderlust, a global series of wellness events that have significantly contributed to popularizing yoga practices and principles in the U.S. and beyond. In 2016, Oprah Winfrey selected him as part of the SuperSoul100, recognizing him as one of the nation's leading entrepreneurs.
Jeff's latest book, "Good Stress: The Health Benefits of Doing Hard Things," co-authored with his wife, Schuyler Grant, is set to be released on March 25, 2025. I've had the opportunity to read the galley and it's a terrific book that will open a lot of doors for each and every one of you in terms of regaining your health.
TIMESTAMPS
00:00 Introduction and Personal Connection with Jeff Regarding the Los Angeles Wildfires
8:51 Introducing Jeff’s Book, Good Stress: The Health Benefits of Doing Hard Things
13:42 The Personal and Societal Costs of Poor Health
18:27 Jeff’s Background and Personal Approach to Wellness
22:54 Homeostasis as the Foundation of Health
25:42 Rethinking "Normal"—The Flaws of the Bell Curve Perspective
29:24 Evolutionary Perspectives on Health and Adaptation
34:55 Thermoregulation as a Pathway to Homeostatic Flexibility
38:15 Hypoxia and Its Role in Physiological Adaptation
47:04 The Therapeutic Potential of Thermal Shock
49:51 The Concept of Good Stress and the Evolutionary Mismatch of Modern Lifestyles
55:01 Optimal Timing and Approaches for Cold Plunging
1:00:46 Jeff’s Personal Biohacking Journey
1:07:08 Exploring the Benefits of Light Therapy and the Revival of Raw Milk Consumption====
Jeff Krasno is the co-founder and CEO of Commune, a masterclass platform for personal and societal well-being and co-creator of Wanderlust, a global series of wellness events. He hosts the Commune podcast, interviewing a wide variety of luminaries from Deepak Chopra and Marianne Williamson to Matthew McConaughey and Gabor Maté. His latest venture expands Jeff’s personal story and protocols into a book, Good Stress: The Benefits of Doing Hard Things (Hay House, March 2025). The book dives deeper into the concepts from the course, distilling insights from over 400 podcast conversations Jeff has conducted, along with his personal experiences applying these ideas to transform his own health. It explores deliberate, self-imposed behaviors that promote social, psychological, and physical well-being, offering both a philosophical exploration of true wellness and practical steps to achieve it.
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We all know that exercise is good for the body and specifically, very good for the brain. In fact, exercise is the most important inroad to better brain health, better brain function, protecting the brain against decline, and even with respect to mood issues like depression.
But it's reasonable to ask how in fact does this work? How is it that exercising muscles does good things for the brain?
On today's episode of the Empowering Neurologist we spent time with Dr. Austin Perlmutter. He takes us on a deep dive exploring the exact connection between muscle and its endocrine function in terms of creating various chemicals that are so helpful for better brain health. It's a great discussion that looks at things like how much exercise is appropriate, what type of exercise is best, how much protein we should be consuming, and what other supplements will augment the benefits of exercise in terms of better brain health. I think you will really enjoy this episode. I know I sure did, after all, getting to spend time with my son is always special!
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00:00:00 Introduction & Welcoming Dr. Austin
00:01:56 The Relationship of Muscle Health, Mental Health, and Brain Health
00:09:15 The Power of Exercise to Improve Cognition vs Pharmaceuticals & The Muscle as an Endocrine Organ
00:16:36 The Molecules Produced by Muscles: Myokines
00:20:10 Myokines, Inflammation, and Metabolic Health
00:26:43 Sarcopenia and The Risk of Dementia
00:31:50 Brain Derived Neurotropic Factor, Neuroplasticity & Weight Training
00:39:40 Animal versus Plant Protein to Build Healthy Muscle
00:46:26 Cycling Anabolic and Catabolic States
00:51:31 Why Women Are 2x More Likely to Develop Alzheimer's and What Supplementation Is Necessary to Compliment Building Muscle
01:05:40 Conclusion and Wrap Up
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Dr. Austin Perlmutter is a board-certified internal medicine physician, New York Times bestselling author, researcher, educator, podcaster and entrepreneur. His mission is to help people get their brains unstuck for better mental and cognitive health. Dr. Perlmutter’s work on how environment and diet influences brain health has been featured on PBS, Rolling Stone, Newsweek, NPR, Fox, CBS and other top media outlets. He has co-produced and hosted some of the world’s largest online brain health events including Alzheimer’s, the Science of Prevention and the Better Brain Blueprint. He is the Managing Director of Big Bold Health, where he led a pioneering study exploring plant nutrient effects on human aging. He is the CEO of Lichen Air, which provides science-backed indoor air solutions for better brain health and longevity. He is also a research consultant to the Helfgott Research Institute, where he studies the epigenetic, metabolic, microbiome and immune effects of ayahuasca.
Website: https://www.austinperlmutter.com/
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IG: https: https://www.instagram.com/draustinperlmutter/
Lichen AIr: https://lichenair.com/
Dr. Austin Perlmutter's Muscle-Brain eGuide: https://www.austinperlmutter.com/muscleguide
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🧠 Stay ahead with the latest in science, nutrition, and wellness by subscribing to Dr. Perlmutter’s newsletter at: www.drperlmutter.com. ✉️🌱Over the last several decades, it’s been interesting to watch the progression of ideas for treating Alzheimer’s change from focusing on brain chemistry to targeting the accumulation of proteins in the brain associated with the disease. Recently, there’s been exciting interest in studying how the brain’s electrical circuits and rhythms change in Alzheimer’s and other brain degenerative disorders.The human brain operates in rhythms, with gamma frequencies playing a critical role in cognitive functions such as memory, attention, and learning. In neurodegenerative diseases like Alzheimer’s, these gamma oscillations are disrupted, contributing to the accumulation of harmful proteins such as amyloid-beta and tau. Cognito Therapeutics has developed a pioneering approach using non-invasive light and sound stimulation to restore these rhythms and trigger natural mechanisms for clearing these toxic proteins.In preclinical and early clinical trials, this method has demonstrated remarkable potential. By stimulating gamma oscillations, the therapy has shown the ability to reduce inflammation, enhance synaptic function, and activate microglia—immune cells responsible for clearing debris and maintaining brain health. For families battling cognitive decline, these results offer hope for improving quality of life and potentially slowing disease progression. Cognito’s research focuses on safety, accessibility, and scalability. Unlike pharmaceutical interventions, this approach avoids invasive procedures or systemic side effects, making it an attractive alternative or complementary treatment for Alzheimer’s.As the company advances its clinical trials, the implications extend far beyond Alzheimer’s. Cognito’s technology could pave the way for treatments for neurological conditions like Parkinson’s, MS, and traumatic brain injury.On our podcast today, we are joined by Christian Howell, CEO of Cognito Therapeutics. Howell is committed to advancing the understanding of brain health and delivering groundbreaking therapeutic solutions to improve patient outcomes. Under his leadership, Cognito Therapeutics has made significant strides in the development of gamma-frequency neuromodulation technologies, leveraging light and sound stimulation to address the mechanisms of Alzheimer’s and other neurodegenerative disorders. Howell is a strong advocate for translating cutting-edge research into real-world applications and has spearheaded the company’s efforts to validate its therapies through rigorous scientific studies and clinical trials.Howell holds advanced degrees in neuroscience and bioengineering and has dedicated his career to bridging the gap between scientific discovery and patient care. His work reflects a commitment to improving the lives of individuals and families impacted by cognitive decline and to shaping the future of brain health through innovation and collaboration.====00:00 Introduction00:59 Optogenetic Light & SoundTherapy 11:28 Innovations in Light and Sound Therapy at 40Hz Interval; Generating Neuroplasticity17:48 Rethinking Alzheimer’s Treatment and Gamma Wave Stimulation’s Impact on Proteins20:43 Overview of Cognito Therapeutics at Home Device25:30 Usage for Therapeutic, Preventative, and Performance Enhancement. 28:37 Disease States: Dysregulation of Microglia; Long Covid, Chemo Brain, Sepsis 30:45: Breakthrough Designation from FDA For the Device38:07 FDA Approval, Distribution, and Insurance Approval; Economic Burdens of Alzheimer’s 44:30 Closing Insights on Revolutionary Therapies====Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1
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After decades of stagnation, the field of psychiatry is undergoing a transformative shift.
For 75 years, mental health issues were largely viewed as “chemical imbalances” best treated with medications. While these medications have helped many, their efficacy is often limited, and they come with common side effects like fatigue, weight gain, and sexual dysfunction.
Enter metabolic psychiatry—a groundbreaking new approach that reimagines mental health challenges as issues rooted in brain metabolism. This fresh perspective is revolutionizing how we perceive and address mental health conditions, offering powerful, practical, and safe solutions that are accessible to everyone.
The most exciting discovery of our time? Robust mental health is deeply connected to robust metabolic health—and achieving metabolic health starts with a brain-friendly diet.
For those struggling with mental health, understanding how dietary changes can provide benefits that no medication can is critical. However, the key lies in making the right changes—ones that go beyond conventional dietary advice.
By integrating cutting-edge research on brain metabolism with evidence-based insights on brain-nourishing foods, we can unlock a powerful formula for optimal mental well-being. This exciting synergy is the focus of our podcast, and today, we’re thrilled to feature an expert in this field: Dr. Georgia Ede, MD, author of Change Your Diet, Change Your Mind.
In this episode, Dr. Ede shares her insights on the revolutionary potential of metabolic psychiatry and the role of diet in mental health. Together, we’ll explore how rethinking the way we nourish our brains can lead to profound changes in how we think, feel, and live.
Join us for a deep dive into the intersection of nutrition and psychiatry and discover how small, actionable dietary changes can unlock a brighter, healthier future for your mind.
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0:05 Introduction
4:15 Welcoming Dr. Ede
5:01 Dr. Ede's Backstory And Experimenting with Her Own Diet
10:46 Shifting Beliefs From Standard Psychiatric Medicine
15:22 SSRI's And Their Efficacy
20:13 Standard American Diet And Widespread Mental Health Crisis
26:21 Inflammation And Its Affect On Mental Health
30:18 Insulin Resistance, The Brain, and Impact on Mental Health
34:49 The Pushback Georgie Has Received W
39:28 Metabolism, Mitochondrial Function Relation To Mental Health Issues
44:36 Using A Ketogenic Diet To Manage Mental Health
52:55 Personalized Medicine Through A Diet That Works For Your Body
1:01:20 Thank you to Dr. Georgia and Conclusion
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Dr. Georgia Ede is an internationally recognized expert in nutritional and metabolic psychiatry. Her
twenty-five years of clinical experience include twelve years at Smith College and Harvard
University, where she was the first psychiatrist to offer students nutrition-based approaches to
mental health conditions.
Dr. Ede co-authored the first inpatient study of the ketogenic diet for serious mental illness, developed the first medically accredited course in ketogenic diets for mental health, and is a recipient of the Baszucki Brain Research Fund’s Metabolic Mind Award. Her bestselling new book Change Your Diet, Change Your Mind was recommended by the New York Times Book Review as among the three best mental health books of 2024.
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Tune in to The Empowering Neurologist Podcast for an Inspiring Conversation with Dr. Jill Carnahan, Author of Unexpected
I’ve just finished recording a very moving interview with Dr. Jill Carnahan—Functional Medicine expert, speaker, and author. This was an unforgettable conversation about her new book, Unexpected. Dr. Carnahan’s story is one of resilience, empathy, and transformation, and her insights have changed countless lives through her compassionate approach to health.
Dr. Carnahan’s journey to becoming a functional medicine leader is anything but conventional. Early in her career, she faced serious health challenges that nearly ended her life and forever transformed her approach to patient care. After being diagnosed with breast cancer at just 25, Dr. Carnahan was forced to confront the fear, uncertainty, and upheaval that accompany life-altering illness. During her treatment, she developed a deeper understanding of what her patients were experiencing, not only physically but also emotionally. Just as she was beginning to regain her health, she was diagnosed with Crohn’s disease, a severe autoimmune disorder that impacted her life for years.
These back-to-back health crises became defining moments for Dr. Carnahan. They pushed her to pursue holistic healing modalities, ultimately shifting her career path toward Functional Medicine. Through her own journey of recovery, she developed a unique perspective on health that goes beyond treating symptoms, instead focusing on addressing the root causes of illness and the interconnectedness of mind, body, and spirit.
In our time together Dr. Carnahan discusses:
☑️ The pivotal moments in her life that led her to Functional Medicine and reshaped her philosophy on health
☑️ How emotional resilience and compassion are critical components of healing
☑️ Practical strategies to detoxify, restore gut health, and promote holistic recovery
☑️ Insights into managing autoimmunity and chronic illness in a way that prioritizes the whole person
☑️ The role of mindset and self-compassion in transforming personal health challenges into opportunities for growth
My hope is that you will find our conversation to be an inspiring and enlightening experience. Her warmth, empathy, and expertise make her a true pioneer in Functional Medicine and a source of hope for anyone on their own health journey.
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00:11 Intro
01:09 Introduction to Dr. Jill
04:30 Dr. Jill’s Cancer Diagnosis
09:16 How She Learned To Trust Herself: Blending Intuition with Logic
11:54 The Illusion of Certainty & Embracing Fear
14:53 Returning to Medical School Post Chemo
20:12 Where Jill’s Cancer May Have Originated
24:24 The Diet That Helped Dr. Jill’s Crohn’s, Colitis, SIBO and SIFO Flare Ups
34:51 Dr. Jill’s Journey Into Functional Medicine as a Doctor
39:45 Dr, Perlmutter Shares His Patient’s Gluten-Free Experience
41:11 Using The Human Genome in Functional & Integrative Medicine
50:00 How Personal Agency Impacts The Healing Process
51:50 Upstream From The Microbiome Is The Soil & Outro
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Dr. Jill Carnahan is Your Functional Medicine Expert® dually board certified in Family Medicine for 10 years and in Integrative Holistic Medicine. She is the founder and Medical Director of Flatiron Functional Medicine, a widely sought-after practice with a broad range of clinical services including functional medical consulting, chiropractic therapy, physical therapy, naturopathic medicine, acupuncture, and therapeutic massage.
Be sure to follow her @drjillcarnahan on Instagram.
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What makes a good brain go bad? And if we can answer that question, how do we fix it? Of all the things that we consider that are important for brain cell function, the activity of the mitochondria is primary. And, what do mitochondria need to function at their best? The answer is not a supplement. It's not other forms of nutrients, it is oxygen. And as it turns out, enhancing, the oxygen availability for mitochondria is a powerful therapeutic tool across a wide variety of neurological issues. Mitochondrial dysfunction is central to things like dementia, autism, stroke, head injury, and even long COVID.
Hyperbaric oxygen is a clearly the most leading edge therapy that targets mitochondrial function and improves blood supply to the brain. This is a technique in which individuals are placed in a chamber, the atmospheric pressure is increased, and they breathe oxygen in varying concentrations through a facemask.
Today we are going to visit the Aviv Clinic in central Florida as I am joined by Amir Hadanny, MD, PhD, Aviv’s Chief Medical Officer and Head of Research. Dr. Hadanny has done and continues to do incredible research using hyperbaric oxygen therapy as an interventional tool to treat a variety of issues, including those mentioned above. The results, that are published in preview journals, are outstanding. Clearly hyperbaric oxygen therapy, when provided with a regimented protocol as we see at the Aviv Clinic, is giving people, a second chance.
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00:00 Intro
00:01:28 The Evolution of Hyperbaric Medicine Research
00:03:00 Clinical Applications: PTSD and Long COVID
00:05:30 Inside the Aviv Clinics Experience
00:09:22 Long COVID Study: Research Design and Findings
00:33:40 Cognitive and Physical Benefits in Healthy Aging
00:37:28 PTSD Breakthrough Study and Government Adoption
00:43:47 Future of Hyperbaric Medicine
00:45:50 Closing Remarks and Future Prospects
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Amir Hadanny, MD, PhD is a neurosurgeon and researcher at Aviv Clinics, specializing in the use of hyperbaric medicine to optimize brain and body performance. He also serves as Chief Medical Officer and Head of Research at Aviv Scientific. Dr. Hadanny completed his MD at Tel Aviv University, his PhD in Bioinformatics and Computational Biology focused on machine learning from Bar Ilan University, and his neurosurgery training at Galilee Medical Center in Israel. He completed a Stereotactic and Functional Neurosurgery fellowship at Albany Medical Center and a Harvard Research Fellowship in the Brain Modulation Lab at Massachusetts General Hospital. Through his work at Aviv Clinics and Aviv Scientific, Dr. Hadanny has published more than 60 scientific studies on the use of a unique hyperbaric oxygen therapy protocol for neurorehabilitation and recovery in different brain pathologies and its effect on the biology of aging.
https://www.nature.com/articles/s41598-022-15565-0
https://pubmed.ncbi.nlm.nih.gov/38360929/#:~:text=The%20results%20indicate%20HBOT%20can,after%20the%20last%20HBOT%20session.
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We are certainly all aware of the health consequences associated with consumption of ultra processed foods. And this discussion always moves to the role of the sugars and refined carbohydrates in these foods in terms of threatening our metabolic health - and rightfully so.
But there’s another threat associated with these and other foods that is equally important. And that’s the type of oils they contain. In this episode of The Empowering Neurologist, I’m thrilled to welcome Dr. Cate Shanahan, a groundbreaking physician and the author of the eye-opening book Dark Calories. Dr. Shanahan dives deep into a topic that is often overlooked in conversations about nutrition: the dangers of seed oils and their pervasive presence in our diets.
In Dark Calories, Dr. Shanahan reveals how seed oils—despite being marketed as healthy alternatives—can have detrimental effects on our brain and overall health. We explore the science behind these oils, explaining how they can lead to inflammation, oxidative stress, and toxicity, and how these mechanisms threaten our health. By bringing awareness to the hidden dangers of these ubiquitous ingredients, Dr. Shanahan encourages us to reconsider what we think we know about healthy eating.
What makes this episode truly valuable is not just the scientific insights Dr. Shanahan shares but also the wealth of actionable material she provides. Throughout our conversation, we discuss practical steps listeners can take to reduce seed oil consumption and make healthier food choices. From understanding food labels to selecting healthier cooking fats, Dr. Shanahan equips us with the tools we need to nourish our bodies and brains effectively.
She emphasizes the importance of whole, nutrient-dense foods, urging us to prioritize traditional fats over industrial seed oils that can contribute to chronic inflammation and cognitive decline. Whether you’re a health enthusiast or simply looking to improve your diet, this episode is packed with invaluable tips, like what to order when you go out to eat, that you can implement immediately.
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00:00 Introduction to Cate + the Dangers of Seed Oils
03:18 The 'Hateful Eight' Oils Explained
06:20 Origins of Vegetable Oils in the Food Supply
10:47 Toxicity of Refined Oils
15:03 Health Risks of Heated Oils
18:01 Medical Industry Conflicts
32:12 Strategies for Avoiding Harmful Oils
37:03 Comparison of Saturated vs. Unsaturated Fats
40:35 Impact of Toxic Oils on Chronic Diseases
53:00 Summary and Closing Out
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Cate Shanahan, MD, has shaped the best parts of today’s food and health landscapes. Her books and other publications have taught a generation of health influencers what an ideal human diet looks like and the damaging effects of a collection of 8 common seed oils (“The Hateful 8”), informing the full spectrum of nutrition leaders, including keto, carnivore, functional medicine and more. Her science backed diet advice has inspired food entrepreneurs to make billions, including bone broth, live-culture ferments, and seed-oil-free business empires like the Primal Kitchen and Bulletproof brands. As a family physician, she has personally worked 1:1 with thousands of patients to improve energy metabolism and reduce fatigue, cellular inflammation, and organ dysfunction. Through her works and influence, she has helped millions escape the vicious cycle of sickness and drug dependence.
Dr. Cate’s Monthly Newsletter signup: https://drcate.com/newsletter-signup/
About Dr. Cate’s Books https://drcate.com/which-drcate-book-should-i-buy/
LinkedIn: @DrCateShanahan
X: @DrCateShanahan
Instagram: @DrCateShanahan
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What can we do to improve our brains? This is clearly a topic that is central to our messaging. And we have focused on a variety of levers to pull, including exercise, sleep, dietary changes, nature, connection, etc. But we've now learned about a powerful input that has proven incredibly effective in improving brain function, especially in a variety pathological situations like cognitive decline, anorexia, depression, and even autism. This innovative approach has been called olfactory enrichment. And basically, this involves stimulating the brain with various types of scents.
Perhaps the top researcher on the planet exploring this subject and creating innovative ways for us to take advantage of olfactory enrichment is Dr. Michael Leon.He received his PhD from the University of Chicago and joined the professoriate at the young age of 24. He is currently Professor emeritus in the Department of Neurobiology and Behavior at the University of California Irvine.
He has received the Research Scientist Development Award from the National Institute for Mental Health for his work on the neurobiology of early learning, the D.G. Marquis Award from the American Psychological Association for developing an effective treatment for children with autism, and the Healthcare Technology Acceleration Award from the California HealthCare Foundation for his work on body weight normalization. In a recent analysis from the Stanford University, he was ranked among the top 2% of scientists in the world.
On the podcast we review this empowering science in detail and I am certain you will be you captivated by the therapeutic potential of this intervention.Also, we’ll explore the device Dr. Leon has created so that everyone can take advantage of these exciting developments.
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0:00 Intro
2:48 Researching Olfactory Enrichment
7:25 Impact of Olfaction on Disease
13:47 Relationship Between Inflammation & Sense of Smell
16:27 Study of Olfactory & Memory Loss
19:41 Losing Sense of Smell In Covid
24:01 Relationship of Taste to Olfaction
26:04 Impact on Depression
27:26 Difference Between this and Aromatherapy
31:59 Treating Anorexia with This
33:11 How This Works on a Subconscious Level
34:50 Memory Air Device
36:25 Conclusion
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Michael Leon received his PhD from the University of Chicago and joined the professoriate at the age of 24. He is currently Professor emeritus (recalled) in the Department of Neurobiology and Behavior at the University of California Irvine. He also is a member of the Center for the Neurobiology of Learning and Memory, as well as the Institute for Memory Impairments and Neurological Disorders at UCI. He has received multiple awards for teaching undergraduates, including the Professor of the Year Award as the best teacher on the UCI campus. He has received the Research Scientist Development Award from the National Institute for Mental Health for his work on the neurobiology of early learning, the D.G. Marquis Award from the American Psychological Association for developing an effective treatment for children with autism, and the Healthcare Technology Acceleration Award, from the California HealthCare Foundation, Booz Allen Hamilton, and the Robert Wood Johnson Foundation for his work on body weight control. In a recent analysis from the Stanford University School of Medicine, he was ranked among the top 2% of scientists in the world for the impact of his research. He is a partner in Science Lab 3 and the Mando Group.
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Our lifestyle choices are fundamental as it relates to the health of our brains. Who knew? Well one person who knows this information and has done an amazing job getting this out to public awareness is Louisa Nicola, neurophysiologist, human performance coach and founder of Neuro Athletics, a human performance coaching firm that supports the highest performing athletes and executives in the world. This organization bring science-based solutions to elite performers who want to perform at their highest level.
Luisa graduated from the university of Sydney medical school and specializes in Neurophysiology. She is currently completing her PhD and has recently published fascinating report on the benefits of resistance exercises as it relates to Alzheimer's disease.
The podcast that you were about to watch extremely empowering. What you will find in Louisa’s messaging is a heartfelt devotion to empowerment for all who will listen that truly, our brain’s destiny is something we can control. I'm very grateful that she joined us on the podcast today.
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0:00 Intro
2:37 How Louisa Got Started
5:00 Exercise’s Impact on Brain Health
11:37 Aerobics vs Strength Training
14:56 Wearable Devices to Track Exercise
19:53 What Happens in the Brain During Exercise
25:11 Importance of Restorative Sleep
30:42 Best Type of Diet for the Brain
33:09 Phd: Resistance Training & Alzheimer’s
36:28 Conclusion
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Neurophysiologist and human performance coach, Louisa Nicola is the founder and head performance advisor of Neuro Athletics - a human performance coaching firm that boasts the highest performing athletes and executives in the world. Neuro Athletics brings science based solutions to elite performers who want to perform at their peak. Louisa graduated from the University of Sydney Medical School and specialises in neurophysiology.
https://www.instagram.com/louisanicola_/
https://apple.co/3H02jPa
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https://www.neuroathletics.com.au/
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Around 60 million people around the world have dementia. 300 million have depression, and billions of people are experiencing brain problems due to chronic stress. These conditions are partially preventable, but most people don’t know the steps to take to decrease their risk and protect their brains. It turns out that the place where our brains are at the highest risk for being damaged is actually in our homes, and that we have an incredible amount of control over what happens here. But sadly, most of us are being unintentionally exposed to things in our houses that are poisoning our brain health. In this episode, we’re going deep into the science that examines those factors in our environments that are damaging our brains. We connect with an expert in environmental and lifestyle medicine, Dr. Austin Perlmutter. We’re going to explore exactly what we are exposing ourselves to, in our homes, cars and offices, that threaten to worsen our cognitive and mental health. And, importantly, Dr. Perlmutter will reveal simple steps we can employ, today, to reduce this threat.
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0:00 Intro
3:06 How our environment threatens our brain
8:18 Health Begins in the Kitchen
12:10 Air Pollution in the Kitchen
18:13 Pollution in our World Today
23:23 Hidden Sources of Pollution: Vacuums & Incense
28:34 Effectiveness of N95 Masks
31:00 We Can’t Overlook This
35:00 Air Fresheners & Perfumes
39:13 Indoor Filtration & Ventilation
46:40 Other Pollutants to Watch Out For
49:25 Conclusion
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Here's more about our guest, and yes, my son:
Dr. Austin Perlmutter is a board-certified internal medicine physician, New York Times bestselling author, published researcher and international educator. His mission is to help people improve their health by targeting the biological basis of “stuckness” in our brains and bodies. His writings, presentations, podcasts, and online educational programs explore how environmental factors influence our cognitive and mental state and have reached millions. Dr. Perlmutter has been featured on PBS, Rolling Stone, MedPage today, Newsweek, Medical News Today, NPR and a wide range of other media outlets. He is a co-producer of the Alzheimer’s, the Science of Prevention series, and host of the Better Brain Blueprint series. Dr. Perlmutter currently serves as the managing director at Big Bold Health, a food-as-medicine company focused on helping people rejuvenate health through better immune function, where he is running a first-of-its kind study exploring the effects of plant nutrients on human aging through epigenetic modulation.
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Researchers around the world are looking at the role of a mechanism, inflammation, in what makes a good brain go bad, and specifically in diseases like Alzheimer’s. Dr. Jack Auty is a Tasmanian researcher who is focused on this process and is exploring a variety of inroads to inflammation, including, zinc deficiency, as well as the possible role of our ever-increasing exposure to microplastics in amplifying this mechanism.
Dr. Auty has a very expansive social media exposure, bringing this information to the public awareness. He’s a very interesting researcher on a number of levels, including fieldwork looking at animals exposed to microplastics as well as translational research from the lab to humans again focused on inflammation and its damaging role throughout the body, and specifically the brain.
Currently, Dr. Auty is a lecturer in the Medical Sciences division in the School of Medicine at the University of Tasmania. He, in addition, serves as a collaborator with an organization called the Adrift Lab, and we will learn more about their mission on our podcast as well.
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0:00 Intro
3:16 Studying the Mechanism of Inflammation
13:12 Optimizing Our Microglia
16:46 Polygenic Influences on Alzheimer’s
21:16 Accumulation of Microplastics
34:35 Avoiding Microplastics
36:53 Zinc’s Impact on Alzheimer’s
43:20 Removing the Blame From Lifestyle Choices
52:00 The Adrift Lab: Studying Microplastics
57:23 Conclusion
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Jack completed a Bachelor of Science in anatomy with a neuroscience focus at the southernmost university in the world – the University of Otago. During his degree Jack took several botany papers and fell in love with the subject, so Jack continued studies at Otago with a post graduate diploma in botany followed by a Ph.D. which combined botany and neuroscience by investigating the effects of marijuana-like synthetic cannabinoids on inflammation in the ischemic brain, combining botany and neuroscience.
After completing his Ph.D., Jack continued his research at the University of Otago with projects on hydrogen sulphide as an inflammatory signaling molecule and kamikaze neutrophils that release their DNA contents onto bacteria. He then moved to the University of Manchester, where he primarily investigated the role of the inflammasome in Alzheimer's disease and age-related cognitive decline. Jack was fortunate to have inspiring, supportive, and scientifically proficient supervisors and collaborators in Dr. Catherine Lawrence and Prof. David Brough, under whose guidance he was able to make significant contributions to the field of inflammation research.
Currently, Jack is a lecturer in Medical Sciences at the University of Tasmania, where he investigates inflammation. He is focused on establishing the inflammatory properties of environmental microplastics and identifying the cellular mechanisms that mediate microplastic-induced inflammation. Additionally, he aims to understand how peripheral and central inflammatory responses contribute to Alzheimer's disease.
https://jackauty.com
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In this episode of The Empowering Neurologist Podcast, we had the profound pleasure of reconnecting with my longtime friend and now filmmaker, Max Lugavere, the creative force behind the deeply moving documentary Little Empty Boxes. Max, who is as articulate as he is passionate, took us through the deeply personal journey that led to the making of his film—a narrative woven from love, loss, and the quest for understanding dementia.
The genesis of Little Empty Boxes is as poignant as it is inspiring. Max shared the moment his life changed during what was meant to be a serene summer vacation: his mother, Kathy, was unable to recall the current year, a lapse that signaled the onset of her cognitive decline. This incident wasn't just a fleeting moment of forgetfulness; it was the beginning of a challenging journey through the landscape of dementia, a condition affecting over 55 million people worldwide.
Moved by his mother's struggle, Max returned to New York City, transitioning from a concerned son to a determined researcher, diving deep into the complexities of dementia. The film follows his exploration of innovative approaches beyond conventional medication, aiming to slow the progression of his mother's illness.
Max described Little Empty Boxes as a project that "crept in, claws out." It wasn’t a film he planned, but one that emerged from necessity. His mother's worsening condition was harrowing to witness, but it birthed a purpose that transcended personal pain. Max emphasized that the film isn’t centered on definitive medical answers or miraculous recoveries. Instead, it presents a raw, messy, and intimately personal look into the life of a dementia patient and the daily realities of their caretakers.
One of the most touching moments in our conversation was Max’s reflection on the film as a tribute to his mother and a love letter to the science of dementia prevention. He hopes that by sharing his mother's story, the film will not only shine a light on ways to delay or prevent this devastating condition but also encourage viewers to cherish every memory. "It's about making the most of what remains, together," Max remarked, highlighting the film’s focus on the human elements of love, memory, and resilience.
Our discussion with Max was more than just an interview; it was an exploration of the emotional and scientific facets of dementia through the lens of a devoted son's experience. For anyone who has witnessed the impacts of dementia firsthand, or for those interested in the intersections of film and real-world issues, Little Empty Boxes offers a compelling narrative that is both educational and deeply moving.
Watch Little Empty Boxes here: https://littleemptyboxes.com/
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0:00 Intro
3:49 The Diagnosis That Changed Everything
8:09 How Medicine Failed Max’s Mom
12:07 How Fraudulent Research Clouded Our Knowledge
18:14 Making “Little Empty Boxes”
26:06 Bringing the Prevention Conversation to the Masses
35:50 Conclusion
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Max Lugavere is a health and science journalist, filmmaker, and bestselling author. He is the author of the Genius trilogy of books, including the New York Times bestseller Genius Foods and the Wall Street Journal bestseller Genius Kitchen. He hosts The Genius Life podcast, one of the top health and wellness podcasts in the U.S, and has an audience of over 1.5 million followers across social media.
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Alzheimer’s disease can be reversed. Need I state that again? That is the subject of our podcast featuring an interview with Dr. Heather Sandison. Dr. Sandison is a renowned naturopathic doctor and a leading expert in neurodegenerative diseases. She has dedicated her career to understanding and reversing cognitive decline, with a particular focus on Alzheimer's disease.
In this episode, we will be discussing her groundbreaking new book, Reversing Alzheimer's. This transformative work offers a comprehensive approach to preventing and reversing Alzheimer’s disease through personalized medicine, lifestyle changes, and cutting-edge therapies. Dr. Sandison’s insights provide hope and practical strategies for those affected by this devastating condition.
Tune in as we explore the innovative methods outlined in her book, the latest research in brain health, and how you can take proactive steps to maintain cognitive function. Whether you’re a caregiver, a healthcare professional, or someone concerned about your brain health, this episode is packed with invaluable information and inspiration.
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0:00 Intro
2:49 Promising Alzheimer’s Breakthrough
7:57 Where We’re Getting it Wrong with Alzheimer’s Prevention
11:00 Solving the Complex Problem of Alzheimer’s
13:33 How Infections & Covid 19 Plays a Role
18:34 A Different View of Beta Amyloid
22:10 Studying the Treatment Plan
26:50 Contrast Oxygen Therapy
33:21 Praise for Dale Bredesen’s Work
35:15 Conclusion
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Dr. Heather Sandison, a distinguished naturopathic doctor, has devoted her career to providing compassionate care and innovative solutions to those affected by dementia. Renowned for her pioneering work, Dr. Sandison has integrated groundbreaking, holistic, and multimodal interventions, seamlessly creating clinical, residential, research, and educational platforms. Her relentless dedication has not only transformed the lives of patients and caregivers she has also set new standards in the field of dementia care. She is the author of Reversing Alzheimer's: The New Toolkit to Improve Cognition and Protect Brain Health, out with HarperCollins June 11th, 2024.
Learn more about brain health by signing up for our mailing list at:
drheathersandison.com
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There’s certainly a lot of interest these days in the idea of having a “total body MRI scan.” And with good reason. This turns out to be a highly sensitive study as it relates to detecting a variety of issues, even including early cancers.
I wanted to learn more about this technique so I traveled to Vancouver, Canada to meet with Dr. Raj Attariwala, developer of the Prenuvo Scan, a popular total body MRI here in America and the scan that I myself underwent.
In this interview we explore the need and utility of total body MRI, its limitations, what the future will likely bring in this area of imaging, as well as Dr. Attariwala’s more recent research dealing with metabolic imaging of the brain.
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0:00 Intro
2:46 How & Why MRIs Work
7:37 Effectiveness for Early Detection
13:13 Cost/ Benefit Ratio of MRI
16:49 The Future of MRI & Metabolic Signature
21:27 Brain Health & Body Mass: Findings From Total Body MRI
27:20 Pushbacks on this Protocol
31:27 Total Body vs Regional MRI
34:00 Who Can't Have an MRI
36:00 Standardization in Interpretation of Scans
45:32 Success Stories
47:25 Detecting Colon Cancer
48:29 Best Protocol for Cancer Detection
51:53 Conclusion
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Dr Rajpaul Attariwala, M.D., PhD, FRCPC
Nuclear Medicine Radiologist & Biomedical Engineer
Dr Attariwala holds a doctorate in Biomedical Engineering from Northwestern University (Evanston, IL) prior to becoming a double board-certified radiologist and nuclear medicine physician certified in both Canada and USA. He received his formal training at UBC, along with specialized training at Memorial Sloan Kettering Cancer Centre (New York), UCLA, and USC. He is the creator of the Prenuvo scan and report which were developed at his MRI facility, AIM Medical Imaging in Vancouver Canada. His passion is to create and advance technology to help patients understand how their body changes in both health and disease. Currently he is working to develop and implement critical tools to promote healthspan in Medicine 3.0 with leading scientists and physicians from around the world.
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In this installment in The Empowering Neurologist Podcast we are thrilled to have a very special guest, and longtime friend, Dr. Casey Means, co-author of the groundbreaking book, Good Energy.
Good Energy is not just a book; it's a movement. It invites us to reconsider our day-to-day choices and their profound impact on our body's energy systems. Dr. Means, a Stanford-trained physician, has beautifully woven her medical expertise with cutting-edge research to craft a guide that’s indispensable for anyone looking to enhance their physical and mental well-being through sustainable energy management.
In this episode, Dr. Means shares insights into how our everyday habits—what we eat, how we sleep, and even how we think—can significantly influence our metabolic processes, mental clarity, and overall vitality. The book delves into the concept of mitochondrial health, a topic we frequently explore, explaining how these tiny powerhouses in our cells are not just biological entities, but pivotal in shaping our health destiny by influencing all manner of our physiology.
Our conversation covers key themes from the book, including:
The Role of Diet in Energy Production: How can the right foods transform your health by optimizing energy production at a cellular level?
Mindfulness and Mental Energy: Exploring the link between mental practices like mindfulness and physical energy levels.
Innovative Health Tracking: Dr. Means is a proponent of leveraging technology (like the continuous glucose monitor) to monitor health markers. We discuss how modern tools can help personalize our health strategies for better energy.
Listeners will come away with practical advice on integrating the principles of Good Energy into their lives.
This episode is a must-watch for anyone interested in stepping up their energy game, enhancing cognitive function, and ultimately taking charge of their health in a holistic and informed manner.
If you want to try Levels today click this link for 2 months free on an annual membership: levels.link/perlmutter
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0:00 Intro
3:27 Where We’re Missing the Mark on Health
8:56 Correlation of Movement and Alzheimer’s
11:34 Learn How to Trust Yourself
18:04 Linking Metabolism & Health: How Levels Health Began
27:18 How to Interpret Levels Data to Optimize Your Wellbeing
31:34 American Children’s Health Crisis
35:56 Take Your Health Back
41:16 How This Information is Helping People
53:03 Conclusion
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Casey Means, MD is the co-founder of Levels, a health technology company with the mission of reversing the world’s metabolic health crisis. She received her BA with honors and MD from Stanford, was President of her Stanford class, and has served on Stanford faculty. She trained in Head & Neck Surgery at Oregon Health and Science University before leaving traditional medicine to devote her life to tackling the root cause of why Americans are sick. She has been featured in The New York Times, The New Yorker, The Wall Street Journal, Forbes, Women’s Health, and more.
Calley Means is the co-founder of Truemed - a company that enables Americans to purchase healthy food and exercise tax-free. He is an advocate/whistleblower about the corruption of the food and pharma industries and need to change incentives - and appeared on over 100 major media outlets to advocate for change. Calley is a graduate of Stanford and Harvard Business School.
Make sure to tune in and join us for this enlightening conversation. Your journey towards better health and Good Energy starts here! This episode will equip you with the knowledge and tools to make a profound impact on your health.
___________________________
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Without question, a pivotal player in our health is the adequate and balanced functioning of the immune system. No matter what disease state you can consider, the immune system is playing an important role.
We now recognize that our metabolic health is hugely influential in determining the functionality of our immune system. As such, we know that our lifestyles influence metabolic health and therefore, with this understanding, we can influence immune function by paying attention to these decisions we make each day that are so influential as it relates to human metabolism.
On today's program, we are going to explore the concept of immune modulation and the relationship between immunity and metabolic health. We are also going to take a deep dive into new some very exciting discoveries as it relates to ancient foods that powerfully influence immune function including Himalayan tartary buckwheat, a modern day superfood that’s getting a lot of attention.
There couldn't be anyone better to walk us through this exciting new science than my longtime friend, Dr. Jeffrey Bland.
This is a fascinating and thought provoking interview. To further explore this science, visit Big Bold Health: https://bigboldhealth.com/the-science
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0:00 Intro
4:25 The Immune System Connects Everything
13:27 Soil Health & Agricultural Toxins
19:01 Looking at the True Quality of Our Food
22:33 Discovering Himalayan Tartary Buckwheat
28:38 Polyphenols & Benefits of HTB
33:38 Longevity & Blue Zones
37:43 Forming a Super Superfood: Sprouting HTB
39:49 The True Interconnected Nature of the Body & Immune System
54:07 The Mystery of Ancient Medicine & Nature’s Intelligence
1:00:01 Taking a Closer Look at Functions
1:02:03 Conclusion
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Jeff Bland, PhD is the founder of Big Bold Health, a company on a mission to transform the way people think about one of nature’s greatest innovations — the immune system. Through Big Bold Health, Jeff is advocating for the power of Immuno-Rejuvenation to enhance immunity at a global level, often through the rediscovery of ancient food crops and superfoods. To get there, Jeff is building a network of small farms and suppliers throughout the US that take a clear stance on regenerative agriculture, environmental stewardship, and planetary health.
Jeff’s career in health spans more than 40 years. A nutritional biochemist by training, he began in academia as a university professor. Jeff then spent three decades in the natural products industry, working alongside other pioneers.
A lifelong educator, Jeff has traveled the world many times over in his role as the “father of functional medicine.” In 1991, he and his wife, Susan, founded The Institute for Functional Medicine. In 2012, Jeff founded another educational nonprofit called the Personalized Lifestyle Medicine Institute. Jeff is the author of The Disease Delusion: Conquering the Causes of Chronic Illness for a Healthier, Longer, and Happier Life, as well as countless additional books and research papers.
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As many of you are aware, much of our information that we present deals with problems of the brain and spinal cord. These have been described as being parts of the central nervous system. However, there is another part of the nervous system called the peripheral nervous system that is basically made up of the peripheral nerves.
Peripheral neuropathy is a term that describes an abnormality with peripheral nerves. This can cause loss of sensation, pain, or even loss of autonomic function. Here in America some 20 million people suffer from peripheral neuropathy. In fact more than half of the people with diabetes will develop prayerful neuropathy at some point in their lifetimes. We are at increased risk for peripheral neuropathy not only as a consequence of diabetes but also as we age. Pray for neuropathy can be caused by chemotherapy and fully 1/4 of all peripheral neuropathy patients do not have an identifiable cost.
There aren't really any FDA approved treatments to actually treat purple neuropathy in terms of the underlying cause of the nerve damage. While we do have drugs that treat, pain for example, again we need to find a way of treating the fire, not just focusing on the smoke. Having said that, there is an exciting new development in this field using drugs that are already available and are called muscarinic antagonists. Basically, they block the transmission of acetylcholine.
In today's podcast, we are going to explore deeply, the mechanisms whereby this approach, using these muscarinic antagonists seems to be incredibly effective in growing new nerve fibers as well as increasing metabolism in the nerve itself leading to improvement ultimately in the manifestation of peripheral neuropathy.
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0:00 Intro
5:35 The Scope of the Problem
8:09 Diabetic Neuropathy
11:49 Neuropathy Following Chemotherapy
14:21 Viral Infections: HIV Treatment & Covid
16:56 Why Mitochondria are Essential in This
19:44 Pharmaceutical Study of Neuropathy
24:57 Aldose reductase inhibitor
29:31 Why This Approach is Different
37:44 How Antimuscarinics Work
48:10 Metrics for Getting FDA Approval
58:42 Funding the Research
1:01:53 Conclusion
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Nigel A. Calcutt, Ph.D. ook both his B.Sc. in Zoology and Ph.D. Physiology and Pharmacology at Nottingham University, England. Dr. Calcutt first began studying nerve damage caused by diabetes as an undergraduate, with a largely unsuccessful but nevertheless entertaining and informative attempt to generate diabetic chickens in the laboratory of the esteemed ornithologist Professor David Tomlinson. Undeterred by the pitiful paucity of pre-diabetic poultry, he has continued to investigate mechanisms of diabetic neuropathy and neuropathic pain throughout his academic career, with a particular interest in translational studies. Dr. Calcutt is also a co-founder of the biotechnology company WinSanTor Inc. and the non-profit organization Diabetes Research Connection.Paul Fernyhough PhD received his PhD in biochemistry from the department of Biochemistry at University of Sheffield. He then carried out postdoctoral research at Colorado State University, Kings College London and as a Wellcome Trust Postdoctoral Fellow at St Bartholomew’s Medical College. Dr. Fernyhough’s research interest is in the cell biology underlying neurodegenerative disorders of the peripheral nervous system with a focus on the impact of diabetes. A biotech start-up, WinSanTor Inc, has been established and is directing phase 2 clinical trials in diabetic neuropathy and chemotherapy-induced peripheral neuropathy. ___________________________Instagram: https://www.instagram.com/davidperlmutter/Website: https://www.drperlmutter.com/Subscribe to our channel:https://www.youtube.com/channel/UCDRl_UAXxbHyOOjklnA0dxQ/?sub_confirmation=1
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In a groundbreaking development, an international team of researchers has unveiled a remarkable advancement in the fight against progressive multiple sclerosis (MS). Their study, led by scientists from the University of Cambridge, the University of Milan Bicocca, and Hospital Casa Sollievo della Sofferenza in Italy, demonstrates the safety, tolerance, and long-lasting effectiveness of injecting a specific type of stem cell directly into the brains of patients living with progressive MS. This breakthrough paves the way for the development of advanced cell therapy treatments for this debilitating disease that affects over 2 million people worldwide.
Multiple sclerosis is a complex autoimmune disease that targets the central nervous system, leading to severe disruption in the transmission of nerve signals. While there are treatments available to alleviate some of the symptoms and reduce the frequency of relapses, many patients still progress into a secondary phase of the disease, which steadily worsens over time, causing severe disability. This secondary progressive phase has long been a significant challenge in the treatment of MS.
In progressive forms of MS, a type of immune cell known as macrophages, specifically microglial cells, plays a crucial role in attacking and damaging the central nervous system. This relentless assault leads to chronic inflammation and extensive nerve cell damage. Recent advances in stem cell therapies have raised hope that they could help mitigate this damage by replacing damaged cells with healthy ones.
Before the current study, the University of Cambridge team had already demonstrated in mouse models that reprogrammed skin cells into brain stem cells, transplanted into the central nervous system, could reduce inflammation and potentially aid in repairing MS-related damage.
This groundbreaking study marks a significant step forward in the pursuit of effective treatments for secondary progressive MS. Although the study is relatively small and may have confounding effects from immunosuppressant drugs, its safety and long-lasting effects over the 12-month trial period have paved the way for further clinical trials. The research team's cautious optimism fuels hope for the development of cell therapy as a potential solution for this debilitating condition. This exciting progress holds the promise of a brighter future for the millions of people living with progressive MS, offering renewed hope for a more effective treatment approach.
Our interview today is with the lead researcher involved in this study at the University of Cambridge, Stefano Pluchino, MD, PhD.
====
0:00 Intro
2:46 Why Stem Cell Therapy Works
5:10 Studying Stem Cells on the Brain
9:15 MS Patients Studied in This Trial
13:43 What the Results Mean for the Public
17:40 The Specifics of the Study
26:18 Rigorous Testing that Sets this Trail Apart
28:25 Findings: Feasibility, Safety, and Biomarkers
34:32 Looking at the Results over 12 months
40:11 Correlation of Metabolic Health and MS
44:55 What Exosomes Reveal About Disease
49:01 Senolytic Therapy & Neurodegenerative Diseases
53:36 Conclusion
====
Stefano Pluchino received his MD and PhD degrees at the University of Siena, Italy,
and additional training at Cambridge University, UK. He is currently Professor of
Regenerative Neuroimmunology (2021) and Honorary Consultant in Neurology, within
the Department of Clinical Neurosciences at Cambridge University.
Twitter: @Pluchinolab
Research: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00393-4
___________________________
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Website: https://www.drperlmutter.com/
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