エピソード
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Parkinson's disease is a neurodegenerative disorder characterized by uncontrollable movements, stiffness, and cognitive decline. Curious? Come learn more!
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscience
I really appreciate it!!!
Citations and relevant papers are below.
National Institute on Aging. Parkinson’s Disease: Causes, Symptoms, and Treatments. National Institute on Aging.Hogg E, Frank S, Oft J, Benway B, Rashid MH, Lahiri S. Urinary Tract Infection in Parkinson’s Disease. Journal of Parkinson’s Disease. 2022;12(3):743-757.
Yu J. Stages of Parkinson’s | Parkinson’s Foundation. www.parkinson.org. Published 2022.
Zhang ZX, Dong ZH, Román GC. Early Descriptions of Parkinson Disease in Ancient China. Archives of Neurology. 2006;63(5):782.
2-Minute Neuroscience: Direct Pathway of the Basal Ganglia. www.youtube.com.
2-Minute Neuroscience: Indirect Pathway of the Basal Ganglia. www.youtube.com.
Thanvi B, Lo N, Robinson T. Levodopa-induced dyskinesia in Parkinson’s disease: clinical features, pathogenesis, prevention and treatment. Postgraduate Medical Journal. 2007;83(980):384-388.
Zhang JF, Wang XX, Feng Y, Fekete R, Jankovic J, Wu YC. Impulse Control Disorders in Parkinson’s Disease: Epidemiology, Pathogenesis and Therapeutic Strategies. Frontiers in Psychiatry. 2021;12.
Hisahara S, Shimohama S. Dopamine Receptors and Parkinson’s Disease. International Journal of Medicinal Chemistry. 2011;2011:1-16.
Houston. Tmc.edu. Published October 20, 2020. https://nba.uth.tmc.edu/neuroscience/m/s3/chapter04.html
Ovallath S, Sulthana B. Levodopa: History and Therapeutic Applications. Annals of Indian Academy of Neurology. 2017;20(3):185-189.
Levodopa | Parkinson’s Foundation. www.parkinson.org. https://www.parkinson.org/living-with-parkinsons/treatment/prescription-medications/levodopa
Kelly MJ, Baig F, Hu MTM, Okai D. Spectrum of impulse control behaviours in Parkinson’s disease: pathophysiology and management. Journal of Neurology, Neurosurgery & Psychiatry. 2020;91(7):703-711.
Gerfen CR, Surmeier DJ. Modulation of Striatal Projection Systems by Dopamine. Annual Review of Neuroscience. 2011;34(1):441-466.
Sayare S. The Woman Who Could Smell Parkinson’s. The New York Times. https://www.nytimes.com/2024/06/14/magazine/parkinsons-smell-disease-detection.html. Published June 14, 2024.
Blandini F, Nappi G, Tassorelli C, Martignoni E. Functional changes of the basal ganglia circuitry in Parkinson’s disease. Progress in Neurobiology. 2000;62(1):63-88.
Lanciego JL, Luquin N, Obeso JA. Functional Neuroanatomy of the Basal Ganglia. Cold Spring Harbor Perspectives in Medicine. 2012;2(12):a009621-a009621
Rossifari Podcast - Zoos, Aquariums, and Animal Conservation
The Rossifari Podcast brings my love of zoos, aquariums, rescues, and rehab facilities...Listen on: Apple Podcasts Spotify
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Dreams are both scientifically fascinating and universal. Everyone dreams, at every age and they are often nonsensical, complex, and deeply subjective. How can you quantify something so personal in the activity of cells, circuits, and systems?
Let's find out together!
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscience
I really appreciate it!!!
Citations and relevant papers are below!
Chip Brown. The Stubborn Scientist Who Unraveled A Mystery of the Night. Smithsonian. Published October 2003. https://www.smithsonianmag.com/science-nature/the-stubborn-scientist-who-unraveled-a-mystery-of-the-night-91514538/Purves D, Augustine GJ, Fitzpatrick D, et al. The Possible Functions of REM Sleep and Dreaming. Nih.gov. Published 2016. https://www.ncbi.nlm.nih.gov/books/NBK11121/
Gott JA, Liley DTJ, Hobson JA. Towards a Functional Understanding of PGO Waves. Frontiers in Human Neuroscience. 2017;11. doi:https://doi.org/10.3389/fnhum.2017.00089
Senzai Y, Scanziani M. A cognitive process occurring during sleep is revealed by rapid eye movements. Science. 2022;377(6609):999-1004. doi:https://doi.org/10.1126/science.abp8852
Crick F, Mitchison G. The function of dream sleep. Nature. 1983;304(5922):111-114. doi:https://doi.org/10.1038/304111a0
Hobson JA, McCarley RW. The brain as a dream state generator: an activation-synthesis hypothesis of the dream process. The American journal of psychiatry. 1977;134(12):1335-1348. doi:https://doi.org/10.1176/ajp.134.12.1335
Caviglia G. Working on dreams, from neuroscience to psychotherapy. Research in Psychotherapy: Psychopathology, Process and Outcome. 2021;24(2). doi:https://doi.org/10.4081/ripppo.2021.540
Hobson, J. A. (1990). Activation, input source, and modulation: A neurocognitive model of the state of the brain-mind. In R. R. Bootzin, J. F. Kihlstrom, & D. L. Schacter (Eds.), Sleep and cognition (pp. 25–40). American Psychological Association. https://doi.org/10.1037/10499-002
Baird B, Mota-Rolim SA, Dresler M. The cognitive neuroscience of lucid dreaming. Neuroscience & Biobehavioral Reviews. 2019;100:305-323. doi:https://doi.org/10.1016/j.neubiorev.2019.03.008
Aspy DJ. Findings From the International Lucid Dream Induction Study. Frontiers in Psychology. 2020;11. doi:https://doi.org/10.3389/fpsyg.2020.01746
Soffer-Dudek N. Are Lucid Dreams Good for Us? Are We Asking the Right Question? A Call for Caution in Lucid Dream Research. Frontiers in Neuroscience. 2020;13. doi:https://doi.org/10.3389/fnins.2019.01423
Gao JX, Gao Y, Li XX, et al. The Ponto-Geniculo-Occipital (PGO) Waves in Dreaming: An Overview.
Rossifari Podcast - Zoos, Aquariums, and Animal Conservation
The Rossifari Podcast brings my love of zoos, aquariums, rescues, and rehab facilities...Listen on: Apple Podcasts Spotify
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エピソードを見逃しましたか？
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Have you ever thought about why some feelings might be described as gut-wrenching? Or why do the first feelings of love make you feel butterflies in the stomach? It's time to explore how your gut and your brain are connected!
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscience
I really appreciate it!!!
Citations and relevant papers are below!
Enteric nervous system. qbi.uq.edu.au. Published October 15, 2018. Accessed May 22, 2023. https://qbi.uq.edu.au/brain/brain-anatomy/peripheral-nervous-system/enteric-nervous-system#:~:text=The%20enteric%20nervous%20system%20neuronsCleveland Clinic. Cranial Nerves: Function, Anatomy and Location. Cleveland Clinic. Published October 27, 2021. https://my.clevelandclinic.org/health/body/21998-cranial-nerves
Mayer EA. Gut feelings: the emerging biology of gut–brain communication. Nature Reviews Neuroscience. 2011;12(8):453-466. doi:https://doi.org/10.1038/nrn3071
Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of gastroenterology. 2015;28(2):203-209.
Oligschlaeger Y, Yadati T, Houben T, Condello Oliván CM, Shiri-Sverdlov R. Inflammatory Bowel Disease: A Stressed “Gut/Feeling.” Cells. 2019;8(7):659. doi:https://doi.org/10.3390/cells8070659
Vancamelbeke M, Vermeire S. The intestinal barrier: a fundamental role in health and disease. Expert Review of Gastroenterology & Hepatology. 2017;11(9):821-834. doi:https://doi.org/10.1080/17474124.2017.1343143
Clapp M, Aurora N, Herrera L, Bhatia M, Wilen E, Wakefield S. Gut microbiota’s effect on mental health: the gut-brain axis. Clinics and Practice. 2017;7(4). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641835/
Zoppi S, Madrigal JLM, Pérez-Nievas BG, et al. Endogenous cannabinoid system regulates intestinal barrier function in vivo through cannabinoid type 1 receptor activation. Am J Physiol Gastr L 2012;302:565.
Radjabzadeh D, Bosch JA, Uitterlinden AG, et al. Gut microbiome-wide association study of depressive symptoms. Nature Communications. 2022;13(1):7128. doi:https://doi.org/10.1038/s41467-022-34502-3
Wapner J. The link between our food, gut microbiome and depression. Washington Post. https://www.washingtonpost.com/wellness/2023/01/31/gut-microbiome-anxiety-depression/. Published January 31, 2023.
Fond G, Loundou A, Hamdani N, et al. Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis. European Archives of Psychiatry and Clinical Neuroscience. 2014;264(8):651-660. doi:https://doi.org/10.1007/s00406-014-0502-z
What’s the Difference Between Probiotics and Prebiotics? www.sclhealth.org. https://www.sclhealth.
Rossifari Podcast - Zoos, Aquariums, and Animal Conservation
The Rossifari Podcast brings my love of zoos, aquariums, rescues, and rehab facilities...Listen on: Apple Podcasts Spotify
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A tragic incident - a brain injury, a stroke, the development of a neurodegenerative disease, and all of a sudden, a patient's arm no longer belongs to them. It will pull their hair, pinch their cheeks, and grab miscellaneous objects, seemingly developing a mind of its own.
How can something that belongs to you and is controlled by your brain, your electrical pulses, and your motor neurons ever develop a mind of its own? Listen to find out more!
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscience
I really appreciate it!!!
Citations and relevant papers are below!
Doody RS, Jankovic J. The alien hand and related signs. Journal of Neurology, Neurosurgery & Psychiatry. 1992;55(9):806-810. doi:https://doi.org/10.1136/jnnp.55.9.806
Panikkath R, Panikkath D, Mojumder D, Nugent K. The alien hand syndrome. Proceedings (Baylor University Medical Center). 2014;27(3):219-220. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059570/#:~:text=Alien%20hand%20syndrome%20is%20a
Caixeta L, Maciel P, Nunes J, Nazareno L, Araújo L, Borges JR. Alien hand syndrome in AIDS: Neuropsychological features and physiopathological considerations based on a case report. Dementia & Neuropsychologia. 2007;1(4):418-421. doi:https://doi.org/10.1590/s1980-57642008dn10400016
Alyssa Anderson. What Is Alien Hand Syndrome? WebMD. Published April 8, 2022. https://www.webmd.com/brain/what-is-alien-hand-syndrome
Parry-Romberg Syndrome | Boston Children’s Hospital. www.childrenshospital.org. https://www.childrenshospital.org/conditions/parry-romberg-syndrome
Feinberg TE, Schindler RJ, Flanagan NG, Haber LD. Two alien hand syndromes. Neurology. 1992;42(1):19-19. doi:https://doi.org/10.1212/wnl.42.1.19
Le K, Zhang C, Greisman L. Alien hand syndrome – a rare presentation of stroke. Journal of Community Hospital Internal Medicine Perspectives. 2020;10(2):149-150. doi:https://doi.org/10.1080/20009666.2020.1756610
Motor Cortex (Section 3, Chapter 3) Neuroscience Online: An Electronic Textbook for the Neurosciences | Department of Neurobiology and Anatomy - The University of Texas Medical School at Houston. nba.uth.tmc.edu. https://nba.uth.tmc.edu/neuroscience/m/s3/chapter03.html#:~:text=The%20premotor%20cortex%20appears%20to
Bru I, Verhamme L, Neve P, Maebe H. Rehabilitation of a patient with alien hand syndrome: A case report of a 61-year old man. Journal of Rehabilitation Medicine – Clinical Communications. 2021;4(1):jrmcc00050. doi:https://doi.org/1Rossifari Podcast - Zoos, Aquariums, and Animal Conservation
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Could a dead salmon be thinking or is something else at play? If you're curious about the answer to that question and want to learn more about magnetic resonance imaging (MRI), come and listen!
Featuring special guest the Eventually To be Dr. Ilya, this episode discusses the science behind MRI, how noise can affect imaging and landmark studies in the field!
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscience
I really appreciate it!!!
Citations and relevant papers are below!
Bennett C, Miller M, Wolford G. Neural correlates of interspecies perspective taking in the post-mortem Atlantic Salmon: an argument for multiple comparisons correction. NeuroImage. 2009;47:S125. doi:10.1016/s1053-8119(09)71202-9
Scicurious. IgNobel Prize in Neuroscience: The dead salmon study. Scientific American Blog Network. https://blogs.scientificamerican.com/scicurious-brain/ignobel-prize-in-neuroscience-the-dead-salmon-study/
Van Dijk KRA, Sabuncu MR, Buckner RL. The influence of head motion on intrinsic functional connectivity MRI. NeuroImage. 2012;59(1):431-438. doi:10.1016/j.neuroimage.2011.07.044
Nishimoto S, Vu An T, Naselaris T, Benjamini Y, Yu B, Gallant Jack L. Reconstructing Visual Experiences from Brain Activity Evoked by Natural Movies. Current Biology. 2011;21(19):1641-1646. doi:10.1016/j.cub.2011.08.031
Will GJ, Rutledge RB, Moutoussis M, Dolan RJ. Neural and computational processes underlying dynamic changes in self-esteem. FeldmanHall O, ed. eLife. 2017;6:e28098. doi:10.7554/eLife.28098
Rossifari Podcast - Zoos, Aquariums, and Animal Conservation
The Rossifari Podcast brings my love of zoos, aquariums, rescues, and rehab facilities...Listen on: Apple Podcasts Spotify
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Two words - Octopus brains! Nine of them!!!
But seriously, if you want to learn about the insanity of the dispersed octopus nervous system, come and take a listen!
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscience
I really appreciate it!!!
Citations and relevant papers are below!
The Many Plurals of “Octopus.” Merriam-webster.com. Published 2019. Accessed September 16, 2019. https://www.merriam-webster.com/words-at-play/the-many-plurals-of-octopus-octopi-octopuses-octopodes
Nine Brains Are Better Than One: An Octopus’ Nervous System | Biomechanics in the Wild. sites.nd.edu. https://sites.nd.edu/biomechanics-in-the-wild/2021/04/07/nine-brains-are-better-than-one-an-octopus-nervous-system/
Sumbre G, Gutfreund Y, Fiorito G, Flash T, Hochner B. Control of Octopus Arm Extension by a Peripheral Motor Program. Science. 2001;293(5536):1845-1848. doi:10.1126/science.1060976
Godfrey-Smith P. The Mind of an Octopus. Scientific American Mind. 2016;28(1):62-69. doi:10.1038/scientificamericanmind0117-62
Hochner B. An Embodied View of Octopus Neurobiology. Current Biology. 2012;22(20):R887-R892. doi:10.1016/j.cub.2012.09.001
Hochner B, Brown ER, Langella M, Shomrat T, Fiorito G. A Learning and Memory Area in the Octopus Brain Manifests a Vertebrate-Like Long-Term Potentiation. Journal of Neurophysiology. 2003;90(5):3547-3554. doi:10.1152/jn.00645.2003
Park M. AMPA Receptor Trafficking for Postsynaptic Potentiation. Frontiers in Cellular Neuroscience. 2018;12. doi:10.3389/fncel.2018.00361
Huang EP. Synaptic plasticity: Going through phases with LTP. Current Biology. 1998;8(10):R350-R352. doi:10.1016/s0960-9822(98)70219-2Support the Show.
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Hello! I return!
Today we will be talking about the neuroscience of seizures and epilepsy. Brought about an imbalance of the accelerators (excitatory circuits) and brakes (inhibitory circuits) of the brain, seizures are pretty terrifying events. They're marked by temporary confusion, a staring spell, uncontrollable jerking of the arms and legs (like what you see when someone depicts a seizure on gray's anatomy), loss of consciousness, or even some cognitive and emotional symptoms. Curious to find out what the heck the brain is up to during seizures? Come and listen to find out more!
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscience
I really appreciate it!!!
Citations and relevant papers are below!
Types of Seizures. www.hopkinsmedicine.org. https://www.hopkinsmedicine.org/health/conditions-and-diseases/epilepsy/types-of-seizures#:~:text=Focal%20onset%20seizures%20start%20in
Rs F, Jh C, Ja F, et al. Operational Classification of Seizure Types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia. Published April 1, 2017. https://pubmed.ncbi.nlm.nih.gov/28276060/
Types of Seizures. Epilepsy Foundation. https://www.epilepsy.com/what-is-epilepsy/seizure-types
Articles. Cedars-Sinai. https://www.cedars-sinai.org/health-library/diseases-and-conditions/m/myoclonic-epilepsy.html
Bromfield EB, Cavazos JE, Sirven JI. Basic Mechanisms Underlying Seizures and Epilepsy. Nih.gov. Published 2015. https://www.ncbi.nlm.nih.gov/books/NBK2510/
Peng SJ, Hsin YL. Functional Connectivity of the Corpus Callosum in Epilepsy Patients with Secondarily Generalized Seizures. Frontiers in Neurology. 2017;8. doi:10.3389/fneur.2017.00446
Kim T, Nguyen P, Pham N, et al. Epileptic Seizure Detection and Experimental Treatment: A Review. Frontiers in Neurology. 2020;11. doi:10.3389/fneur.2020.00701
Ammothumkandy A, Ravina K, Wolseley V, et al. Altered adult neurogenesis and gliogenesis in patients with mesial temporal lobe epilepsy. Nature Neuroscience. 2022;25(4):493-503. doi:10.1038/s41593-022-01044-2
CDKL5 cyclin dependent kinase like 5 [Homo sapiens (human)] - Gene - NCBI. www.ncbi.nlm.nih.gov. Accessed August 3, 2022. https://www.ncbi.nlm.nih.gov/gene/6792
CDKL5 Deficiency Disorder. Epilepsy Foundation. Accessed August 3, 2022. https://www.epilepsy.com/causes/genetic/cdkl5-disorder
Sørensen AT, Kokaia M. Novel approaches to epilepsy treatment. Epilepsia. 2012;54(1):1-10. doi:10.1111/epi.12000
Rogawski MA, Löscher W. The neurobiology of antiepileptic drugs. Nature Reviews Neuroscience. 2004;5(7):553-564. doi:10.1038/nrn1430Support the Show.
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That's a wrap on Season 1 folks! See you all in a few weeks with more episodes about epilepsy, alcohol, and more!
Happy researching and I'll see you all again soon!Support the Show.
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Apologies for the absolute chaos that is this episode.
Today I wanted to cover some foundational background concepts, including how a signal travel within a neuron from dendrites to the tip of the axon and how that neuron then communicates to other neurons and parts of the body.
Curious? Come and listen to find out more!!!
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscience
I really appreciate it!!!
Citations and relevant papers are below!
Guy-Evans O. What Is a Neuron? Function, Parts, Structure, and Types | Simply Psychology. www.simplypsychology.org. Published February 15, 2021. https://www.simplypsychology.org/neuron.html
Khan Academy. Neuron action potentials: The creation of a brain signal. Khan Academy. Published 2016. https://www.khanacademy.org/test-prep/mcat/organ-systems/neuron-membrane-potentials/a/neuron-action-potentials-the-creation-of-a-brain-signal
Purves D, Augustine GJ, Fitzpatrick D, et al. Increased Conduction Velocity as a Result of Myelination. Neuroscience 2nd edition. Published online 2001. https://www.ncbi.nlm.nih.gov/books/NBK10921/#:~:text=By%20acting%20as%20an%20electrical
Chen I, Forshing Lui. Neuroanatomy, Neuron Action Potential. Nih.gov. Published August 27, 2019. https://www.ncbi.nlm.nih.gov/books/NBK546639/
Guy-Evans O. Synapse Definition and Function | Simply Psychology. www.simplypsychology.org. Published February 21, 2021. https://www.simplypsychology.org/synapse.html
my brainnnnnnnnnSupport the Show.
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This episode is part two of my miniseries on the neuroscience of language production and processing and today we're touching on how the brain regions encoding those concepts change in deaf individuals. It turns out that the brain is the literal embodiment of that "its free real estate" meme and vision input takes over the auditory cortex!
If you're curious to know more - come and take a listen!
Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscience
I really appreciate it!!!
Citations and relevant papers are below!
CDC. Genetics of Hearing Loss | CDC. Centers for Disease Control and Prevention. Published February 18, 2015. https://www.cdc.gov/ncbddd/hearingloss/genetics.html#:~:text=50%25%20to%2060%25%20of%20hearing
Deafness causes before birth | Deafness in childhood. www.ndcs.org.uk. https://www.ndcs.org.uk/information-and-support/childhood-deafness/causes-of-deafness/#:~:text=Deafness%20can%20also%20be%20caused
Simon M, Campbell E, Genest F, MacLean MW, Champoux F, Lepore F. The Impact of Early Deafness on Brain Plasticity: A Systematic Review of the White and Gray Matter Changes. Frontiers in Neuroscience. 2020;14. doi:10.3389/fnins.2020.00206
Sharma A, Dorman MF, Spahr AJ. A Sensitive Period for the Development of the Central Auditory System in Children with Cochlear Implants: Implications for Age of Implantation. Ear and Hearing. 2002;23(6):532-539. https://journals.lww.com/ear-hearing/Abstract/2002/12000/A_Sensitive_Period_for_the_Development_of_the.4.aspx
Voss P, Thomas ME, Cisneros-Franco JM, de Villers-Sidani É. Dynamic Brains and the Changing Rules of Neuroplasticity: Implications for Learning and Recovery. Frontiers in Psychology. 2017;8. doi:10.3389/fpsyg.2017.01657
Purves D, Augustine GJ, Fitzpatrick D, et al. The Auditory Cortex. Nih.gov. Published 2016. https://www.ncbi.nlm.nih.gov/books/NBK10900/
Bola Ł, Zimmermann M, Mostowski P, et al. Task-specific reorganization of the auditory cortex in deaf humans. Proceedings of the National Academy of Sciences. 2017;114(4):E600-E609. doi:10.1073/pnas.1609000114
Fougnie D, Cockhren J, Marois R. A common source of attention for auditory and visual tracking. Attention, Perception, & Psychophysics. 2018;80(6):1571-1583. doi:10.3758/s13414-018-1524-9
Campbell R, MacSweeney M, Waters D. Sign Language and the Brain: A Review. The Journal of Deaf Studies and Deaf Education. 2008;13(1):3-20. doi:10.1093/deafed/enm035Support the Show.
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Tobacco has a long and storied history but its effects on the modern world cannot be ignored. It was hailed as a cure to many ailments for years but as we understand more - we understand that its REALLY bad for you. Something like 80-90% of lung cancer cases are related to smoking along with a plethora of other diseases.
Curious? Want to learn more about the receptors and brain areas affected by nicotine, the active ingredient in cigarettes? Come and take a listen!
Also if you have the means/desire to financially support this podcast - please go to https://www.buymeacoffee.com/neuroscience
I really appreciate it!!!
Citations and relevant papers are below!
1907 - Handbook of American Indians north of Mexico, Part I; Frederick Webb Hodge. Internet Archives; Bureau of American Ethnology. Published online January 21, 2019. Accessed June 13, 2022. https://digitalcommons.csumb.edu/hornbeck_ind_3/3/Baron JA. Beneficial effects of nicotine and cigarette smoking: the real, the possible and the spurious. British medical bulletin. 1996;52(1):58-73. doi:10.1093/oxfordjournals.bmb.a011533
Centers for Disease Control and Prevention. Health Effects of Smoking and Tobacco Use. Centers for Disease Control and Prevention. Published February 9, 2017. https://www.cdc.gov/tobacco/basic_information/health_effects/index.htm#:~:text=Smoking%20causes%20cancer%2C%20heart%20disease
Psychopharmacology 3e Web Box 13.1 - Pharmacology in Action: Why Do Tobacco Plants Make Nicotine? learninglink.oup.com. Accessed June 13, 2022. https://learninglink.oup.com/access/content/psychopharmacology-3e-student-resources/psychopharmacology-3e-web-box-13-1-pharmacology-in-action-why-do-tobacco-plants-make-nicotine
PubChem. Nicotine. Nih.gov. Published 2019. https://pubchem.ncbi.nlm.nih.gov/compound/nicotine
Holz RW, Fisher SK. Synaptic Transmission. Basic Neurochemistry: Molecular, Cellular and Medical Aspects 6th edition. Published online 1999. https://www.ncbi.nlm.nih.gov/books/NBK27911/
Hogg RC, Raggenbass M, Bertrand D. Nicotinic acetylcholine receptors: from structure to brain function. Reviews of Physiology, Biochemistry and Pharmacology. 2003;147:1-46. doi:10.1007/s10254-003-0005-1
Taly A, Corringer PJ, Guedin D, Lestage P, Changeux JP. Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nature Reviews Drug Discovery. 2009;8(9):733-750. doi:10.1038/nrd2927
Abuse NI on D. How does tobacco deliver its effects? National Institute on Drug Abuse. https://nida.nih.gov/publications/research-reports/tobacco-nicotine-e-cigarettes/how-does-tobacco-deliver-its-effects
Chen X, Stacy A, Zheng H, et al. Sensations from initial exposure to nicotine predicting adolescent smoking in China: A potential measure of vulnerability to nicotine. Nicotine & Tobacco Research. 2003;5(4):455-463. doi:10.1080/14622200307239
Laviolette SR, van der Kooy D. The neurobiology of nicotine addiction: bridging the gap from molecules to behaviour. Nature Reviews Neuroscience. 2004;5(1):55-65. doi:10.1038/nrn1298
Marshall AM, Heffernan T. Smoking harms not just your physical health, but your mental health too. The Conversation. https://theconversation.com/smoking-harms-not-just-your-physical-health-but-your-mental-health-too-69021#:~:text=Long%2Dterm%20smoki
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So this week’s episode is all about speech production. Speech is a fundamental way of communicating our needs, desires, threats, resources, etc to our conspecifics. But do you know about the circuits and muscles and brain regions responsible for our ability to physically produce speech?
Curious? Come and take a listen!
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Citations and relevant papers below:
Birds Raised In Complete Isolation Evolve “Normal” Species Song Over Generations. ScienceDaily. Accessed June 6, 2022. https://www.sciencedaily.com/releases/2009/05/090503132617.htmHuman language may have evolved to help our ancestors make tools. www.science.org. https://www.science.org/content/article/human-language-may-have-evolved-help-our-ancestors-make-tools
Ludlow CL. Central nervous system control of the laryngeal muscles in humans. Respiratory physiology & neurobiology. 2005;147(2-3):205-222. doi:10.1016/j.resp.2005.04.015
Petko B, Tadi P. Neuroanatomy, Nucleus Ambiguus. PubMed. Published 2022. Accessed June 6, 2022. https://www.ncbi.nlm.nih.gov/books/NBK547744/#:~:text=The%20nucleus%20ambiguus%20is%20the
Guy-Evans O. Motor Cortex Function and Location | Simply Psychology. www.simplypsychology.org. Published September 8, 2021. https://www.simplypsychology.org/motor-cortex.html#:~:text=The%20motor%20cortex%20is%20an
Simonyan K. The Laryngeal Motor Cortex: Its Organization and Connectivity. Current opinion in neurobiology. 2014;0:15-21. doi:10.1016/j.conb.2014.05.006
Kearney E, Guenther FH. Articulating: the neural mechanisms of speech production. Language, Cognition and Neuroscience. 2019;34(9):1214-1229. doi:10.1080/23273798.2019.1589541
@neurochallenged. Know Your Brain: Broca’s Area. @neurochallenged. https://neuroscientificallychallenged.com/posts/know-your-brain-brocas-area
University of California San Francisco. Speech & Language. Memory and Aging Center. Published 2019. https://memory.ucsf.edu/symptoms/speech-language
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Today’s episode is inspired by a historical nightmare and the subsequent decades-long experiment that shaped the way we understand childhood neglect and its effects on the developing brain.
In 1989, Romanian dictator Nicolae Ceausescu was overthrown and the rest of the world discovered that over 170,000 Romanian children were being kept in impoverished institutions and orphanages.
These children were raised, not by loving parents or guardians, but by the metal bars of their beds and impersonal nurses. This neglect resulted in severe, lifetime, neurological issues including altered structure, function, and connectivity among different brain regions important for integrating complex information, including cognitive, social, and emotional competencies.
Curious about the decades-long project that followed these children for 21 years and documented the adverse effects of neglect on the developing brain? Come and take a listen!
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Citations and relevant papers below:
Weir K. https://www.apa.org/monitor/2014/06/neglect. www.apa.org. Published June 2014. https://www.apa.org/monitor/2014/06/neglect
Greene MF. 30 years ago, Romania deprived thousands of babies of human contact. The Atlantic. Published June 23, 2020. https://www.theatlantic.com/magazine/archive/2020/07/can-an-unloved-child-learn-to-love/612253/
Publications. www.bucharestearlyinterventionproject.org. Accessed May 21, 2022. https://www.bucharestearlyinterventionproject.org/publications
The Science of Neglect: The Persistent Absence of Responsive Care Disrupts the Developing Brain. https://developingchild.harvard.edu/wp-content/uploads/2012/05/The-Science-of-Neglect-The-Persistent-Absence-of-Responsive-Care-Disrupts-the-Developing-Brain.pdf
Teicher MH, Samson JA, Anderson CM, Ohashi K. The effects of childhood maltreatment on brain structure, function and connectivity. Nature Reviews Neuroscience. 2016;17(10):652-666. doi:10.1038/nrn.2016.111
Teicher MH, Dumont NL, Ito Y, Vaituzis C, Giedd JN, Andersen SL. Childhood neglect is associated with reduced corpus callosum area. Biological Psychiatry. 2004;56(2):80-85. doi:10.1016/j.biopsych.2004.03.016
FeaturedGeneticsNeurosciencePsychology·January 19, 2021. Childhood Neglect Leaves Generational Imprint. Neuroscience News. Published January 19, 2021. https://neurosciencenews.com/childhood-neglect-generational-17597/
Keim B. How Childhood Neglect Stunts the Brain. Wired. Accessed June 1, 2022. https://www.wired.com/2012/09/neuroscience-of-neglect/Support the Show.
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This week we will be learning about bipolar disorder! It's a condition characterized by extreme mood swings from emotional highs to emotional lows. One week someone may end up sleeping 24 hours straight and the next week go on a $10,000 gambling spree in Vegas.
Are you curious about the neural activity and neurotransmitters involved in these sudden shifts in mood? Come and take a listen to Episode 20!
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Citations below:
Bipolar disorder - Symptoms and causes. Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/bipolar-disorder/symptoms-causes/syc-20355955#:~:text=Overview
National Alliance on Mental Illness. Bipolar disorder | NAMI: National Alliance on Mental Illness. nami.org. Published August 2017. https://www.nami.org/About-Mental-Illness/Mental-Health-Conditions/Bipolar-Disorder
How Is Bipolar Disorder Diagnosed? WebMD. Accessed May 17, 2022. https://www.webmd.com/bipolar-disorder/guide/bipolar-disorder-diagnosis#091e9c5e800091a5-1-1
Craddock N, Jones I. Genetics of bipolar disorder. Journal of Medical Genetics. 1999;36(8):585-594. doi:10.1136/jmg.36.8.585
Barnett JH, Smoller JW. The genetics of bipolar disorder. Neuroscience. 2009;164(1):331-343. doi:10.1016/j.neuroscience.2009.03.080
Ahmed NY, Knowles R, Dehorter N. New Insights Into Cholinergic Neuron Diversity. Frontiers in Molecular Neuroscience. 2019;12. doi:10.3389/fnmol.2019.00204
van Enkhuizen J, Janowsky DS, Olivier B, et al. The catecholaminergic-cholinergic balance hypothesis of bipolar disorder revisited. European journal of pharmacology. 2015;753:114-126. doi:10.1016/j.ejphar.2014.05.063
Keck PE, McElroy SL, Arnold LM. BIPOLAR DISORDER. Medical Clinics of North America. 2001;85(3):645-661. doi:10.1016/s0025-7125(05)70334-5
Machado-Vieira R, Manji HK, Zarate Jr CA. The Role of Lithium in the Treatment of Bipolar disorder: Convergent Evidence for Neurotrophic Effects as a Unifying Hypothesis. Bipolar Disorders. 2009;11:92-109. doi:10.1111/j.1399-5618.2009.00714.x
Malhi GS, Tanious M, Das P, Coulston CM, Berk M. Potential Mechanisms of Action of Lithium in Bipolar Disorder. CNS Drugs. 2013;27(2):135-153. doi:10.1007/s40263-013-0039-0Support the Show.
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Welcome back!
This week, I want to talk about your ears and how going to super loud concerts can impact your ability to hear. You might be thinking wait - ears aren’t brains. But the way we process sound in our ears is a part of the peripheral nervous system so I say close enough!
Come and listen to learn a little bit more about your auditory system, your peripheral nervous system, hair cells, and the absolutely insane feat of biological engineering that allows for sound to go from your surroundings to your brain.
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Citations below:
The Physics Classroom. Sound Waves as Pressure Waves. Physicsclassroom.com. Published 2019. https://www.physicsclassroom.com/class/sound/u11l1c.cfm
How the Ear Works. www.hopkinsmedicine.org. https://www.hopkinsmedicine.org/health/conditions-and-diseases/how-the-ear-works#:~:text=The%20Inner%20Ear
Petitpré C, Wu H, Sharma A, et al. Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system. Nature Communications. 2018;9(1). doi:10.1038/s41467-018-06033-3
Purves D, Augustine GJ, Fitzpatrick D, et al. The Auditory Cortex. Nih.gov. Published 2016. https://www.ncbi.nlm.nih.gov/books/NBK10900/
Purves D, Augustine GJ, Fitzpatrick D, et al. The Inner Ear. Nih.gov. Published 2018. https://www.ncbi.nlm.nih.gov/books/NBK10946/
Ruggero MA. Responses to sound of the basilar membrane of the mammalian cochlea. Current Opinion in Neurobiology. 1992;2(4):449-456. doi:10.1016/0959-4388(92)90179-o
Wagner EL, Shin JB. Mechanisms of Hair Cell Damage and Repair. Trends in Neurosciences. 2019;42(6):414-424. doi:10.1016/j.tins.2019.03.006
Youm I, Li W. Cochlear hair cell regeneration: an emerging opportunity to cure noise-induced sensorineural hearing loss. Drug Discovery Today. 2018;23(8):1564-1569. doi:10.1016/j.drudis.2018.05.001
Santaolalla F, Salvador C, Martínez A, Sánchez JM, del Rey AS. Inner ear hair cell regeneration: A look from the past to the future. Neural Regeneration Research. 2013;8(24):2284-2289. doi:10.3969/j.issn.1673-5374.2013.24.008Support the Show.
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Social media is omnipresent. Mindless scrolling through TikTok and Instagram reels is just a part of our daily lives now. Whether it's cat videos, funny dances, or cool outfits, online content fills our excess time, entertains us, and keeps us connected with our friends and the people we look up to. As my housemate says, sometimes, we’re living in the REEL world, not the REAL world.
But it's also no secret that too much social media is not very good for our psyche and our brains. Curious why? Come and listen to learn a little bit more about the neuroscience of spending tooooooo much time on InstaSnapTok.
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Citations below:
Börchers S. Your Brain on Instagram, TikTok, & Co – The Neuroscience of Social Media. Published June 29, 2020. https://biologista.org/2020/06/29/your-brain-on-instagram-tiktok-co-the-neuroscience-of-social-media/Montag C, Markowetz A, Blaszkiewicz K, et al. Facebook usage on smartphones and gray matter volume of the nucleus accumbens. Behavioral Brain Research. 2017;329:221-228. doi:10.1016/j.bbr.2017.04.035
Arias-Carrión O, Stamelou M, Murillo-Rodríguez E, Menéndez-González M, Pöppel E. Dopaminergic reward system: a short integrative review. International Archives of Medicine. 2010;3(1):24. doi:10.1186/1755-7682-3-24
Jan M, Soomro S, Ahmad N. Impact of social media on self-esteem. Ssrn.com. Published August 31, 2017. https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3030048
Pittman M, Reich B. Social media and loneliness: Why an Instagram picture may be worth more than a thousand Twitter words. Computers in Human Behavior. 2016;62:155-167. doi:10.1016/j.chb.2016.03.084
Will GJ, Rutledge RB, Moutoussis M, Dolan RJ. Neural and computational processes underlying dynamic changes in self-esteem. FeldmanHall O, ed. eLife. 2017;6:e28098. doi:10.7554/eLife.28098
Cacioppo JT, Cacioppo S. The growing problem of loneliness. The Lancet. 2018;391(10119):426. doi:10.1016/s0140-6736(18)30142-9
Chunliang Feng, Li Wang, Ting Li, Pengfei Xu, Connectome-based individualized prediction of loneliness, Social Cognitive and Affective Neuroscience, Volume 14, Issue 4, April 2019, Pages 353–365, https://doi.org/10.1093/scan/nsz020
Alkozei A, Smith R, Pisner DA, et al. Exposure to Blue Light Increases Subsequent Functional Activation of the Prefrontal Cortex During Performance of a Working Memory Task. Sleep. 2016;39(9):1671-1680. doi:10.5665/sleep.6090
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When I was a kid, I thought two things were going to be much bigger problems in my life than they actually are - quicksand and mad cow disease.
Turns out that they aren't but mad cow disease is still the stuff of science-fiction nightmares. Mad cow disease is caused by the spread of prions, proteins that weaponize our own cells against us and cause proteins to misfold and aggregate, slowly killing neurons throughout the brain. The disease is characterized by rapid and fatal neurodegeneration.
Want to get the shit scared out of you by learning about the truth behind mad cow disease? Come and listen!
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Citations below:
About BSE BSE (Bovine Spongiform Encephalopathy). Centers for Disease Control and Prevention. Published 2019. https://www.cdc.gov/prions/bse/about.htmlLegname G. Elucidating the function of the prion protein. True HL, ed. PLOS Pathogens. 2017;13(8):e1006458. doi:10.1371/journal.ppat.1006458
Jung MJ, Pistolesi D, Panà A. Prions, prion diseases and decontamination. Igiene E Sanita Pubblica. 2003;59(5):331-344. https://pubmed.ncbi.nlm.nih.gov/14981553/
Lanska DJ. The mad cow problem in the UK: risk perceptions, risk management, and health policy development. Journal of Public Health Policy. 1998;19(2):160-183. Accessed April 11, 2022. https://pubmed.ncbi.nlm.nih.gov/9670700/
MRI used to detect vCJD. CMAJ: Canadian Medical Association Journal. 2000;163(3):324. Accessed April 11, 2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC80326/
Macfarlane RG, Wroe SJ, Collinge J, Yousry TA, Jäger HR. Neuroimaging findings in human prion disease. Journal of Neurology, Neurosurgery, and Psychiatry. 2007;78(7):664-670. doi:10.1136/jnnp.2006.094821
NHS Choices. Overview - Creutzfeldt-Jakob disease. NHS. Published 2019. https://www.nhs.uk/conditions/creutzfeldt-jakob-disease-cjd/
Mead S, Khalili-Shirazi A, Potter C, et al. Prion protein monoclonal antibody (PRN100) therapy for Creutzfeldt–Jakob disease: evaluation of a first-in-human treatment programme. The Lancet Neurology. 2022;21(4):342-354. doi:10.1016/s1474-4422(22)00082-5
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For the low, low price of $15.95 on Amazon, you can purchase a little spray bottle of pheromones that supposedly will trigger "animal attraction" in your partner. But is it true???
Pheromones are a well-known system of communicating territory, alarms, and sexual needs to other animals but is this system present in humans? We know that smell is an important component of sexual attraction and arousal but human beings seem to lack both the organ and brain region needed to process pheromone information. But maybe???
If you're curious, come and listen to learn a little bit more about what's happening upstairs!
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Citations below:
Jimenez J, Hughes K, Alaks G, Graham L, Lacy R. An experimental study of inbreeding depression in a natural habitat. Science. 1994;266(5183):271-273. doi:10.1126/science.7939661Keverne EB. The Vomeronasal Organ. Science. 1999;286(5440):716-720. doi:10.1126/science.286.5440.716
Kang N, Baum MJ, Cherry JA. Different Profiles of Main and Accessory Olfactory Bulb Mitral/Tufted Cell Projections Revealed in Mice Using an Anterograde Tracer and a Whole-Mount, Flattened Cortex Preparation. Chemical Senses. 2010;36(3):251-260. doi:10.1093/chemse/bjq120
Wang L, Zhang Z, Chen J, et al. Cell-Type-Specific Whole-Brain Direct Inputs to the Anterior and Posterior Piriform Cortex. Frontiers in Neural Circuits. 2020;14. doi:10.3389/fncir.2020.00004
Wedekind, C., Seebeck, T., Bettens, F. and Paepke, A. J. MHC-dependent mate preferences in humans. Proceedings of the Royal Society of London Series B. 1995: 260: 245-249
Meredith M. Human Vomeronasal Organ Function: A Critical Review of Best and Worst Cases. Chemical Senses. 2001;26(4):433-445. doi:10.1093/chemse/26.4.433
D’Aniello B, Semin GR, Scandurra A, Pinelli C. The Vomeronasal Organ: A Neglected Organ. Frontiers in Neuroanatomy. 2017;11. doi:10.3389/fnana.2017.00070
Rodriguez I, Greer CA, Mok MY, Mombaerts P. A putative pheromone receptor gene expressed in human olfactory mucosa. Nature Genetics. 2000;26(1):18-19. doi:10.1038/79124
Verhaeghe J, Gheysen R, Enzlin P. Pheromones and their effect on women’s mood and sexuality. Facts, Views & Vision in ObGyn. 2013;5(3):189-195. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987372/
Miller SL, Maner JK. Scent of a Woman. Psychological Science. 2009;21(2):276-283. doi:10.1177/0956797609357733
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Migraines are PAINFUL! And neuroscience speaking - super cool and complicated. It involves your blood vessels constricting and dilating and your brain going haywire and spreading a wave of neuron depression across your entire cortex.
Sound interesting? Come and take a listen to learn a little bit more about what happens in your brain!
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Citations below:
Headache disorders. www.who.int. https://www.who.int/news-room/fact-sheets/detail/headache-disorders#:~:text=Half%20to%20three%20quarters%20ofMigraine Headaches: Symptoms, Causes, Treatment & Prevention. Cleveland Clinic. Published March 3, 2021. https://my.clevelandclinic.org/health/diseases/5005-migraine-headaches
Ruthirago D, Julayanont P, Kim J. Translational Correlation. Conn’s Translational Neuroscience. Published online 2017:159-165. doi:10.1016/b978-0-12-802381-5.00013-0
Mason BN, Russo AF. Vascular Contributions to Migraine: Time to Revisit? Frontiers in Cellular Neuroscience. 2018;12. doi:10.3389/fncel.2018.00233
Wikipedia Contributors. Aristides Leão. Wikipedia. Published January 9, 2022. Accessed March 22, 2022. https://en.wikipedia.org/wiki/Aristides_Le%C3%A3o
Lauritzen M. Pathophysiology of the migraine aura. Brain. 1994;117(1):199-210. doi:10.1093/brain/117.1.199
Schain AJ, Melo-Carrillo A, Stratton J, Strassman AM, Burstein R. CSD-Induced Arterial Dilatation and Plasma Protein Extravasation Are Unaffected by Fremanezumab: Implications for CGRP’s Role in Migraine with Aura. The Journal of Neuroscience. 2019;39(30):6001-6011. doi:10.1523/jneurosci.0232-19.2019
Charles A, Brennan K. Cortical Spreading Depression—New Insights and Persistent Questions. Cephalalgia. 2009;29(10):1115-1124. doi:10.1111/j.1468-2982.2009.01983.x
Pietrobon D, Striessnig J. Neurobiology of migraine. Nature Reviews Neuroscience. 2003;4(5):386-398. doi:10.1038/nrn1102
Eisenstein M. Closing the gender gap in migraine research. Nature. 2020;586(7829):S16-S17. doi:10.1038/d41586-020-02867-4
Sutherland HG, Albury CL, Griffiths LR. Advances in genetics of migraine. The Journal of Headache and Pain. 2019;20(1). doi:10.1186/s10194-019-1017-9
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Itch is... uncomfortable. We've all been there before, one motivated mosquito takes a bite out of you, and you are left with an itchy red spot for a few days that only scratching can temporarily relieve. Have you ever wondered how that sensation is transferred to the brain and processed? How about why pain, like pressing really hard on that mosquito bite makes the itching go away. If the answer to any of these questions is YES, come and take a listen to learn a little bit more about what's happening upstairs!
Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at [email protected] or DM me at NeuroscienceAmateurHour on Instagram.
Citations below:
Henley C. Touch: The Skin. openbookslibmsuedu. Published online January 1, 2021. https://openbooks.lib.msu.edu/neuroscience/chapter/touch-the-skin/#:~:text=with%20the%20skin.-Feher J. 4.3 - Cutaneous Sensory Systems. ScienceDirect. Published January 1, 2012. Accessed March 13, 2022. https://www.sciencedirect.com/science/article/pii/B9780128008836000355
Ringkamp M, Meyer R. Pruriceptors. PubMed. Published 2014. Accessed March 13, 2022. https://www.ncbi.nlm.nih.gov/books/NBK200917/
Schmelz M. Itch Processing in the Skin. Frontiers in Medicine. 2019;6. doi:10.3389/fmed.2019.00167
Ikoma A, Cevikbas F, Kempkes C, Steinhoff M. Anatomy and Neurophysiology of Pruritus. Seminars in cutaneous medicine and surgery. 2011;30(2):64-70. doi:10.1016/j.sder.2011.04.001
Potenzieri C, Undem BJ. Basic mechanisms of itch. Clinical & Experimental Allergy. 2011;42(1):8-19. doi:10.1111/1.
Shim W-S, Oh U. Histamine-Induced Itch and its Relationship with Pain. Molecular Pain. 2008;4:1744-80694-29. doi:10.1186/1744-8069-4-29j.1365-2222.2011.03791.x
Forster C, Handwerker HO. Central Nervous Processing of Itch and Pain. PubMed. Published 2014. https://www.ncbi.nlm.nih.gov/books/NBK200926/
Papoiu ADP, Coghill RC, Kraft RA, Wang H, Yosipovitch G. A Tale of Two Itches. Common Features and Notable Differences in Brain Activation Evoked by Cowhage And Histamine Induced Itch. Neuroimage. 2012;59(4):3611-3623. doi:10.1016/j.neuroimage.2011.10.099
Ishiuji Y. Addiction and the itch‐scratch cycle. What do they have in common? Experimental Dermatology. 2019;28(12):1448-1454. doi:10.1111/exd.14029
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