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Elevated lipoprotein(a) levels increase the risk of atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis. Cleveland Clinic’s Steven E. Nissen, MD, speaks with JAMA Executive Editor Gregory Curfman, MD, about how zerlasiran produced more than 80% reductions in time-averaged lipoprotein(a) concentration.
Zerlasiran—A Small-Interfering RNA Targeting Lipoprotein(a)
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Preterm birth is the greatest cause of neonatal mortality and morbidity, with infants born extremely preterm at highest risk. Author Brett J. Manley, PhD, the Royal Women’s Hospital, Melbourne, Australia, discusses a new study of the effect of intratracheal corticosteroid administration on survival free of bronchopulmonary dysplasia in preterm infants, with JAMA Deputy Editor Tracy A. Lieu, MD, MPH.
Intratracheal Budesonide Mixed With Surfactant for Extremely Preterm Infants
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Preventing obesity in early childhood is challenging for clinicians and families. Authors Eliana M. Perrin, MD, MPH, of Johns Hopkins University, and William J. Heerman, MD, MPH, of Vanderbilt University, join JAMA Deputy Editor Tracy Lieu, MD, to discuss "A Digital Health Behavior Intervention to Prevent Childhood Obesity: The Greenlight Plus Randomized Clinical Trial."
A Digital Health Behavior Intervention to Prevent Childhood Obesity
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A new study published in JAMA found that drug-related supply chain issue reports were 40% less likely to result in meaningful drug shortages in Canada compared with the US. Authors Kate Suda, PharmD, MS, of University of Pittsburgh School of Medicine, and Mina Tadrous, PharmD, PhD, of University of Toronto, discuss this and more with JAMA Deputy Editor Joseph S. Ross, MD, MHS.
Differences in Drug Shortages in the US and Canada Understanding Drug Supply Shortages in the US and Canada
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In the US, childbirth typically occurs in hospitals or accredited birth centers. President of the American College of Obstetricians and Gynecologists Stella Marie Dantas, MD, speaks with JAMA Deputy Editor Linda Brubaker, MD, MS, about newly proposed advanced birth centers that would permit higher-risk births, with concerns for patient safety and rural obstetric care access.
Advanced Birth Centers and the Effect on Maternity Care
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The Declaration of Helsinki originated in 1964, developed by the World Medical Association (WMA). Process Chair Jack S. Resneck Jr, MD, discusses the 2024 updates to the Declaration of Helsinki with JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS.
Revisions to the Declaration of Helsinki on Its 60th Anniversary World Medical Association Declaration of Helsinki Making the Ethical Oversight of All Clinical Trials Fit for Purpose The Revised Declaration of Helsinki—Considerations for the Future of Artificial Intelligence in Health and Medical Research Revisiting the Declaration of Helsinki—A Patient-Centered Perspective Future-Proofing Research Ethics—Key Revisions of the Declaration of Helsinki 2024 The Revision of the Declaration of Helsinki Viewed From the Americas—Paving the Way to Better Research Declaration of Helsinki—Revisions for the 21st Century Facilitating Efficient and Ethical Trials at the Intersection of Research and Clinical Care The 2024 Revision to the Declaration of Helsinki
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Transfusion strategy for patients with acute brain injury, telehealth care, acute kidney injury after cardiac surgery, and weaning ventilatory support are the topics of 4 trials published in JAMA and presented at the 2024 European Society of Intensive Care Medicine meeting. JAMA Associate Editor Christopher Seymour, MD, MSc, joins Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss.
Shifting Balance of the Risk-Benefit of Restrictive Transfusion Strategies in Neurocritically Ill Patients—Is Less Still More? Evaluating Complex Technological Innovations in Critical Care—Current Challenges and Future Directions Impact of Adsorptive Blood Purification on Kidney Outcomes Ventilator Weaning Strategies—Managing Interaction Between Randomized Treatments Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury Effect of Tele-ICU on Clinical Outcomes of Critically Ill Patients Extracorporeal Blood Purification and Acute Kidney Injury in Cardiac Surgery Frequency of Screening and Spontaneous Breathing Trial Techniques
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Gastric cancer is a leading cause of cancer death globally. Chronic H pylori infection is the primary cause of gastric cancer, responsible for at least 80% of the new cases. Constanza Camargo, PhD, of the National Cancer Institute joins JAMA Associate Editor John M. Inadomi, MD, to discuss co-testing with FIT and H pylori stool antigen to help prevent gastric cancer.
Fecal Immunochemical Test and Helicobacter pylori Stool Antigen Co-Testing Screening for Helicobacter pylori to Prevent Gastric Cancer
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Fever is associated with worse outcomes in patients with stroke, but whether preventing fever improves outcomes is unclear. David M. Greer, MD, MA, speaks with JAMA Associate Editor Jeffrey L. Saver, MD, about fever prevention in patients with acute stroke and its impact on functional outcomes.
Fever Prevention in Patients With Acute Vascular Brain Injury Feasibility of Fever Prevention in Vascular Brain Injury
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The 2024 Lasker–DeBakey Clinical Medical Research Award has been presented for the discovery of GLP-1 and its application to the treatment of obesity. Lasker winner Svetlana Mojsov, PhD, discusses her role in this innovative discovery and more with JAMA Senior Editor Anne Rentoumis Cappola, MD, ScM.
Chemistry Matters—From a Putative Peptide to Effective Treatments for Diabetes and Obesity Discovery of cGAS as a DNA-Sensing Enzyme That Triggers Inflammation GLP-1 for Treating Obesity—Origin, History, and Evolution AIDS in Africa—Impact of Research
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Palliative care is an essential component to high-quality care for patients with cancer. How can access to palliative care be expanded? Eduardo Bruera, MD, from MD Anderson Cancer Center speaks with JAMA Editor in Chief Kirsten Bibbins-Domingo about 2 new trials in JAMA that address access to care and what more it will take for executives, insurers, and regulators to support palliative care programs.
Improving Palliative Care Access for Patients With Cancer Telehealth vs In-Person Early Palliative Care for Patients With Advanced Lung Cancer
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A new trial assessed whether balloon angioplasty plus aggressive medical management was superior to aggressive medical management alone for patients with symptomatic intracranial atherosclerotic stenosis. Author Zhongrong Miao, MD, PhD, from Beijing Tiantan Hospital, discusses the BASIS randomized clinical trial with JAMA Deputy Editor Christopher C. Muth, MD.
Balloon Angioplasty vs Medical Management for Intracranial Artery Stenosis Is Balloon Angioplasty the Future for Intracranial Stenosis?
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The abating COVID-19 pandemic brings attention to rising mortality rates from non-COVID causes in the US, a trend that predates the COVID-19 pandemic. Viewpoint author Steven H. Woolf, MD, MPH, discusses this and more with JAMA Executive Editor Gregory Curfman, MD.
Increasing Mortality Rates in the US, but Not From COVID-19
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Nonhormonal treatments for menopausal vasomotor symptoms may benefit symptomatic patients who cannot take or prefer to avoid systemic hormones. Author JoAnn V. Pinkerton, MD, MSCP, discusses the efficacy and safety of elinzanetant for the treatment of moderate to severe vasomotor symptoms associated with menopause with JAMA Deputy Editor Linda Brubaker, MD, MS.
Elinzanetant for the Treatment of Vasomotor Symptoms Associated With Menopause A New Era in Menopause Management?
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To address the need to characterize long COVID in children and adolescents, the National Institutes of Health funded a pediatric program in the Researching COVID to Enhance Recovery (RECOVER) Initiative. Editorialist Suchitra Rao, MBBS, MSCS, University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora, discusses this and more with JAMA Senior Editor Tracy A. Lieu, MD, MPH.
Uncovering Long COVID in Children Characterizing Long COVID in Children and Adolescents
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A new study looks at uterus transplant to determine if it is safe, feasible, and results in births of healthy infants. Editorialist Emily Jungheim, MD, MSCI, Northwestern University, discusses this innovative treatment with JAMA Deputy Editor Linda Brubaker, MD, MS.
Uterus Transplant—The Frontier of Innovative Fertility Treatment Uterus Transplant in Women With Absolute Uterine-Factor Infertility
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Ten percent of US adolescents use e-cigarettes, and many want to quit. However, evidence on the effectiveness of vaping cessation interventions is lacking. Amanda L. Graham, PhD, of the Truth Initiative discusses with JAMA Senior Editor Tracy Lieu, MD, MPH, how a tailored, interactive text message intervention increased vaping cessation among adolescents recruited via social media channels.
A Vaping Cessation Text Message Program for Adolescent E-Cigarette Users Supporting Adolescents’ Desire to Quit E-Cigarettes What Are E-Cigarettes? Variability in Constituents of E-Cigarette Products Containing Nicotine Analogues E-Cigarette Use in Adults Controversial FDA Decision Authorizes Menthol-Flavored E-Cigarettes Despite Risks to Youth Vaping in Youth E-Cigarette Use in Adolescents and Adults—A JAMA Collection
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Gestational age estimation is foundational for obstetric care. In resource-limited settings, an integrated AI tool allows novice users to improve gestational age estimates. Author Jeffrey Stringer, MD, University of North Carolina, joins JAMA Deputy Editor Linda Brubaker, MD, MS, to discuss Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age From Blind Ultrasound Sweeps.
Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age From Blind Ultrasound Sweeps Enhancing Obstetric Ultrasonography With Artificial Intelligence in Resource-Limited Settings
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Biomarkers for Alzheimer disease (AD) provide insight into disease processes and may aid clinical diagnosis for individuals with cognitive impairment. Author Stephen Salloway, MD, MS, of Brown University joins JAMA Deputy Editor Christopher Muth, MD, to discuss 2 articles and an accompanying editorial about blood biomarkers for AD and potential implications for clinical practice.
Are Blood Tests for Alzheimer Disease Ready for Prime Time? Blood Biomarkers to Detect Alzheimer Disease in Primary Care and Secondary Care Changes in Alzheimer Disease Blood Biomarkers and Associations With Incident All-Cause Dementia
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Ulcerative colitis can significantly decrease quality of life. A third of patients have persistent symptoms with tumor necrosis factor inhibitors and nearly 1 in 5 patients will be hospitalized within 5 years of diagnosis. Author Gilaad G. Kaplan, MD, MPH, of the University of Calgary joins JAMA Associate Editor John M. Inadomi, MD, to discuss Risankizumab for Ulcerative Colitis.
Monoclonal Antibody Risankizumab for Ulcerative Colitis Risankizumab for Ulcerative Colitis
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