Episodios
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How much influence does the gut microbiome have on developing eczema or allergies? Turns out, quite a lot. Join this special excerpt from our research symposium to learn how antibiotics in pregnancy and early childhood increases eczema risk and how adding "biotics" might prevent it in the first place. Our speakers are Dr. David Margolis (University of Pennsylvania) and Dr. Nikole Kimes (Siolta Therapeutics). If you like our podcast, please consider supporting it with a tax deductible donation.
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Traditional Chinese Medicine (TCM) uses biological extracts to treat disease. Eczema sufferers may take a herbal bath, apply a specially formulated cream or drink herbal tea as part of TCM treatment. Dr. Xiu Min Li from New York Medical College explains TCM and we ask: Is Traditional Chinese Medicine (TCM) safe for newborns? Can you use TCM and topical steroids simultaneously? Could TCM prevent the allergic march?
Research mentioned
Investigation of Berberine's Potential in Attenuating Staphylococcus aureus-Induced Inflammatory Responses
Investigation of In vitro Anti-inflammatory and Antimicrobial Effects of Berberine
Effect of Traditional Chinese Medicine (TCM) in moderate-to-severe eczema in clinic and animal model: beyond corticosteroids
Traditional Chinese medicine for food allergy and eczema
Effect of traditional Chinese medicine on skin lesions and quality of life in patients with moderate to severe eczema
Efficacy and safety of Chinese herbal medicine for atopic dermatitis: Evidence from eight high-quality randomized placebo-controlled trials.
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Are you feeling lost and donât know where to find trusted advice on managing eczema? Introducing ECZHALE, your one-stop-shop for reliable information and resources on eczema care. Join Dr. Jennifer LeBovidge, psychologist and Assistant Professor at the Atopic Dermatitis Center at Boston Childrenâs Hospital, and GPERâs Christine Pham Cutaran as they discuss the challenges of being an eczema caregiver and where you can turn for help.
Literature mentioned
Multidisciplinary interventions in the management of atopic dermatitis
Atopic dermatitis: therapeutic care delivery: therapeutic education, shared decision-making, and access to care
Improving patient education for atopic dermatitis
Resources
ECZHALE wellness hub
Support for Eczema Caregivers
Treatment Navigator
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Is getting rid of Staph aureus in the gut the key to improving eczema? And can we control it without antibiotics? Join us as we ask these questions and more of Dr. Michael Otto, Chief of the Pathogen Molecular Genetics Section at the National Institute of Allergies and Infectious Diseases. (And if you like our podcast, consider supporting it with a tax deductible donation).
Research mentioned
Probiotic for pathogen-specific Staphylococcus aureus decolonisation in Thailand: a phase 2, double-blind, randomised, placebo-controlled trial
Commensal Staphylococcus epidermidis contributes to skin barrier homeostasis by generating protective ceramides
The association between Staphylococcus aureus colonization on cheek skin at 2â months and subsequent atopic dermatitis in a prospective birth cohort
Skin microbiota analysis-inspired development of novel anti-infectives
Combined antibiotic, steroid, and moisturizer for atopic dermatitis: A twoâyear case series of patientâreported outcomes
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Korey Capozza travels to Spain for the European Academy of Allergy and Clinical Immunology Congress where she speaks to researchers that are trying to explain the allergy epidemic and what we can do about it. Highlights: Dr. Magdalena Zemelka-Wiacek (Poland) explains microplastics cause inflammation. Tami Landau (Israel) uses âbig dataâ to determine which children will develop eczema, and Dr Thomas Bieber (Germany) accesses the German Biobank to understand why some children go into remission.
Research Mentioned
Mechanisms of gut epithelial barrier impairment caused by food emulsifiers polysorbate 20 and polysorbate 80
Follow-up to adolescence after early peanut introduction for allergy prevention
The potential impact of nano-and microplastics on human health: Understanding human health risks
Biomarkers for phenotype-endotype relationship in atopic dermatitis
Development of a predictive model for pediatric atopic dermatitis
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Could the diet and lifestyle of a mother during pregnancy influence whether her baby will develop eczema? Our podcast guests are studying the role that diet and the gut microbiome play in pregnancy. Join Dr. Carina Venter and Dr. Susan Lynch as we discuss what pregnant mothers can do to reduce the chances of baby developing eczema or allergies. (And if you like our podcast, consider supporting it with a tax deductible donation).
Research mentioned
Delayed gut microbiota development in high-risk for asthma infants is temporarily modifiable by Lactobacillus supplementation
Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy
Different Measures of Diet Diversity During Infancy and the Association with Childhood Food Allergy in a UK Birth Cohort Study
The Maternal Diet Index and Offspring Microbiota at 1 Month of Life: Insights from the Mediterranean Birth Cohort MAMI
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Frustrated by eczema care that ignores patient priorities? New guidelines from the medical societies for allergists and immunologists may help change that. These guidelines were informed by the views of eczema patients and caregivers and based in evidence (hallelujah!). We chat with the guideline co-authors Dr. Lynda Schneider, founder and director of the Atopic Dermatitis Center at Boston Childrenâs Hospital, and Dr. Derek Chu, director of the challenge clinic for allergy diagnosis, research and treatment at McMaster University, about some of the new and surprising ideas they recommend. (And if you like our podcast, consider supporting it with a tax deductible donation). Read the transcript.
Research mentioned
Atopic dermatitis guidelines: 2023
Is Food-Triggered Atopic Dermatitis a Form of Systemic Contact Dermatitis?
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Five GPER staff members attended the American Academy of Dermatology conference in February, the biggest gathering of dermatologists worldwide. We bring you the newest treatments and latest research straight from the source. Join our conversation with GPER staffers Korey Capozza, Kara Orevillo, Christine Cutaran and Michelle Tu about what stood out this year. (And if you like our podcast, consider supporting it with a tax deductible donation).
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Could we cure allergies by taking probiotics or transplanting the gut microbiome from a healthy person? What does all this mean for eczema/allergy prevention? To find out, join our conversation with Dr. Rima Rachid, allergist and immunologist at Harvard Childrenâs Hospital, and Meenal Lele, eczema mom and author of Baby and the Biome. We discuss the promising trials with fecal microbiota transplants for food allergic children as well as the best probiotic to take for eczema and when itâs important to take it. (And if you like our podcast, consider supporting it with a tax deductible donation).
Literature featured in this podcast
The microbial origins of food allergy
Evaluating the Safety and Efficacy of Oral Encapsulated Microbiota Transplantation Therapy in Peanut Allergic Patients
Lactobacillus rhamnosus Used in the Perinatal Period for the Prevention of Atopic Dermatitis in Infants
The Baby and the Biome book
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The winners of the 2023 Big Ideas for Eczema contest share their novel ideas and how they came up with them. Our citizen scientist winners are Elizabeth Shores, Hannah Mitchell and Armando de la Libertad. Would you try these ideas? (If you like our podcast consider supporting it with a tax deductible donation.)
If you have an idea of your own, find out more about the Big Ideas 2024 competition here.
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What are the top research discoveries of 2023 related to eczema? Tune in to learn about new, needle-free Epi-Pen alternatives, painless tests for detecting eczema before it appears, and insights about how to address anxiety and depression related to eczema. Guests include Albert Chong of University of Southern California, Dr. Ruchi Gupta of Northwestern University, Dr. Ian Myles of NIH, and Dr. Kiwako Yamamoto-Hanada of National Children's Hospital, Tokyo. P.S. If you like our podcast, consider making a donation to GPER!
Research discussed in this podcast
mRNAs in skin surface lipids unveiled atopic dermatitis at 1âmonth
Patients' and Caregivers' Preferences for Mental Health Care and Support in Atopic Dermatitis
Innovations in the treatment of anaphylaxis: A review of recent data - ScienceDirect
Pharmacokinetics and pharmacodynamics of epinephrine sublingual film versus intra-muscular epinephrine - Journal of Allergy and Clinical Immunology
Shotgun metagenomic sequencing on skin microbiome indicates dysbiosis exists prior to the onset of atopic dermatitis
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Can moisturizers help prevent eczema? If so: when, what and how should they be applied? Can probiotics help? If so: who should take them - mother or baby? These questions and more are answered by Helen Brough, pediatric allergist and head of service at Evelina London Children's Hospital (UK). As part of our recent research symposium, she explains what research is going on in eczema management and prevention and what is still needed to make prevention a reality. She also has important tips for eczema care now. (If you like our podcast consider supporting it with a tax deductible donation.)
Research discussed in this episode
Early initiation of short-term emollient use for the prevention of atopic dermatitis in high-risk infantsâThe STOP-AD randomised controlled trial
Skin care interventions in infants for preventing eczema and food allergy
Probiotic supplementation for prevention of atopic dermatitis in infants and children: a systematic review and meta-analysis
Early intervention and prevention of allergic diseases
Emollients in infancy to prevent atopic dermatitis: a systematic review and metaâanalysis
Epicutaneous sensitization in the development of food allergy: what is the evidence and how can this be prevented?
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New biological therapies like dupilumab target Type 2 inflammation, but new research shows they are also modifying the skin microbiome. In this episode we discuss what Type 2 inflammation is, why it matter in eczema, and how it modifies the microbiome. Our guest is Dr. Lisa Beck (Co-Director of the Center for Allergic Disease Research, University of Rochester Medical Center, NY) who has dedicated her 35 year career to understanding why some eczema patients are susceptible to skin infections and finding safe and effective eczema treatments.
Research associated with this podcast
Type 2 Inflammation Contributes to Skin Barrier Dysfunction in Atopic Dermatitis
Tralokinumab treatment improves the skin microbiota by increasing the microbial diversity in adults with moderate-to-severe atopic dermatitis
Rapid Reduction in Staphylococcus aureus in Atopic Dermatitis Subjects Following Dupilumab Treatment
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Dupixent has transformed the lives of people with moderate to severe eczema, but will patients need to use it indefinitely? In this episode we explore tapering Dupixent (also known as dupilumab) with two researchers from University Medical Center Utrecht in the Netherlands that have created a patient-led roadmap for successful tapering. They are: Pediatric Dermatologist Dr. Marlies de Graaf, Head of the National Expertise Center of Atopic Dermatitis in Children; and Dr. Celeste Boesjes, who is a PhD candidate and Medical Doctor.
Research Discussed in this Podcast
Successful tapering of dupilumab in atopic dermatitis patients with low disease activity: a large pragmatic daily practice study from the BioDay registry
Association of serum dupilumab levels at 16 weeks with treatment response and adverse effects in patients with atopic dermatitis: a prospective clinical cohort study from the BioDay registry
Patientâcentered dupilumab dosing regimen leads to successful dose reduction in persistently controlled atopic dermatitis
Dupilumab in daily practice for the treatment of pediatric atopic dermatitis: 28âweek clinical and biomarker results from the BioDay registry
Dupilumab dose spacing after initial successful treatment or adverse events in adult patients with atopic dermatitis: a retrospective analysis
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Itch. Itâs the hallmark symptom of eczema and the most troublesome. In this podcast we discuss why the eczema itch is so hard to treat and explore effective treatment options. We have the privilege of speaking with Dr. Shawn Kwatra, international leader in chronic itch research and Director of John Hopkins Itch Centre in Baltimore, and Dr. Shivani Patel, a practicing pediatric dermatologist who specializes in treating children with eczema. (If you like our podcast consider supporting it with a tax deductible donation.)
Research discussed in this podcast
Molecular and cellular mechanisms of itch and pain in atopic dermatitis and implications for novel therapeutics
Cumulative Use of Strong Anticholinergics and Incident Dementia
Living with Itch - A Patient's Guide
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What do microplastics, dishwasher rinse-aid, air pollution and processed foods have to do with eczema? Join us as we explore why allergic diseases were rare for our grandparents but now affect two billion people worldwide. Explaining the link is our guest, Professor Cezmi Akdis. He is a global leader in immunology, specializing in allergic diseases, editor-in-chief of Allergy, and a Professor at the University of Zurich in Switzerland. (If you like our podcast consider supporting it with a tax deductible donation.)
Research discussed in this podcast:
Scrubbing away our collective health
Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?
Gut epithelial barrier damage caused by dishwasher detergents and rinse aids
Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease
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Have you ever wondered if there is anything you can do during pregnancy to lower the chance of your baby developing eczema? Join our discussion with Dr. Suzanne Barshow from Stanford University who is overseeing the SUNBEAM study which investigates which factors lead to the development of allergic diseases, and Kortney Kwong Hing, co-host of The Itch Podcast and eczema sufferer who would like to avoid passing on her allergies to her future children. (If you like our podcast consider supporting it with a tax deductible donation.)
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In our very first âBig Ideasâ competition, we asked those who live with eczema for big ideas that could lead to better treatments or a cure. Learn about three brilliant ideas from the winners to help kids with eczema in the future. Our guests are Armando de la Libertad, Nic Novac and Angela Tiru, parents and patients who used their experiences and insights to come up with innovative research ideas. (If you like our podcast consider supporting it with a tax deductible donation.)
Have a Big Idea of your own? Enter this yearâs Big Ideas competition here.
More information about Big Ideas 2022
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Could allergy drops (or shots) be the answer to reducing eczema flares? Recent research suggests that immunotherapy can improve eczema symptoms, and it is safe for kids, easy to use and inexpensive. We discuss how the treatment works and itâs potential to improve lives, especially for kids who canât access expensive treatment programs. Our guests are Dr. Derek Chu, professor of medicine at McMaster University in Canada, and Dr. Sarah Langer, a pediatric immunologist from the University of Sao Paulo, Brazil. (P.S. If you like our podcast consider supporting it with a tax deductible donation).
Research in this podcast:
Allergen immunotherapy for atopic dermatitis: Systematic review and meta-analysis of benefits and harms
Efficacy of House Dust Mite Sublingual Immunotherapy in Patients with Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Trial
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Imagine if doctors could use a non-invasive test on newborns to predict their risk of developing eczema? Now it might be possible. Whatâs more, new research suggests there is something you can do for high risk babies. Join us as we learn about an innovative test for eczema and what you might do with this information. Our guest speakers are Dr. Anne-Sofie Halling who is completing a PhD on biomarkers of atopic dermatitis at Copenhagen University, Denmark; Prof. Alan Irvine a professor of dermatology at Trinity College, Dublin Ireland; and, Prof. Jonathan Hourihane a professor of pediatrics and child health at Royal College of Surgeons in Ireland. (If you like our podcast consider supporting it with a tax deductible donation.)
Research discussed in this podcast:
Skin biomarkers predict development of atopic dermatitis in infancy
Early initiation of short-term emollient use for the prevention of atopic dermatitis in high-risk infantsâThe STOP-AD randomised controlled trial
Skin care interventions in infants for preventing eczema and food allergy
Preventing Atopic Dermatitis and ALLergies in Children-the PreventADALL study.
Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial
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