Episodes
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Mitrix Bio
Website:
https://www.mitrix.bio/
Contact form on Website
Show notes:
Personal introduction:
Bioreactor-grown mitochondria
8-9 years old field
Grow young healthy mitochondrial and transplant them into the cells
Had a few software companies on the 1990’s and fusion start-ups
Stanford accelerator
Lasers
Molecular and biological imaging
Mito-field is booming
The mechanisms of the mitochondria than the biologics of them
Gas turbines Little rotating turbines
Combust fuel and oxygen
That does anything to power the cell
The main question:
What is aging?
Aging is healing, and the loss of the ability to heal
The body and cells are not static
There is enough rebuilding capacity when you are young
As you age, the energy available to rebuild your cells slacks off
They can’t replicate as fast
Your body can’t afford to maintain large muscles so they shrink
“We have made older animals younger…”
They just need the higher levels of energy that is lost after youth
The theory: texting and repairing mechanisms weaken and don’t have enough energy to do their jobs as effectively
The brain and heart don’t decline as fast as the rest of the body
The kidneys and skin and muscles decline the fastest
Mitochondria are fundamental to all of your cells and organs and muscles
10% of you body weight and generate 90% of your energy in your body
Merged a billion years ago with simple-celled organisms
Mitochondrial dna
You start with One nuclear dna and 500,000 mtDNA
26 major groups of mtDNA
As you age the dna acquires copying errors like a computer disk that needs to be cleaned up
Mitochondrial energy decline IS aging
Hallmarks of aging : Both nuclear dna and mtDNA are decaying and declining
You have to replace a car battery, and we should be able to do the same thing with ourselves: the body and car can just keep going….
The cells will scoop up the new mitochondria and use the new fresh free mitochondria
75 years old, you can feel 40-45 years old again
Skin will get tighter and muscles will regrow
Reversing aging and not just slowing it down
Starting with the longevity market / field
Most of it is fluff and noise and bubbles that pop
We have a bubble because there’s a huge opportunity and a lot of people dive in
A lot of billionaires investing
Altos Laboratories from Jeff Bezos, Amazon
Retro.bio by Sam Altman /Open Ai, ChatGPT
New Limit from Brian Armstrong, coinbase
Hevolution Project by Saudi Arabia
One or two good approaches:
Mitochondria transplants
Epigentic reprogramming. Future biogenetic mitochondria producing machines in every house as a daily treatment/supplement
Holy Fire book
Correlation vs causation
Secondary and tertiary effects
Mitochondria is a primary cause of aging
Telomere is secondary or just correlary effect
“Allow aging to happen” as a compromise that’s a trade off
Famine and intermittent fasting vs caloric restriction
The body uses the muscles to funnel to the heart and brain
Intermittent feasting
Saunas are recommended
There are a lot of excesses in the longevity field
Lots of vitamins
Lots of running
More is not always better
Minimum effective dose
Maximum effective dose
Homeostasis -
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