Episodes
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In this episode, I had an engaging conversation with Stacie Frye, co-founder and Chief Commercial Officer of StimulusBio, a life sciences commercialization and venture studio for biotech startups. We discussed how StimulusBio aids startups in operational and commercialization aspects, leveraging Stacie's unique journey across marketing, chemical engineering, and her experience with successful biotech exits. Experience from previous startups profoundly informs StimulusBio’s approach to helping startups transition from incubation to market. We explored the critical stages of startup growth, emphasizing the importance of marketing, storytelling, team building, and experience-based advice. Stacie also shared her insights into the emerging trends in the biotech industry, particularly in Houston's growing biotech ecosystem, and the importance of balancing innovation with practical business needs.
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00:00 Introduction to Stacie Frye and StimulusBio
00:51 Stacie's Unique Career Path
01:56 Early Career and Transition to Bioengineering
03:32 Startup Experiences and Lessons Learned
08:46 Challenges in Transitioning from Incubator to Market
12:44 The Importance of Marketing and Team Building
32:17 Emerging Trends and Future Goals
37:09 Conclusion and Contact Information
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This week, I had an insightful conversation with David Sans, PhD, FAARM, MBA, who heads healthcare investment banking at EF Hutton. We discussed the intricacies of different Public Offering strategies, including micro IPOs, which offer a unique avenue for biotech companies. David provides a deep perspective on the strategic implications of IPOs for biotech funding. He emphasized the importance of investor support and strategic banking partnerships, especially for micro IPOs. We also discussed the potential of AI in reshaping financial services and the future of outcome-based pricing models in investment. David's personal insights reveal the demanding yet rewarding nature of investment banking and highlight crucial aspects to consider for those pursuing a career in this field.
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00:00 Introduction to Biotech and Investment Banking
00:48 David Sands' Background and Career Journey
02:12 Transition from Biotech to Finance
04:53 Understanding Micro IPOs
06:37 Challenges and Strategies in Biotech IPOs
16:38 The Role of the FDA in Biotech IPOs
18:30 Understanding IPO Disparities
18:42 Key Factors for a Successful IPO
19:29 Aftermarket Support and Investor Relations
20:59 The Role of Long-Term Investors
21:34 Personal Investment Strategies
22:29 Innovations in Financial Services
24:40 Challenges for Biotech CEOs
26:32 Career Path in Investment Banking
28:50 Future of Financial Services and AI
33:37 Book Recommendations and Closing Thoughts
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This week I had a great conversation with Iva Toudjarska, founder and CEO of Zeal Therapeutics. From earning a PhD in molecular biology to a solid scientific career at Alnylam, to working in venture capital, to selling a successful SaaS company, Iva’s career that’s set her up well to enjoy this new challenge – founding a baby biotech. Her expertise marries business development, venture capital, and company-building. Iva shared valuable advice for biotech founders on securing funding, making strategic decisions, and building effective partnerships. Tune in to hear her experiences, lessons learned, and her current work leading Zeal Therapeutics, a precision kidney RNA therapeutics company.
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00:00 - Intro to Iva Toudjarska's Career
00:48 - Career overview, Iva Toudjarska, Zeal Therapeutics
04:26 - Successful biotech strategies, industry insights
07:02 - Building successful partnerships, collaboration tips
12:15 - Angel investing, funding strategies, biotech financing
20:20 - Leveraging background, skills for biotech success
24:38 - Setbacks in biotech, lessons learned, resilience
27:20 - Bootstrapping a company, startup funding, entrepreneurship
28:23 - Support for Eva, mentorship, biotech advice
29:18 - Future goals, biotech vision, 10-year plan
30:45 - Current reading, professional development, industry literature
24:24 Lessons Learned and Future Goals
28:08 Conclusion and Final Thoughts
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This week I had a fun conversation with Jason Cordeiro, Chief Operating and Innovation Officer at MassBio. We dissect MassBio's newly announced five-year strategic plan that includes a multi-pronged set of initiatives aimed at advancing the biotech industry. From supporting early-stage startups to advocating for policy changes and fostering talent development, Jason details the excellent resources available and in development. Whether you're based in Massachusetts or global, this session provides valuable information on how MassBio is working to catalyze innovation and growth in biotech, and how you can leverage these opportunities.
00:00 - Intro
01:24 - Jason Cordeiro, MassBio’s COO
02:48 - What is MassBio
05:54 - MassBio’s MassCONNECT Program
08:15 - MassCONNECT Support for Non-Local Companies
13:15 - How to Get Involved in MassBio
17:24 - Next Level One Initiative
19:58 - MassBio Align Summit Overview
21:40 - Educating Investors through MassBio
27:11 - MassBio Pharma Days Event
31:00 - The Link Program
34:54 - MassBio’s 5-Year Strategic Plan
41:14 - Connecting with MassBio Resources
42:11 - Outro
Learn about Align Summit - MassBioLearn about Partnering Opportunities - MassBioLearn about the CEO & Founder Link - MassBioLearn about MassBio’s Vision 2030 strategic planLearn about MassBioDrive!Learn about MassBio InnovationLearn more about Massachusetts Biotechnology CouncilLinked In with Jason!Connect with us!
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In this episode, we revisit a fun conversation with Mike LaRhette, Chief Business Officer at LabCentral. Mike outlines the essentials for startups, including funding, lab space, mentorship, and resources. He shares his journey from aspiring architect to an architect of biotech ecosystems, detailing his experiences with MassChallenge and LabCentral. Mike offers insights into the key elements that make thriving ecosystems, like government support, industry collaboration, and a density of entrepreneurs. He also discusses how LabCentral supports startups through challenging markets, diverse talent acquisition, and successful graduations. The episode concludes with a lighthearted look at LabCentral's unique culture and the balance between hard work and fun.
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00:00 Introduction and Episode Overview
00:49 Meet Mike LaRhette: From Architect Aspirations to Ecosystem Builder
01:59 Journey into the Biotech Sector
04:34 A Day in the Life at LabCentral
07:32 The Human Side of Biotech Entrepreneurship
09:55 LabCentral Ignite: Bridging Talent and Opportunity
12:08 Effective Communication Strategies at LabCentral
18:13 Key Elements of a Successful Ecosystem
24:30 Debunking Myths About Entrepreneurs
25:58 Challenges in Post-COVID Event Engagement
26:58 Navigating the Tight Market
28:35 Golden Tickets Program
30:40 Support for New Founders at LabCentral
33:16 Transitioning Out of LabCentral
36:22 Balancing Fun and Seriousness at LabCentral
40:00 Future Directions and Personal Growth
41:49 Favorite Books and Final Thoughts
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This week I spoke with Bogdan Knezevic, founder of Kaleidoscope Bio, about optimizing biotech workflows and achieving milestones efficiently. Bogdan shared insights into how his platform helps companies manage research and development processes, reducing operational inefficiencies and saving time, resources, and money. He discussed the importance of setting clear goals, breaking down complex workflows, and avoiding shiny object syndrome (a common ailment among scientists). Bogdan also emphasized the value of keeping teams focused and aligned, leveraging automation, and integrating existing tools to minimize manual work. We explored how to empower teams, balance short-term and long-term goals, and pivot gracefully when needed. Additionally, Bogdan touched on the importance of understanding the true cost of operations and making strategic investments in tools that drive productivity.
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00:00 Introduction to Systems and Workflow
01:10 Meet Bogdan Knezevic: From Childhood Dreams to Biotech CEO
02:22 The Frustration and Vision Behind Kaleidoscope Bio
04:01 Use Cases and Value Propositions for Biotech Companies
07:50 Empowering Teams and Setting Priorities
11:38 Balancing Short-Term and Long-Term Goals
18:22 Reducing Operational Overhead and Streamlining Processes
31:07 Common Mistakes and Lessons for Biotech Leaders
36:19 Book Recommendations and Closing Thoughts
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This week I spoke with Jon Hu, CEO and co-founder of Pepper Bio, about his journey from pharma consulting and venture capital to founding a tech-enabled biotech company. Pepper Bio created an AI and machine learning platform accelerating drug discovery for untreatable diseases. In addition to the platform, Pepper is currently navigating their asset for liver cancer into phase 2 clinical trials. Jon highlighted the differences between tech and biotech, emphasizing the importance of dreaming big and aligning vision with employees. He shared insights on the importance of hiring, learning to learn, and overcoming challenges in transitioning from tech-enabled discovery to drug development. We also discussed Pepper Bio's computational platform, long-term strategy, and their Series A fundraising to support their clinical trial efforts. Jon’s personal story of family health challenges driving his passion for biotech underscored the company's mission to transform patient care.
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00:00 Introduction to John Hu and Pepper Bio
00:54 John's Early Aspirations and Career Path
02:27 Founding Pepper Bio and Its Mission
05:15 Tech vs. Biotech: Ambitions and Challenges
10:42 Project Optimist and Pepper's Role
11:53 Pepper's Computational Platform and Future Goals
16:14 Navigating the Biotech Industry and Hiring Strategies
33:35 Personal Motivations and Future Aspirations
36:03 Book Recommendations and Closing Remarks
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This week we chatted with Cheri Ackerman, PhD, Cofounder & CEO of Concerto Biosciences. During her postdoctoral work at MIT, she developed the groundbreaking kChip technology that led to the formation of Concerto Biosciences. We discuss the challenges and opportunities of building a company during the pandemic and the importance of learning the business side of biotech as a scientific founder. As always, we trumpet the value of building a network to leverage during the growth process. Cheri gives really great advice for aspiring entrepreneurs, which is to keep learning and embrace asking questions when you don’t know something. I also loved her views on adapting and experimenting in business, which is one of the key values at Concerto.
00:00 Introduction and Early Career Aspirations
00:09 Journey to Becoming a CEO
01:12 Founding Concerto Biosciences
02:31 Understanding the Microbiome
04:56 Concerto's Innovative Approach
07:53 Challenges and Opportunities in Building a Company
08:58 Navigating the Funding Climate
13:00 Building a Strong Team
21:57 Advice for Aspiring Entrepreneurs
29:34 Future Goals and Aspirations
31:55 Conclusion and Contact Information
Get Cheri's recommended books! Measure What MattersThe Founder's Dilemmas: Anticipating and Avoiding the Pitfalls That Can Sink a Startup (The Kauffman Foundation Series on Innovation and Entrepreneurship, 13)No Rules Rules: Netflix and the Culture of ReinventionGood to Great: Why Some Companies Make the Leap...And Others Don'tWhoLearn more about Concerto BiosciencesLink In with Cheri!Connect with us!
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This week I sat down with Krysta Pellegrino, Chief Client Officer at Health+Commerce, a public relations and marketing agency specifically focused on healthcare. Krysta shared her unique perspective on how biotech companies can leverage communications strategies to tell their stories effectively, attract talent, and navigate complex challenges. She offered insights on the importance of integrated communications, the evolving landscape of media, and how agencies like H+C can help startups and established companies alike build their brands and communicate their innovations. We also touched on the importance of media training, investor pitch decks, and future trends in biotech communications, including the growing role of AI and integrated digital strategies.
00:00 Introduction and Guest Welcome
00:15 Early Career Aspirations and Path
01:03 Journey in Healthcare Communications
03:23 Role and Impact of PR in Biotech
05:40 Talent Acquisition and Company Culture
07:43 Leveraging Social Media and Video
10:52 Strategies for Startups and Established Companies
18:16 Investor Relations and Pitch Decks
22:02 Media and Presentation Training
27:01 Future Trends in Biotech Communications
31:37 Crisis Management and Scenario Planning
35:19 Conclusion and Final Thoughts
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In this episode, I had the privilege to interview Bonnie Bertolaet, Ph.D, Executive Director of Science Club for Girls, and Ashley Cooper, MS, MPhil, Curriculum Writer and Evaluation Manager at Science Club for Girls and former Co-Director of the Harvard Chapter of Science Club for Girls. Science Club for Girls aims to ignite excitement, confidence, and literacy in STEM among girls and gender-expansive youth from underrepresented communities. Bonnie and Ashley shared insights into how the organization operates, from engaging young students through hands-on activities to providing valuable mentorship opportunities for biotech employees. They discussed the importance of starting STEM education early, the transformative impact of mentorship, and the ways companies can get involved and contribute. Success stories and the personal experiences of the guests offered a powerful testament to the program's effectiveness in fostering a diverse and inclusive pipeline for future scientists.
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00:00 Introduction to the Episode
00:51 Meet the Guests: Bonnie and Ashley
02:37 What is Science Club for Girls?
03:47 Engaging Young Minds in STEM
10:26 Mentorship and Corporate Engagement
21:06 Success Stories and Impact
23:16 Virtual Clubs and Future Expansion
26:22 How to Get Involved and Support
32:01 Recommended Reads and Final Thoughts
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In this episode, we had the pleasure of welcoming back Lynn Walder, our first repeat guest, to dive into the pitfalls and best practices of defining culture and core values for growing companies. There has been a shift in how companies invest in and operationalize culture over the past two decades. Lynn shares insights from her extensive experience, including the importance of early core value implementation, the challenges of aligning leadership actions with stated values, and the need for clear communication and accountability. We also discuss various assessments Lynn uses to help biotech companies define and uphold their foundational values, and how these values guide companies through times of change and crisis.
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00:00 Introduction and Welcome Back
00:34 The Evolution of Culture in Biotech
03:01 Defining and Implementing Core Values
05:52 Challenges in Aligning Leadership with Core Values
10:27 The Importance of Early Implementation
16:32 Assessments and Frameworks for Leadership
23:59 Operationalizing Values in Biotech
37:49 Transparency and Communication in Leadership
39:58 Conclusion and Contact Information
Mentioned in this episode:
lynn walder intro
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Today, I had the opportunity to speak with Amogha Tadimety, PhD, CEO, and Alison Burklund, PhD, President & CTO, co-founders of Nanopath, an innovative company specializing in women’s health diagnostics. Both hailing from Dartmouth’s Thayer School of Engineering, Amogha and Alison walk us through the challenges and opportunities of founding a diagnostic company during the COVID era. We chatted about the intricacies of bringing foundational technology to consumers, including the importance of navigating the insurance system and the specific focus of their technology on improving point-of-care diagnostics in women's health. They highlighted the need for innovative tools in OB-GYN practices, the strategic decisions that shaped Nanopath's direction, and the significant milestones they have achieved. They also emphasized the importance of building a strong team and network, overcoming healthcare system challenges, and their vision for the company's future, which includes creating a comprehensive well-woman panel and expanding the technology for broader applications.
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00:00 Introduction to Nanopath Founders
00:59 Career Paths and Early Inspirations
01:42 The PhD Innovation Program
02:16 Founding Nanopath: The Journey Begins
04:58 Nanopath's Mission and Technology
08:13 Navigating the Healthcare System
10:14 Challenges and Opportunities During COVID-19
16:05 Building a Strong Team and Network
24:02 Future Vision and Goals
25:38 Reading Recommendations and Closing Thoughts
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In this episode, I sat down with Ben Hemani from Bison Ventures, a venture capital firm that invests in early-stage frontier technology companies. We explore his background in environmental engineering and his transition into the venture capital world, driven by a passion for technology and sustainability. Ben elaborates on the interconnected areas Bison Ventures invests in, such as biotech, high-performance computing, and climate sustainability, emphasizing the critical role cross-pollination plays in innovation. We explore the nuances of assessing early-stage companies, focusing on the importance of founder teams, technical maturity, and long-term planning. Ben also shares insights on the current funding landscape and the strategic support Bison Ventures offers its portfolio companies.
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00:00 Introduction to Ben Hemani and Bison Ventures
00:34 Ben Hemani's Background and Career Path
02:48 Transition into Venture Capital
04:37 Overview of Bison Ventures
06:13 Investment Strategies and Challenges
14:49 Supporting Founding Teams
19:11 Life Cycle of Portfolio Companies
23:07 Current Trends and Future Prospects
25:34 Day in the Life of a VC
27:05 Personal Insights and Recommendations
28:21 Conclusion and Contact Information
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This week I sat down with Krisha Panchalingham, Director of Lab and Scientific Operations at Portal Innovations. Krisha shares how she and her team support early-stage biotech companies through the operational intricacies of setting up labs, handling logistics, maintaining equipment, and complying with regulations. We also discuss the importance of vendor management, the role of external consultants, and the strategic partnerships required to efficiently run lab operations. Krisha also emphasizes the significance of mentorship and the strategic role of operational support in the success of biotech startups. We also discuss how Portal Innovations fosters a nurturing ecosystem for biotech startups, underscoring the balance between scientific discovery and operational excellence.
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00:00 Introduction to Krisha Penchalingham and Portal Innovations
00:57 Krisha's Journey: From Childhood to Biotech
03:58 Role and Responsibilities at Portal Innovations
04:24 Supporting Early-Stage Biotech Companies
06:20 Challenges and Successes in Lab Operations
07:47 Team Dynamics and Growth at Portal Innovations
08:28 Expanding Ecosystems and Future Plans
22:26 Mentorship and Career Advice
27:31 Conclusion and Contact Information
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This week, Carina Clingman, PhD, Founder and Principal of Recruitomics Consulting, outlines an actionable 3-Step framework to simplify the recruitment process and hire top-quality talent. The discussion covers common challenges faced by small companies, such as desperation hiring and inefficiencies, and offers solutions like implementing applicant tracking systems (ATS), streamlining processes, and leveraging data-driven hiring. The episode also emphasizes the significance of proper training and compliance in conducting fair and effective interviews. Listeners will learn how to audit current processes, install a sustainable hiring engine, and ensure they attract and select the best talent, even on a limited budget.
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00:00 Introduction: The Importance of Talent in Biotech
00:54 Why Systems Matter in Talent Acquisition
02:05 Common Challenges in Small Companies
04:20 The Concept of Chicken Math in Startups
07:58 Auditing Your Hiring Process
09:31 Building a Sustainable Hiring Engine
10:54 The Role of Applicant Tracking Systems
19:08 The Importance of Training and Legalities
24:31 Data-Driven Hiring Decisions
31:42 Conclusion: Implementing Effective Hiring Strategies
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This week I chatted with Oriana Papin-Zoghbi, CEO and co-founder of AOA Dx. Oriana shares insights on the challenges of fundraising and the importance of building a network for startup success. She highlights her career shift from biochemistry to economics and international relations, finally leading to her involvement in women's health diagnostics. Oriana emphasizes the significance of finding one's passion for excelling in their field and the role of previous startup successes in her current venture. I also loved learning more about AOA Dx's mission to revolutionize women's health diagnostics, focusing on unmet needs such as early ovarian cancer detection through innovative biomarker research. Oriana highlights the impact of leadership, resilience, and the pursuit of innovation in healthcare.
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00:00 Introduction to Oriana Papin-Zoghbi and AOA DX
00:37 Oriana's Journey: From Aspiring Doctor to Women's Health Innovator
04:06 Challenges and Triumphs in Women's Health Innovation
07:38 The Founding of AOA DX: A Mission to Transform Women's Health
07:57 Lessons Learned from Successful Exits and Setting Up AOA DX
09:28 AOA DX's Vision and Mission: Advancing Women's Health Diagnostics
12:57 Fundraising Journey: Overcoming Skepticism and Building Trust
15:21 Leveraging Business Development Skills in Fundraising
16:31 Y Combinator Experience and the Value of Community
18:23 Advice for Aspiring Founders in Women's Health
20:29 Future Plans for AOA DX and Personal Aspirations
23:48 Oriana's Reading Recommendations and Closing Thoughts
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This week, I chatted with leadership advisor, speaker, entrepreneur, and podcast host Tony Martignetti, MBA, CPC, Founder, and Chief Inspiration Officer of Inspired Purpose Partners. We both agree there’s a critical need for more comprehensive coaching and support for leaders in the biotech industry. Drawing from his diverse career that spans from art to finance and biotech, Tony shares insights into how leaders can become more grounded. He highlights his three Cs of grounded leadership - Connection, Curiosity, and Compassion - and underscores the significance of mental health, adapting to rapid change, and maintaining authenticity in the workplace. These qualities, he argues, are paramount for building strong companies and navigating the complexities of leadership in fast-evolving sectors like biotech.
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00:00 Introduction to Tony Martignetti: A Multifaceted Leadership Advisor
00:11 The Importance of Leadership Coaching in Biotech
00:57 Tony's Journey: From Childhood Dreams to Leadership Advisory
02:37 The Pivotal Shift: Embracing Leadership Advisory After Burnout
04:42 Addressing Burnout: Personal Insights and Industry Observations
08:06 Navigating Post-Pandemic Challenges and Emphasizing Connection
11:11 The Three Cs of Grounded Leadership: Connection, Curiosity, Compassion
25:17 Incorporating Experience Design in Leadership Coaching
27:58 Campfire Lessons for Leaders: Tony's Book and Vision for the Future
35:44 Final Thoughts and Resources for Aspiring Leaders
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In this episode, Heather E. Williams, PhD, MBA, MS, PgD, ErCLG, CG (ASCP) MB, the Chief Operating Officer of Cache DNA, chats about her career journey and the importance of always learning. Heather's passion for medicine and genetics has led her from childhood dreams of being like Dr. Quinn, Medicine Woman to training as a clinical laboratory geneticist and eventually becoming a COO. She talks about the value of making connections, grabbing every chance to learn, and how genetic results can really make a difference in patient care. Tune in to hear more about Heather's career story and get a sneak peek into what she does at Cache DNA.
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00:00 Introduction and Guest Overview
00:30 Heather's Early Career Aspirations
01:28 Current Role at CacheDNA
02:34 Building and Leading a Team
03:36 Transition to Flagship and Executive MBA
07:27 Gene Between and Endless Frontier Labs
11:28 Networking and Mentorship Insights
21:29 Challenges in Precision Medicine
28:27 Future Goals and Book Recommendations
30:46 Conclusion and Contact Information
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This week, we had a conversation with Catharine Smith - the Executive Director at the Termeer Foundation. Catharine is passionate about supporting biotech founders in growing patient-centric companies. We are thrilled about the Termeer Foundation and have been delighted to witness the Termeer Fellows thrive through the support, training, and community that this organization provides. If you're interested in making a difference in human health through biotech, this episode is definitely for you.
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00:00 Introduction to Catherine Smith and the Termeer Foundation
00:20 Catherine's Early Career and Passion for Healthcare
01:57 Role and Mission of the Termeer Foundation
04:04 Challenges and Support for Early Stage Biotech Leaders
06:56 Day-to-Day Life as Executive Director
08:56 Previous Experience at the Clinton Health Matters Initiative
11:46 The Termeer Fellows Program
13:48 Common Challenges for First-Time Founders
16:36 Global Reach and Diversity in Biotech
23:06 Nonprofit Career Insights and Mentorship
31:31 Future Aspirations and Book Recommendations
34:54 Conclusion and How to Connect with Catherine
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In this episode, we chatted with Isaac Stoner, M.B.A., the CEO of Octagon Therapeutics. Isaac is known for his expertise in building small companies and embarking on adventurous missions such as recovering airplane black boxes (yes, you read that correctly!). He also hosts a science enthusiast networking group in Cambridge, where attendees drink beer and discuss science.
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00:00 Introduction and Background
02:41 Isaac's Early Aspirations and Career Path
05:17 Insight into Octagon Therapeutics
08:20 Company Focus and Structure
13:00 Guidance on Business Operations and Growth
16:13 Networking and Community Building
19:37 Industry Trends and Future Prospects
25:23 Fundraising Strategy and Advice
30:02 Building an Effective Board
34:12 Managing Company Growth and Exit Strategies
38:00 Long-term Plans and Personal Goals
40:10 Book Recommendations and Closing Thoughts
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