Episoder
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We talk to the experts in the Neonatal Kidney Collaborative (NKC) about the recently published guidelines regarding kidney follow-up for NICU graduates, a product of the NIH-supported workshop in 2024 spearheaded by Dr. Michelle Starr of Indiana University/Riley Children's Hospital. Guests include Dr. Marissa DeFreitas, pediatric nephrologist at the University of Miami, Dr. Matt Harer, neonatologist at the University of Wisconsin, Dr. Kat Gist, pediatric cardiac intensivist at Cincinnati Children's, Dr. Heidi Steflik, neonatologist at the Medical University of South Carolina, and Dr. Tom Forbes, pediatric nephrologist at Royal Children's Hospital in Melbourne, Australia.
Links
Kidney Monitoring for NICU Grads Follow-Up Guidelines: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2823652
AWAKEN study: https://pmc.ncbi.nlm.nih.gov/articles/PMC5933049/
Join the NKC! https://www.babykidney.org/
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Dr. Matthew Sampson, a pediatric nephrologist and associate professor of pediatrics at Harvard Medical School, walks us through genetic testing for pediatric patients with kidney disease. He discusses indications for genetic testing and how to interpret results. He also talks about his lab and work as a genomics researcher.
Episode References
Sampson Lab: https://www.sampsonlab.org/ClinVar: https://www.ncbi.nlm.nih.gov/clinvar/KDIGO genetic testing guidelines: https://kdigo.org/wp-content/uploads/2022/05/KDIGO-Genetics-in-CKD-Conference-Report-Corrected-Proof.pdfNKF genetic testing guidelines: https://www.ajkd.org/article/S0272-6386(24)00871-0/fulltextCJASN Genomics of Kidney Disease Series: https://journals.lww.com/CJASN/Documents/collections/kidney.pdf -
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Join us for an episode on anemia of chronic kidney disease with two pediatric nephrology experts on the topic, Dr. Meredith Atkinson, Associate Professor of Pediatrics at Johns Hopkins, and Dr. Mark Hanudel, Associate Professor of Medicine at UCLA. We will explore the underlying mechanisms behind anemia of CKD, novel treatments for anemia, thoughts on preventing hemoglobin cycling in the setting of Epoetin Alfa, and various iron supplementation tips.
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Join us for a journal-style episode covering 2023 CJASN article, "Timing of Kidney Replacement Therapy among Children and Young Adults." Drs. Nick Larkins and Simon Carter discuss the findings from the Australia and New Zealand Dialysis and Transplant Registry and compare and contrast it to United States, Canada and European data.
Article link: https://pubmed.ncbi.nlm.nih.gov/37279903/
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Dr. Clemens Bergwitz, an associate professor of endocrinology at Yale University, walks us through how to work-up and treat patients with calcium and phosphorus disorders. He helped to discover the disease HHRH (hereditary hypophosphatemic rickets with hypercalciuria) and has wonderful knowledge to share with listeners regarding the bone-mineral axis!
References
2024 KIR Update on HHRH https://pubmed.ncbi.nlm.nih.gov/38364990/
2009 Ped Nephrology Genetic causes of hypercalciuric nephrolithiasis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770137/
TMP calculation and reference ranges https://www.nbt.nhs.uk/sites/default/files/Protocol%20for%20measurement%20of%20TmP.pdf
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Join us to learn about hyperoxaluria from nephrolithiasis expert and division director of pediatric nephrology at Mayo Clinic, Dr. David Sas! We discuss pathophysiology, work-up and management of primary hyperoxaluria, including new game-changing therapies. Dr. Sas also answers other high-yield kidney stone management questions.
Resources:
Novodetect primary hyperoxaluria/nephrolithiasis genetic panel testing: file:///Users/student/Downloads/BpG_GTP-for-NovoDetect-Panels-Form_GTP-NVDT-2P-B.pdf
Rare Kidney Stone Consortium (RKSC): 800-270-4637 or [email protected]
Resources for physicians and patients regarding all forms of rare kidney stone diseases
Oxalosis and Hyperoxaluria Foundation (OHF): www.ohf.org
Resources for patients, parents, and physicians regarding primary hyperoxaluria
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Dr. Laura Hesemann, a med/peds-trained adult and pediatric nephrologist and Chair of Pediatrics at the University of Missouri, shares her expertise about SGLT-2 inhibitors and their utility in clinical practice.
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Drs. Donna Claes, Vivian Shih and Annie Kouri (our co-host) discuss their roles as pediatric dialysis directors at their institutions. Donna Claes is an associate professor of pediatric nephrology and chronic dialysis director at Cincinnati Children's and Vivian Shih is an assistant professor of pediatric nephrology and acute dialysis director at Children's Hospital Colorado. We talk about the road to becoming a dialysis director, what the job entails, the challenges, the rewarding aspects of the job and tips for those who are considering stepping into this position at their institution.
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Dr. Katherine Twombley, professor and chief of pediatric nephrology at the Medical University of South Carolina, shares her knowledge on FSGS recurrence after transplant. She discusses the diseases that cause FSGS and her strategy for managing these complex patients. Dr. Twombley is the director of dialysis and kidney transplantation, and does clinical research in the area of transplant. She is involved with leadership roles both in ASPN and AST.
If you have any feedback or would like to come onto the podcast, please email [email protected]
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As part of the leadership series of podcast episodes, this episode discusses life as a pediatric kidney transplant director. Dr. Jodi Smith, Seattle Children's transplant director and ASPN president, Dr. Gina Barletta, Phoenix Children's transplant director, and Dr. Sarah Kizilbash, co-host and University of Minnesota transplant director, talk about why and how they got to be transplant director, their program's structure, strengths, weaknesses and the greatest joys of their job.
For more information about the ASPN transplant interest group, check out this link https://aspneph.org/transplant-interest-group/ or email [email protected]
For information about UNOS, check out the calendar of events https://optn.transplant.hrsa.gov/news/calendar-of-events/
For UNOS requirements to become a transplant physician, check out this link https://optn.transplant.hrsa.gov/media/2785/membership_requirements-for_pediatric_components.pdf
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Join us in our discussion with Dr. Deepa Chand, who is a pediatric nephrologist, former dialysis and division director, and now director of patient safety in immunology at Novartis. She also continues to practice pediatric nephrology at the University of Illinois-Peoria. She talks about her journey to where she is today, behind-the-scenes information regarding drug development and approval, and provides practical advice that is valuable for clinicians and researchers alike.
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This is the first episode in our leadership series! We talk with Drs. Sudha Garimella, associate professor of pediatrics at Prisma Health, and Priya Verghese, professor of pediatrics at Lurie Children's/Northwestern University about their roles as division directors in pediatric nephrology. They discuss their career paths, challenges and rewards of the job, tips for recruitment and general leadership advice, helpful for all pediatric nephrologists!
ASNP
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Dr. Vikas Dharnidharka, Professor of Pediatrics and Pediatric Nephrology Division Director at Washington University School of Medicine in St. Louis, shares his extensive knowledge on PTLD (post-transplant lymphoproliferative disorders) in pediatric kidney transplant recipients. He is the first author of a PTLD textbook (https://link.springer.com/book/10.1007/978-3-030-65403-0) and has published numerous studies and guideline recommendations on the subject. We discuss the pathophysiology, risk factors, clinical presentation, work-up, treatment and prognosis of PTLD in this episode.
References
North American Pediatric Renal Trials and Collaborative Studies Registry (NAPRTCS) and Pediatric Nephrology Research Consortium (PNRC) studies regarding the advantages of lower dose thymoglobulin induction therapy in kidney transplantation
https://pubmed.ncbi.nlm.nih.gov/32903852/
https://pubmed.ncbi.nlm.nih.gov/33912749/
International Pediatric Transplant Association (IPTA) PTLD guidelines
https://pubmed.ncbi.nlm.nih.gov/36369733/
https://pubmed.ncbi.nlm.nih.gov/36369745/
https://pubmed.ncbi.nlm.nih.gov/37294621/
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We have two fantastic Canadian guest nephrologists discussing IgA nephropathy on this episode. Dr. Sean Barbour is an adult nephrologist and associate professor at the University of British Columbia. He is a glomerulonephritis and epidemiology expert and serves as the chair of the British Columbia GN Committee and Registry. He developed and validated the IgA clinical prediction tool for both adults and children and has participated in the TESTING and NefIgArd clinical trials. Dr. Alexandra Cambier is a clinician-scientist and an associate professor of pediatric nephrology at Montreal University. She also worked on the pediatric IgA prediction tool and has numerous publications regarding biomarkers and genetic variants in children with IgA nephropathy.
Publications that we discuss in this episode-
IgA prediction tool validation:
https://pubmed.ncbi.nlm.nih.gov/30980653/ https://pubmed.ncbi.nlm.nih.gov/35490842/
https://pubmed.ncbi.nlm.nih.gov/33220356/
CD89 in childhood IgA nephropathy:
https://pubmed.ncbi.nlm.nih.gov/34756952/
IgA nephropathy therapies in children:
https://pubmed.ncbi.nlm.nih.gov/34756952/
Targeted-release budesonide in adults with IgA nephropathy:
https://pubmed.ncbi.nlm.nih.gov/36270561/
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Join us for this special episode regarding how to apply for pediatric nephrology fellowship. We will give residents the inside scoop on succeeding in landing their top match in the application and interview process! Guests on this podcast are pediatric nephrology program directors- Drs. Erum Hartung (CHOP), Julie Goodwin (Yale), Elizabeth Ingulli (UCSD/Rady Children's), Carla Nester (University of Iowa) and current pediatric nephrology fellows- Emily Zangla (University of Minnesota), Carlos Becerril-Romero (Lurie Children's), Emilia Cadiz (Emory), Uche Nwaogazie (CHOP), and Kelly Garrity (UCLA).
Questions? Reach out to Emily at [email protected]
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Join us for the discussion on neonatal dialysis with expert Dr. David Askenazi from the University of Alabama who pioneered the adaptation of the Aquadex machine to infants!
We cover acute kidney injury, the utilization of peritoneal dialysis, CRRT, Aquadex and Carpediem in neonates and the logistics behind the use of these novel new machines.
To get involved, visit the Neonatal Kidney Collaborative website at: https://babykidney.org/
High-yield papers on neonatal AKI and dialysis:
AWAKEN Study: https://pubmed.ncbi.nlm.nih.gov/29732396/
Aquapheresis case series in children: https://pubmed.ncbi.nlm.nih.gov/31462396/
CRRT vs. Carpediem outcomes: https://pubmed.ncbi.nlm.nih.gov/34414499/
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Dr. Brad Rovin, director of the Division of Nephrology and the Vice Chair of Research in Internal Medicine at the Ohio State University, discusses recent advances in lupus nephritis treatment. Dr. Rovin is deputy editor of Kidney International and the co-chair of glomerular disease guidelines for KDIGO. He has published many major landmark nephrology clinical trials in lupus nephritis (listed below), which he highlights in this episode. It's the "golden age" of lupus nephritis treatment!
Papers we discuss:
BLISS (Belimumab) https://www.nejm.org/doi/full/10.1056/NEJMoa2001180
AURORA (Voclosporin) https://www.thelancet.com/article/S0140-6736(21)00578-X/fulltext
LUNAR (Rituximab) https://onlinelibrary.wiley.com/doi/epdf/10.1002/art.34359
NOBILITY (Obinutuzumab) https://ard.bmj.com/content/81/1/100
TULIP-LN (Anifrolumab) https://ard.bmj.com/content/81/4/496
Also check out https://kidney.wiki/ pediatric nephrology platform created by Ryan Town, a fellow from Stanford!
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(*OK, maybe not EVERYTHING, but a very thorough and worthwhile review!)
Dr. Michelle O'Shaughnessy, a consultant nephrologist at Galway University Hospitals in Ireland, and Dr. Tiffany Caza, a renal pathologist at Arkana Labs, give us the high-yield points on membranous nephropathy, in both pediatric and adult patients! They are both well published and have excellent clinical experiences to share with listeners.
Check out Michelle's Cure GN paper on membranous treatment in children: https://pubmed.ncbi.nlm.nih.gov/31844809/
Check out Tiffany's newest paper on novel membranous antigens: https://pubmed.ncbi.nlm.nih.gov/36638888/
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Dr. Lyndsay Harshman, an Associate Professor of Pediatric Nephrology and Director of the Pediatric Kidney Transplantation Program at the University of Iowa, explains how and why kids with chronic kidney disease have different brain structures and cognitive abilities, compared to their healthy peers. She discusses her research discoveries regarding brain imaging in kids with CAKUT and shares her tips so that clinicians can best help their at-risk patients.
Please provide any feedback you have! We love to hear it! https://s.surveyplanet.com/dmmriui5
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Dr. Brad Rovin, director of the Division of Nephrology and the Vice Chair of Research in Internal Medicine at the Ohio State University, discusses IgA nephrology. Dr. Rovin is deputy editor of Kidney International and the co-chair of glomerular disease guidelines for KDIGO. He has published many major landmark nephrology clinical trials, including the BLISS and AURORA trials in lupus nephritis and the NefIgArd targeted-release budesonide trial in IgA nephropathy, which he highlights in this podcast.
Links to mentioned publications in this episode:
BLISS https://www.nejm.org/doi/10.1056/NEJMoa2001180?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
AURORA https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00578-X/fulltext
TESTING https://jamanetwork.com/journals/jama/fullarticle/2792252 NefIgArd https://www.kidney-international.org/article/S0085-2538(22)00836-5/fulltext
Meta-analysis SGLT2 inhibitors https://www.thelancet.com/action/showPdf?pii=S0140-6736%2822%2902074-8
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