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Ep. 15 - Beyond One-Size-Fits-All: The Science of Drug-Gene Interactions with Michelle Beckwith
This episode features Michelle "Shelly" Beckwith, a genetics pioneer since the 1990s who worked on the Human Genome Project. She breaks down how pharmacogenetic testing helps optimize medication choices by analyzing how patients' genetic variations affect drug metabolism. The discussion covers testing methods, insurance challenges, and the real-world implementation of pharmacogenetics in clinical practice. Through her work with MedTrait, Shelly explains how understanding a patient's genetic profile can lead to more precise medication dosing and better outcomes.
https://www.medtrait.net/
Timestamps:
00:02:34 - 00:04:18: Michelle Beckwith's Professional Background
00:04:19 - 00:08:34: Different Types of Genetic Testing
00:08:34 - 00:12:34: Technical Details of Testing Methods
00:12:34 - 00:27:24: Drug Metabolism & Clinical Applications
00:27:24 - 00:35:42: Population Genetics & Healthcare Access
00:35:42 - 00:45:52: Regulatory Environment & Future Challenges
00:45:52 - 01:12:32: Implementation & Practical Applications
01:12:32 - 01:14:10: Closing Remarks
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Michelle Beckwith
Michelle Beckwith has been at the forefront of genetics since the 90s, contributing to projects like the Human Genome Project and co-founding a laboratory specializing in DNA Human Identity testing. Her work in clinical pharmacogenetics has evolved into the foundation of MedTrait, one of our key partners at Biography Health, providing genetic insights for personalized medicine.
Dr. William Stanford MD PHD FACP
Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.
A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine
Sponsored by: Biography Health
Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.
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Genotyping vs. Sequencing: What's the Difference?
In this episode, Dr. William Stanford, Dr. Yelena Bykhovskaya and Taylor Cu discuss various genetic testing methods. The conversation compares genotyping, exome sequencing, and whole genome sequencing, with an emphasis on whole genome sequencing, which provides the most comprehensive genetic information.
Timestamps:
00:03:22 - Discussion begins on what popular genetic testing companies use (genotyping)
00:05:09 - Explanation of how genotyping chips (microarrays) work
00:17:24 - Clarification on the difference between genotyping and sequencing
00:20:31 - Introduction of the book analogy to explain different genetic testing methods
00:23:32 - Discussion on the pros and cons of whole genome sequencing vs. exome sequencing
00:25:48 - Conclusion on why whole genome sequencing is becoming the preferred method
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Dr. William Stanford MD PHD FACP
Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.
A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine
Dr. Yelena Bykhovskaya
Dr. Yelena Bykhovskaya is an accomplished scientist specializing in genetics and precision medicine. As the former Principal Scientist at Avellino Labs, she developed genetic tests for Mendelian and complex eye diseases using national and international collaborations. As the former Research Scientist at Cedars-Sinai, she made major advances in complex genetic eye diseases with groundbreaking genome-wide genetic analyses. Her earlier work in mitochondrial genetics led to major discoveries in maternally inherited deafness and other rare mitochondrial disorders. Holding a PhD in Biochemistry, Yelena has a publication record of widely cited forty-five articles in high-impact journals and delivered numerous oral and poster presentations at the national and international conferences, solidifying her leadership in genetic research.
Sponsored by: Biography Health
Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.
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In this episode, Dr. Yelena Bykhovskaya, Chief Scientific Officer at Biography Health, shares her expertise in genetics. We explore the importance of both polygenic and monogenic risk scores in patient care. The conversation underscores the value of combining cutting-edge genetic analysis with traditional clinical factors in the evolving field of precision medicine, emphasizing the need for a comprehensive approach to patient care.
Resources Mentioned:
https://www.genomeweb.com/
https://www.insideprecisionmedicine.com/
Timestamps:
00:03:34 - LinkedIn sparks Bykhovskaya-Stanford collaboration
00:06:27 - Stanford highlights Bykhovskaya's genetic risk expertise
00:13:13 - Genetic risk vs. family history explained
00:18:18 - Human Genome Project revolutionizes genetic analysis
00:24:54 - Whole genome sequencing: Key to comprehensive risk assessment
00:28:49 - High polygenic scores rival monogenic variants in risk
00:33:33 - Early intervention: Combating genetic predispositions
00:38:09 - Integrated risk scores: Combining genetics and clinical factors
00:44:00 - Basic genetic knowledge empowers doctors
00:52:59 - Addressing European bias in genetic studies
Dr. William Stanford MD PHD FACP
Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.
A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills
Sponsored by: Biography Health
Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.
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How Doctors are Using Genetic Data to Transform Patient Care with Philip Bretsky MD PhD MPH FACP
In this episode, we're joined by Dr. Philip Bretsky, a board-certified internist from Santa Monica with expertise in epidemiology and Alzheimer's research. Dr. Bretsky discusses how precision medicine is transforming healthcare by integrating genetics, biomarkers, and lifestyle factors. He explores the challenges and opportunities in implementing this approach, the evolving role of general practitioners, and how patients can advocate for personalized care. Dr. Bretsky also shares valuable resources for both health-conscious individuals and primary care providers interested in precision medicine. Join us for insights into the future of healthcare and strategies for better disease prevention and treatment.
Dr. Philip Bretsky's Contact Information:
Philip M. Bretsky MD PhD MPH FACP
1301 20th Street, Suite 230
Santa Monica, CA 90404
TEL: 310.828.4411
FAX: 310.828.2411
Facebook:@santamonicaprimarycare
Twitter / X: @santa_care
Instagram: @santa_monica_primary_care
Web: www.drbretsky.com & www.santamonicaprimarycare.com
My monthly newsletter: https://lp.constantcontactpages.com/su/JtF9zzR
Timestamps:
03:18 – Dr. Philip Bretsky’s career path and personalized care.
09:26 – Shifting from treating to preventing disease.
12:02 – Gene-environment interactions and polygenic risk scores.
19:15 – Managing complex health problems as a general practitioner.
29:06 – Reflections on the Human Genome Project’s impact.
36:29 – Case study: Preventing coronary events.
44:17 – Advice for patients on advocating for personalized
Resources Mentioned:
Books:
"Outlive" by Peter Attia"The Age of Scientific Wellness" by Leroy Hood"The Covenant of Water" by Abraham Verghese (fiction, but related to genetic conditions)Podcasts/Newsletters:
Eric Topol's substack and Twitter feedPeter Attia's podcastDr. William Stanford MD PHD FACP
Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.
A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford...
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Redefining the Healthcare Model: Insights from 20-Year Executive Lucy Janoyan
In this episode, we're joined by special guest Lucy Janoyan, Chief Strategy Officer at Biography Health. With over two decades of healthcare executive experience, Lucy explores the transition from reactive to proactive healthcare. She discusses the challenges facing primary care providers, the role of genetic testing in personalized medicine, and how Biography Health is working to empower both patients and doctors. Lucy shares insights on continuous health monitoring, patient engagement, and the future of healthcare, offering valuable perspectives for healthcare professionals and health-conscious individuals alike.
Timestamps:
00:02:09 - Introduction of guest Lucy Janoyan, Chief Strategy Officer at Biography Health
00:03:28 - Lucy discusses her background and connection with Dr. Stanford
00:06:55 - Discussion of challenges in current healthcare system and move towards precision medicine
00:16:27 - Discussion of issues with current reactive "sick care" system
00:25:52 - Discussion of barriers for physicians in providing preventive care
00:32:28 - Overview of how Biography Health platform works for providers
00:48:56 - Details on Biography Health's features and benefits for providers and patients
00:56:53 - Discussion of ongoing patient monitoring and updates through the platform
01:18:51 - Closing thoughts and how listeners can learn more about Biography Health
Dr. William Stanford MD PHD FACP
Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.
A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field.
Sponsored by: Biography Health
Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.
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Gen Z Takes Action: The Preventive Health Shift
In this episode, we're joined by two younger guests for our Gen Z special featuring Eliana Stanford, Dr. Stanford's daughter, and Lexie Horizon, whose parents are fellow doctors and friends of Dr. Stanford, and who recently interned at Biography Health. This unique conversation explores why younger generations should care about and take action towards preventive healthcare.
Timestamps:
03:39:19 - Elena and Lexie introduce themselves and their backgrounds.
07:50:13 - Discussion on why younger generations are becoming interested in preventive healthcare.
11:37:23 - Dr. Stanford explains what whole genome sequencing is and how it differs from other genetic testing methods.
25:28:19 - Conversation about privacy concerns related to genetic data.
38:46:12 - Discussion on how precision medicine can benefit mental health treatment.
46:57:18 - Exploration of the challenges in making preventive care accessible and affordable.
54:35:01 - Dr. Stanford discusses the potential for precision medicine to improve healthcare in developing countries.
01:05:06 - Concluding remarks on the future of healthcare and the role of the younger generation in shaping it.
Dr. William Stanford MD PHD FACP
Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.
A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field.
Sponsored by: Biography Health
Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.
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Taylor Can't Outrun His Genetics: Lipid Panel Reality Check
In this episode, Dr. Stanford and I uncover surprising truths from my advanced lipid panel. Despite my active lifestyle, the results reveal hidden risks for heart disease and diabetes. We explore how genetic factors and subtle imbalances can impact long-term health, and discuss targeted interventions that could make all the difference.
Timestamps:
00:02:39 - Overview of advanced lipid panel and family history
00:05:16 - Discussion of lipoprotein and genetic risk factors
00:08:31 - Analysis of lab results and inflammation markers
00:13:06 - Exploration of uric acid levels and gout risk
00:17:11 - Review of A1C levels and insulin resistance
00:23:33 - Realization of potential atherosclerosis at age 30
00:27:31 - Discussion on genetics vs. lifestyle choices
00:32:10 - Conversation about sugar alternatives and diet
00:38:17 - Projections of future health issues without intervention
00:49:14 - Recap of interventions and lifestyle changes
00:55:07 - Closing thoughts and importance of preventive care
Dr. William Stanford MD PHD FACP
Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.
A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field.
Sponsored by: Biography Health
Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.
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In this informative episode of the Precision Medicine Made Simple Podcast, we delve into the world of lipids with Dr. Stanford. Learn what lipids are and why they're crucial for your health, especially regarding heart disease prevention. We explore the differences between HDL and LDL cholesterol, discuss genetic factors influencing lipid levels, and explain why even vegetarians need to pay attention to their lipid profiles.
Dr. Stanford breaks down advanced lipid panels, explaining key markers like apolipoprotein B and lipoprotein(a). We address when to start checking your lipids and why family history is a powerful tool in assessing your risk. The episode also touches on exciting developments in lipid management, including potential new treatments for high lipoprotein(a) levels.
Timestamps:
03:12 - Explanation of what lipids are and their importance
06:02 - Discussion of atherosclerosis and heart disease risk
07:35 - Explanation of "good" vs "bad" cholesterol (HDL vs LDL)
11:28 - Discussion of vegetarian diets and cholesterol levels
13:16 - Introduction of familial hypercholesterolemia and lipoprotein(a)
16:21 - Lifestyle factors and genetic predisposition to high cholesterol
19:36 - Discussion of new medications and treatments in development
25:53 - Guidelines for lipid testing and personalized medicine approach
34:22 - Detailed explanation of advanced lipid panel markers
46:56 - Explanation of new drug development processes for lipid management
Dr. William Stanford MD PHD FACP
Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.
A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field.
Sponsored by: Biography Health
Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.
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From Genes to Actions: Taylor's DNAbled Blueprint Experience
Today marks the beginning of an ongoing series where I'm pulling back the curtain on my personal journey through the DNAbled Blueprint process. You'll get an exclusive, firsthand look at:
My own intake form: Revealing insights from my personal and family health historyOne of my genetic reports: Dr. Stanford examines my polygenic risk score, discussing my genetic predisposition to certain health conditionsMy personalized DNAbled Blueprint consultation: Experience the moment I receive my tailored health recommendations and action planThis intimate look at my health journey aims to demystify the process and inspire you to take charge of your own wellbeing.
Dr. Stanford has equipped me with specific action items, so we'll be recording numerous episodes discussing my results and the strategies I'm implementing. Join me as we explore the ongoing impact of precision medicine in real-time.
Plus, our sponsor Biography Health is offering early access users a special introductory rate for the DNAbled Blueprint. This includes app access, reports, and a personalized recommended health strategy.
If you're interested in participating, feel free to email me directly at [email protected].
Timestamps:
00:04:36 - Intake Form Walkthrough
00:38:26 - Allelica Report, Polygenic Risk Scores
00:53:25 - DNAbled Blueprint Consultation
Dr. William Stanford MD PHD FACP
Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.
A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field.
Sponsored by: Biography Health
Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.
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Cracked the Genetic Code! Methylation and the Future of Precision Medicine
This is the second half of the two part series to Dr. Stanford’s presentation called, “Optimizing Healthspan and Longevity by Implementing Personalized Precision Medicine.” For this episode, we dive into the science of methylation patterns and how we can use it to detect various cancers and their tissue origins enabling early intervention for better treatment outcomes and ultimately paving the way for tailored therapies. Similar to the last episode, there are supporting graphics and diagrams so we highly recommend watching this episode on our YouTube channel as this discussion does get pretty technical in various parts of the conversation.
Timestamps:
[00:04:22] Detecting cancer through DNA methylation patterns.
[00:08:56] DNA sequencing reveals gene expression patterns.
[00:12:15] Cancer turns off genes, DNA sequencing detects.
[00:16:01] Detect tumor DNA in bloodstream. Identify cancer signal.
[00:19:20] Methylation patterns in DNA detect cancer.
[00:22:55] Screening for cancer over fifty. Insurance doesn't cover yet.
[00:26:09] Precision medicine case study on heart health.
[00:29:25] Imaging center found life-saving genetic risk.
[00:32:24] Personalized medicine increases health span, reduces costs.
Dr. William Stanford MD PHD FACP
Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.
A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field.
Sponsored by: Biography Health
Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.
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These next two episodes are a two part series to Dr. Stanford’s presentation called “Optimizing Healthspan and Longevity by Implementing Personalized Precision Medicine. Think of this episode like Precision Medicine 101. Dr. Stanford dives into a number of different topics including the evolution of personalized precision medicine and how its changing healthcare, the significance of knowing your risks by looking at genetics, family history, monogenic risks and polygenic risk scores, and pharmacogenomics which is tailoring drug treatments based on individual genetic variations. While this episode is available on audio platforms, we highly recommend watching this episode on YouTube as Dr. Stanford references numerous visuals and graphs.
Timestamps:
[00:06:05] Personalized precision medicine focuses on prevention and early detection. Patient-centered care needed for effectiveness. Regulatory bodies must adapt to rapid advancements.
[00:11:48] Genetic sequencing now faster, cheaper. Exciting advancements.
[00:18:06] Genetic variation leads to personalized medicine.
[00:22:53] Future of healthcare: personalized, predictive, proactive.
[00:28:20] Combining genetic and clinical factors.
[00:33:32] Assess risk using family history and polygenic risk scores.
[00:39:43] Risk stratification crucial for preventive care.
[00:45:03] Genetic testing can personalize drug treatment.
[00:49:39] Precision medicine improves drug reactions prediction.
Dr. William Stanford MD PHD FACP
Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.
A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field.
Sponsored by: Biography Health
Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.
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For this episode, Dr. Stanford, Alyssa Stanford, and Taylor Cu discuss the topic of cancer. Dr. Stanford provides a comprehensive breakdown of cancer cells, stressing the need for genetic and molecular profiling to tailor treatments. They explore the factors that contribute to cancer development, including lifestyle choices and genetic mutations, and emphasize the importance of early detection through screenings and genetic analysis. They also dive into the exciting advancements in early cancer identification, as well as the role of the immune system in fighting cancer cells.
Timestamps:
[00:15:36] Preventative measures key to reducing cancer.
[00:30:57] Early detection key for cancer survival.
[00:47:08] Precision medicine uses genetic risk factors to predict future cancer risk and inform treatment decisions. Inflammation and oxidative stress play a role in cancer development.
[01:02:36] Cancer complexity and precision medicine summary.
Dr. William Stanford MD PHD FACP
Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.
A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist.
Sponsored by: Biography Health
Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.
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For this episode, Dr. Stanford, Alyssa Stanford, and Taylor Cu dive into the complexities of metabolic syndrome, how it can relate to several chronic diseases and discuss the impact of genetics, diet, and exercise on our overall health. We also touch on the importance of precision medicine and continuous glucose monitoring in managing conditions like diabetes and touch on some of the benefits of medications currently out there like Ozempic.
Timestamps:
[00:05:44] Metabolic syndrome increases chronic disease risk.
[00:10:26] Fatty liver disease is a modern problem.
[00:16:27] Processed foods worsen metabolic health, inflammation.
[00:22:40] Eating standing up may worsen insulin resistance.
[00:29:05] High insulin levels lead to diabetes.
[00:35:15] Dexcom for diabetics, Ozempic for symptoms.
[00:40:59] Medications show promise for various benefits.
[00:46:22] Metabolic syndrome is often overlooked.
[00:52:39] Improve health with precision medicine steps.
Dr. William Stanford MD PHD FACP
Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.
A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist.
Sponsored by: Biography Health
Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.
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In this episode, we’re joined by Dr. Stanford and Taylor Cu to explore neurodegenerative diseases such as Alzheimer’s and Parkinson's. It's a particularly personal discussion as Dr. Stanford shares his own genetic risk for Alzheimer’s, linked to the APOE4 gene. Dr. Stanford explains what neurodegenerative diseases are and dives into the specifics of Alzheimer's, including how genetics play a role in its risk. We wrap up the episode by looking at lifestyle changes that could make a significant impact in prevention.
Timestamps:
[00:04:50] Degenerative diseases share commonality in brain shrinkage. Alzheimer's is most common, starts early.
[00:09:24] APOE Epsilon four leads to abnormal function in cholesterol transport, amyloid plaques and tau proteins play a role in Alzheimer's disease progression.
[00:14:03] Alzheimer's disease is complex and mysterious.
[00:18:00] Lifestyle impacts neurodegenerative disease risk.
[00:22:37] Difference between Alzheimer's and general dementia.
[00:27:07] Inflammation bad for heart and brain.
[00:32:23] Genetic testing can predict future health.
[00:37:44] Prevent dementia with lifestyle changes.
[00:43:01] Improve brain health with exercise, socialization.
Dr. William Stanford MD PHD FACP
Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.
A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist.
Sponsored by: Biography Health
Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.
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Dr. Stanford, Alyssa Stanford, and Taylor Cu explore the fascinating world of heart disease and personalized health care. They dive into the complexities of heart disease, discussing the crucial role of genetics, family history, lifestyle, and biochemistry in assessing heart disease risk. Tune in to discover the power of early detection, personalized health plans, and integrative approaches to effectively address heart disease and more.
Timestamps:
[00:05:14] Arterial hardening and narrowing cause issues.
[00:09:11] Early onset heart disease linked to genetics.
[00:13:28] Genetic sequencing can predict heart attack.
[00:18:01] Improve lipid profile with medication, lifestyle.
[00:22:44] Genetic testing predicts future disease risk.
[00:27:35] Genetics and lifestyle impact heart disease.
[00:32:02] Gene editing for liver disease treatment.
[00:36:52] Liver cells have receptors for particles.
[00:42:23] Coronary disease and vascular health summary.
Dr. William Stanford MD PHD FACP
Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.
A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist.
Sponsored by: Biography Health
Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.
