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Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Gilberto Lopes, Chief of Medical Oncology at the Sylvester Comprehensive Cancer Center, to discuss the highlights from the World Conference on Lung Cancer 2024.
Join us as we dive into four key studies that could reshape our understanding and approach to lung cancer treatment:
1. Checkmate 816 vs. Checkmate 77T: An exploratory analysis of neoadjuvant chemoimmunotherapy and the ongoing debate about the benefits of post-operative immunotherapy.
2. SKIPPirr Study: Discover how prophylactic strategies can reduce infusion-related reactions with amivantamab.
3. HARMONi-2: A look at a novel PD-1 and VEGF inhibitor compared to Pembrolizumab in metastatic non-small cell lung cancer.
4. TROPION-Lung01: Insights into the performance of the antibody-drug conjugate Dato-DXd against docetaxel, particularly in non-squamous histology.
Tune in for an informative discussion that highlights the latest advancements in lung cancer research and treatment strategies.
Don't forget to like, subscribe, and check out our other episodes for more insights into the current standard of care in oncology!
#OncologyBrothers #LungCancer #WCLC2024 #CancerResearch #MedicalOncology
Website: http://www.oncbrothers.com/
Twitter: https://twitter.com/oncbrothers
Contact us at [email protected]
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Join the Oncology Brothers, Drs. Rahul and Rohit Gosain, as they dive into the world of Chronic Myeloid Leukemia (CML) with world-renowned hematologist Dr. Jorge Cortes from the Georgia Cancer Center. In this episode, they discuss the current standard of care treatment options for CML, including risk stratification, monitoring, treatment algorithms, and side effects of first, second, and third-generation TKIs.
Dr. Cortes provides valuable insights on when to consider treatment holidays, switching therapies, and the potential benefits of upcoming treatments like asciminib. The discussion also covers the importance of deep molecular responses, the role of bone marrow biopsies, and the decision-making process for patients in accelerated phase CML.
Tune in to gain a comprehensive understanding of managing CML patients in the community setting and stay updated on the latest advancements in hematology and oncology. Don't miss out on this informative episode with the Oncology Brothers podcast!
Website: http://www.oncbrothers.com/
Twitter: https://twitter.com/oncbrothers
Contact us at [email protected]
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In this episode of the Oncology Brothers podcast, Drs. Rahul & Rohit Gosain are joined by Dr. Pallawi Torka from Memorial Sloan Kettering Cancer Center to discuss the current treatment landscape for low-grade lymphomas, specifically follicular and mantle cell lymphoma.
Key Points Covered:• Follicular Lymphoma: The discussion includes the minimum workup required for treatment planning, frontline treatment options, nuances of PFS with different anti-CD20 agents, and considerations for relapse or refractory cases.• Mantle Cell Lymphoma: The conversation delves into initial treatment paradigms, the role of BTK inhibitors, considerations for TP53 mutations, and options for relapsed or refractory cases, including the growing importance of CAR T cell therapy.
Highlights:• Treatment Options: From chemoimmunotherapy to novel agents like BTK inhibitors and CAR-T cell therapy, the podcast explores the evolving landscape of treatment options for these low-grade lymphomas.• TP53 Mutations: The discussion sheds light on how treatment decisions are influenced by the presence of TP53 mutations, with a focus on recent studies and promising combinations.• Relapse Management: Insights are shared on managing relapsed or refractory cases, including the role of BTK inhibitors, CAR-T cell therapy, and other emerging options.
Join the Oncology Brothers as they navigate through the complexities of treating low-grade lymphomas with expert insights from Dr. Torka. Stay informed about the latest advancements in oncology and the changing standards of care for these challenging diseases.
Website: http://www.oncbrothers.com/
Twitter: https://twitter.com/oncbrothers
Contact us at [email protected]
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Welcome back to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain dive into the world of diffused large B-cell lymphoma with special guest Dr. Carla Casulo from the Wilmot Cancer Institute in Rochester, New York.
Key Points Covered:• Understanding the importance of accurate diagnosis through excisional biopsy in diffused large B-cell lymphoma.• Exploring the significance of cell of origin in guiding treatment decisions.• Initial treatment approaches for stage 1 and 2 disease, including the use of Polatuzumab based on the POLARIX trial.• Treatment options for relapsed or refractory disease, including CAR-T therapy, BiTE therapy, and anti-CD19 antibody agents.• Managing toxicities associated with different treatment regimens, such as cytopenias, infections, and neurotoxicity.
Join us as we unravel the complexities of diffused large B-cell lymphoma and discuss the latest advancements in treatment options with Dr. Carla Casulo. Stay informed and up to date with the Oncology Brothers podcast!
Don't forget to like, share, and subscribe for more insightful discussions on oncology topics. Thank you for tuning in to the Oncology Brothers podcast.
Website: http://www.oncbrothers.com/
Twitter: https://twitter.com/oncbrothers
Contact us at [email protected]
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In this episode of the Oncology Brothers podcast, Dr. Allison Betof Warner from Stanford University joins hosts Drs. Rahul and Rohit Gosain discuss the current standard of care and recent advances in cutaneous melanoma treatment.
Key Points Covered:• Early Stage Melanoma: Discussion on the standard of care for different stages, including the role of neoadjuvant immunotherapy.• Adjuvant Therapy: Controversies and considerations for stage 2 and beyond, including the use of ctDNA as a predictive tool.• Neoadjuvant Therapy: Insights into recent trials and the evolving landscape of neoadjuvant treatment for melanoma.• Metastatic Stage: Exploration of treatment options, including immunotherapy combinations and BRAF MEK inhibitors.• TILS Therapy: Overview of the recent approval of Tumor Infiltrating Lymphocytes (TILS) therapy for melanoma patients.
Stay informed on the latest in melanoma treatment by listening to this insightful discussion with Dr. Warner. Don't miss out on valuable insights that can impact patient care and treatment decisions. Subscribe now to the Oncology Brothers podcast for more updates on oncology practices and advancements.
Website: http://www.oncbrothers.com/
Twitter: https://twitter.com/oncbrothers
Contact us at [email protected]
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Welcome to another episode of the Oncology Brothers podcast! In this enlightening discussion, Rohit and Rahul Gosain delve into the crucial topic of cardio-oncology with special guest Dr. Susan Dent, President of the International Cardio-Oncology Society.
Discover the intersection between cardiology and oncology, exploring the importance of treating the whole patient, not just the cancer. Dr. Dent sheds light on key cardiovascular risks and toxicities associated with various cancer treatments, from anthracyclines to immune checkpoint inhibitors.
Learn about the necessity of collaboration between oncologists and cardiologists, especially in assessing cardiovascular risk factors and monitoring patients throughout their cancer therapy. Dr. Dent also touches on the significance of early intervention and prevention strategies to safeguard patients' cardiovascular health.
Join the Oncology Brothers as they emphasize the proactive approach to cardio-oncology, aiming to not only cure cancer but also save hearts. Stay informed, stay proactive, and tune in for more insightful discussions on cancer care. Don't miss out on this informative episode!
Website: http://www.oncbrothers.com/
Twitter: https://twitter.com/oncbrothers
Contact us at [email protected]
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In this episode of the Oncology Brothers podcast, hosts Rahul and Rohit Gosain are joined by Dr. Patrick Forde from the Johns Hopkins University to discuss the latest advancements in early stage non-small cell lung cancer. The conversation delves into treatment options for resectable and unresectable disease, including the use of neoadjuvant and perioperative therapies, as well as the role of immunotherapy in different scenarios. Dr. Forde provides insights on actionable mutations, adjuvant treatments, and the impact of targeted therapies like osimertinib and alectinib have.
Tune in to learn about the current standard of care for early stage non-small cell lung cancer and gain valuable clinical pearls from this informative discussion.
Don't miss out on this insightful episode of the Oncology Brothers podcast!
Website: http://www.oncbrothers.com/
Twitter: https://twitter.com/oncbrothers
Contact us at [email protected]
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Welcome back to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Isabel Preeshagul from Memorial Sloan Kettering Cancer Center to discuss metastatic non-small cell lung cancer treatment without actionable mutations in first-line settings.
They dive into the importance of comprehensive testing, strategies for using immunotherapy and chemotherapy combinations, and emerging second-line treatment options. Dr. Preeshagul shares insights on targeting KRAS G12C, HER2 mutation with TDXD, and the potential combination of ramucirumab with pembrolizumab.
Tune in for a detailed discussion on the latest advancements in non-small cell lung cancer treatment. Don't miss out on valuable insights from this informative episode of the Oncology Brothers podcast!
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Welcome to the Oncology Brothers Podcast! Join Drs. Rahul & Rohit Gosain in this episode as they welcome Dr. Balazs Halmos, a thoracic medical oncologist from Montefiore-Einstein Comprehensive Cancer Center, to discuss the current landscape of metastatic non-small cell lung cancer with actionable mutations in first-line settings.
In this informative episode, they cover a wide range of topics including the importance of NGS testing, treatment options for various actionable mutations such as EGFR, ALK, ROS1, RET rearrangements, and more. Dr. Halmos provides valuable insights into decision-making processes, sequencing treatments, and managing toxicities associated with targeted therapies.
Don't miss out on this insightful discussion that sheds light on the rapidly evolving space of precision medicine in lung cancer treatment. Stay informed and learn how identifying and targeting specific mutations can optimize treatment outcomes and improve patient quality of life.Tune in to the Oncology Brothers Podcast for expert insights and discussions on the latest developments in oncology.
Subscribe now to stay updated on their informative episodes!
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Join the Oncology Brothers, Rahul and Rohit Gosain, in this insightful podcast episode as they dive into the world of small cell lung cancer with special guest Dr. Eric Singhi, a thoracic medical oncologist from MD Anderson Cancer Center.
Key Points:• The Adriatic study's impact on improving survival with Durvalumab in limited-stage disease.• Treatment options for extensive-stage disease, including second-line therapies like Lurbinectedin and the recent approval of Tarlatamab.• The significance of individualized treatment decisions and ongoing research in small cell lung cancer management.
In this episode, Dr. Singhi discusses the management of limited-stage small cell lung cancer, the impact of the recent Adriatic study on treatment approaches, and the use of immunotherapy in both limited and extensive-stage disease. The conversation also delves into the role of PCI, the use of Trilaciclib in extensive stage, and the recent FDA approval of Tarlatamab for small cell lung cancer.
Discover the latest advancements and treatment options for small cell lung cancer, including insights on second-line treatments, consolidation radiation, and the management of patients with driver mutations. Dr. Singhi also highlights the importance of patient advocacy groups like the Small Cell Smashers in providing support for individuals with small cell lung cancer.
Tune in to this episode for a comprehensive overview of the current treatment landscape for small cell lung cancer and gain valuable insights from Dr. Singhi's expertise in the field. Don't miss out on this informative discussion on the Oncology Brothers podcast!
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Join Drs. Rohit Gosain and Rahul Gosain as they dive into the practice-changing updates from ASCO 2024 conference. In this episode, they are joined by Dr. Mark Lewis to cover key studies in GI malignancies from the conference.
In this episode, they discuss:• The ESOPEC study comparing concurrent chemoradiation versus periop FLOT regimen for upper GI adenocarcinoma.• The ARMANI trial on switch maintenance with ramucirumab plus paclitaxel.• The TRANSMET trial exploring chemotherapy followed by liver transplantation for metastatic liver-confined colorectal cancer.• The COLLISION trial comparing surgery versus ablation for small size colorectal liver metastatic disease.• The COMMIT study looking at the use of atezolizumab with chemotherapy in first-line treatment for MSI high metastatic colorectal cancer.These studies highlight the importance of biomarker testing and a multidisciplinary approach in the treatment of cancer.
Tune in to gain valuable insights from ASCO 2024 and stay informed about the latest advancements in oncology. Don't forget to check out their lung, GU, and breast cancer highlights from the conference as well.Stay connected with the Oncology Brothers for more updates and discussions on the latest in the world of oncology. Thank you for tuning in!
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Welcome to another insightful episode of the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Toni Choueiri, a GU Medical Oncologist from Dana-Farber Cancer Institute, to discuss key abstracts from ASCO 2024.
They delve into topics such as the impact of the EV302 study on metastatic bladder cancer, the potential role of ctDNA as a biomarker in bladder cancer, real-world data on metastatic RCC, and the PSMA-4 study in prostate cancer. The discussion covers patient-reported outcomes, treatment strategies, and the evolving landscape of oncology care.
Tune in to gain valuable insights into the latest advancements in oncology and how they are shaping the standard of care for patients. Don't miss out on this engaging conversation with experts in the field. Subscribe to the Oncology Brothers podcast for more updates from the world of oncology.
Website: http://www.oncbrothers.com/
Twitter: https://twitter.com/oncbrothers
Contact us at [email protected]
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Join the Oncology Brothers podcast as they dive into the highlights from ASCO 2024 with special guest Dr. Erika Hamilton, a breast medical oncologist from the Sarah Cannon Research Institute. In this episode, they discuss key abstracts in the world of breast cancer, including updates on RxPonder, PostMonarch, INAVO120, DESTINY-Breast06, and the Emerald Trial. Dr. Hamilton provides valuable insights on biomarker testing, CDK4/6 inhibitors, and groundbreaking advancements in HER2-targeted therapies. Discover how these studies are shaping treatment strategies for hormone receptor positive, HER2-low, and HER2-positive breast cancer patients. Don't miss out on this informative discussion packed with practical insights for community oncologists. Stay tuned for more ASCO 2024 highlights from the Oncology Brothers podcast.
Website: http://www.oncbrothers.com/
Twitter: https://twitter.com/oncbrothers
Contact us at [email protected]
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In this episode, hosts Drs. Rahul and Rohit Gosain are joined by special guest Dr. Joshua Sabari, a thoracic medical oncologist from NYU Langone Health. Together, they dive into the highlights from ASCO 2024, focusing on key studies in lung cancer.Here's a quick summary of what you can expect in this episode:• LAURA Trial: Discussing the use of Osimertinib as a consolidation approach after chemoradiation in unresectable stage 3 non-small cell lung cancer patients with common EGFR mutation.• MARIPOSA Study: Exploring the potential of Amivantamab and Lazertinib in common EGFR mutations.• CROWN Study and other ALK inhibitors: Alectinib, Lorlatinib, and Brigatinib for metastatic non-small cell lung cancer.• ADRIATIC Study: Examining the use of Durvalumab after concurrent chemoradiation in limited-stage small cell lung cancer.
• PALOMA-3 Trial: Discussing subcutaneous Amivantamab vs. IV Amivantamab with Lazertinib
Join the Oncology Brothers and Dr. Sabari as they break down these practice-changing studies and provide insights into the latest advancements in lung cancer treatment. Don't miss out on this informative and engaging discussion!
Stay tuned for more ASCO 2024 highlights and updates on GI, GU, and breast cancer in the upcoming episodes. Subscribe to the Oncology Brothers Podcast for the latest in oncology news and research. Thank you for listening!
Website: http://www.oncbrothers.com/
Twitter: https://twitter.com/oncbrothers
Contact us at [email protected]
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Welcome to another insightful episode of the Oncology Brothers podcast! In this episode, hosts Rahul and Rohit Gosain delve into the world of locally advanced rectal cancer, focusing on the latest treatment strategies and advancements in the field.
Joined by esteemed guests Dr. Deborah Schrag, a medical oncologist from Memorial Sloan Kettering Cancer Center, and Dr. Krishan Jethwa, a radiation oncologist from the Mayo Clinic, the discussion centers around the groundbreaking Prospect study. This study challenges the traditional approach to rectal cancer treatment, emphasizing the importance of balancing therapeutic efficacy with minimizing chronic side effects.
The conversation covers a range of topics, from the utilization of different chemotherapy regimens to the evolving paradigm of radiation therapy. Dr. Schrag and Dr. Jethwa provide valuable insights into determining the optimal treatment course for patients with locally advanced rectal cancer, including the selective omission of surgery and the significance of MSI high status in treatment decisions.
Tune in to learn about the latest advancements in rectal cancer treatment, the implications of the Prospect study, and the importance of personalized, multidisciplinary approaches in oncology care. Don't miss out on this informative discussion that sheds light on the complexities of managing rectal cancer and the evolving treatment landscape.
Stay informed and up-to-date with the Oncology Brothers podcast as they continue to explore the dynamic world of oncology treatment. Subscribe now and join the conversation!
Guests:
Dr. Deborah Schrag, Medical Oncologist, Memorial Sloan Kettering Cancer CenterDr. Krishan Jethwa, Radiation Oncologist, Mayo Clinic -
Join Rahul and Rohit Gosain, the Oncology Brothers, in this insightful podcast episode where they discuss the latest advancements in hematology and oncology. In this episode, they are joined by Dr. Mazyar Shadman from Fred Hutch Cancer Center to delve into the Sequoia and Alpine trials that led to the approval of Zanubrutinib in CLL.
Key Points Discussed:
• The Sequoia trial focused on Zanubrutinib in first-line CLL treatment, showcasing its superiority over traditional chemotherapy.
• The Alpine study compared Zanubrutinib to Ibrutinib in relapsed/refractory settings, demonstrating Zanubrutinib's efficacy and safety profile.
• Acalabrutinib and Zanubrutinib were indirectly compared in a post-analysis, shedding light on their differences.
• Dr. Shadman provides insights on managing common side effects of Zanubrutinib, highlighting its improved tolerability.
Tune in to this episode for a comprehensive discussion on Zanubrutinib in CLL, including trial outcomes, comparisons, and practical considerations for patient care. Stay informed with the Oncology Brothers as they navigate the evolving landscape of oncology treatments
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Join the Oncology Brothers, Rahul and Rohit Gosain, in this informative podcast episode as they discuss the complexities of myelofibrosis, a challenging blood cancer. They are joined by expert Dr. Naveen Pemmaraju from MD Anderson Cancer Center, who provides valuable insights into diagnosing and managing myelofibrosis.
In this episode, they discuss the importance of a thorough diagnostic workup, including bone marrow biopsy, laboratory values, and clinical history. Dr. Pemmaraju highlights the significance of risk stratification using various scoring systems and the role of molecular analysis in determining prognosis.The conversation also covers the current treatment landscape for myelofibrosis, focusing on JAK inhibitors such as ruxolitinib, fadratinib, pacritinib, and momelotinib. The hosts and guest expert explore the unique side effects of these medications and strategies for managing them effectively.
Listeners will gain valuable insights into supportive care options for anemia, thrombocytopenia, and leukopenia, including the use of erythropoietin-stimulating agents and other therapeutic interventions. The episode emphasizes the importance of considering allogeneic stem cell transplant as a potential curative option for high-risk patients.
Don't miss this comprehensive discussion on myelofibrosis, packed with practical information and expert advice. Tune in to the Oncology Brothers podcast to stay informed about the latest developments in hematology and oncology.
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In this podcast episode from the Oncology Brothers delve into the needs of different patient populations in colorectal cancer. Joined by Dr. Tanios Bekaii-Saab, a medical oncologist, and Ms. Deneen Richmond, a patient advocate, nurse, and the President of the Doctors Community Medical Center, the discussion highlights disparities in access to colorectal cancer screening and treatments among various communities. Deneen shares her personal journey as a patient, emphasizing the importance of trust and being heard in healthcare. The episode also explores strategies to raise awareness and educate different patient groups, including leveraging trusted voices and community outreach. Tune in for valuable insights on understanding and addressing the diverse needs of patients in colorectal cancer care.
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In this episode of our hematology podcast, we delve into the world of relapsed and refractory multiple myeloma with Dr. Samir A. Al-Hadidi from the University of Arkansas.
Join us as we discuss the evolving treatment options for patients who experience relapse or disease progression after initial therapy. Dr. Al-Hadidi provides valuable insights into monitoring patients, discussing escalating treatments, and the role of novel therapies such as CAR-T and bispecific antibodies.
From monitoring strategies to managing side effects, this episode of oncology podcast covers essential information for community oncologists caring for patients with relapsed or refractory multiple myeloma.
Don't miss out on this informative discussion on the current treatment landscape for multiple myeloma. Stay informed and stay connected with the latest advancements in hematology.
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In this episode of the Oncology Brothers podcast, join Drs. Rahul and Rohit Gosain as they delve into the world of localized treatment options for gastrointestinal malignancies. They are joined by experts in the field, Drs. Nina Sanford, Jeffrey Ryckman, and Harris Chengazi, who provide insights into radiation oncology and interventional radiology modalities for treating liver cancer.
The discussion covers the basics of radiation oncology terminology, including SRS, SBRT, and proton therapy, and how these modalities have evolved over the last decade. The experts also discuss the various tools available in the interventional radiology toolkit, such as ablation techniques, chemoembolization, and radioembolization.
Listeners gain valuable insights into the considerations for referring patients with liver-confined hepatocellular carcinoma to radiation oncologists or interventional radiologists, depending on the size of the tumor and underlying liver function. The experts emphasize the importance of a multidisciplinary approach in cancer care to ensure the best treatment outcomes for patients.
Tune in to learn about the side effects of SBRT, the nuances of combining different treatment modalities, and the significance of collaboration among oncology specialists. This episode highlights the importance of understanding and appreciating the diverse treatment options available for cancer patients.
Don't miss out on this informative discussion on localized treatment options for gastrointestinal malignancies with the Oncology Brothers podcast.
Website: http://www.oncbrothers.com/
Twitter: https://twitter.com/oncbrothers
Contact us at [email protected]
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