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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.
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Hessam Akhlaghpour is a postdoctoral researcher at Rockefeller University in the Maimon lab. His experimental work is in fly neuroscience mostly studying spatial memories in fruit flies. However, we are going to be talking about a different (although somewhat related) side of his postdoctoral research. This aspect of his work involves theoretical explorations of molecular computation, which are deeply inspired by Randy Gallistel and Adam King's book Memory and the Computational Brain. Randy has been on the podcast before to discuss his ideas that memory needs to be stored in something more stable than the synapses between neurons, and how that something could be genetic material like RNA. When Hessam read this book, he was re-inspired to think of the brain the way he used to think of it before experimental neuroscience challenged his views. It re-inspired him to think of the brain as a computational system. But it also led to what we discuss today, the idea that RNA has the capacity for universal computation, and Hessam's development of how that might happen. So we discuss that background and story, why universal computation has been discovered in organisms yet since surely evolution has stumbled upon it, and how RNA might and combinatory logic could implement universal computation in nature.
Hessam's website.Maimon Lab.Twitter: @theHessam.Related papersAn RNA-based theory of natural universal computation.The molecular memory code and synaptic plasticity: a synthesis.Lifelong persistence of nuclear RNAs in the mouse brain.Cris Moore's conjecture #5 in this 1998 paper.(The Gallistel book): Memory and the Computational Brain: Why Cognitive Science Will Transform Neuroscience.Related episodesBI 126 Randy Gallistel: Where Is the Engram?BI 172 David Glanzman: Memory All The Way DownRead the transcript.
0:00 - Intro4:44 - Hessam's background11:50 - Randy Gallistel's book14:43 - Information in the brain17:51 - Hessam's turn to universal computation35:30 - AI and universal computation40:09 - Universal computation to solve intelligence44:22 - Connecting sub and super molecular50:10 - Junk DNA56:42 - Genetic material for coding1:06:37 - RNA and combinatory logic1:35:14 - Outlook1:42:11 - Reflecting on the molecular world
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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.
Read more about our partnership.
Sign up for the “Brain Inspired” email alerts to be notified every time a new “Brain Inspired” episode is released: https://www.thetransmitter.org/newsletters/
To explore more neuroscience news and perspectives, visit thetransmitter.org.
Tony Zador runs the Zador lab at Cold Spring Harbor Laboratory. You've heard him on Brain Inspired a few times in the past, most recently in a panel discussion I moderated at this past COSYNE conference - a conference Tony co-founded 20 years ago. As you'll hear, Tony's current and past interests and research endeavors are of a wide variety, but today we focus mostly on his thoughts on NeuroAI.
We're in a huge AI hype cycle right now, for good reason, and there's a lot of talk in the neuroscience world about whether neuroscience has anything of value to provide AI engineers - and how much value, if any, neuroscience has provided in the past.
Tony is team neuroscience. You'll hear him discuss why in this episode, especially when it comes to ways in which development and evolution might inspire better data efficiency, looking to animals in general to understand how they coordinate numerous objective functions to achieve their intelligent behaviors - something Tony calls alignment - and using spikes in AI models to increase energy efficiency.
Zador LabTwitter: @TonyZadorPrevious episodes:BI 187: COSYNE 2024 Neuro-AI Panel.BI 125 Doris Tsao, Tony Zador, Blake Richards: NAISysBI 034 Tony Zador: How DNA and Evolution Can Inform AIRelated papersCatalyzing next-generation Artificial Intelligence through NeuroAI.Encoding innate ability through a genomic bottleneck.EssaysNeuroAI: A field born from the symbiosis between neuroscience, AI.What the brain can teach artificial neural networks.Read the transcript.
0:00 - Intro3:28 - "Neuro-AI"12:48 - Visual cognition history18:24 - Information theory in neuroscience20:47 - Necessary steps for progress24:34 - Neuro-AI models and cognition35:47 - Animals for inspiring AI41:48 - What we want AI to do46:01 - Development and AI59:03 - Robots1:25:10 - Catalyzing the next generation of AI
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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.
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Sign up for the “Brain Inspired” email alerts to be notified every time a new “Brain Inspired” episode is released.
To explore more neuroscience news and perspectives, visit thetransmitter.org.
Karen Adolph runs the Infant Action Lab at NYU, where she studies how our motor behaviors develop from infancy onward. We discuss how observing babies at different stages of development illuminates how movement and cognition develop in humans, how variability and embodiment are key to that development, and the importance of studying behavior in real-world settings as opposed to restricted laboratory settings. We also explore how these principles and simulations can inspire advances in intelligent robots. Karen has a long-standing interest in ecological psychology, and she shares some stories of her time studying under Eleanor Gibson and other mentors.
Finally, we get a surprise visit from her partner Mark Blumberg, with whom she co-authored an opinion piece arguing that "motor cortex" doesn't start off with a motor function, oddly enough, but instead processes sensory information during the first period of animals' lives.
Infant Action Lab (Karen Adolph's lab)Sleep and Behavioral Development Lab (Mark Blumberg's lab)Related papersMotor Development: Embodied, Embedded, Enculturated, and EnablingAn Ecological Approach to Learning in (Not and) DevelopmentAn update of the development of motor behaviorProtracted development of motor cortex constrains rich interpretations of infant cognitionRead the transcript.
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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.
This is the second conversation I had while teamed up with Gaute Einevoll at a workshop on NeuroAI in Norway. In this episode, Gaute and I are joined by Cristina Savin and Tim Vogels. Cristina shares how her lab uses recurrent neural networks to study learning, while Tim talks about his long-standing research on synaptic plasticity and how AI tools are now helping to explore the vast space of possible plasticity rules.
We touch on how deep learning has changed the landscape, enhancing our research but also creating challenges with the "fashion-driven" nature of science today. We also reflect on how these new tools have changed the way we think about brain function without fundamentally altering the structure of our questions.
Be sure to check out Gaute's Theoretical Neuroscience podcast as well!
Mikkel LepperødCristina SavinTim VogelsTwitter: @TPVogelsGaute EinevollTwitter: @GauteEinevollGaute's Theoretical Neuroscience podcast.Validating models: How would success in NeuroAI look like?Read the transcript, provided by The Transmitter.
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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.
This is the first of two less usual episodes. I was recently in Norway at a NeuroAI workshop called Validating models: How would success in NeuroAI look like? What follows are a few recordings I made with my friend Gaute Einevoll. Gaute has been on this podcast before, but more importantly he started his own podcast a while back called Theoretical Neuroscience, which you should check out.
Gaute and I introduce the episode, then briefly speak with Mikkel Lepperød, one of the organizers of the workshop. In this first episode, we're then joined by Ken Harris and Andreas Tolias to discuss how AI has influenced their research, thoughts about brains and minds, and progress and productivity.
Validating models: How would success in NeuroAI look like?Mikkel LepperødAndreas ToliasTwitter: @AToliasLabKen HarrisTwitter: @kennethd_harrisGaute EinevollTwitter: @GauteEinevollGaute's Theoretical Neuroscience podcast.Read the transcript, provided by The Transmitter.
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https://youtu.be/lbKEOdbeqHoThe Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.
The Transmitter has provided a transcript for this episode.
Vijay Namoodiri runs the Nam Lab at the University of California San Francisco, and Ali Mojebi is an assistant professor at the University of Wisconsin-Madison. Ali as been on the podcast before a few times, and he's interested in how neuromodulators like dopamine affect our cognition. And it was Ali who pointed me to Vijay, because of some recent work Vijay has done reassessing how dopamine might function differently than what has become the classic story of dopamine's function as it pertains to learning. The classic story is that dopamine is related to reward prediction errors. That is, dopamine is modulated when you expect reward and don't get it, and/or when you don't expect reward but do get it. Vijay calls this a "prospective" account of dopamine function, since it requires an animal to look into the future to expect a reward. Vijay has shown, however, that a retrospective account of dopamine might better explain lots of know behavioral data. This retrospective account links dopamine to how we understand causes and effects in our ongoing behavior. So in this episode, Vijay gives us a history lesson about dopamine, his newer story and why it has caused a bit of controversy, and how all of this came to be.
I happened to be looking at the Transmitter the other day, after I recorded this episode, and low and behold, there was an article titles Reconstructing dopamine’s link to reward. Vijay is featured in the article among a handful of other thoughtful researchers who share their work and ideas about this very topic. Vijay wrote his own piece as well: Dopamine and the need for alternative theories. So check out those articles for more views on how the field is reconsidering how dopamine works.
Nam Lab.Mohebi & Associates (Ali's Lab).Twitter:@vijay_mkn@mohebialTransmitterDopamine and the need for alternative theories.Reconstructing dopamine’s link to reward.Related papersMesolimbic dopamine release conveys causal associations.Mesostriatal dopamine is sensitive to changes in specific cue-reward contingencies.What is the state space of the world for real animals?The learning of prospective and retrospective cognitive maps within neural circuitsFurther reading(Ali's paper): Dopamine transients follow a striatal gradient of reward time horizons.Ali listed a bunch of work on local modulation of DA release:Local control of striatal dopamine release.Synaptic-like axo-axonal transmission from striatal cholinergic interneurons onto dopaminergic fibers.Spatial and temporal scales of dopamine transmission.Striatal dopamine neurotransmission: Regulation of release and uptake.Striatal Dopamine Release Is Triggered by Synchronized Activity in Cholinergic Interneurons.An action potential initiation mechanism in distal axons for the control of dopamine release.Read the transcript, produced by The Transmitter.
0:00 - Intro3:42 - Dopamine: the history of theories32:54 - Importance of learning and behavior studies39:12 - Dopamine and causality1:06:45 - Controversy over Vijay's findings
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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.
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Check out this story: Monkeys build mental maps to navigate new tasks
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Kim Stachenfeld embodies the original core focus of this podcast, the exploration of the intersection between neuroscience and AI, now commonly known as Neuro-AI. That's because she walks both lines. Kim is a Senior Research Scientist at Google DeepMind, the AI company that sprang from neuroscience principles, and also does research at the Center for Theoretical Neuroscience at Columbia University. She's been using her expertise in modeling, and reinforcement learning, and cognitive maps, for example, to help understand brains and to help improve AI. I've been wanting to have her on for a long time to get her broad perspective on AI and neuroscience.
We discuss the relative roles of industry and academia in pursuing various objectives related to understanding and building cognitive entities
She's studied the hippocampus in her research on reinforcement learning and cognitive maps, so we discuss what the heck the hippocampus does since it seems to implicated in so many functions, and how she thinks of reinforcement learning these days.
Most recently Kim at Deepmind has focused on more practical engineering questions, using deep learning models to predict things like chaotic turbulent flows, and even to help design things like bridges and airplanes. And we don't get into the specifics of that work, but, given that I just spoke with Damian Kelty-Stephen, who thinks of brains partially as turbulent cascades, Kim and I discuss how her work on modeling turbulence has shaped her thoughts about brains.
Kim's website.Twitter: @neuro_kim.Related papersScaling Laws for Neural Language Models.Emergent Abilities of Large Language Models.Learned simulators:Learned coarse models for efficient turbulence simulation.Physical design using differentiable learned simulators.Check out the transcript, provided by The Transmitter.
0:00 - Intro4:31 - Deepmind's original and current vision9:53 - AI as tools and models12:53 - Has AI hindered neuroscience?17:05 - Deepmind vs academic work balance20:47 - Is industry better suited to understand brains?24?42 - Trajectory of Deepmind27:41 - Kim's trajectory33:35 - Is the brain a ML entity?36:12 - Hippocampus44:12 - Reinforcement learning51:32 - What does neuroscience need more and less of?1:02:53 - Neuroscience in a weird place?1:06:41 - How Kim's questions have changed1:16:31 - Intelligence and LLMs1:25:34 - Challenges
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Àlex Gómez-Marín heads The Behavior of Organisms Laboratory at the Institute of Neuroscience in Alicante, Spain. He's one of those theoretical physicist turned neuroscientist, and he has studied a wide range of topics over his career. Most recently, he has become interested in what he calls the "edges of consciousness", which encompasses the many trying to explain what may be happening when we have experiences outside our normal everyday experiences. For example, when we are under the influence of hallucinogens, when have near-death experiences (as Alex has), paranormal experiences, and so on.
So we discuss what led up to his interests in these edges of consciousness, how he now thinks about consciousness and doing science in general, how important it is to make room for all possible explanations of phenomena, and to leave our metaphysics open all the while.
Alex's website: The Behavior of Organisms Laboratory.Twitter: @behaviOrganisms.Previous episodes:BI 168 Frauke Sandig and Eric Black w Alex Gomez-Marin: AWARE: Glimpses of Consciousness.BI 136 Michel Bitbol and Alex Gomez-Marin: Phenomenology.Related:The Consciousness of Neuroscience.Seeing the consciousness forest for the trees.The stairway to transhumanist heaven.0:00 - Intro4:13 - Evolving viewpoints10:05 - Near-death experience18:30 - Mechanistic neuroscience vs. the rest22:46 - Are you doing science?33:46 - Where is my. mind?44:55 - Productive vs. permissive brain59:30 - Panpsychism1:07:58 - Materialism1:10:38 - How to choose what to do1:16:54 - Fruit flies1:19:52 - AI and the Singularity
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Damian Kelty-Stephen is an experimental psychologist at State University of New York at New Paltz. Last episode with Luis Favela, we discussed many of the ideas from ecological psychology, and how Louie is trying to reconcile those principles with those of neuroscience. In this episode, Damian and I in some ways continue that discussion, because Damian is also interested in unifying principles of ecological psychology and neuroscience. However, he is approaching it from a different perspective that Louie. What drew me originally to Damian was a paper he put together with a bunch of authors offering their own alternatives to the computer metaphor of the brain, which has come to dominate neuroscience. And we discuss that some, and I'll link to the paper in the show notes. But mostly we discuss Damian's work studying the fractal structure of our behaviors, connecting that structure across scales, and linking it to how our brains and bodies interact to produce our behaviors. Along the way, we talk about his interests in cascades dynamics and turbulence to also explain our intelligence and behaviors. So, I hope you enjoy this alternative slice into thinking about how we think and move in our bodies and in the world.
Damian's website.Related papersIn search for an alternative to the computer metaphor of the mind and brain.Multifractal emergent processes: Multiplicative interactions override nonlinear component properties.0:00 - Intro2:34 - Damian's background9:02 - Brains12:56 - Do neuroscientists have it all wrong?16:56 - Fractals everywhere28:01 - Fractality, causality, and cascades32:01 - Cascade instability as a metaphor for the brain40:43 - Damian's worldview46:09 - What is AI missing?54:26 - Turbulence1:01:02 - Intelligence without fractals? Multifractality1:10:28 - Ergodicity1:19:16 - Fractality, intelligence, life1:23:24 - What's exciting, changing viewpoints
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Luis Favela is an Associate Professor at Indiana University Bloomington. He is part philosopher, part cognitive scientist, part many things, and on this episode we discuss his new book, The Ecological Brain: Unifying the Sciences of Brain, Body, and Environment.
In the book, Louie presents his NeuroEcological Nexus Theory, or NExT, which, as the subtitle says, proposes a way forward to tie together our brains, our bodies, and the environment; namely it has a lot to do with the complexity sciences and manifolds, which we discuss. But the book doesn't just present his theory. Among other things, it presents a rich historical look into why ecological psychology and neuroscience haven't been exactly friendly over the years, in terms of how to explain our behaviors, the role of brains in those explanations, how to think about what minds are, and so on. And it suggests how the two fields can get over their differences and be friends moving forward. And I'll just say, it's written in a very accessible manner, gently guiding the reader through many of the core concepts and science that have shaped ecological psychology and neuroscience, and for that reason alone I highly it.
Ok, so we discuss a bunch of topics in the book, how Louie thinks, and Louie gives us some great background and historical lessons along the way.
Luis' website.Book:The Ecological Brain: Unifying the Sciences of Brain, Body, and Environment0:00 - Intro7:05 - Louie's target with NEXT20:37 - Ecological psychology and grid cells22:06 - Why irreconcilable?28:59 - Why hasn't ecological psychology evolved more?47:13 - NExT49:10 - Hypothesis 155:45 - Hypothesis 21:02:55 - Artificial intelligence and ecological psychology1:16:33 - Manifolds1:31:20 - Hypothesis 4: Body, low-D, Synergies1:35:53 - Hypothesis 5: Mind emerges1:36:23 - Hypothesis 6:
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Jovo, as you'll learn, is theoretically oriented, and enjoys the formalism of mathematics to approach questions that begin with a sense of wonder. So after I learn more about his overall approach, the first topic we discuss is the world's currently largest map of an entire brain... the connectome of an insect, the fruit fly. We talk about his role in this collaborative effort, what the heck a connectome is, why it's useful and what to do with it, and so on.
The second main topic we discuss is his theoretical work on what his team has called prospective learning. Prospective learning differs in a fundamental way from the vast majority of AI these days, which they call retrospective learning. So we discuss what prospective learning is, and how it may improve AI moving forward.
At some point there's a little audio/video sync issues crop up, so we switched to another recording method and fixed it... so just hang tight if you're viewing the podcast... it'll get better soon.
0:00 - Intro05:25 - Jovo's approach13:10 - Connectome of a fruit fly26:39 - What to do with a connectome37:04 - How important is a connectome?51:48 - Prospective learning1:15:20 - Efficiency1:17:38 - AI doomerism
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Jolande Fooken is a post-postdoctoral researcher interested in how we move our eyes and move our hands together to accomplish naturalistic tasks. Hand-eye coordination is one of those things that sounds simple and we do it all the time to make meals for our children day in, and day out, and day in, and day out. But it becomes way less seemingly simple as soon as you learn how we make various kinds of eye movements, and how we make various kinds of hand movements, and use various strategies to do repeated tasks. And like everything in the brain sciences, it's something we don't have a perfect story for yet. So, Jolande and I discuss her work, and thoughts, and ideas around those and related topics.
Jolande's website.Twitter: @ookenfooken.Related papersI am a parent. I am a scientist.Eye movement accuracy determines natural interception strategies.Perceptual-cognitive integration for goal-directed action in naturalistic environments.0:00 - Intro3:27 - Eye movements8:53 - Hand-eye coordination9:30 - Hand-eye coordination and naturalistic tasks26:45 - Levels of expertise34:02 - Yarbus and eye movements42:13 - Varieties of experimental paradigms, varieties of viewing the brain52:46 - Career vision1:04:07 - Evolving view about the brain1:10:49 - Coordination, robots, and AI
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Recently I was invited to moderate a panel at the annual Computational and Systems Neuroscience, or COSYNE, conference. This year was the 20th anniversary of COSYNE, and we were in Lisbon Porturgal. The panel goal was to discuss the relationship between neuroscience and AI. The panelists were Tony Zador, Alex Pouget, Blaise Aguera y Arcas, Kim Stachenfeld, Jonathan Pillow, and Eva Dyer. And I'll let them introduce themselves soon. Two of the panelists, Tony and Alex, co-founded COSYNE those 20 years ago, and they continue to have different views about the neuro-AI relationship. Tony has been on the podcast before and will return soon, and I'll also have Kim Stachenfeld on in a couple episodes. I think this was a fun discussion, and I hope you enjoy it. There's plenty of back and forth, a wide range of opinions, and some criticism from one of the audience questioners. This is an edited audio version, to remove long dead space and such. There's about 30 minutes of just panel, then the panel starts fielding questions from the audience.
COSYNE. -
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Mazviita Chirimuuta is a philosopher at the University of Edinburgh. Today we discuss topics from her new book, The Brain Abstracted: Simplification in the History and Philosophy of Neuroscience.
She largely argues that when we try to understand something complex, like the brain, using models, and math, and analogies, for example - we should keep in mind these are all ways of simplifying and abstracting away details to give us something we actually can understand. And, when we do science, every tool we use and perspective we bring, every way we try to attack a problem, these are all both necessary to do the science and limit the interpretation we can claim from our results. She does all this and more by exploring many topics in neuroscience and philosophy throughout the book, many of which we discuss today.
Mazviita's University of Edinburgh page.The Brain Abstracted: Simplification in the History and Philosophy of Neuroscience.Previous Brain Inspired episodes:BI 072 Mazviita Chirimuuta: Understanding, Prediction, and RealityBI 114 Mark Sprevak and Mazviita Chirimuuta: Computation and the Mind0:00 - Intro5:28 - Neuroscience to philosophy13:39 - Big themes of the book27:44 - Simplifying by mathematics32:19 - Simplifying by reduction42:55 - Simplification by analogy46:33 - Technology precedes science55:04 - Theory, technology, and understanding58:04 - Cross-disciplinary progress58:45 - Complex vs. simple(r) systems1:08:07 - Is science bound to study stability?1:13:20 - 4E for philosophy but not neuroscience?1:28:50 - ANNs as models1:38:38 - Study of mind
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As some of you know, I recently got back into the research world, and in particular I work in Eric Yttris' lab at Carnegie Mellon University.
Eric's lab studies the relationship between various kinds of behaviors and the neural activity in a few areas known to be involved in enacting and shaping those behaviors, namely the motor cortex and basal ganglia. And study that, he uses tools like optogentics, neuronal recordings, and stimulations, while mice perform certain tasks, or, in my case, while they freely behave wandering around an enclosed space.
We talk about how Eric got here, how and why the motor cortex and basal ganglia are still mysteries despite lots of theories and experimental work, Eric's work on trying to solve those mysteries using both trained tasks and more naturalistic behavior. We talk about the valid question, "What is a behavior?", and lots more.
Yttri Lab
Twitter: @YttriLabRelated papersOpponent and bidirectional control of movement velocity in the basal ganglia.B-SOiD, an open-source unsupervised algorithm for identification and fast prediction of behaviors.0:00 - Intro2:36 - Eric's background14:47 - Different animal models17:59 - ANNs as models for animal brains24:34 - Main question25:43 - How circuits produce appropriate behaviors26:10 - Cerebellum27:49 - What do motor cortex and basal ganglia do?49:12 - Neuroethology1:06:09 - What is a behavior?1:11:18 - Categorize behavior (B-SOiD)1:22:01 - Real behavior vs. ANNs1:33:09 - Best era in neuroscience
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Peter Stratton is a research scientist at Queensland University of Technology.
I was pointed toward Pete by a patreon supporter, who sent me a sort of perspective piece Pete wrote that is the main focus of our conversation, although we also talk about some of his work in particular - for example, he works with spiking neural networks, like my last guest, Dan Goodman.
What Pete argues for is what he calls a sideways-in approach. So a bottom-up approach is to build things like we find them in the brain, put them together, and voila, we'll get cognition. A top-down approach, the current approach in AI, is to train a system to perform a task, give it some algorithms to run, and fiddle with the architecture and lower level details until you pass your favorite benchmark test. Pete is focused more on the principles of computation brains employ that current AI doesn't. If you're familiar with David Marr, this is akin to his so-called "algorithmic level", but it's between that and the "implementation level", I'd say. Because Pete is focused on the synthesis of different kinds of brain operations - how they intermingle to perform computations and produce emergent properties. So he thinks more like a systems neuroscientist in that respect. Figuring that out is figuring out how to make better AI, Pete says. So we discuss a handful of those principles, all through the lens of how challenging a task it is to synthesize multiple principles into a coherent functioning whole (as opposed to a collection of parts). Buy, hey, evolution did it, so I'm sure we can, too, right?
Peter's website.Related papersConvolutionary, Evolutionary, and Revolutionary: What’s Next for Brains, Bodies, and AI?Making a Spiking Net Work: Robust brain-like unsupervised machine learning.Global segregation of cortical activity and metastable dynamics.Unlocking neural complexity with a robotic key0:00 - Intro3:50 - AI background, neuroscience principles8:00 - Overall view of modern AI14:14 - Moravec's paradox and robotics20:50 -Understanding movement to understand cognition30:01 - How close are we to understanding brains/minds?32:17 - Pete's goal34:43 - Principles from neuroscience to build AI42:39 - Levels of abstraction and implementation49:57 - Mental disorders and robustness55:58 - Function vs. implementation1:04:04 - Spiking networks1:07:57 - The roadmap1:19:10 - AGI1:23:48 - The terms AGI and AI1:26:12 - Consciousness
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You may know my guest as the co-founder of Neuromatch, the excellent online computational neuroscience academy, or as the creator of the Brian spiking neural network simulator, which is freely available. I know him as a spiking neural network practitioner extraordinaire. Dan Goodman runs the Neural Reckoning Group at Imperial College London, where they use spiking neural networks to figure out how biological and artificial brains reckon, or compute.
All of the current AI we use to do all the impressive things we do, essentially all of it, is built on artificial neural networks. Notice the word "neural" there. That word is meant to communicate that these artificial networks do stuff the way our brains do stuff. And indeed, if you take a few steps back, spin around 10 times, take a few shots of whiskey, and squint hard enough, there is a passing resemblance. One thing you'll probably still notice, in your drunken stupor, is that, among the thousand ways ANNs differ from brains, is that they don't use action potentials, or spikes. From the perspective of neuroscience, that can seem mighty curious. Because, for decades now, neuroscience has focused on spikes as the things that make our cognition tick.
We count them and compare them in different conditions, and generally put a lot of stock in their usefulness in brains.
So what does it mean that modern neural networks disregard spiking altogether?
Maybe spiking really isn't important to process and transmit information as well as our brains do. Or maybe spiking is one among many ways for intelligent systems to function well. Dan shares some of what he's learned and how he thinks about spiking and SNNs and a host of other topics.
Neural Reckoning Group.Twitter: @neuralreckoning.Related papersNeural heterogeneity promotes robust learning.Dynamics of specialization in neural modules under resource constraints.Multimodal units fuse-then-accumulate evidence across channels.Visualizing a joint future of neuroscience and neuromorphic engineering.0:00 - Intro3:47 - Why spiking neural networks, and a mathematical background13:16 - Efficiency17:36 - Machine learning for neuroscience19:38 - Why not jump ship from SNNs?23:35 - Hard and easy tasks29:20 - How brains and nets learn32:50 - Exploratory vs. theory-driven science37:32 - Static vs. dynamic39:06 - Heterogeneity46:01 - Unifying principles vs. a hodgepodge50:37 - Sparsity58:05 - Specialization and modularity1:00:51 - Naturalistic experiments1:03:41 - Projects for SNN research1:05:09 - The right level of abstraction1:07:58 - Obstacles to progress1:12:30 - Levels of explanation1:14:51 - What has AI taught neuroscience?1:22:06 - How has neuroscience helped AI?
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Check out my free video series about what's missing in AI and Neuroscience
John Krakauer has been on the podcast multiple times (see links below). Today we discuss some topics framed around what he's been working on and thinking about lately. Things like
Whether brains actually reorganize after damageThe role of brain plasticity in generalThe path toward and the path not toward understanding higher cognitionHow to fix motor problems after strokesAGIFunctionalism, consciousness, and much more.Relevant links:
John's Lab.Twitter: @blamlabRelated papersWhat are we talking about? Clarifying the fuzzy concept of representation in neuroscience and beyond.Against cortical reorganisation.Other episodes with John:BI 025 John Krakauer: Understanding CognitionBI 077 David and John Krakauer: Part 1BI 078 David and John Krakauer: Part 2BI 113 David Barack and John Krakauer: Two Views On CognitionTime stamps0:00 - Intro2:07 - It's a podcast episode!6:47 - Stroke and Sherrington neuroscience19:26 - Thinking vs. moving, representations34:15 - What's special about humans?56:35 - Does cortical reorganization happen?1:14:08 - Current era in neuroscience
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Check out my free video series about what's missing in AI and Neuroscience
By day, Max Bennett is an entrepreneur. He has cofounded and CEO'd multiple AI and technology companies. By many other countless hours, he has studied brain related sciences. Those long hours of research have payed off in the form of this book, A Brief History of Intelligence: Evolution, AI, and the Five Breakthroughs That Made Our Brains.
Three lines of research formed the basis for how Max synthesized knowledge into the ideas in his current book: findings from comparative psychology (comparing brains and minds of different species), evolutionary neuroscience (how brains have evolved), and artificial intelligence, especially the algorithms developed to carry out functions. We go through I think all five of the breakthroughs in some capacity. A recurring theme is that each breakthrough may explain multiple new abilities. For example, the evolution of the neocortex may have endowed early mammals with the ability to simulate or imagine what isn't immediately present, and this ability might further explain mammals' capacity to engage in vicarious trial and error (imagining possible actions before trying them out), the capacity to engage in counterfactual learning (what would have happened if things went differently than they did), and the capacity for episodic memory and imagination.
The book is filled with unifying accounts like that, and it makes for a great read. Strap in, because Max gives a sort of masterclass about many of the ideas in his book.
Twitter:@maxsbennettBook:A Brief History of Intelligence: Evolution, AI, and the Five Breakthroughs That Made Our Brains.0:00 - Intro5:26 - Why evolution is important7:22 - Maclean's triune brain14:59 - Breakthrough 1: Steering29:06 - Fish intelligence40:38 - Breakthrough 3: Mentalizing52:44 - How could we improve the human brain?1:00:44 - What is intelligence?1:13:50 - Breakthrough 5: Speaking
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Welcome to another special panel discussion episode.
I was recently invited to moderate at discussion amongst 6 people at the annual Aspirational Neuroscience meetup. Aspirational Neuroscience is a nonprofit community run by Kenneth Hayworth. Ken has been on the podcast before on episode 103. Ken helps me introduce the meetup and panel discussion for a few minutes. The goal in general was to discuss how current and developing neuroscience technologies might be used to decode a nontrivial memory from a static connectome - what the obstacles are, how to surmount those obstacles, and so on.
There isn't video of the event, just audio, and because we were all sharing microphones and they were being passed around, you'll hear some microphone type noise along the way - but I did my best to optimize the audio quality, and it turned out mostly quite listenable I believe.
Aspirational NeurosciencePanelists:Anton Arkhipov, Allen Institute for Brain Science.@AntonSArkhipovKonrad Kording, University of Pennsylvania.@KordingLabTomás Ryan, Trinity College Dublin.@TJRyan_77Srinivas Turaga, Janelia Research Campus.Dong Song, University of Southern California.@dongsongZhihao Zheng, Princeton University.@zhihaozheng0:00 - Intro1:45 - Ken Hayworth14:09 - Panel Discussion
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