Episodios
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This interview is an exception to our “single author monographs” rule, because the edited collection that is its topic is an intellectual achievement worth making an exception for in over 12 years of New Books in Philosophy podcasts. Emotion Theory: The Routledge Comprehensive Guide: Volume I and Volume II (Routledge, 2024) is a two-volume compendium of 62 chapters on emotion theory written by 101 leading theorists from philosophy, psychology, biology, sociology, neuroscience, and other fields, all grappling with the question: What is an emotion? Editor Andrea Scarantino, who is a professor of philosophy at George State University, has compiled a synoptic and thematically organized collection that covers the history of emotion theory, the main contemporary theories of emotions, individual chapters on 35 distinct emotions, and more. The volumes bring together theorists from distinct disciplines that don’t normally engage with each others’ work, and provide readers with a one-stop-shop for clearly written introductions to the current states of play in emotion research.
Andrea Scarantino is Professor of Philosophy at Georgia State University, where he has taught since 2005.
Carrie Figdor is professor of philosophy at the University of Iowa.
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People with dementia are uniquely qualified to discuss the challenges of their condition and the features of effective support, but their voices are all too often drowned out in research and debates about policy. According to People with Dementia at the Heart of Research: Co-Producing Research through The Dementia Enquirers Model (Jessica Kingsley Publishers, 2024) by Rachael Litherland & Philly Hare, it's time for that to change.
Dementia Enquirers is an ambitious and novel programme of work which has tested out what it means for people with dementia to lead research and has developed a new 'driving seat' approach to co-research.
This ground-breaking book features 26 research projects led by groups of people with dementia, supported by group facilitators and academics, to make their voices heard. Topics include giving up driving, GP dementia reviews, living alone with dementia, and using AI platforms such as smart speakers. The book also describes how people with dementia shaped the entire programme, and addressed head-on issues such as ethics approval processes and complex research language. The book is a key read for anyone involved in dementia support, this research brings the voices of people with dementia to the fore to explore their experiences of researching the condition.
This interview was conducted by Dr. Miranda Melcher whose new book focuses on post-conflict military integration, understanding treaty negotiation and implementation in civil war contexts, with qualitative analysis of the Angolan and Mozambican civil wars.
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The question of whether mental disorders are disorders of the brain has led to a long-running and controversial dispute within psychiatry, psychology and philosophy of mind and psychology. While recent work in neuroscience frequently tries to identify underlying brain dysfunction in mental disorders, detractors argue that labelling mental disorders as brain disorders is reductive and can result in harmful social effects.
Are Mental Disorders Brain Disorders? (Routledge, 2024) brings a much-needed philosophical perspective to bear on this important question. Anneli Jefferson argues that while there is widespread agreement on paradigmatic cases of brain disorder such as brain cancer, Parkinson's or Alzheimer’s dementia, there is far less clarity on what the general, defining characteristics of brain disorders are. She identifies influential notions of brain disorder and shows why these are problematic. On her own, alternative, account, what counts as dysfunctional at the level of the brain frequently depends on what counts as dysfunctional at the psychological level. On this notion of brain disorder, she argues, many of the consequences people often associate with the brain disorder label do not follow. She also explores the important practical question of how to deal with the fact that many people do draw unlicensed inferences about treatment, personal responsibility or etiology from the information that a condition is a brain disorder or involves brain dysfunction.
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In his marvelous new book, When Animals Dream: The Hidden World of Animal Consciousness (Princeton UP, 2023), David Peña-Guzmán (SF State as well as the lovely philosophical podcast Overthink) offers up something new in animal studies--"a philosophical interpretation of biological subjectivity." Although we share no linguistic schema with animals there is lots more evidence than just YouTube (octopuses, dogs, signing chimpanzees, brain scans of dreaming birds etc) to suggest oneiric behaviors and underlying mental states occur all over the animal kingdom. So, David discusses with John his interest in using dreaming as a window into consciousness. Here is what it means that we are not alone in our dreams...
David details the "flattening and impoverishing effect on the natural sciences" wrought by 20th century behaviorist paradigms. He also expresses skepticism about the likelihood of AI ever achieving more than a "zombie" state; it now and perhaps always will profoundly differ from animals' varied experiences of our shared world.
The biological commonality that most strikes David is the idea it is logically inconceivable that there might be a dreamer devoid of consciousness or sentience. Dreaming, he argues may be the key to acknowledging animal's "moral considerability"--the right to have their consciousness, sentience and in the deepest sense their standing taken into account. . Finally David admits to a feeling of tragedy in writing this book: he has had to engage with experimentation that crosses boundaries in animal treatment in order to make the case for those boundaries. He understands his decision as tragic because either way--to engage or to ignore the science--would be to lose something.
Mentioned in the episode:
New Wave of "inner space" SF authors who focus on the alien nature of humanity itself: J. G. Ballard, Philip K. Dick, and John's hero Ursula Le Guin.
Recallable Books:
Susana Monso, Playing Possum a newly translated book on the ways that animals mourn their beloveds.
Charles Darwin, Descent of Man and The expression of the emotions in man and animals (both 1872) are two of the crucial 19th century texts begin to think of animals as complete subjects. Charles Darwin as an early theorist of biosemiosis who deserves, Jain and David agree, to be reactivated.
Listen and Read here.
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Francisco Aboitiz is a professor at the Medical School and the director of the Interdisciplinary Center for Neuroscience at Pontificia Universidad Católica de Chile. A History of Bodies, Brains, and Minds: The Evolution of Life and Consciousness (MIT Press, 2024) tells the story of life and nervous systems. It introduces the conceptual framework and terminology of evolution, gives a great overview of our current knowledge and a thorough discussion of open questions.
The first part defines two basic concepts: evolution and life. Surprisingly, we learn that the first definition is more straightforward. If you are challenged by some terminology in the later chapters - like phylogeny, ontogeny, or the different types of homology - it is highly recommended to revisit the definitions in the first chapter.
The story begins in the second part. Chapter 3 introduces multiple theories on how the first cells might have appeared. In the next chapter, these cells start to form more complex, multicellular organisms. Chapter 5 is dedicated to the main characteristics and early history of neurons.
In the third part, we get acquinted with more complex animals. In chapter 6 with the bilaterians, in chapter 7 and 8 with the vertebrates and their nervous system, in chapter 9 with mammals. Chapter 10 provides a deep dive into the neocortex and its role in cognition.
The fourth part of the book is about "a singular ape". Chapter 11 describes the history of primates, focusing on Hominins. It goes into details on various aspects like walking, the growth of brains, toolmaking, and social life. Chapter 12 describes the evolution of vocal communication. Chapter 13 discusses how speech has influenced communication and social life. Chapter 14 explores numerous open questions around consciousness. How to define it? When and how did it emerge in evolution? Which animals are conscious and in which ways? After this long history, chapter 15 arrives in the present and the future. What are some current evolutionary trends? How do cultural and technological changes influence our nervous systems?
In our conversation with Professor Aboitiz, we focused on a few remarkable milestones in this story. For start, he outlined some theories how life might have begun.
Then a huge jump in time followed: How the first mammals appeared and survived in a world dominated by dinosaurs. Professor Aboitiz elaborated on how the brains of mammals differ from the brains of other vertebrates. He described the cerebral cortex, a new part in the mammalian brain. The role of senses changed significantly: The early mammals had worse vision, but better smell, touch, and audition compared to other vertebrates. Changes in the anatomy of the head and neck supported these more developed senses. The enhanced olfactory system is also related to the hippocampus, where some new skills appeared: advanced spatial orientation and short-term memory.
The next milestone we discussed in detail is the appearance of language. Professor Aboitiz shared some fascinating facts about the vocal communication of birds and primates. He explained the connection between toolmaking and language. He described the speech loop and the connection between working memory and talking. He proposes that manual gestures and vocal communication have evolved together, and communication has always been multi-modal.
The last part of our conversation focused on the current and future situation. How culture and technology has changed our nervous system, e.g. how a brain area is particularly involved in reading. Professor Aboitiz also discussed the more recent technological innovations and their effects on society and the environment. He introduced the social projects conducted by the Interdisciplinary Center for Neuroscience. The project RIEN (Robótica Integral Educativa & Neurociencia) facilitates workshops where kids work in teams with rotating roles to build and program robots.
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In Successful Aging: A Neuroscientist Explores the Power and Potential of Our Lives (Dutton Books, 2020), Daniel J. Levitin delivers powerful insights:
• Debunking the myth that memory always declines with age
• Confirming that “health span”—not “life span”—is what matters
• Proving that sixty-plus years is a unique and newly recognized developmental stage
• Recommending that people look forward to joy, as reminiscing doesn’t promote health
Levitin looks at the science behind what we all can learn from those who age joyously, as well as how to adapt our culture to take full advantage of older people’s wisdom and experience. Throughout his exploration of what aging really means, using research from developmental neuroscience and the psychology of individual differences, Levitin reveals resilience strategies and practical, cognitive- enhancing tricks everyone should do as they age.
Successful Aging inspires a powerful new approach to how readers think about our final decades, and it will revolutionize the way we plan for old age as individuals, family members, and citizens within a society where the average life expectancy continues to rise.
Victoria Reedman is a resident doctor in Toronto studying neurology with some health systems work on the side.
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A serious illness often changes the way others see us. Few, if any, relationships remain the same. The sick become more dependent on partners and family members, while more distant contacts become strained. The carers of the ill are also often isolated. This book focuses on our sense of self when ill and how infirmity plays out in our relationships with others.
In Being Ill: On Sickness, Care and Abandonment (Reaktion, 2024) Dr. Neil Vickers and Dr. Derek Bolton offer an original perspective, drawing on neuroscience, psychology and psychoanalysis, as well as memoirs of the ill or their carers, to reveal how a sense of connectedness and group belonging can not only improve care, but make societies more resilient to illness. This is an essential book on the experience of major illness.
This interview was conducted by Dr. Miranda Melcher whose new book focuses on post-conflict military integration, understanding treaty negotiation and implementation in civil war contexts, with qualitative analysis of the Angolan and Mozambican civil wars.
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There are many routes to mental well-being. In this groundbreaking book, neuroscientist Camilla Nord offers a fascinating tour of the scientific developments that are revolutionising the way we think about mental health, showing why and how events--and treatments--can affect people in such different ways.
In The Balanced Brain: The Science of Mental Health (Princeton UP, 2024), Nord explains how our brain constructs our sense of mental health--actively striving to maintain balance in response to our changing circumstances. While a mentally healthy brain deals well with life's turbulence, poor mental health results when the brain struggles with disruption. But just what is the brain trying to balance? Nord describes the foundations of mental health in the brain--from the neurobiology of pleasure, pain and desire to the role of mood-mediating chemicals like dopamine, serotonin and opioids. She then pivots to interventions, revealing how antidepressants, placebos and even recreational drugs work; how psychotherapy changes brain chemistry; and how the brain and body interact to make us feel physically (as well as mentally) healthy. Along the way, Nord explains how the seemingly small things we use to lift our moods--a piece of chocolate, a walk, a chat with a friend--work on the same pathways in our brains as the latest treatments for mental health disorders.
Understanding the cause of poor mental health is one of the crucial questions of our time. But the answer is unique to each of us, and it requires finding what helps our brains rebalance and thrive. With so many factors at play, there are more possibilities for recovery and resilience than we might think.
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Psychologists and neuroscientists struggle with how best to interpret human motivation and decision making. The assumption is that below a mental “surface” of conscious awareness lies a deep and complex set of inner beliefs, values, and desires that govern our thoughts, ideas, and actions, and that to know this depth is to know ourselves. In the The Mind Is Flat: The Remarkable Shallowness of the Improvising Brain (Yale UP, 2019), behavioural scientist Nick Chater contends just the opposite: rather than being the plaything of unconscious currents, the brain generates behaviors in the moment based entirely on our past experiences. Engaging the reader with eye-opening experiments and visual examples, Chater first demolishes our intuitive sense of how our mind works, then argues for a positive interpretation of the brain as a ceaseless and creative improviser.
Dr. Nick Chater is Professor of behavioral science at the Warwick Business School and cofounder of Decision Technology Ltd. He has contributed to more than two hundred articles and book chapters and is author, co-author, or co-editor of fourteen books.
Dr. John Griffiths (@neurodidact) is an Assistant Professor at the University of Toronto, and Head of Whole Brain Modelling at the CAMH Krembil Centre for Neuroinformatics. His research group (www.grifflab.com) works at the intersection of computational neuroscience and neuroimaging, building simulations of human brain activity aimed at improving the understanding and treatment of neuropsychiatric and neurological illness.
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Do newborns think-do they know that 'three' is greater than 'two'? Do they prefer 'right' to 'wrong'? What about emotions--do newborns recognize happiness or anger? If they do, then how are our inborn thoughts and feelings encoded in our bodies? Could they persist after we die? Going all the way back to ancient Greece, human nature and the mind-body link are the topics of age-old scholarly debates. But laypeople also have strong opinions about such matters. Most people believe, for example, that newborn babies don't know the difference between right and wrong-such knowledge, they insist, can only be learned. For emotions, they presume the opposite-that our capacity to feel fear, for example, is both inborn and embodied. These beliefs are stories we tell ourselves about what we know and who we are. They reflect and influence our understanding of ourselves and others and they guide every aspect of our lives. In a twist that could have come out of a Greek tragedy, Berent proposes that our errors are our fate. These mistakes emanate from the very principles that make our minds tick: our blindness to human nature is rooted in human nature itself.
An intellectual journey that draws on philosophy, anthropology, linguistics, cognitive science, and Berent's own cutting-edge research, The Blind Storyteller: How We Reason about Human Nature (Oxford UP, 2020) grapples with a host of provocative questions, from why we are so infatuated with our brains to what happens when we die. The end result is a startling new perspective on our humanity.
You can find Dr. Berent on Twitter at @berent_iris.
Joseph Fridman is a researcher, science communicator, media producer, and educational organizer. He lives in Boston with two ragdoll kittens and a climate scientist.You can follow him on Twitter @joseph_fridman, or reach him at his website, https://www.josephfridman.com/.
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On Task: How Our Brain Gets Things Done (Princeton UP, 2020) is a look at the extraordinary ways the brain turns thoughts into actions—and how this shapes our everyday lives.
Why is it hard to text and drive at the same time? How do you resist eating that extra piece of cake? Why does staring at a tax form feel mentally exhausting? Why can your child expertly fix the computer and yet still forget to put on a coat? From making a cup of coffee to buying a house to changing the world around them, humans are uniquely able to execute necessary actions. How do we do it? Or in other words, how do our brains get things done?
In On Task, cognitive neuroscientist David Badre presents the first authoritative introduction to the neuroscience of cognitive control—the remarkable ways that our brains devise sophisticated actions to achieve our goals. We barely notice this routine part of our lives. Yet, cognitive control, also known as executive function, is an astonishing phenomenon that has a profound impact on our well-being. Drawing on cutting-edge research, vivid clinical case studies, and examples from daily life, Badre sheds light on the evolution and inner workings of cognitive control. He examines issues from multitasking and willpower to habitual errors and bad decision making, as well as what happens as our brains develop in childhood and change as we age—and what happens when cognitive control breaks down. Ultimately, Badre shows that cognitive control affects just about everything we do. A revelatory look at how billions of neurons collectively translate abstract ideas into concrete plans, On Task offers an eye-opening investigation into the brain’s critical role in human behavior.
Joseph Fridman is a researcher, science communicator, media producer, and educational organizer. He lives in Boston with two ragdoll kittens and a climate scientist.You can follow him on Twitter @joseph_fridman, or reach him at his website, https://www.josephfridman.com/.
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John T. Maier's The Disabled Will: A Theory of Addiction (Routledge Press, 2024) defends a comprehensive new vision of what addiction is and how people with addictions should be treated. The author argues that, in addition to physical and intellectual disabilities, there are volitional disabilities - disabilities of the will - and that addiction is best understood as a species of volitional disability. This theory serves to illuminate long-standing philosophical and psychological perplexities about addiction and addictive motivation. It articulates a normative framework within which to understand prohibition, harm reduction, and other strategies that aim to address addiction. The argument of this book is that these should ultimately be evaluated in terms of reasonable accommodations for addicted people and that the priority of addiction policy should be the provision of such accommodations. What makes this book distinctive is that it understands addiction as a fundamentally political problem, an understanding that is suggested by standard legal approaches to addiction, but which has not received a sustained defense in the previous philosophical or psychological literature. This text marks a significant advance in the theory of addiction, one which should reshape our understanding of addiction policy and its proper aims.
Jeff Adler is an ex-linguist and occasional contributor to New Books Network!
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A nuanced, science-based understanding of the creative mind that dispels the pervasive myths we hold about the human brain—but also uncovers the truth at their cores. What is the relationship between creativity and madness? Creativity and intelligence? Do psychedelics truly enhance creativity? How should we understand the left and right hemispheres of the brain? Is the left brain, in fact, the seat of reasoning and the right brain the seat of creativity?
These are just some of the questions Anna Abraham, a renowned expert of human creativity and the imagination, explores in The Creative Brain: Myths and Truths (MIT Press, 2024), a fascinating deep dive into the origins of the seven most common beliefs about the human brain. Rather than endorse or debunk these myths, Abraham traces them back to their origins to explain just how they started and why they spread—and what at their core is the truth. Drawing on theoretical and empirical work in cognitive psychology and neuroscience, Abraham offers an examination of human creativity that reveals the true complexity underlying our conventional beliefs about the brain.
The chapters in the book explore the myth of the right brain as the hemisphere responsible for creativity; the relationship between madness and creativity, psychedelics and creativity, atypical brains and creativity, and intelligence and creativity; the various functions of dopamine; and lastly, the default mode revolution, which theorized that the brain regions most likely to be involved in the creative process are those areas of the brain that are most active during rest or mind-wandering. An accessible and engaging read, The Creative Brain gets to the heart of how our creative minds work and why some people are more creative than others, offering illuminating insights into what on its surface seems to be an endlessly magical phenomenon.
Jeff Adler is an ex-linguist and occasional contributor to New Books Network!
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If you’ve ever worked with dementia patients before, you know how unique and bizarre the experience can be, and how little the stereotypes actually hold up to the experience. Even knowing about the diagnosis often does little to help us in caring for people, and many caregivers find themselves getting sucked into behavioral loops of their own. This is because your brain is not wired to deal with the altered form of reality that dementia patients inhabit. Evolution has not equipped us to deal with these dynamics.
Unpacking all this is our guest today, Dasha Kiper in her book Travelers to Unimaginable Lands: Stories of Dementia, the Caregiver, and the Human Brain (Random House, 2023). Having both worked with dementia patients and run support groups for caregivers, she’s seen patterns play out over countless situations, and has mapped the cognitive landscape of people working to take care of those afflicted with the disease. In a series of engaging and provocative essays, she’s able to elucidate our limitations, the various neurological traps we are often tempted to fall into, hopefully offering caregivers some clarity on themselves and just how far from reality this work often takes them.
Dasha Kiper is the consulting clinical director of support groups at an Alzheimer’s organization, and holds an MA in clinical psychology from Columbia University.
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In this episode we speak with Dr. John W. Cave, a scientist and thought leader who has been in the research world for over 20 years. Dr. Cave has worked at a variety of elite research institutions at the intersection of biochemistry, neurology, and brain injury and has long history of mentoring younger scientists. Listen to our conversation for his insight into the reality of research in the sciences, from the complexity of grant writing to the management of institutional politics, and for his advice to early-career scientists on a successful career in research.
Towards Knowledge is a Latent Knowledge podcast series where we interview industry and academic leaders about research in the real world — from career development to the most pressing philosophical questions in today’s changing research landscape.
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In Do I Know You? From Faceblindness to Super Recognition (Johns Hopkins University Press, 2023), Dr. Sharrona Pearl explores the fascinating category of face recognition and the "the face recognition spectrum," which ranges from face blindness at one end to super recognition at the other. Super recognizers can recall faces from only the briefest exposure, while face blind people lack the capacity to recognize faces at all, including those of their closest loved ones. Informed by archival research, the latest neurological studies, and testimonials from people at both ends of the spectrum, Dr. Pearl tells a nuanced story of how we relate to each other through our faces.
The category of face recognition is relatively new despite the importance of faces in how we build relationships and understand our own humanity. Dr. Pearl shows how this most tacit of knowledge came to enter the scientific and diagnostic field despite difficulties with identifying it. She offers a grounded framework for how we evaluate others and draw conclusions about them, with significant implications for race, gender, class, and disability. Dr. Pearl explores the shifting ideas around the face-recognition spectrum, explaining the effects of these diagnoses on real people alongside implications for how facial recognition is studied and understood. Face blindness is framed as a disability, while super recognition is framed as a superpower with no meaningful disadvantages. This superhero rhetoric is tied to the use of super recognizers in criminal detection, prosecution, and other forms of state surveillance. Do I Know You? demonstrates a humanistic approach to the study of the brain, one that offers an entirely new method for examining this fundamental aspect of human interaction.
This interview was conducted by Dr. Miranda Melcher whose new book focuses on post-conflict military integration, understanding treaty negotiation and implementation in civil war contexts, with qualitative analysis of the Angolan and Mozambican civil wars.
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Eric Kandel was born in Vienna in 1929. In 1938 he and his family fled to Brooklyn, where he attended the Yeshiva of Flatbush. He studied history and literature at Harvard, and received an MD from NYU. He is a professor of biochemistry at Columbia University, and won the 2000 Nobel Prize in Medicine for his research on memory.
In addition to his science textbooks, Kandel has written several books for a general readership, including In Search of Memory: The Emergence of a New Science of Mind (2007), and The Disordered Mind: What Unusual Brains Tell Us About Ourselves (2018).
In 2012 he spoke to the Institute about his book The Age of Insight: The Quest to Understand the Unconscious in Art, Mind, and Brain, from Vienna 1900 to the Present (Random House, 2012).
About the book:
At the turn of the century, Vienna was the cultural capital of Europe. Artists and scientists met in glittering salons, where they freely exchanged ideas that led to revolutionary breakthroughs in psychology, brain science, literature, and art. Kandel takes us into the world of Vienna to trace, in rich and rewarding detail, the ideas and advances made then, and their enduring influence today.
The Vienna School of Medicine led the way with its realization that truth lies hidden beneath the surface. That principle infused Viennese culture and strongly influenced the other pioneers of Vienna 1900. Sigmund Freud shocked the world with his insights into how our everyday unconscious aggressive and erotic desires are repressed and disguised in symbols, dreams, and behavior. Arthur Schnitzler revealed women's unconscious sexuality in his novels through his innovative use of the interior monologue. Gustav Klimt, Oscar Kokoschka, and Egon Schiele created startlingly evocative and honest portraits that expressed unconscious lust, desire, anxiety, and the fear of death.
Kandel tells the story of how these pioneers--Freud, Schnitzler, Klimt, Kokoschka, and Schiele--inspired by the Vienna School of Medicine, in turn influenced the founders of the Vienna School of Art History to ask pivotal questions such as What does the viewer bring to a work of art? How does the beholder respond to it? These questions prompted new and ongoing discoveries in psychology and brain biology, leading to revelations about how we see and perceive, how we think and feel, and how we respond to and create works of art. Kandel, one of the leading scientific thinkers of our time, places these five innovators in the context of today's cutting-edge science and gives us a new understanding of the modernist art of Klimt, Kokoschka, and Schiele, as well as the school of thought of Freud and Schnitzler. Reinvigorating the intellectual enquiry that began in Vienna 1900, The Age of Insight is a wonderfully written, superbly researched, and beautifully illustrated book that also provides a foundation for future work in neuroscience and the humanities. It is an extraordinary book from an international leader in neuroscience and intellectual history.
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Ecological psychology holds that perception and action are best explained in terms of dynamic interactions between brain, body, and environment, not in classical cognitivist terms of the manipulation of representations in the head. This anti-representationalist stance, argues Luis Favela, makes ecological psychology deeply at odds with dominant trends in some parts of neuroscience.
In The Ecological Brain: Unifying the Sciences of Brain, Body, and Environment (Routledge, 2024), Favela lays out the seemingly irreconciliable theoretical commitments of ecological psychology and neuroscience, and then defends a framework for reconciling them: the NeuroEcological Nexus Theory (NExT). According to Favela, who is an associate professor of philosophy and cognitive sciences at the University of Central Florida, complexity science provides the conceptual tools that can help integrate these frameworks, such as by articulating the key notion of affordances in ecological psychology as a kind of dimensional reduction in complexity science.
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If you're interested in memory, you'll find a lot in Memory Makes the Brain: The Biological Machinery That Uses Experiences To Shape Individual Brains (World Scientific, 2021), from cellular processes to unique and interesting perspectives on autism.
Detailed descriptions of cellular processes involved in forming a memory.
Connecting those cellular processes to everyday experiences - like the memorable image of a butterfly seen during a hike decades ago.
Comparisons of plasticity in different brain areas, like cortex, hippocampus, cerebellum.
Comparisons of plasticity and learning in different phases of the human life.
Important milestones in the history of neuroscience. Like Wiesel and Hubel's work identifying the critical period for plasticity, or Huttenlocher's discovery of synaptic pruning.
Up-to-date science and open questions about autism, a wide range of phenomena that seems to be connected both to synaptic pruning and to the funtion of the cerebellum.
An outlook on non-synaptic plasticity.
Professor Christian Hansel starts both the book and the conversation with establishing a very broad definition of memory. Traditionally, a lot of research focused on the "observable outcome" of learning: acquiring new skills, changing behavior. Instead, he defines memory as any event that changes the brain.
The first 2 chapters introduce major discoveries from the 1960s and 1970s. David Hubel and Thorsten Wiesel examined the visual system of kittens. They recognized that it's much more adaptive in a "critical period", ca. 4-8 weeks after birth. Peter Huttenlocher discovered another fascinating phenomena during childhood: synaptic pruning. In the years 2-12, a lot of synapses (connections between neurons) disappear.
Chapter 3 describes the molecular machinery behind all these observations. We'll get to know the terms LTP (long-term potentiation) and LTD (long-term depression), which mean the long-term strengthening and weakening of synaptic connections respectively. We find a detailed description of these processes, incl. the enzymes, neurotransmitters and receptors contributing to them.
Chapter 4 continues examining these processes across the human life span. The (perhaps surprising) conclusion: The machinery for synaptic plasticity is quite similar in a small child an in an adult. What's different is the magnitude of these processes.
Autism is a central topic both in the book and in the Hansel Lab's work. Chapter 5 starts with describing the difficulties of a definition. ASD (autism spectrum disorder) is an umbrella term encompassing several symptoms and intensities. In the last years, it has turned out that low degree of synaptic pruning plays a significant role in multiple forms of autism. We'll see in the next years how the research about synaptic pruning and learning can be used for clinical purposes. Understanding the biological mechanism can also make it easier to relate to some peculiar-sounding symptoms. If we consider that an individual's brain contains an unusually high number of synapses, their reports about unusually intense perceptions suddenly become more understandable.
A thought-provoking chapter is number 6. It describes various experiments with mouse models to study autism-like symptoms. The chapter might also make you reflect about the merits and shortcomings of animal models generally.
The cerebellum was long considered to be the brain area for finetuning movements. Now, it's clear that its repertoire is much bigger. In the interview, Christian describes a hypothesis that the cerebellum has a capability of timing. This in turn makes it a crucial factor in several behaviors beyond sophisticated movements, including speech.
We know a lot about synaptic plasticity and its significance in learning. Chapter 8 tackles the big, open question, what else? Which other processes contribute to memory formation? It presents some hypotheses about intrinsic plasticity.
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A new understanding of memory is emerging from the latest scientific research. In Why We Remember: Unlocking Memory's Power to Hold on to What Matters (Doubleday, 2024), pioneering neuroscientist and psychologist Charan Ranganath radically reframes the way we think about the everyday act of remembering. Combining accessible language with cutting-edge research, he reveals the surprising ways our brains record the past and how we use that information to understand who we are in the present, and to imagine and plan for the future.
Memory, Dr. Ranganath shows, is a highly transformative force that shapes how we experience the world in often invisible and sometimes destructive ways. Knowing this can help us with daily remembering tasks, like finding our keys, and with the challenge of memory loss as we age. What's more, when we work with the brain's ability to learn and reinterpret past events, we can heal trauma, shed our biases, learn faster, and grow in self-awareness.
Including fascinating studies and examples from pop culture, and drawing on Ranganath's life as a scientist, father, and child of immigrants, Why We Remember is a captivating read that unveils the hidden role memory plays throughout our lives. When we understand its power-- and its quirks--we can cut through the clutter and remember the things we want to remember. We can make freer choices and plan a happier future.
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