エピソード
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In today’s episode, we discuss how to approach AML treatment for patients who are unfit for intensive therapy.
Episode contents:
- How do we assess fitness for intensive AML?
- What are options for patients who are unfit for intensive chemotherapy for AML?
- What are important genetic mutations are important to check for?
- What are the key trials that inform our management in this space?
- How do we dose venetoclax?
- How do we sequence the available agents?
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** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes
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In today’s episode, we welcome back Dr. Amar Kelkar for part 2 of our two-part discussion on allogeneic transplant. In this episode, we build on our prior discussion regarding transplant, this time focusing on transplant for the treatment of AML.
Episode contents:
- What are the different conditioning regimens available?
- How do we decide which regimen is optimal for our patients?
- What is the role of MRD testing?
- What is the role of maintenance therapy post-transplant?
- What are treatment options for GVHD?
- A discussion on racial disparities in transplant
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** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes
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Twitter: @TheFellowOnCall
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エピソードを見逃しましたか？
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In today’s episode, we welcome back Dr. Amar Kelkar for part 1 of our two-part discussion on allogeneic transplant. In this episode, we discuss the fundamental approach to patient selection and stem cell source selection. As you all know from this series, allogeneic transplants play a pivotal role in the management of AML. Dr. Kelkar’s pearls of wisdom help make this confusing topic so much more approachable!
Episode contents:
- What factors do we incorporate when considering a patient for allogeneic transplant?
- How do we use HLA-matching?
- What are the pros and cons of the different sources of stem cells?
****Get paid to participate in market research surveys: https://affiliatepanel.members-only.online/FOC_24?utm_campaign=FOC&utm_source=email&utm_medium=email
** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes
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Twitter: @TheFellowOnCall
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This week, we continue our series focusing on acute myeloid leukemia. In this episode, we talk about maintenance therapies in AML.
Episode contents:
- A recap of cytarabine consolidation
- Why do we do maintenance therapy?
- What are hypomethylating agents and how do they work?
- Important targeted agents that play a role in maintenance therapy
****This episode is sponsored by our Global Research Partners! Get paid to participate in market research surveys: https://affiliatepanel.members-only.online/FOC_24?utm_campaign=FOC&utm_source=email&utm_medium=email
** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes
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Twitter: @TheFellowOnCall
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This week, we continue our discussion on consolidation and maintenance therapies for AML, this time highlighting the role of allogeneic stem cell transplants. This episode builds on our prior episode, so if you have not listened to this just yet, we highly recommend doing so!
Episode contents:
- A recap on approach to AML consolidation
- The role of allogeneic transplants
- The role of MRD testing in AML management
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Twitter: @TheFellowOnCall
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This week, we move to our next phases of therapy for AML, which are consolidation and maintenance. Be sure to check out our prior episodes for a discussion on initial workup and how we incorporate recurrent genetic abnormalities into how we think about AML. Check out figure 1 from this paper for a helpful diagram!
Episode contents:
- A recap on approach to AML treatment
- Who do we consider for allogeneic transplant?
- What are common therapy-related AML cytogenetic abnormalities to be aware of?
- How do we approach consolidation? Role of G-CSF?
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Twitter: @TheFellowOnCall
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This week, we round out our discussion regarding AML induction, this time focusing on the treatment options in the first line setting. We go through the various options, the dosing strategies, and the data behind them.
Be sure to check out parts one and two of this three-part induction discussion, as we continue to build on these concepts! Also, if you have not done so, please do check out our hemepath series to ensure you can more easily follow along with this conversation!
Episode contents:
- What are our options for upfront induction therapy?
- How do we select patients for the "add-ons" to induction therapy?
- What is the data behind these options?
****This episode is sponsored by our Global Research Partners! Have some time and want to make some extra money? Get paid to participate in market research surveys: https://affiliatepanel.members-only.online/FOC_24?utm_campaign=FOC&utm_source=email&utm_medium=email
** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes
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Twitter: @TheFellowOnCall
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In this week’s episode, we continue onto part two of our three-part discussion on AML induction, this week focusing on selecting our up-front regimen.
Be sure to check out last week’s episode, as this one builds on that one. Also, if you have not done so, please do check out our hemepath series to ensure you can more easily follow along with this conversation!
Episode contents:
- What is "7+3"?
- How do we pick our approach to management?
- Do we ever add anything else to our induction back bone?
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Twitter: @TheFellowOnCall
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In this week’s episode, we start our three-part discussion on AML induction, this week focusing on key definitions and an overview of treatment. Also, if you have not done so, please do check out our hemepath series to ensure you can more easily follow along with this conversation!
Episode contents:
- What are "blasts"?
- If there is concern for AML, then what?
- Role of leukapheresis or cytoreduction
- Diagnostic workup
- Risk stratification
- Approach to treatment
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** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes
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Twitter: @TheFellowOnCall
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In this week’s episode, we discuss the diagnostic criteria and risk stratification for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), building on our discussion from last week. Also, if you have not done so, please do check out our hemepath series to ensure you can more easily follow along with this conversation!
Episode contents:
- A review of what to look at on the bone marrow biopsy report
- WHO and ICC classification for AML and MDS
- Disease-defining cytogenetic markers to be aware of and their prognostic implications
****Have some time and want to make some extra money? Get paid to participate in market research surveys: https://affiliatepanel.members-only.online/FOC_24?utm_campaign=FOC&utm_source=email&utm_medium=email
** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes
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Twitter: @TheFellowOnCall
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This week, we kick off a new series focusing on myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). In this first episode, we discuss the alphabet soup of premalignant hematologic conditions including CHIP, CCUS, and ICUS, before moving onto MDS and AML in future episodes.
Episode contents:
- What is CHIP vs. CCUS vs. ICUS?
- What is the mechanism of hematopoiesis?
- What is clonality?
- What is a variant allele frequency?
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** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes
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Twitter: @TheFellowOnCall
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By popular demand, our next series that we are excited to share with you is on MDS/AML! As we prepare for the release of the first episode next week, let’s throw it back to Episode 019 in our Heme/Onc Emergencies Series and talk about APL!
Episode contents:
- How do we diagnose APL?
- What are characteristic findings of APL?
- What is the acute management of this disease?
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Twitter: @TheFellowOnCall
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This week, we have an INCREDIBLE episode for you. We welcome Titilope Fasipe, MD, PhD, who not only is the Co-Director of the Sickle Cell and Thalassemia Program at Texas Children’s and an Assistant Professor in the Department of Pediatrics at the Baylor College of Medicine, she herself also has sickle cell disease! Dr. Fasipe takes us through her life story, from childhood to now. Conducting this interview was such an eye-opening experience for us, and we hope that her message resonates with you when you care for your patients with sickle cell disease.
Contents:
- What it is like growing up with sickle cell disease?
- Pearls to ensure that our practice provides excellent care for our patients with SCD
- Important resources when caring for patients
****Have some time and want to make some extra money? Get paid to participate in market research surveys: https://affiliatepanel.members-only.online/FOC_24?utm_campaign=FOC&utm_source=email&utm_medium=email
** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes
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Twitter: @TheFellowOnCall
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In this week’s episode, we discuss the management of sickle cell disease in the chronic setting. This is a follow up to episode 111 where we discussed acute management of SCD. And furthermore, this is also in addition to our prior discussion about long-term chronic complications from SCD in episode 110. We highly recommend checking out these prior episodes if you haven’t done so already!
Contents:
- Use of hydroxyurea in SCD management
- Newer adjunctive therapies for SCD management
- Perioperative management
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** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes
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Twitter: @TheFellowOnCall
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In this week’s episode, we discuss the management of acute complications of sickle cell disease including acute pain episodes and acute chest syndrome as well as a discussion of hyperhemolytic syndrome.
Contents:
- How to manage patients with sickle cell disease presenting for acute pain crises
- How to approach management of acute chest syndrome
- What is hyperhemolytic crisis?
- What is splenic and hepatic sequestration syndrome?
**This episode is sponsored by our global research partners! Have some time and want to make some extra money? Get paid to participate in market research surveys: https://affiliatepanel.members-only.online/FOC_24?utm_campaign=FOC&utm_source=email&utm_medium=email
** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes
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Twitter: @TheFellowOnCall
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In this week’s episode, we discuss chronic complications that can arise in patients with sickle cell disease. The reality is, that unless we have an outpatient clinic or rotate through an outpatient clinic, there is a small chance that we will come across many of these issues. However, screening for and managing these chronic complications can have significant implications on our patients’ lives.
Contents:
- What are the current screening guidelines for sickle cell disease complications?
- What are key studies in pediatric SCD management?
- Management of stroke, avascular necrosis, pain, pulmonary hypertension, kidney disease, iron overload, and other important complications to be aware of
**Have some time and want to make some extra money? Get paid to participate in market research surveys: https://affiliatepanel.members-only.online/FOC_24?utm_campaign=FOC&utm_source=email&utm_medium=email
** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes
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Twitter: @TheFellowOnCall
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It’s time for another new series, this time focusing on Sickle Cell Disease! In this first episode, we lay the foundation for our future discussions. This episode can be dense, but rest assured we will revisit these concepts and expand on them throughout the series.
Contents:
- What is hemoglobin?
- What is the underlying problem in sickle cell disease genotypically?
- Why is the presence of sickled cells problematic?
- What is sickle cell trait?
- What are other presentations similar to sickle cell disease/HbSS?
- What are common electrophoresis patterns?
- What is "hereditary persistence of hemoglobin"?
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Twitter: @TheFellowOnCall
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This week, we round out our discussion on metastatic colorectal cancer, focusing on more targeted therapies for this disease. If you have not done so already, be sure to check out episode 107 for the first part of our metastatic colorectal cancer discussion.
Contents:
- What is the role of immunotherapy?
- What is the role of BRAF inhibition?
- Can we use HER2 targeted therapies?
- What is the role of more intensive chemotherapy regiments for patients?
**Have some time and want to make some extra money? Get paid to participate in market research surveys: https://affiliatepanel.members-only.online/FOC_24?utm_campaign=FOC&utm_source=email&utm_medium=email
** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes
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Twitter: @TheFellowOnCall
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This week, we continue our discussion of colorectal cancer, turning our attention to metastatic disease, specifically for cancers without targetable mutations. If you have not done already, we highly recommend you check out episode 104 for our GI oncology pharmacology discussion!
Contents:
- What information do we need when we approach a new patient with metastatic colorectal cancer?
- How did we get to our current treatment paradigm?
- Is there a role for maintenance 5-FU?
- What is the role of EGFR-inhibitor bevacizumab?
- Why does mutational analysis matter?
- Why does sidedness of the tumor matter?
- Is there a role for treatment holidays?
- What do we do at the time of disease progression?
**This episode is sponsored by our Global Research Partners! Get paid to participate in market research surveys: https://affiliatepanel.members-only.online/FOC_24?utm_campaign=FOC&utm_source=email&utm_medium=email
** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes
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Twitter: @TheFellowOnCall
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** Be sure to check out our rotation guide for more show notes and episodes organized by disease type: https://www.thefellowoncall.com/rotation-guides
** Want to review the show notes for this episode and others? Check out our website: https://www.thefellowoncall.com/our-episodes
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Twitter: @TheFellowOnCall
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