Episodios

  • There were two reasons why Dr. Valter Longo was featured so prominently in my longevity book Evigt Ung (2022).


    First, if you had to name a single scientific thread running through the history of longevity research, calorie restriction is hard to beat. And few have done more to modernize and translate that insight into real-world practice than Longo.


    Second, I hold Valter Longo in the highest regard. I've tried his Fasting-Mimicking Diet (FMD), I’ve followed his work on The Longevity Diet, and I find his scientific contributions both rigorous and unusually translational. He doesn’t just publish papers - he builds systems, tests interventions in clinical trials, and tries to implement science into healthcare.


    In this conversation, we cover the science, history, and application of fasting, nutrition, and longevity - including new work on cancer, metabolism, and organ regeneration. We also discuss the philosophical and political obstacles that stand in the way of real change.


    What you'll learn in this episode:

    ✅ The story of Longo’s early music career - and why he left it to study aging.

    ✅ How calorie restriction shaped modern longevity science.

    ✅ Why Biosphere 2 and Roy Walford's work was both inspiring and cautionary.

    ✅ The origins and mechanisms of the Fasting-Mimicking Diet.

    ✅ What Longo learned about autophagy, stem cells, and organ regeneration.

    ✅ Why protein intake before and after age 65 should be treated differently.

    ✅ What the media and doctors get wrong about obesity, food, and metabolism.

    ✅ The dangers of high-protein and ketogenic diets.

    ✅ Why Longo is deeply skeptical of TRT, growth hormone, and biohacking shortcuts.

    ✅ How fasting can enhance cancer treatment - and why Longo wrote his new book Fasting Cancer.

    ✅ Why we need a new kind of “digital school” for lifestyle medicine.


    🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership


    🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: reachlevity.com


    --CHAPTERS--


    00:00 Introduction to Dr. Valter Longo

    02:44 From Music to Aging Biology

    06:40 The Supposed Longevity Zones of Italy

    09:04 Personal Experiences Shaping Research

    12:04 The Path to Aging Biology

    13:15 Calorie Restriction and Roy Walford

    26:25 Transitioning to Fasting Mimicking Diet Research

    34:56 The Eureka Moment

    39:51 The Rationale For the 5-Day FMD

    52:54 The Un-conspired Conspiracy

    01:01:18 Conflicts of Interest

    01:04:52 Protein Intake: Balancing Muscle Health and Longevity

    01:14:30 Autophagy: The Body's Self-Repair Mechanism

    01:21:12 The Power of Genetic Variants in Longevity

    01:27:18 The Debate on Growth Hormone and Aging

    01:36:18 Insights from Laron Syndrome and Longevity

    01:40:10 Fasting Mimicking Diet: A Path to Health

    01:46:06 Valter's New Book, Fasting Cancer

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  • This is our first — and probably our last — episode where the guest has brought with him an actual punch card and proceeds to explain why it is, in fact, caca (which is Spanish for 💩, by the way).


    Welcome to the wild world of José Cordeiro. Stick around and you might hear anecdotes about Robert Kennedy Jr. in Memphis 🎸, late-night karaoke sessions 🎤, and a man shouting “immortality!” to anyone and everyone. But behind the eccentric props and the shameless self-promotion (José didn’t just bring punch cards — he also brought his books 📚, his merch 👔, and his signature Death of Death tie — to the point where we had to clarify we’re not actually sponsored), there’s a deadly serious mission: José wants to end aging and defeat death.


    A futurist, MIT-trained engineer, and bestselling author, José Cordeiro argues that humanity is on the brink of longevity escape velocity 🚀 — the moment when medical advances will start adding more years to our lives than time takes away. In this episode, we explore his bold predictions, from reversing aging by 2045 to launching a global “war on aging.” We cover the science 🔬, the politics 🏛️, the money 💰, and the wild optimism driving the longevity movement — with cryonics ❄️, Martians 👽, and €10 immortality claims all making appearances.


    This might be our strangest — and most fascinating — conversation yet. Buckle up.


    -- IN THIS EPISODE YOU'LL LEARN ABOUT --


    ✅ Why longevity escape velocity may be closer than we think

    ✅ How AI will aid longevity

    ✅ Why technological optimism is rational

    ✅ How the Covid pandemic was a relatively minor pandemic

    ✅ How the concept of work will change

    ✅ What the future of energy may be

    ✅ A personal history of Marvin Minsky, Ray Kurzweil and José Cordeiro

    ✅ Where to meet Cordeiro and demonstrate against aging

    ✅ Why immortality is probable by 2045


    🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership


    🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: reachlevity.com


    -- CHAPTERS --


    00:00 Introduction

    05:33 Cordeiro's struggle to end aging

    12:28 Traveling the world to spread the word of The Death of Death

    18:36 The small Covid Pandemic vs the huge aging pandemic

    26:00 Scientific optimism

    29:37 "Next time we meet we will be younger."

    32:28 The concept of work through history

    35:50 Exponentiality of progress - a personal history of computers

    43:30 Kurzweil and Cordeiro mentored by Marvin Minsky

    50:26 The future of energy

    57:56 When will we reach LEV and what happens 2045?

    01:03:00 Madrid as a Blue Zone

    01:06:30 AI coming and helping with science

    01:17:00 The amazing point of the human timeline we are on - biology can be immortal

    01:19:50 We are mostly water - immortality for 10 Euros per year

    01:22:40 Advanced bio engineering and disruption from outside

    01:24:30 Zuckerberg to cure all diseases in this generation - billionaires to the rescue

    01:28:40 Elon Musk will change his mind

    01:29:34 Trump administration and visiting Elvis with RFK

    01:36:40 The importance of campaigning for life - we need action now

    01:47:22 Cryonics

    01:51:56 Sing karaoke

    01:53:00 What to read

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  • Lately, there's been growing pushback against the idea that AI will transform geroscience in the short term.

    When Nobel laureate Demis Hassabis told 60 Minutes that AI could help cure every disease within 5–10 years, many in the longevity and biotech communities scoffed. Leading aging biologists called it wishful thinking - or outright fantasy.

    They argue that we still lack crucial biological data to train AI models, and that experiments and clinical trials move too slowly to change the timeline.


    Our guest in this episode, Professor Derya Unutmaz, knows these objections well. But he’s firmly on Team Hassabis.

    In fact, Unutmaz goes even further. He says we won’t just cure diseases - we'll solve aging itself within the next 20 years.


    And best of all, he offers a surprisingly detailed, concrete explanation of how it will happen:

    building virtual cells, modeling entire biological systems *in silico*, and dramatically accelerating drug discovery — powered by next-generation AI reasoning engines.


    🧬 In this wide-ranging conversation, we also cover:


    ✅ Why biological complexity is no longer an unsolvable barrier.

    ✅ How digital twins could revolutionize diagnosis and treatment.

    ✅ Why clinical trials as we know them may soon collapse.

    ✅ The accelerating timeline toward longevity escape velocity.

    ✅ How reasoning AIs (like GPT-4o, o1, DeepSeek) are changing scientific research.

    ✅ Whether AI creativity challenges the idea that only biological minds can create.

    ✅ Why AI will force a new culture of leisure, curiosity, and human flourishing.

    ✅ The existential stress that will come as AI outperforms human expertise.

    ✅ Why “Don’t die” is no longer a joke — it's real advice.


    🎙️ Hosted - as always - by Peter Ottsjö (tech journalist and author of Evigt Ung) and Dr. Patrick Linden (philosopher and author of The Case Against Death).


    🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership


    🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: reachlevity.com


    -- CHAPTERS --

    00:00 Introduction to Derya Unutmaz

    05:22 Derya’s work at Jackson Laboratory

    09:37 The impact of AI on research

    15:04 AI as a collaborative partner

    20:50 The nature of creativity in AI

    30:21 Predictions for the future of AI and humanity

    37:46 The future of AI in medicine

    44:35 The impact of AI on professional identity

    47:45 Education in the age of AI

    01:01:32 The ethics of AI development

    01:14:46 Longevity and AI's role in accelerating science

    01:20:55 Virtual cells and digital twins

    01:29:02 Can we do it in silico all the way?

    01:33:08 Derya and Patrick will both talk at Vitalist Bay

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  • Peter Fedichev is a visionary scientist, biotech entrepreneur, and physicist at the forefront of longevity research. With a background in theoretical physics, he has seamlessly merged cutting-edge science with real-world applications, making groundbreaking contributions to the fields of aging, biotechnology, and artificial intelligence in healthcare. As the co-founder and CEO of Gero, a pioneering biotech company, Fedichev is revolutionizing our understanding of biological aging, using AI-driven approaches to uncover ways to extend human lifespan and combat age-related diseases. His work has been featured in leading scientific journals, and his insights are shaping the future of personalized medicine and longevity science. Driven by a relentless curiosity and a passion for pushing the boundaries of human potential, Fedichev is not just studying aging - he’s working to redefine it.


    🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership


    🚀 Show notes for this episode is available here: https://reachlevity.com/p/age-reversal-will-never-work-a-controversial-take-from-a-physicist-5935af91034fd123


    -- EPISODE HIGHLIGHTS --


    ✅ The founding of Gero

    ✅ The physics of aging

    ✅ Why age reversal will not work

    ✅ What SENS gets right

    ✅ What SENS gets wrong

    ✅ AI and the longevity industry

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  • In this episode of LEVITY, we speak with Laurence Ion, a tech entrepreneur whose experience with a rare genetic disease led him to tackle one of humanity's greatest challenges: aging.

    Starting as a shy coder who 'couldn't talk to strangers,' Laurence has become a movement leader pioneering a bold new approach: creating specialized cities where extending human lifespan isn't just a goal - it's the future of humanity.


    -- EPISODE HIGHLIGHTS --

    ✅ Laurence's personal journey with multiple hereditary exostoses and how it shaped his perspective on aging and mortality.

    ✅ The founding and evolution of VitaDAO, a decentralized science organization funding longevity research.

    ✅ How crypto-based communities are accelerating anti-aging research outside traditional funding models.

    ✅ The concept of special jurisdictions for medical innovation where regulatory frameworks can move at "warp speed".

    ✅ Viva City's vision to create physical communities and hubs focused on longevity.

    ✅ The $2 million recursive finder's fee for anyone who helps secure a location for the first major Viva City jurisdiction.

    ✅ How living in community environments like Zuzalu and Aevitas House naturally promotes healthier lifestyle choices.

    ✅ The Frontier Tower project - a 16-story "vertical village" designed for longevity-minded living.

    ✅ JellyfishDAO's mission to change cultural narratives around aging through film and media.

    ✅ The relationship between AI advancement and longevity research.

    ✅ How decentralized clinical trials could dramatically reduce the cost and time of bringing treatments to people.

    ✅ Real-world examples of companies already offering experimental longevity treatments in special jurisdictions.

    Hosted on Acast. See acast.com/privacy for more information.

  • We have another amazing guest for this episode: Anders Sandberg is a visionary philosopher, futurist, and transhumanist thinker whose work pushes the boundaries of human potential and the future of intelligence. As a senior research fellow at Oxford University’s Future of Humanity Institute until its closing in 2024 Sandberg explores everything from cognitive enhancement and artificial intelligence to existential risks and space colonization. With a background in computational neuroscience, he bridges science and philosophy to tackle some of the most profound questions of our time: How can we expand our cognitive capacities? What are the ethical implications of radical life extension? Could we one day transcend biological limitations entirely? Known for his sharp intellect, playful curiosity, and fearless speculation, Sandberg challenges conventional wisdom, inviting us to imagine—and shape—a future where humanity thrives beyond its current constraints.


    00:00 introduction

    04:18 exersise & David Sinclair

    06:10 Will we survive the century?

    18:18 Who can we trust? Knowledge and humility

    23:17 Nuclear armaggedon

    39:51 Technology as a double-edged sword

    44:30 Sandberg origin story

    56:54 Computational neuroscience

    01:00:30 Personal identity and neural simulation

    01:05:24 Personal identity and reasons to want to continue living

    01:09:39 The psychology of behind different philosophical intutions and judgments

    01:17:48 Is death bad for Anders Sandberg?

    01:25:00 Altruism and individual rights

    01:31:29 Elon Musk says we must die for progress

    01:35:10 Artificial Intelligence

    01:55:08 AI civilization

    01:02:07 Cryonics

    02:04:00 Book recommendations

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  • In this in-depth conversation, Dr. Aubrey de Grey discusses his Robust Mouse Rejuvenation (RMR) studies at the LEV Foundation and why he believes we're close to achieving the crucial RMR milestone within just three years - a breakthrough that could transform aging research forever.


    You'll also hear about:

    His predictions for reaching Longevity Escape Velocity by the late 2030s

    What he would change about Bryan Johnson's longevity algorithm

    How reaching RMR could trigger a global "war on aging"

    Why AI won't solve aging without proper experimental data

    How Demis Hassabis is the smartest person Aubrey's ever met

    His involvement in designing the XPRIZE Healthspan competition

    His rebuttal to Mark Hamalainen's "replacement strategy" approach

    The divide-and-conquer approach to aging and why it's superior


    🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/


    -- CHAPTERS --

    00:00 Introduction and Welcome

    03:15 The Background to LEV Foundation and the Robust Mouse Rejuvenation Studies

    12:05 The Robust Mouse Rejuvenation Studies

    18:10 Latest Results from the Mouse Rejuvenation Experiments

    25:42 Reaching RMR soon and LEV in 12-15 years

    33:47 Healthspanners in public - lifespanners in private?

    37:03 The Replacement Strategy Debate with Mark Hamalainen

    45:40 The Very, Very Difficult Challenge of Gradually Replacing the Brain

    54:46 Advanced bioengineering

    57:34 The Debate with Peter Fedichev

    01:11:57 Understanding Aging from an Evolutionary Perspective

    01:17:05 Artificial Intelligence and Longevity Research

    01:26:42 Is believing in AI hopium?

    1:28:27 Aubrey’s Involvement in the XPRIZE Healthspan Competition

    1:38:56 Special Economic Zones and Regulatory Challenges

    1:47:27 What Aubrey would do with Bryan Johnson’s algorithm

    1:50:49 What Excites Aubrey Most About the Future

    1:51:57 Book Recommendations and Closing Thoughts

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  • Jamie Justice takes us inside the $101M XPRIZE Healthspan competition - one of the world's largest efforts to develop therapeutics that could reverse aging.

    As Executive Vice President of XPRIZE Healthspan, Jamie reveals how teams must demonstrate they can restore muscle, cognitive, and immune function in older adults within just one year. The stakes? $81M for achieving a 20-year reversal of aging markers, with $71M and $61M prizes for lesser but still remarkable achievements.

    Jamie shares her fascinating journey from studying crickets' lifespans in elementary school to leading groundbreaking aging research, including work on the TAME trial with metformin. She explains why they chose these specific biological systems to measure, how they'll determine success, and what kinds of interventions teams are exploring - from repurposed drugs to gene therapies.

    We discuss:


    * Why Peter Diamandis pushed for more ambitious goals

    * How over 550 teams from 55 countries are approaching the challenge EDIT: Since we recorded this in late 2024 they've now reached over 600 teams.

    * The role of biomarkers in measuring aging

    * Why they chose to measure actual restoration rather than just preventing decline

    * The challenges and opportunities in aging clinical trials

    * Her vision for an integrated, multi-generational society that values aging populations


    🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership


    🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/


    CHAPTERS:

    00:00 Introduction

    03:00 background

    21:30 XPRIZE sculpted by experience

    25:20 Collaborating with the entrant teams

    29:00 Why muscle, mind and immune functions as targets

    36:30 What if no one wins in 7-years?

    41:05 Investors attracted

    45:01 Does this give us increased longevity?

    51:05 What kind of approaches have been entered?

    01:00:30 AI

    01:09:20 Composit end-points

    01:13:10 TAME trial stuck because ...

    01:19:10 Biomarkers of aging

    01:26:50 AI and Biomarkers

    01:29:02 The longbio track (be lucky)

    01:36:20 Optimism about what?

    01:41:00 3 book you have to read

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  • A pediatric cardiac surgeon turned longevity pioneer, Dr. David Luu shares his journey from humanitarian medical missions to building a global network of physicians focused on prevention. Learn about critical health markers your doctor might be missing, how AI is transforming healthcare, the truth about longevity interventions, and why the future belongs to prevention rather than treatment. Plus, discover the vital link between community, lifestyle, and longevity, and why creating modern "blue zones" might be key to living longer, healthier lives.


    🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership

    🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/


    CHAPTERS

    00:00 Introduction 02:33 A Family Legacy in Medicine 10:41 From Heart Surgeon to Tech Innovator with JuiSci and Hearty 13:47 Building AI-Powered Medical Platforms 21:33 The Heart Fund: Surgery for Those in Need 35:06 The Role of AI in Healthcare 45:22 Creating Longevity Docs Community 01:07:13 Hidden Cardiovascular Risk Factors 01:10:38 The Lp(a) Test Everyone Should Know About

    01:18:50 Why Call it ”Longevity Docs” When We Have No Approved Aging Interventions? 01:28:14 Different Levels of Longevity Interventions 01:38:42 Risk vs. Reward in Preventive Medicine 01:43:30 Building Modern Blue Zones 01:47:11 The Future of Medicine 01:52:07 Connecting with David

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  • 🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership


    🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/


    Meet one of the true legends of the longevity space, James Strole, the visionary founder of RAADfest who embodies relentless optimism and dedication to advancing the frontiers of longevity and human potential. His passion for creating a world where individuals can live longer, healthier lives shines through in every aspect of RAADfest, inspiring countless people to embrace the possibilities of radical life extension.


    We will learn about RAADfest and the history of the longevity movement. We will also explore Strole's philosophy of immortality.


    - CHAPTERS --

    00:00 introduction to James Strole

    04:20 RAADfest is the largest longevity event in the world

    11:50 personal awakening and the early days of the longevity movement

    22:00 longevity as a counter-culture

    23:00 death-program vs superlongevity

    26:30 1960s spreading the word and rebirthing

    31.00 people unlimited and science of superlongevity

    33:00 a holistic approach science of mind-set

    34:00 alternative medicine not always taken seriously

    37:40 the immortality mindset

    38:50 aged by culture

    44:20 optimism vs pessimism

    46:10 optimism about longevity science?

    58:50 death-program runs deep

    01:03:30 Ray Kurzweil's optimistic prognosis

    01:11:00 social consequences of longevity

    01:12:30 cryonics is an ambulance to the future

    01:15:05 imaginary mortality

    01:18:18 immortality via children

    01:19:19 is superlongevity egoistic?

    01:23:10 handle the loss of near and dear as an immortalist

    01:37:50 advice on health and where to be in contact with People Unlimited and James Strole

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  • 🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership


    🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/


    -- IN THIS EPISODE --

    Nora Cavani, CEO of Alba Health, shares her journey from struggling with severe eczema and allergies to pioneering breakthrough solutions in children's gut health. After reversing her own chronic conditions through lifestyle changes, she learned how the first years of life critically shape our immune system, metabolism, and lifelong health through the gut microbiome.

    As the first company to collaborate with leading microbiome research institutions, Alba Health uses cutting-edge metagenomics technology to analyze children's gut bacteria and provide personalized recommendations. Cavani explains why modern factors like C-sections, antibiotics, and processed foods are leading to a concerning loss of essential gut bacteria in Western children - with many babies now lacking microbes crucial for immune development.

    Learn how the gut microbiome affects everything from common childhood ailments to chronic disease risk, why diversity in diet matters, and practical steps parents can take during the critical early window of their child's development. A vital conversation for parents, health optimizers, and anyone interested in preventing chronic disease through early intervention.


    -- CHAPTERS --

    00:00 Introduction to Nora Cavani

    05:08 Microbiome and child health

    07:16 Nora’s journey from Italy to Sweden

    10:43 Meeting the scientist and microbiologist Willem de Vos

    15:20 Laying the groundwork for Alba Health

    18:45 Gut microbiome is linked to afflictions in newborns

    19:29 The ecosystem of the gut microbiome

    21:00 The Ecosystem of the Gut Microbiome

    28:33 Gut-brain axis

    30:50 C-section and antibiotics

    35:10 Alba's testing methodology and insights

    41:38 Predicting health through microbiome analysis

    45:23 The best time to take the test

    54:20 Has Nora managed to get rid of her health issues?

    57:19 The role of diet diversity in gut health

    01:07:52 What can we still discover about the microbiome?

    01:10:05 The role of exercise, sleep and stress in adults

    01:12:40 Child health and longevity

    01:16:40 Nora’s personal longevity regimen and testing

    01:23:36 Oura’s investment i Alba Health

    01:28:18 Future of microbiome research

    01:32:28 Scientific consensus and controversy

    01:43:37 The future for Alba Health

    01:45:52 How to get in touch with Nora and Alba

    Hosted on Acast. See acast.com/privacy for more information.

  • 🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership


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    Sergey Jakimov is a founding partner of LongeVC, a VC fund supporting early-stage biotech and longevity-focused founders who are changing the world.

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    Niklas Anzinger is the founder of Infinita VC based in the charter city of Prospera in Honduras. He is the co-founder of Vitalia, a longevity focused community. His fund Infinita focuses on a new trend of charter cities and other forms of alternative jurisdictions. He also hosts a podcast about how to accelerate the future by unblocking “stranded technologies”.

    Hosted on Acast. See acast.com/privacy for more information.

  • 🚀 Special offer for our LEVITY audience: Join Vitalism today and receive a 30% discount on your membership using the code LEVITY at checkout. https://www.vitalism.io/membership

    🚀 Show notes for this episode will be available soon after this airs. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/


    When I first met Emil Kendziorra at the Longevity Biotech Fellowship retreat in Sweden, I found myself captivated by his ability to explain every aspect of cryopreservation for hours. His deep knowledge, combined with his remarkable skill in communicating complex ideas, made me realize this conversation needed to reach a broader audience.

    In this comprehensive episode, Emil, CEO of Tomorrow Bio, takes us through the fascinating world of cryopreservation, leaving no stone unturned. We explore:

    The science behind cryopreservation and how it differs from simple freezingThe history of cryonics and its evolution into modern cryopreservationStep-by-step details of the preservation processThe logistics of emergency response and stabilizationLong-term storage solutions and safety measuresThe challenges and possibilities of future revivalEthical considerations and philosophical implicationsThe current state of research and future developmentsPractical aspects of signing up and fundingCommon misconceptions and concerns

    Whether you're curious about cryopreservation as a backup plan for longevity or simply interested in understanding this fascinating field, this episode provides a comprehensive overview of what might be our best bridge to a longer-lived future.

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    Todays guest is another California resident, distinguished Professor John Martin Fisher at University of California Riverside. Professor Fischer has as worked on the metaphysics of death and philosophy of religion and led a multi-year, multi-pronged research project on "immortality," funded in 2012 by the John Templeton Foundation. 

    He is the author of several books including Death, Immortality, and Meaning in Life. (Oxford University Press, 2019). And Near-Death Experiences: Understanding Visions of the Afterlife (co-authored with Benjamin Mitchell-Yellin) (Oxford University Press, 2016)


    Learn about:

    ✅ Near-death experiences

    ✅ The fear of death

    ✅ The desirability of immortality

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    🚀 Show notes for this episode will be available Wednesday Oct 2. Sign up for the LEVITY newsletter to get them straight to your inbox: https://peterottsjo.beehiiv.com/


    Longevity superstar Bryan Johnson made waves when he traveled to the Bahamas for a stem cell treatment. But who's behind this cutting-edge therapy? Meet Maria Rankka, co-founder of Cellcolabs, the Swedish startup that's caught the attention of one of the world's biggest longevity influencers.

    In this episode of LEVITY, hosts Peter Ottsjö and Patrick Linden dive deep into Cellcolabs' ambitious mission: to revolutionize healthcare by producing cheap and abundant mesenchymal stromal cells (MSCs). Could this be the key to combating inflammation and extending healthspan on a global scale?

    Maria Rankka shares the inside story of Cellcolabs' journey, from its inception during the COVID-19 pandemic to its current position at the forefront of regenerative medicine.


    Learn about:

    ✅ The science behind MSCs and why they're creating buzz in longevity circles

    ✅ Cellcolabs' innovative approach to scaling stem cell production

    ✅ Maria's personal experience with MSC treatment

    ✅ The potential of MSCs to transform preventative medicine

    ✅ Making regenerative treatments accessible to the masses

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  • This is one of the most amazing new discoveries: We can rejuvenate cells. Next step is to rejuvenate entire organisms, and ultimately human beings including our brains. Yuri Deigin, CEO of YouthBio Therapeutics, is a pioneering drug developer and longevity maximalist currently working on partial reprogramming gene therapies for Alzheimer’s and other diseases.


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  • There are countless reasons to admire Mark Hamalainen, and one of them is his brutal honesty. While many longevity influencers confidently declare that longevity escape velocity and indefinite lifespans are just around the corner, you won’t get such easy assurances from Mark.

    That’s because, and this might seem counterintuitive at first, he’s one of the most deeply committed advocates for solving aging that I’ve encountered. Mark, a former director of science at Synthego and a former researcher at SENS Research Foundation (Aubrey de Grey has called him his protégé), has dedicated over two decades to tackling humanity’s greatest challenge.

    You see, Mark's honesty doesn't stem from pessimism, but from a deep commitment to reality-based thinking. His mission isn’t driven by hype but by a relentless pursuit of tangible progress in the fight against aging.

    I (Peter) first met Mark at the Longevity Biotech Fellowship (LBF) retreat in Sweden in January 2024, where I had the opportunity to witness his vision and dedication firsthand. It left a lasting impression, not only on me but likely on everyone who attended. Here was someone who wasn’t just dreaming about a future where aging is solved - he was meticulously planning it, working hard to remove the roadblocks that stand in the way.

    His work with the LBF, the Longevity Acceleration Roadmap, and his broader efforts in the longevity community are all about taking concrete, actionable steps toward a future where the passing of time is not a death sentence - all the while knowing that this goal is one of the most complex challenges humanity has ever faced.

    In this episode, Mark discusses several key strategies that he believes are essential to making real progress. These include advancing bioengineering to gain precise control over biological processes, developing comprehensive data sets to better understand aging at a molecular level, and exploring visionary ideas like the replacement strategy. He also highlights the potential of biostasis and cryopreservation as a last resort, potentially offering a way to preserve life until future technologies can fully reverse aging.

    So, while Mark may not offer the easy assurances that some in the longevity space do, he offers something far more valuable: a realistic and deeply informed plan of action, a commitment to truth over convenience, and above all, a profound hope that by facing the realities of aging head-on, we can one day overcome them.

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  • In this podcast we are not only concerned with how we can prolong human life, but also whether it is a good idea, morally speaking.

    Professor John K. Davies of California State University in Fullerton. He has written a book called New Methuselahs - the ethics of life extension published by MIT Press in 2018. In it he defends the conclusion that life extension science should be promoted.

    He has been quoted on life extension in interviews with The Daily Beast, Science News, Newsweek, The Financial Times of London, Canadian Broadcasting Corporation, and Allure Magazine, among other places.

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  • Prof. Alexandra Stolzing is a pioneer in biogerontological engineering at Loughborough University. With over two decades of experience, including work at SENS Research Foundation, Prof. Stolzing shares insights on:

    Targeting senescent cells for anti-aging therapies

    Revolutionizing cryopreservation techniques

    Developing breath-based aging biomarkers

    Harnessing AI for rapid drug discovery in aging research

    Learn how her journey from Germany to the UK shaped her multidisciplinary approach to solving aging. Discover the challenges and opportunities in longevity research, including the critical need for basic science funding.


    Show notes here: https://peterottsjo.beehiiv.com/

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