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Episode 68! Today we talk about modes of mechanical ventilation with the first author Dr. Kevin Seitz. This was published in CHEST April of 2025 as "Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial".
Disclaimer, this is stated in the episode but Todd and I are authors on this paper. Please keep that in mind as you enjoy the episode!
Pubmed: https://pubmed.ncbi.nlm.nih.gov/40189043/
CHEST: https://journal.chestnet.org/article/S0012-3692(25)00417-9/fulltext
If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 67! Today we do a quick overview of the presentations from the Critical Care Reviews 2025 (CCR25) Conference!
If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 66! Today we talk about Acute Chest Syndrome in Sickle Cell Disease with one of our favorite hematologists, Benjamin Tillman! We base our discussion around the TASC trial or "Comparison of Prophylactic and Therapeutic Doses of Anticoagulation for Acute Chest Syndrome in Sickle Cell Disease" published by Dessap et al in AJRCCM April of 2025.
Pubmed: https://pubmed.ncbi.nlm.nih.gov/40209087/
AJRCCM: https://www.atsjournals.org/doi/10.1164/rccm.202409-1727OC
If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 65! Though this is during ATS, this episode was pre-recorded so you will get some reactions to the conference in the coming episodes. Instead we have a short episode where we talk about risk factors for stress ulcers and transfusion threshold in upper GI bleeding!
Risk factors: https://pubmed.ncbi.nlm.nih.gov/40315134/
Transfusion threshold: https://pubmed.ncbi.nlm.nih.gov/23281973/
Transfusion threshold (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa1211801If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 64! We talk more about steroids in severe community acquired pneumonia with "Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia : The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial" published in Intensive Care Medicine April of 2025.
Pubmed: https://pubmed.ncbi.nlm.nih.gov/40261382/
If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 63! We talk about intermediate risk PE in "Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism" by Jaber et al published in Circulation in February 2025. Then we talk about "Fibrinolysis for patients with intermediate-risk pulmonary embolism" by Meter et al in NEJM 2014.
PEERLESS: https://pubmed.ncbi.nlm.nih.gov/39470698/
PEITHO: https://pubmed.ncbi.nlm.nih.gov/24716681/
PE Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/24938564/If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 62! We talk briefly about two of the analyses that dropped with the ISICEM conference and then talk in depth about SESAR or "Inhaled Sedation in Acute Respiratory Distress Syndrome" by Jabudon et al in JAMA 2025. Then was answer a question on sleep in the ICU. Eddie did misspeak when he said one of the dexmedetomidine articles was in Lancet Respiratory medicine, rather, it was published in eClinical Medicine part of the Lancet network.
SESAR (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2831857
SESAR (pubmed): https://pubmed.ncbi.nlm.nih.gov/40098564/
OVISS (pubmed): https://pubmed.ncbi.nlm.nih.gov/40098600/
Nocturnal dexmedetomidine (pubmed): https://pubmed.ncbi.nlm.nih.gov/29498534/
Nocturnal dexmedetomidine cardiac surgery (pubmed): https://pubmed.ncbi.nlm.nih.gov/36590787/If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 61! We talk about HFNC including extubation to HFNC in "Early weaning from invasive mechanical ventilation via high-flow nasal oxygen versus conventional weaning in patients with hypoxemic respiratory failure" by Ayyawar et al published in Critical Care Science. Then we talk about weaning HFNC from the "How I do it" series from CHEST.
Auto-PEEP (NEJM): https://www.nejm.org/doi/full/10.1056/NEJM199307153290322
Extubate to HFNC (pubmed): https://pubmed.ncbi.nlm.nih.gov/39879434/
Extubate to HFNC (CCS): https://criticalcarescience.org/article/early-weaning-from-invasive-mechanical-ventilation-via-high-flow-nasal-oxygen-versus-conventional-weaning-in-patients-with-hypoxemic-respiratory-failure-a-prospective-randomized-controlled-study/
Weaning HFNC (pubmed): https://pubmed.ncbi.nlm.nih.gov/39929280/
Weaning HFNC (CHEST): https://journal.chestnet.org/article/S0012-3692(25)00155-2/abstractIf you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 60! We jump to SCCM where we talk about 2 late breakers - PROACTIVE or "Propranolol As an Anxiolytic to Reduce the Use of Sedatives for Critically Ill Adults Receiving Mechanical Ventilation" by Downar et al and "Acetylsalicylic Acid Treatment in Patients With Sepsis and Septic Shock" by Almeida et al both published in CCM in 2025.
PROACTIVE (pubmed): https://pubmed.ncbi.nlm.nih.gov/39982178/
PROACTIVE (CCM): https://pmc.ncbi.nlm.nih.gov/articles/PMC11801419/
ASA in sepsis (pubmed): https://pubmed.ncbi.nlm.nih.gov/39982179/
ASA in sepsis (CCM): https://journals.lww.com/ccmjournal/fulltext/2025/02000/acetylsalicylic_acid_treatment_in_patients_with.2.aspxIf you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 59! We finish our CCR down under coverage with TRAUMOX2 or "Early Restrictive vs Liberal Oxygen for Trauma Patients" published in JAMA by Arleth et al and then switch to SAHARA or "Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage" by English et al published in NEJM. We then frustrate Todd with questions from our mailbag, a good episode!
TRAUMOX2 (pubmed): https://pubmed.ncbi.nlm.nih.gov/39657224/
TRAUMOX2 (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2827980
SAHARA (pubmed): https://pubmed.ncbi.nlm.nih.gov/39655786/
SAHARA (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2410962If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 58! We talk about non-invasive oxygen support and RENOVATE or "High-Flow Nasal Oxygen vs Noninvasive Ventilation in Patients With Acute Respiratory Failure" published in JAMA December 2024 and presented at the CCR Down Under Conference. We supplement this by first talking about FLORALI or "High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure" published in NEJM May 2015
RENOVATE (pubmed): https://pubmed.ncbi.nlm.nih.gov/39657981/
RENOVATE (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2828065
FLORALI (pubmed): https://pubmed.ncbi.nlm.nih.gov/25981908/
FLORALI (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa1503326If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 57! We were excited to have on this episode Dr. Adam Wright who is a PhD in Bioinformatics to discuss SCREEN or "Electronic Sepsis Screening Among Patients Admitted to Hospital Wards: A Stepped-Wedge Cluster Randomized Trial" published by Arabi et al in JAMA 2024 and presented at the CCR Down Under Conference. A long episode but a lot of good discussion
SCREEN (pubmed): https://pubmed.ncbi.nlm.nih.gov/39658862/
SCREEN (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2828069If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 56! In this episode we spend a few minutes talking about making decisions on ECMO initiation but spend most of the episode talking about ADAPT-Sepsis or "Biomarker-Guided Antibiotic Duration for Hospitalized Patients
With Suspected Sepsis" published by Dark et al in JAMA 2024 and presented at the CCR Down Under Conference.
ADAPT-Sepsis (pubmed): https://pubmed.ncbi.nlm.nih.gov/39652885/
ADAPT-Sepsis (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2828036If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 55 and Happy New Year! In this episode we talk broad strokes about the CCR Down Under Conference and the trials that were presented, then Todd and Eddie go over a bunch of articles from the year 2024 that they didn't have time to go over or want to re-emphasize for whatever reason. Big show and we hope you enjoy!
TIGHT K: https://pubmed.ncbi.nlm.nih.gov/39215972/
PROPHY VAP: https://pubmed.ncbi.nlm.nih.gov/38262428/
REVISE: https://pubmed.ncbi.nlm.nih.gov/38875111/
Point (withdrawal of ECMO): https://pubmed.ncbi.nlm.nih.gov/39663030/
Counterpoint: https://pubmed.ncbi.nlm.nih.gov/39663031/
DanGer SHOCK: https://pubmed.ncbi.nlm.nih.gov/38587239/
Intubation in physiologic difficult airway guidelines: https://pubmed.ncbi.nlm.nih.gov/39162823/If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 54! In this episode we talk about antibiotic duration in bacteremia (BALANCE) and also antibiotic duration in Pseudomonas Ventilator associated pneumonia (iDIAPASON).
BALANCE (NEJM): https://www.nejm.org/doi/full/10.1056/NEJMoa2404991
BALANCE (pubmed): https://pubmed.ncbi.nlm.nih.gov/39565030/
iDIAPASON (ICM): https://link.springer.com/article/10.1007/s00134-022-06690-5
iDIAPASON (pubmed): https://pubmed.ncbi.nlm.nih.gov/35552788/If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 53! In this episode we talk about access in patients with out of hospital cardiac arrest. Both articles are similar so we talk in depth about IVIO and then bringing PARAMEDIC-3 to round out our discussion. A good acronym discussion too, don't miss it!
IVIO (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2407616
IVIO (pubmed): https://pubmed.ncbi.nlm.nih.gov/39480221/
PARAMEDIC-3 (NEJM): https://www.nejm.org/doi/full/10.1056/NEJMoa2407780
PARAMEDIC-3 (pubmed): https://pubmed.ncbi.nlm.nih.gov/39480216/If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 52! In this episode we talk about fevers in acute neurologic injury and double that up with talking about low tidal volume ventilation in patients with neurologic injury
INTREPID (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2824088
INTREPID (pubmed): https://pubmed.ncbi.nlm.nih.gov/39320879/
PROLABI (Blue): https://www.atsjournals.org/doi/full/10.1164/rccm.202402-0375OC
PROLABI (pubmed): https://pubmed.ncbi.nlm.nih.gov/39288368/If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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We are (were) LIVE at ACNP Critical Care Bootcamp 2024! Thank you to the organizers of the conference for inviting us do a live show and thank you to everyone who came out to listen! We talk about the NONSEDA trial or "Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients" by Olsen et al published in the New England Journal of Medicine February 2020
NONSEDA (pubmed): https://pubmed.ncbi.nlm.nih.gov/32068366/
NONSEDA (NEJM): https://www.nejm.org/doi/full/10.1056/NEJMoa1906759If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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Episode 50! In this episode we talk about SBT frequency and "Frequency of Screening and Spontaneous Breathing Trial Techniques" by Burns et al from JAMA 2024 that was released with the ESICM conference. In our second segment, instead of another trial we talk a little bit about the IV fluid shortage happening in the United States.
FAST (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2824928
FAST (pubmed): https://pubmed.ncbi.nlm.nih.gov/39382222/If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
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We are LIVE at CHEST2024! Thank you to the organizers of the conference for inviting us do a live show and thank you to everyone who came out to listen! We talk about a few articles that were recently published in CHEST - "Prophylactic Minocycline for Delirium in Critically Ill Patients: A Randomized Controlled Trial" published by Dal-Pizzol et al and then "Comparative Effectiveness of Amiodarone and Lidocaine for the Treatment of In-Hospital Cardiac Arrest" by Wagner et al.
We then touch briefly on some articles being presented later at the conference which we might cover soon (stay tuned)!
Minocycline for Delirium (pubmed): https://pubmed.ncbi.nlm.nih.gov/38043911/
Minocycline for Delirium (CHEST): https://journal.chestnet.org/article/S0012-3692(23)05833-6/abstract
Amio vs Lido (pubmed): https://pubmed.ncbi.nlm.nih.gov/36332663/
Amio vs lido (CHEST): https://journal.chestnet.org/article/S0012-3692(22)04039-9/abstractIf you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at [email protected] with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!
- Se mer
