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In this episode of Longevity By Design, Dr. Layne Norton, Founder of BioLayne and Carbon app, joins Gil Blander to discuss optimizing nutrition and fitness for a longer, healthier life. Layne emphasizes the importance of prioritizing scientific evidence over popular narratives, highlighting how easily isolated studies can be misinterpreted. He stresses the power of personalized approaches to nutrition and fitness, advocating for a critical approach to information consumption.
Layne dives into the complexities of protein intake, challenging common misconceptions. He advocates for a protein intake above the recommended daily allowance, stressing the role of muscle mass in overall health and longevity. Layne explains the importance of resistance training, even for older adults, to maintain muscle mass and reduce fall risk. He advocates for finding enjoyment in exercise, stressing that passion fuels consistency.
Beyond physical health, Layne underscores the impact of mental health on longevity. He discusses the detrimental effects of stress, provides practical stress management tips, and encourages healthy boundaries. Layne’s holistic approach highlights lifestyle factors, nutrition, training, and stress management , as key drivers of a longer, healthier lifespan.Guest-at-a-Glance
💡 Name: Dr. Layne Norton
💡What they do: Owner of BioLayne
💡Company: BioLayne and the Carbon app
💡Noteworthy: Nutrition scientist, fitness expert, and evidence-based educator bridging the gap between science and application.
Episode highlights:
[00:00:52] Introduction to Longevity By Design
[00:01:03] Meet Dr. Layne Norton
[00:02:00] Layne's Academic Journey
[00:03:48] Choosing the Right Advisor
[00:06:56] The Importance of Critical Analysis in Research
[00:10:00] Transitioning from Academia to Public Communication
[00:11:29] The Role of Social Media in Science Communication
[00:13:33] Launching a Podcast and Future Plans
[00:17:09] Understanding Risk and Misconceptions in Health
[00:22:59] The Importance of Protein in Aging
[00:41:50] Protein Consumption for Non-Daily Lifters
[00:43:07] Debunking the Protein Timing Myth
[00:45:31] Protein Distribution and Muscle Growth
[00:50:09] Resistance Training for Older Adults
[00:53:45] The Importance of Recovery and Sleep
[00:56:15] Managing Psychological Stress
[01:01:31] Wearable Data and Subjective Feelings
[01:04:42] The Impact of GLP-1 Agonists on Weight Loss
[01:09:47] Supplements for Health and Longevity
[01:13:32] AI in Health and Wellness
[01:14:46] Advice for Different Life Stages
[01:17:45] Top Tips for Health and LongevityWe Appreciate You!
As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast
For science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast -
On this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Evelyne Bischof, President of the Healthy Longevity Medicine Society. Evelyne discusses her background in internal medicine and oncology and how her work puzzling together patient diagnoses led her to the field of longevity medicine. She highlights the importance of optimizing health span, not just lifespan, and how healthy longevity medicine benefits not only individuals, but population health and the world economy as well.
Gil and Evelyne explore the difference between longevity medicine and traditional healthcare. Evelyne explains that longevity medicine uses a broader range of diagnostics, including advanced biomarkers, imaging, and cognitive tests. This approach aims to build a personalized health trajectory for each patient. They also discuss the role of AI in healthcare, with Evelyne expressing hope for faster, AI-driven diagnostics and drug discovery in the future.
Finally, they touch upon the Healthy Longevity Medicine Society, its mission to establish longevity medicine as a recognized medical discipline, and the exciting developments in the field, such as the SHARP study at the Sheba Longevity Center. Evelyne emphasizes the importance of being data-driven and encourages listeners to collect and track their own health data. She believes this empowers individuals to make informed decisions about their health and longevity.Guest-at-a-Glance
💡 Name: Dr. Evelyne Bischof
💡What they do: President
💡Company: Healthy Longevity Medicine Society (HLMS)
💡Noteworthy: Physician-scientist specializing in longevity and precision medicine.
💡 Where to find her:LinkedIn
Episode highlights:
[00:01:24] Meet Dr. Evelyne Bischof
[00:05:12] The Concept of Longevity Medicine
[00:08:42] Health Span vs. Lifespan
[00:11:39] The Role of Diagnostics in Longevity Medicine
[00:22:54] Global Landscape of Longevity Medicine
[00:29:50] Collaborations and Growth Initiatives
[00:30:30] Monthly Case Studies and Activities
[00:31:27] Membership and Target Audience
[00:34:42] Organizational Structure and Leadership
[00:39:52] Shiba Longevity Center Overview
[00:45:22] Future of Longevity Medicine
[00:50:27] Top Healthspan Tips and Final ThoughtsWe Appreciate You!
As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast
For science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast -
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In this episode of Longevity by Design, our host, Dr. Gil Blander talks with Dr. Renee Deehan and Paul Fabian about Inside Tracker's new Healthspan Habits Score feature. This innovative tool analyzes data from wearable devices and daily journal entries to identify the most impactful habit to improve each week for better health span and longevity.
The guests explain how the algorithm processes up to 15 different variables, including sleep quality, step count, and lifestyle factors to create a personalized weekly score. Rather than overwhelming users with multiple recommendations, the report focuses on one key habit to change, applying behavioral science principles for sustainable improvement.
Deehan and Fabian detail how the system evaluates six weeks of data to identify trends and provide targeted recommendations, helping users bridge the gap between blood tests with actionable weekly guidance based on scientific research linking these habits to longevity outcomes.
Guest-at-a-Glance
💡 Name: Dr. Renee Deehan
💡 What she does: Senior Vice President of Science and Artificial Intelligence
💡 Company: InsideTracker
💡 Noteworthy: Expert in precision health with a PhD from UC Berkeley
💡 Where to find her:LinkedIn
Guest-at-a-Glance
💡 Name: Paul Fabian
💡 What he does: Researcher
💡 Company: InsideTracker
💡 Noteworthy: Specializes in genetics, exercise biomarkers, and data-driven health recommendations
💡 Where to find him:LinkedIn
Episode highlights:
Introduction to Healthspan and Lifespan 00:00:00
Meet the Experts: Dr. Renee Dhan and Paul Fabian 00:01:07
Paul Fabian's Journey to Science 00:03:24
Introducing the Health Span Habits Core Tool 00:04:31
Inspiration Behind the Health Span Habits Core 00:05:07
How the Health Span Habits Core Works 00:06:40
Personalized Health Recommendations 00:08:02
How does Insight Tracker turn intent into action 00:10:16
How the Health Span Habit Score is Calculated 00:13:25
The Importance of Bedtime Consistency 00:22:00
Behavioral Science in Health Tracking 00:25:35
User Feedback and Future Directions 00:31:38
Final Thoughts and Tips for Longevity 00:42:20We Appreciate You!
As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast
For science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast -
Dr. Gil Blander welcomes Dr. Daniel Durand, Chief Medical Officer at Prenuvo, to Longevity by Design for a deep dive into the future of preventative healthcare. Dr. Durand shares how full-body MRI is redefining early detection by making advanced imaging accessible, non-invasive, and radiation-free. He explains why MRI, as a soft tissue imaging modality, offers unmatched insight into early-stage cancers and chronic conditions.
The conversation unpacks misconceptions around overdiagnosis and false positives, challenging the idea that “not knowing” is safer. Dr. Durand outlines how AI-enhanced imaging, paired with structured follow-up care, reduces unnecessary biopsies and improves diagnostic accuracy. He also discusses the emotional and systemic costs and benefits of proactive screening.
Looking ahead, Dr. Durand envisions a healthcare model built on data, personalization, and patient empowerment. He argues that gathering better information, earlier, will shift the focus from treatment to prevention and help more people maintain peak health for longer.Guest-at-a-Glance
💡 Name: Dr. Daniel Durand
💡What he does: Chief Medical Officer
💡Company: Prenuvo
💡Noteworthy: Leader in radiology innovation and early detection through full-body MRI.
💡 Where to find him: LinkedIn
Episode highlights:
Introduction to MRI and Its Advancements 00:00:00
Welcome and Guest Introduction 00:00:59
Dr. Durand's Career Journey 00:02:07
Choosing Radiology and MRI 00:03:09
The Future of Radiology and AI 00:04:48
Early Detection and Preventative Health 00:11:21
The Patient Experience at Pvo 00:29:27
Capabilities and Benefits of MRI 00:35:47
Liquid Biopsy vs. Whole Body MRI 00:44:00
Combining Diagnostic Methods 00:46:31
Colonoscopy and MRI: Complementary Tools 00:48:30
Risks and Benefits of Full Body MRI 00:51:28
Addressing Concerns and Criticisms 00:54:37
Patient Empowerment and the Future of Diagnostics 00:55:44
Emotional Impact of Diagnostic Information 00:57:00
Consultation and Communication with Patients 01:01:14
Technological Innovations in MRI 01:05:07
Target Audience for Full Body MRI 01:10:52
Future of Healthspan and Longevity 01:16:18We Appreciate You!
As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast
For science-backed ways to live a healthier, longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast -
In this episode of Longevity by Design, host Dr. Gil Blander welcomes Dr. Eran Segal, Professor at the Weizmann Institute of Science, to explore the intersection of artificial intelligence (AI) and personalized health. The conversation dives into how AI and machine learning are transforming our understanding of nutrition, disease prediction, and overall longevity. Eran provides a clear overview of AI, machine learning, and deep learning, explaining how these technologies can be applied to various health domains.
Eran discusses the potential of AI agents in healthcare, such as scheduling appointments, managing medications, and even creating personalized dietary recommendations. He highlights the importance of data in training AI models, noting that the healthcare industry lags behind in publicly available and diverse data sets. The 10K Initiative, a project Eran leads, aims to address this issue by collecting comprehensive data on individuals to build more holistic AI models for personalized health.
Gil and Eran consider the future, envisioning AI-powered digital twins that can simulate the impact of lifestyle changes on disease development. While AI offers exciting possibilities, Eran cautions against over-reliance, emphasizing the need for continued human oversight and validation. He reiterates that the foundation of longevity still relies on simple habits: sleep well, eat well, and exercise regularly.Guest-at-a-Glance
💡 Name: Dr. Eran Segal
💡What they do: Professor
💡Company: Weizmann Institute of Science
💡Noteworthy: Computional biologist revolutionizing precision medicine with AI and personalized nutrition.
💡 Where to find them: LinkedIn
Episode highlights:
Meet Dr. Eran Sega: 00:01:19
Eran's Journey to Becoming a Scientist: 00:02:25
Understanding Personalized Nutrition: 00:04:40
The Link Between Nutrition and Longevity: 00:07:02
Introduction to AI and Machine Learning: 00:08:07
Deep Learning and Generative Models Explained: 00:10:09
The Revolution of Large Language Models (LLMs): 00:13:42
Practical Use Cases of AI Tools: 00: 19:12
The Future of Programming with AI: 00:23:54
The Rise of AI Agents: 00:28:20
AI in Health and Wellness: 00:29:27
Exploring the Best Uses of LLM and ChatGPT: 00:33:23
Real-World Examples of LLM Applications: 00:34:23
Limitations and Risks of LLM Technology: 00: 36:08
Comparing ChatGPT with Other LLM Tools: 00:39:01
Generative AI in Healthcare: Applications and Limitations: 00:39:57
The 10K Initiative: Revolutionizing Health Data: 00:45:31
Future Applications of LLM in Personalized Health: 00:49:19
Looking Ahead: The Future of AI and Healthcare: 00:56:11
Key Takeaways for Health and Longevity: 00:58:10For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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Dr. Gil Blander and Ashley Reaver dive into the science behind GLP-1 agonists, a class of drugs originally developed for type 2 diabetes but now widely used for weight management and longevity. They explore how these medications work, their effects on appetite, metabolism, and inflammation, and why they might be a game-changer for cardiovascular health, brain function, and fertility. While promising, they emphasize the importance of long-term research and consulting with medical professionals before considering these treatments.
The conversation shifts to the role of wearables in health tracking. Gil shares insights on devices like the Apple Watch, Oura Ring, and Whoop, highlighting their capabilities in tracking sleep, fitness, illness detection, and fall prevention—especially for older adults. They break down how different wearables cater to specific needs and the future of personalized health monitoring.
As the science of longevity evolves, Gil and Ashley stress the importance of staying informed, making data-driven decisions, and using technology wisely. Whether through cutting-edge pharmaceuticals or smart wearables, optimizing health is now more accessible than ever.
Host-at-a-Glance💡 Name: Gil Blander
💡What he does: Founder and CSO
💡Company: InsideTracker
Host-at-a-Glance
💡 Name: Ashley Reaver
💡What she does: Lead Nutrition Scientist
💡Company: InsideTracker
Episode highlights:
[00:00:00] Introduction
[00:02:02] Understanding GLP-1 Hormones
[00:04:26] GLP-1 Receptor Agonists: Mechanism and Benefits
[00:06:50] Impact of GLP-1 on Weight and Health
[00:21:16] Side Effects and Considerations of GLP-1 Agonists
[00:26:31] The Future of GLP-1 Agonists
[00:34:54] Exploring Wearables for Health
[00:36:08] Choosing the Right Wearable
[00:40:29] Wearables for Detecting Illness and Falls
[00:47:12] Conclusion and Final ThoughtsKey Insights
GLP-1 Agonists: A Breakthrough for Weight and Metabolic Health
GLP-1 agonists, originally developed for type 2 diabetes, have become a game-changer for weight loss, appetite control, and longevity. These drugs mimic natural gut hormones that regulate hunger and insulin secretion, helping people feel full longer and stabilizing blood sugar levels. Studies show that GLP-1 agonists can reduce body weight by up to 25%, a level comparable to bariatric surgery. Beyond weight management, these drugs may lower inflammation, improve cardiovascular health, and even reduce the risk of certain cancers. However, long-term use is likely necessary, as stopping the medication often leads to weight regain. Gil and Ashley emphasize the importance of medical supervision and highlight ongoing research into how GLP-1 impacts cognitive function and fertility.Wearables: The Future of Personalized Health Tracking
Wearables are reshaping how individuals monitor their health from fitness to disease prevention. Gil and Ashley break down Apple Watch, Oura Ring, and Whoop, each catering to different needs. Apple Watch excels at fall detection and emergency response, making it ideal for older adults. Oura Ring provides early illness detection through temperature and heart rate variability tracking. Whoop is favored by athletes for its detailed recovery insights and sleep monitoring. Wearables aren’t just for data collection—they drive behavior change, encouraging users to improve sleep, exercise, and stress management. With AI-driven health coaching on the rise, the hosts predict that wearables will play a central role in proactive healthcare and longevity strategies.
For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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In this episode of Longevity by Design, host Dr. Gil Blander welcomes Dr. Gabrielle Lyon, a board-certified family physician and New York Times bestselling author of Forever Strong. Gabrielle discusses the growing epidemic of sarcopenia, the loss of muscle mass and strength, accelerated by the use of GLP-1 medications. She emphasizes the importance of muscle health for overall longevity and introduces the concept of "muscle span."
Gil and Gabrielle explore the critical role of skeletal muscle as a metabolically active organ, its impact on longevity, and the best ways to build and maintain muscle throughout life. They delve into the public's misconception of prioritizing today's needs over tomorrow's health, highlighting the need for preventative measures like strength training. The conversation touches upon the complexities of protein consumption, emphasizing the importance of meeting daily protein goals and the often-overlooked nutritional needs for healthy aging.
Finally, they address common misconceptions regarding hormone replacement therapy and the importance of prioritizing muscle-centric medicine. This episode offers actionable insights and valuable knowledge for anyone seeking to optimize their health and longevity through a deeper understanding of muscle health.Guest-at-a-Glance
💡 Name: Dr. Gabrielle Lyon
💡What they do: N/A
💡Company: Dr. Gabrielle Lyon
💡Noteworthy: Physician and New York Times bestselling author specializing in muscle-centric medicine and longevity.
💡 Where to find them: LinkedIn, InstagramEpisode highlights:
[01:09] Meet Dr. Gabrielle Lyon
[06:09] The Importance of Muscle Health
[09:37] Writing and Impact of 'Forever Strong'
[14:45] The Role of Skeletal Muscle
[21:54] Building and Maintaining Muscle
[26:40] The New Epidemic: Muscle Loss
[30:22] Optimizing Health with InsideTracker
[39:41] The Importance of Healthy Skeletal Muscle
[43:03] The Reality of Aging and Taking Action
[45:43] Hormone Replacement Therapy: A Controversial Topic
[53:52] Understanding Dietary Protein
[01:00:23] Protein Consumption and Distribution
[01:03:33] The Role of Animal-Based Products in Human Health
[01:15:55] Supplements for Muscle Building and Health
[01:17:51] Top Tips for Health Span and LongevityFor science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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On this episode of Longevity by Design, Dr. Gil Blander speaks with Dr. Michael Ringel, COO of Life Biosciences, about the science of aging and longevity. Michael discusses how evolution influences lifespan and why aging occurs. He explains the trade-off between resource allocation for reproduction versus maintenance and repair within the body. Caloric restriction and its effects on lifespan are explored through an evolutionary lens.
Michael highlights the challenges and breakthroughs in longevity research. He touches upon the role of genetics and pharmaceuticals in manipulating lifespan and healthspan. He points to the Pacific rockfish as an example of varying lifespans within a closely related group of species, demonstrating the genetic component of aging. He also notes the impact of Cell reprogramming, referencing a study on how specific Cell reprogramming can regenerate optic nerves.
The conversation shifts to the business of longevity, where Michael discusses the increased interest and investments from big pharma and billionaires. He examines the economic benefits of extending healthspan, citing a potential value of $300 trillion from a 10-year healthspan extension in the US alone. Michael and Gil also explore the importance of lifestyle choices for healthy aging, emphasizing diet, exercise, sleep, stress management, and social connections.Guest-at-a-Glance
💡 Name: Dr. Michael Ringel
💡What they do: COO
💡Company: Life Biosciences
💡Noteworthy: Biotechnology COO bridging science and business for longevity breakthroughs.
💡 Where to find them: LinkedIn
Episode highlights:
[00:00:56] Meet Dr. Michael Ringel
[00:02:30] Journey to Becoming a Scientist
[00:04:26] Interest in Longevity and Aging
[00:07:59] Evolution and Aging
[00:21:04] Caloric Restriction and Lifespan
[00:25:07] InsideTracker: Personalized Healthspan Optimization
[00:26:02] Pharma's Role in Aging Research
[00:37:32] Understanding Causality in Medical Research
[00:38:09] Challenges of Observational Studies
[00:39:40] Experimental Studies and the TAME Trial
[00:40:21] Pharmaceutical Incentives and Metformin
[00:40:56] Exploring Rapalogs and Patent Issues
[00:43:39] Hallmarks of Aging and Future Prospects
[00:45:59] Investment in Aging Research
[00:52:35] Economic and Social Impacts of Longevity
[01:02:30] Practical Tips for Extending Lifespan
For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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In this episode of Longevity by Design, Dr. Gil Blander sits down with Dr. Jay Olshansky, a leading professor at the University of Illinois Chicago and a renowned expert in aging and biodemography. Together, they delve into the science of longevity, exploring how public health advancements in the 20th century revolutionized life expectancy and what lies ahead in the quest to extend both lifespan and healthspan.
Dr. Olshansky unpacks the biological limits of human longevity, shedding light on why life expectancy gains are slowing despite medical advancements. He explains the interplay between genetics, lifestyle choices, and aging, emphasizing how societal factors like inequality and access to healthcare impact longevity outcomes. Key concepts like "life table entropy" reveal why breakthroughs in aging science are essential to push beyond the current boundaries.
Tune in to gain actionable insights on diet, exercise, and monitoring health—all crucial for maximizing healthspan, regardless of your genetic blueprint.Guest-at-a-Glance
💡Name: S. Jay Olshansky, Ph.D.
💡What he does: Professor at the University of Illinois Chicago School of Public Health
💡Company: University of Illinois Chicago
💡Noteworthy: Expert in aging, biodemography, and the biological limits of longevity.
💡Where to find them: LinkedIn
Episode highlights:
Introduction: 00:00:00Dr. Olshansky book: 00:05:40What was the lifespan 100 years ago and what is it today?
: 00:08:00Average vs longer lifespan: 00:19:00Death rate at extreme old ages: 00:22:00What can break the lifespan ceiling?: 00:26:27What are the chances of someone living up to 120 years old?: 00:28:00Disparities in Longevity: The Social Determinants of Health: 00:32:00GLP-1 as a longevity drug: 00:37:00Why women live longer than men: 00:41:00How does becoming a U.S. president impact lifespan and healthspan?: 00:46:00How long can our listeners aim to live?: 00:50:00What are the key milestones in longevity discoveries over the past few decades?: 00:55:00What is your top tip for a health span and longevity: 01:15:33For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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Can personalized medicine unlock the secrets to living longer and healthier lives? In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. David Barzilai, a renowned longevity physician and founder of Barzilai Longevity Consulting, to explore the science of extending healthspan through precision and innovation.
Dr. Barzilai shares his journey into biogerontology and longevity science, unpacking key concepts like the hallmarks of aging, the potential of lifestyle interventions, and the translation of findings from animal models to human health. He highlights how evidence-based lifestyle medicine—centered on nutrition, exercise, sleep, and stress management—can be tailored to individual needs using biomarker-driven strategies for maximum impact.
The conversation delves into some of the most promising longevity interventions, from gerotherapeutics to cutting-edge supplements. Dr. Barzilai emphasizes the power of personalized approaches in optimizing healthspan and lifespan, offering listeners practical, science-backed insights to take charge of their longevity journey.
Engaging and informative, this episode is essential listening for anyone curious about the future of longevity medicine and the innovations shaping how we age.
Guest-at-a-Glance
💡 Name: Dr. David Barzilai, MD, PhD
💡What he does: Founder and CEO
💡Company: Healthspan Coaching LLC
💡Noteworthy: Renowned longevity physician integrating science and personalized health strategies.
💡 Where to find them: LinkedIn, TwitterEpisode highlights:
Introduction: 00:00:00Dr. Barzilai’s Journey into Science: 00:03:43The Importance of Translating Science into Practice: 00:10:00The Role of Social Media in Longevity Science: 00:16:37Defining Biogerontology: 00:22:32Understanding the Hallmarks of Aging: 00:24:27The Role of Lifestyle Medicine in Preventing Premature Mortality: 00:36:13Caloric Restriction and Its Effects on Lifespan: 00:37:33Human Trials and the Challenges of Compliance: 00:41:13The Potential of Rapamycin and mTOR Inhibitors: 00:42:05The Importance of Lifestyle Medicine: 00:51:25Precision Medicine: Tailoring Health Interventions: 01:02:56GLP-1 and Alcohol Absorption: 01:12:30Exercise and Mortality Reduction: 01:15:33Biomarkers and Metabolic Health: 01:19:38Longevity Drugs and Supplements: 01:25:43Epigenetic Reprogramming and Aging: 01:45:06For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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On this episode of Longevity by Design, Dr. Gil Blander hosts Dr. Dmitriy Richard Starson, Founder and CEO of Passio, an AI-powered nutrition coaching platform. Dmitriy discusses his career path from astrophysics to the world of nutrition tracking. He explains how his company seeks to make healthy eating more accessible. Passio aims to achieve this through user-friendly technology like food scanning, voice logging, and personalized AI coaching.
Introduction: 00:00:00From Astrophysics to Nutrition: An Unlikely Journey?: 00:06:00The Power of AI in Food Logging: 00:11:00The "Human" Factor: Addressing Challenges with Data Accuracy: 00:22:00AI and the Healthcare System: A Balancing Act?: 00:45:00Top tip to improve healthspan: 00:50:00
Dmitriy believes this technology will revolutionize how people approach nutrition. He envisions a future where food tracking is as commonplace as step tracking. This shift, combined with insights from companies like InsideTracker, could lead to personalized nutrition and supplementation plans. Such advances have the potential to slow or even reverse aging and age-related diseases.
While acknowledging the influence of the food industry, Dmitriy remains optimistic. He sees a future where individuals have the knowledge and tools to make informed decisions about their health. Through personalized nutrition and data-driven insights, people can optimize their health and work toward increased longevity.
Episode highlights:We Appreciate You!
As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast
For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast -
In this episode of Longevity by Design, our host Dr. Gil Blander welcomes Dr. Aubrey de Grey, a biomedical gerontologist, to explore the frontiers of aging research and lifespan extension. Dr. de Grey shares his work identifying and addressing the seven major categories of aging-related diseases. He discusses how targeted damage repair offers a promising alternative to traditional methods to slow aging, providing a path to longer, healthier lives.
The conversation delves into the hallmarks of aging, their implications for medical research, and the challenges of translating results from animal models to human applications. Dr. de Grey emphasizes the importance of combining multiple interventions, such as senolytics, gene therapy, and stem cell treatments, to achieve significant gains in lifespan. He also shares insights from his work with the LEV Foundation and the Methuselah Foundation.
Listeners will gain a deeper understanding of the science behind rejuvenation and the potential for humanity to reach longevity escape velocity within the coming decades. Dr. de Grey underscores the critical role of continued research, innovation, and funding in accelerating progress toward defeating aging-related diseases.Episode highlights:
Introduction: 00:00:00The Seven Hallmarks of Aging: A Foundational Framework: 00:07:00Challenges in Funding Longevity Research: 00:15:00Lifestyle, Genetics, and the Limits of Current Longevity: 00:23:00The Methuselah Foundation and Early Longevity Advocacy: 00:37:00Top tip to improve healthspan: 00:52:00We Appreciate You!
As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast
For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast -
On this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. John Erdman to discuss prostate cancer and the impact of diet on disease progression. John shares his personal connection to this disease and why he’s dedicated his research to understanding dietary interventions.
John explains that prostate cancer is often slow-growing, with most men experiencing decades between early mutations and noticeable tumor growth. He stresses the importance of early detection through regular checkups, including digital exams and PSA tests. While the medical community debates the effectiveness of these tests, John advocates for establishing a baseline to monitor for any sudden changes.
John's research reveals a strong link between tomato consumption and reduced prostate cancer risk. He believes this protective effect stems from lycopene and its metabolites, which may influence gene expression. John emphasizes that while tomato consumption shows promise, maintaining a healthy weight and regular exercise are equally crucial for long-term health.
Episode highlights:
Introduction: 00:00:00The Stages and Progression of Prostate Cancer: 00:06:00Diagnosing Prostate Cancer: Methods and Considerations: 00:11:00The Role of Specific Foods in Prostate Cancer Risk Reduction: 00:22:00Exploring the Link Between Gut Microbes and Prostate Cancer: 00:30:00Top tip to improve healthspan: 00:34:00
For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast -
In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Jens Juul Holst, a renowned Danish physician and physiologist, to discuss GLP-1, a hormone transforming our understanding of metabolic health. Dr. Holst, who discovered and described GLP-1, explains its role as a gut-derived hormone that regulates appetite, insulin secretion, and digestion, offering a groundbreaking approach to managing obesity and type 2 diabetes.
The conversation explores how GLP-1 receptor agonists, have evolved into powerful medications. These drugs help patients achieve significant weight loss, reverse diabetes, improve cardiovascular health, reduce inflammation, and potentially enhance cognitive function. Dr. Holst delves into their long-term implications for preventing diabetes, extending health spans, and even reducing the risks of obesity-related cancers and improving fertility.
Dr. Holst emphasizes that while GLP-1 offers life-changing benefits, sustainable health still hinges on balanced diets and regular physical activity. This episode provides a fascinating look at the intersection of science, medicine, and lifestyle in promoting longevity.
Introduction: 00:00:00What is GLP-1: 00:03:00what is a GLP-1 agonist: 00:04:15what are the target organs of the GLP-1 agonist?: 00:06:30what is the effect of the GLP-1 agonist on a diabetic patient?
Episode highlights:
: 00:10:00What percentage of a diabetic patient on GLP-1 have complete remission: 00:11:30How long did it take to bring a drug to market from the moment you first discovered it: 00:23:30What is the GLP-1 effect on cognition and dementia: 00:29:00GLP-1 effect on kidney diseases: 00:32:00GLP-1 positive effect on fertility: 00:35:00GLP-1 positive effect on cancer: 00:37:30Should a patient be on GLP-1 for life: 00:41:00GLP-1 related side effects: 00:48:00GLP-1 effect on resting heart rate: 00:52:30GLP-1 related side effects: 00:48:00GLP-1 from Lilly vs novo nordisk: 00:55:00GLP-1 oral versus the injectable: 00:58:00GLP-1 effect on lifespan: 01:00:30GLP-1 effect on lifespan: 01:00:30What led you to become a scientist: 01:03:00The story of discovering the GLP-1: 01:04:30How did you successfully extend the half-life of the GLP-1 agonist: 01:09:00GLP-1 moving from once a day to once a week: 01:16:00Top tip to improve healthspan: 01:18:00GLP-1 Agonists: A Game-Changer for Diabetes and Obesity
Dr. Jens Juul Holst explores the revolutionary impact of GLP-1 agonists in treating diabetes and obesity. These medications mimic a natural gut hormone to regulate insulin secretion, appetite, and weight. Through their ability to normalize blood glucose levels and promote significant weight loss, GLP-1 agonists have transformed the lives of patients with type 2 diabetes and obesity. Holst highlights their success in enabling over 50% of diabetes patients to achieve normal glucose levels while addressing the systemic health risks tied to obesity. This innovation represents a monumental leap in metabolic disease management.
For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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Episode highlights:
Introduction: 00:00:00Why have you decided to become a scientist: 00:02:30What is fermentation: 00:07:45What microbes are involved in fermentation: 00:08:40How those microbes get into the fermented food: 00:09:35When the Humankind started to utilize fermentation: 00:11:20What is the difference between Probiotics and Live Cultures: 00:15:15What are the benefits of fermented food consumption: 00:17:43What foods are produced through lactic acid fermentation, and what are the best methods for making them at home: 00:23:10What is the positive effect of fermented foods on inflammation: 00:29:18What impact do fermented foods have on longevity: 00:32:10What are Postbiotics: 00:35:05Top tip for healthspan: 00:44:20Not all Fermented Foods Are Equal
While many cultures around the world have enjoyed the benefits of fermented foods for centuries, modern consumers need to be savvier about what they’re buying. Just because a food is fermented or contains live cultures doesn’t mean it offers proven health benefits. The term "probiotics" is specifically defined and requires scientific evidence to support health claims, so don’t be afraid to read labels carefully and choose fermented foods backed by research.
Lactic Acid Fermentation May Be a Key Player in Health
While there are many types of fermentation, lactic acid fermentation, which is responsible for foods like yogurt, kimchi, and sauerkraut, is of particular interest to researchers. Early studies show promising links between consuming lactic acid-fermented foods and positive impacts on gut health, immune function, and even potentially longevity. The specific mechanisms are still being investigated, but it seems these foods offer more than just interesting flavors.
Scientists Are Unlocking the Power of Postbiotics
Scientists are going beyond probiotics and exploring the potential of “postbiotics” – those beneficial compounds produced by bacteria during fermentation. These metabolites may hold the key to unlocking even more targeted health benefits from fermented foods. Dr. Allen and Dr. Miller’s research on aryl lactates, for instance, suggests that some postbiotics could help modulate immune responses and address inflammation. This area of study is rapidly evolving and offers an exciting frontier in food science and human health.
The History and Significance of Fermentation
Long before refrigeration, humans discovered the magic of fermentation. This process, dating back thousands of years, involves harnessing the power of microbes to transform food. What began as a way to preserve food has evolved into an art form, with diverse cultures developing unique fermentation traditions that add flavor and depth to their cuisines.
"A lot of these fermentation practices keep foods for a much longer period of time without refrigeration and we did not have refrigeration until 100 years ago." - Dr. Jacob AllenUnderstanding the Difference: Probiotics vs. Live Cultures
While often used interchangeably, “probiotics” and “live cultures” have distinct meanings. Probiotics refer to specific strains of live microorganisms scientifically proven to provide health benefits when consumed in adequate amounts. In contrast, “live cultures” indicate the presence of live microbes in food but don't guarantee specific health benefits without further research.
“Probiotics are things that have documented clinical evidence. Live cultures, on the other hand, are you eating live microorganisms.” - Dr. Mike MillerWe Appreciate You!
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On this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Yanina Pepino, Professor of Ingestive Behavior at the University of Illinois, to discuss the fascinating link between taste, personal preferences, and long-term health. Yanina's research shows our food environment significantly shapes cravings. This exposure starts as early as the womb, impacting future preferences.
Yanina explains that bariatric surgery and GLP-1 medications are powerful tools for weight management. However, she emphasizes the importance of using these interventions as opportunities to adopt healthier eating habits. She highlights the potential of GLP-1 agonists as a treatment for alcohol use disorder, noting their ability to reduce alcohol cravings.
The conversation also explores the impact of non-nutritive sweeteners. While generally considered safe, Yanina's research suggests that these sweeteners may have metabolic effects. She encourages listeners to be mindful of their intake and to prioritize natural sugars in moderation.Episode highlights:
Introduction: 00:00:00Why have you decided to be a scientist: 00:03:40How did you get interested in the taste & smell preference in humans: 00:04:40The Impact of Maternal Alcohol Consumption During Pregnancy on Newborn Alcohol Preferences: 00:06:00What you consume during pregnancy can influence your newborn’s preferences: 00:08:00What Are the Individual Differences in Human Taste: 00:08:20Do you know if taste perception is influenced by an individual’s specific macro- and micronutrient needs: 00:14:00What are the effects of bariatric surgery-induced weight loss on flavor perception, eating behavior, and alcohol drinking: 00:16:00The Impact of GLP-1 Drug Use on flavor perception: 00:26:45The Impact of lifestyle-related Weight Loss on flavor perception: 00:30:10The Negative Impact of Alcohol Consumption on Bariatric Surgery Patients: 00:34:30The potential positive impact of GLP-1 injection on Alcohol Consumption: 00:39:30What Is the Effect of Non-Caloric Sweeteners on Post-Meal Glucose Spikes and Health: 00:41:30Bitter taste and why some of us don't like it: 00:52:00Lessons from the COVID-19 Pandemic on Taste and Smell Perception: 00:54:30Yanina's top tip for healthspan: 00:42:10Early Taste Exposure Shapes Lifelong Preferences
What we eat during pregnancy and infancy might pre-program a child's future food preferences. Yanina's research reveals that exposure to flavors, even in the womb, can influence what we enjoy eating later in life. This highlights the importance of establishing healthy eating patterns from the very beginning, as those early experiences can have lasting effects. Parents and caregivers have a powerful role in shaping those early preferences for a healthier future generation.
Bariatric Surgery and GLP-1 Offer a Chance to "Reset"
Both bariatric surgery and GLP-1 medications are not just quick fixes, but opportunities to rewire your relationship with food. While these interventions can significantly impact hunger hormones and promote weight loss, their long-term success relies on behavioral change. Yanina stresses the importance of using this period of altered appetite to explore new, healthier food choices and establish lasting dietary habits.
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In this special "Ask Me Anything" episode of the Longevity by Design podcast, Ashley Reaver and Dr. Gil Blander from InsideTracker delve into their latest innovation, the Nutrition Nutrition Deep Dive Solution. After years of research and development, they share the journey of creating a food recognition platform that helps users track their food intake in real time. The goal is to provide users with personalized recommendations for better health and nutrition based on their dietary habits.
Dr. Blander explains the challenges that arose over nearly a decade of development, including the complexity of assessing nutritional needs accurately. Through collaboration with experts from Tufts School of Nutrition, InsideTracker has refined its approach, incorporating not only food frequency questionnaires but also real-time food logging. This solution enables users to optimize their intake of macro and micronutrients to improve health outcomes.
Ashley emphasizes how this technology allows for a more holistic view of a person's nutrition and its impact on biomarkers, performance, and sleep. With the addition of real-time data, users can now receive tailored insights that align with their fitness and wellness goals.Episode highlights
Introduction: 00:00:00Nutrition Deep Dive Ideation: 00:01:35Why the Development of the Nutrition Solution Took So Long: 00:02:50What is the problem we tried to solve: 00:05:25What is the Value of the Nutrition Deep Dive for the User: 00:07:00
What Are the Expectations for a Nutrition Deep Dive User: 00:09:25What Does a Nutrition Deep Dive User Receive in Exchange for One Week of Nutrition Logging: 00:11:50How Often Should Nutrition Deep Dive Users Complete the 7-Day Logging: 00:16:35Why 7-Days Logging: 00:19:00Summary 00:21:10The Evolution of the Nutrition Deep Dive
InsideTracker's Nutrition Deep Dive was a decade-long project aimed at solving the challenge of personalized nutrition. Dr. Blander explains that the project began with the realization that no one had figured out how to match the right food with the right person at the right time. The team worked extensively, developing multiple iterations, collaborating with leading scientists, and employing cutting-edge technology, including food recognition platforms and barcode readers. Despite the prolonged process, their persistence led to a comprehensive solution that analyzes user input, such as food consumption and biomarker data, to offer personalized nutritional insights.
Food Tracking Technology: A Game-Changer
One of the most exciting aspects of InsideTracker’s Nutrition Deep Dive innovation is its food recognition technology. Users can log food through various methods, including scanning barcodes or using their iPhone camera to identify food items. The system is capable of analyzing over 4,000 foods, and the database is continuously expanding. This ability to gather real-time nutrition data revolutionizes how users can assess their diet. When paired with data from fitness trackers, the insights help to better understand the connection between food, sleep, exercise, and overall performance, thus optimizing health.
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In this episode of Longevity by Design, our host Dr. Gil Blander speaks with Dr. David Sinclair, a professor of genetics at Harvard Medical School, about the science behind aging and how we can extend both lifespan and healthspan. Dr. Sinclair shares his groundbreaking research on the role of epigenetic changes in aging and the potential to reverse this process.
He explains how lifestyle factors, such as diet and exercise, can greatly impact our longevity, and highlights the importance of regularly monitoring health markers like blood glucose and cholesterol. Dr. Sinclair emphasizes the power of technology, including blood tests and personalized health tracking, to help individuals live healthier, longer lives.
The conversation also dives into cutting-edge research on longevity drugs and therapies, including gene therapy and reprogramming cells to a younger state. Dr. Sinclair discusses the promising future of treatments aimed at reversing aging and improving the quality of life well into old age.
Episode highlights:
Introduction: 00:00:00Why have you decided to be a scientist and not a painter: 00:02:40What is the difference between healthspan and lifespan: 00:06:00Can we extend our lifespan: 00:07:10What should you do to increase your healthspan: 00:09:40How can we increase our lifespan: 00:14:45Upcoming Season of David’s Podcast: 00:19:40GLP-1 as a longevity drug: 00:21:40The information theory of aging: 00:25:40How are cells and organisms reprogrammed in the lab: 00:30:10What are the future opportunities in cell reprogramming: 00:32:50What is the effect of reprogramming on cancer cells: 00:36:00What is the effect of reprogramming on senescent cells: 00:38:50David's top tip for healthspan: 00:42:10Epigenetic Changes Drive the Aging Process
David Sinclair explains that aging is not just wear and tear on the body, but a loss of information within cells. This concept, known as epigenetic aging, involves cells losing their ability to read the right genes at the right time. As cells age, they lose their identity, leading to aging and age-related diseases. The exciting part of this discovery is that these changes may be reversible. Dr. Sinclair’s research focuses on reprogramming cells to restore their youthful function, potentially turning back the biological clock and extending healthspan and lifespan.
Lifestyle Choices Are Key to Longevity
David Sinclair emphasizes that simple lifestyle choices—like diet, exercise, and regular health monitoring—can have a profound impact on both healthspan and lifespan. He stresses the importance of moving regularly, avoiding processed foods, and maintaining a healthy weight. These actions, along with monitoring key biomarkers such as glucose and cholesterol, are crucial in delaying the onset of age-related diseases. Sinclair’s father, who at 85 is in excellent health, serves as a prime example of how these practices can help people live healthier, longer lives.
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In this episode of Longevity by Design, Dr. Gil Blander talks with Dr. Renee Deehan, Senior Vice President of Science and AI at InsideTracker. They explore the world of artificial intelligence and its applications in health and wellness.
Renee explains the differences between AI, machine learning, and large language models (LLMs). She discusses how InsideTracker has developed a specialized LLM called Ask InsideTracker. This tool allows users to interact with a vast knowledge base of health and wellness information.
The conversation delves into the potential future applications of AI in personalized health recommendations. Renee emphasizes the importance of data privacy and security when developing these tools. She also shares her perspective on the broader impact of AI in various industries and its potential to enhance decision-making processes.
Episode highlights:
Introduction: 00:00:00Defining AI and Machine Learning in Simple Terms: 00:04:00AI is a branch of computer science: 00:05:00The Power and Limitations of Large Language Models: 00:08:00Developing Specialized AI Tools for Health and Wellness: 00:25:00GPT general foundational model: 00:26:00The Future of AI in Personalized Health Recommendations: 00:37:00A balance between nutrition, exercise, and recovery: 00:47:00The best habit that you can do: 00:48:00Specialized LLMs Enhance Health Information Accuracy
LLMs tailored to specific domains can significantly improve the quality and reliability of information provided to users. By constraining general AI models with specialized knowledge, such as InsideTracker's corpus of health and wellness blog posts, these tools can deliver more accurate and relevant answers. This approach helps filter out noise and misinformation often found in general internet searches. For health and wellness applications, specialized LLMs can offer personalized insights based on high-quality, expert-reviewed content. This method bridges the gap between vast amounts of available information and individual user needs, potentially revolutionizing how people access and understand health-related information.
AI in Health: Balancing Personalization and Privacy
The integration of AI in health and wellness platforms promises highly personalized recommendations but raises important privacy concerns. As these systems evolve to incorporate individual health data, such as biomarkers and lifestyle information, the potential for tailored advice increases dramatically. However, this advancement requires robust security measures to protect sensitive personal information. The challenge lies in creating AI systems that can access and analyze personal health data while maintaining strict privacy standards. Striking this balance is crucial for the widespread adoption and trust in AI-powered health tools, potentially transforming how individuals manage their health and make lifestyle decisions.
Continuous Refinement Key to AI Tool Effectiveness
The development and improvement of AI tools, particularly in health and wellness, require ongoing refinement based on user interactions and feedback. This iterative process involves analyzing user queries, identifying areas of improvement, and continuously updating the AI model. By studying how users interact with the tool and the types of questions they ask, developers can enhance the AI's ability to provide relevant and accurate information. This approach ensures that AI tools evolve to meet user needs more effectively over time. The continuous refinement process is crucial for maintaining the tool's reliability and relevance, especially in rapidly evolving fields like health and wellness.
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On this episode of Longevity by Design, Ashley Reaver, MS, RD, CSSD, and Dr. Gil Blander, delve into the intricate world of the immune system and its impact on aging with Dr. David Furman, Associate Professor at the Buck Institute for Research on Aging. David discusses his groundbreaking research on inflammaging— uncovering how chronic, low-grade inflammation can accelerate the aging process.
Discover how David's team developed a new inflammatory age test, soon to be available from his company Edifice Health, that uses five key proteins to assess an individual's inflammatory state and predict future health risks. We also explore the surprising link between space travel and accelerated aging, examining the impact of microgravity on the body.
Tune in to learn practical tips on combating inflammation and promoting longevity through lifestyle choices and a deeper understanding of your own personal health data.
Episode highlights:
Introduction: 00:00:00Why have you decided to be a scientist and not a painter: 00:04:001000 Immunomes: 00:06:00What is the immune system: 00:16:00Biomarkers related to the immune system: 00:18:00The development of frailty during the aging process: 00:21:00what inflammation is: 00:27:00Lifestlye dependent chronic stress: 00:31:00Inflammation-related biological clock: 00:34:00Epigenetic age: 00:38:00Centenarians and inflammatory markers: 00:48:00Space flight and inflammation: 00:51:00Astronauts aging: 00:55:00Microgravity as a stressor: 00:59:00Future of David's work: 01:04:00Summary: 01:06:00Not All Biological Age Clocks Are Created Equal
While various biological age clocks exist, including epigenetic and glycan clocks, David's research highlights the benefits of protein-based clocks like his inflammatory age test. Unlike other clocks that closely correlate with chronological age, inflammatory age reveals more about an individual's biological state and potential health risks, offering valuable insights beyond simply reflecting the passage of time. Additionally, understanding how specific proteins link to inflammation allows for actionable lifestyle and dietary changes to positively impact those markers and potentially slow down the aging process.
Lifestyle Choices Directly Impact Our Inflammatory Levels
Many modern lifestyle factors, often a far cry from our evolutionary past, contribute to chronic inflammation. These include exposure to environmental toxins like plastics and pesticides, poor sleep quality, disruptions to our circadian rhythm, social isolation, and chronic stress. By minimizing these exposome factors and adopting healthier habits—such as consuming whole foods, prioritizing sleep hygiene, and managing stress—we can potentially lower inflammation and support healthier aging.
Space Travel Offers a Unique Perspective on Accelerated Aging
Astronauts, despite being otherwise healthy individuals, experience accelerated aging due to the stressors of space travel, particularly the effects of microgravity. This provides valuable data on aging mechanisms that can be applied to Earth-bound research. By studying the physiological changes astronauts undergo, scientists can gain a deeper understanding of aging processes and potentially develop interventions to mitigate age-related decline for everyone.
For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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