Episoder
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Episode 19 (April 26, 2024): This week, the GEN editors celebrated DNA Day by sharing some stories about their favorite observations and applications of DNA research.
Featuring Kevin Davies, PhD (Editorial Director, GEN), John Sterling (Editor in Chief, GEN), Uduak Thomas (Senior Editor, GEN), Alex Philippidis (Senior Business Editor, GEN), Fay Lin, PhD (Senior Editor, GEN Biotechnology), Jonathan Grinstein, PhD (Senior Editor, GEN), and moderated by Corinna Singleman, PhD (Managing Editor, GEN and IPM).
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base:
The Life and Times of Rosalind Franklin
GEN Webinar presented by Matthew Cobb, PhD, Oct 16, 2020.
"Life Story"
BBC film (1987).
Nobel Winner Svante Pӓӓbo Discovered the Neandertal in Our Genes
By Daniela Mocker, Scientific American, Oct 4, 2022.
“Svante Pӓӓbo, reader of the Neanderthal genome”
Wielgus, Danielewski, and Walkowiak, Acta Physiol, Nov 23, 2022.
Colossal’s Woolly Mammoth Project Advances as Elephant iPSCs Clear Milestones
GEN, Mar 7, 2024.
The State of Omics 2024
GEN Summit.
“Genetic Ancestry Testing What is it and Why is it Important?”
Jorde and Bamshad, JAMA, Mar 27, 2020.
A Leading Cause of Autism Spectrum Disorders May Be Prevented by Novel Approach
GEN, May 21, 2023.
AI Finds Autism-Causing Mutations in “Junk” DNA
GEN, May 28, 2024.
Pollution and Stress Alter Brain Development and Social Behavior in Male Mice
GEN, Aug 3, 2022.
“Mechanistic Basis of Resistance to PCBs in Atlantic Tomcod from the Hudson River”
Wirgin, et al., Science, Mar 11, 2011.
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Episode 18 (April 19, 2024):
Biology’s exploding data streams continue to leverage artificial intelligence (AI) tools to streamline drug development. How do we define AI in drug discovery? Who are notable players in the space? How do humans fit into these growing computational pipelines?
This week, Jonathan Grinstein, PhD (Senior Editor, GEN) and Fay Lin, PhD (Senior Editor, GEN Biotechnology) unpack one of the fastest growing topics in the biotech field, AI in drug discovery.
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base:
The Difference Is the Data: Drug Discovery’s AI Revolution
By Fay Lin, PhD, GEN Biotechnology, April 18, 2024
Archimedes’ Box: Diagonal Therapeutics Raises $128 Million to Discover Agonist Antibodies
By Jonathan Grinstein, PhD, GEN Edge, April 3, 2024
Generate:Biomedicines Raises Largest Biotech Series C of 2023
By Jonathan Grinstein, PhD, GEN Edge, September 14, 2023
Alex Zhavoronkov Aims to Take Over the Drug Development World with AI
By Jonathan Grinstein, PhD, GEN Edge, June 20, 2023
Diffusion Evolution: New Artificial intelligence Models Break Barriers in Protein Design
By Fay Lin, PhD, GEN Biotechnology, October 16, 2023
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Episode 17 (April 12, 2024):
This week, the GEN editors discuss the launch of Nvelop Therapeutics, a new start-up leveraging approaches developed by gene editing pioneers David Liu, PhD, and J. Keith Joung, MD, PhD, to advance delivery of genetic cargo. The GEN editors also recap highlights from the American Association for Cancer Research (AACR) annual meeting held in San Diego, California.
Featuring Uduak Thomas (Senior Editor, GEN), Alex Philippidis (Senior Business Editor, GEN), Julianna LeMieux, PhD (Deputy Editor-in-Chief, GEN), and Jonathan Grinstein, PhD (Senior Editor, GEN), and moderated by Fay Lin, PhD (Senior Editor, GEN Biotechnology)
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base:
The State of Omics 2024 Registration
GEN Summit
Cloaking Device: Liu, Joung Launch $100M Nvelop Therapeutics to Advance Delivery of Genetic Cargo
By Alex Philippidis, GEN Edge, April 9, 2024
Bertozzi, Regev, and More Inspire During the Opening Plenary Session of AACR
By Julianna LeMieux, PhD, GEN, April 8, 2024
AACR 2024: Aviv Regev Shows How Single-Cell Atlases Foster New Axis to Genentech’s Drug Discovery
By Jonathan Grinstein, PhD, GEN, April 8, 2024
AACR 2024: A Video Update from San Diego
By Julianna LeMieux, PhD, and Jonathan Grinstein, PhD, GEN, April 8, 2024
A Video Update from Day Two of the AACR Meeting
By Julianna LeMieux, PhD, and Jonathan Grinstein, PhD, GEN, April 9, 2024
AACR 2024: EpiBiologics Advances Degraders of Membrane-Bound Proteins
By Jonathan Grinstein, PhD, GEN, April 8, 2024
Celebrating National Robotics Week
By Uduak Thomas, GEN, April 12, 2024
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Episode 16 (April 5, 2024): This week, the GEN editors discussed deep proteome profiling of home-sampled dried blood spots to assess the effects of SARS-CoV-2 in mildly symptomatic or asymptomatic, rapid liquid nitrogen treatment for converting tumor cells into carriers for gene editing tools that target cancer in vivo, Verve Therapeutics’ pausing of a clinical trial due to a serious adverse event, Iambic Therapeutics’ advancement of its first AI-designed candidate into the clinic, and the launch of Diagonal Therapeutics to find agonist antibodies for heteromeric receptor complexes.
Featuring Uduak Thomas (Senior Editor, GEN), Alex Philippidis (Senior Business Editor, GEN), Jonathan Grinstein, PhD, (Senior Editor, GEN), and moderated by Corinna Singleman, PhD, (Managing Editor, GEN and IPM)
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base:
The State of Omics 2024 Registration
GEN Summit
COVID-19 Infections Detected in Dried Blood Spots via At-Home Proteomic Profiling
By GEN, April 2, 2024.
CRISPR-Cas9 Targets Lung Cancer Using Cryo-Shocked Tumor Cells
By GEN, March 31, 2024.
Iambic Rhythm: AI Drug Developer Enters the Clinic, Targeting HER2 Cancers
By Alex Philipidis, GEN, April 3, 2024.
Archimedes' Box: Diagonal Therapeutics Raises $128 Million to Discover Agonist Antibodies
By Jonathan D. Grinstein, PhD, GEN Edge, April 3, 2024.
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Episode 15 (March 29, 2024): From the expansion of Nvidia's generative artificial intelligence (AI) platform for drug discovery to AI notetakers that coach doctors to be more human, the GEN editors discuss the latest news in AI from two conferences in California: Nvidia GTC (San Jose) and Precision Med TRI-CON (San Diego).
Featuring Alex Philippidis (Senior Business Editor, GEN), Fay Lin, PhD (Senior Editor, GEN Biotechnology), Jonathan D. Grinstein, PhD (Senior Editor, GEN), moderated by Corinna Singleman, PhD (Managing Editor, GEN and IPM).
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base:
GTC 2024: Nvidia Highlights AI ‘Revolution’ in Drug Discovery, Genomics
By Alex Philippidis, GEN, March 19, 2024.
GTC 2024: Nvidia’s Quantum Expansion Runs through the Cloud
By Alex Philippidis, GEN, March 20, 2024.
Machines Bring Efficiency…and Empathy? Eric Topol Talks AI in Precision Medicine
By Fay Lin, PhD, GEN Edge, March 28, 2024.
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Episode 14 (March 22, 2024): This week, the GEN editors cover identifying receptors and proteins for cellular uptake and intracellular processing of nanoparticles, and a new mRNA structure by adding multiple “tails” to the molecules that boosted mRNA activity levels in cells by 5 to 20 times.
Featuring Jonathan D. Grinstein, PhD, (Senior Editor, GEN), Uduak Thomas (Senior Editor, GEN), and moderated by Fay Lin, PhD, (Senior Editor, GEN Biotechnology)
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base:
Nanoparticle Uptake Screen Informs Nanomedicine Design
By GEN, March 19, 2024.
mRNA Therapeutics May Act Longer If Given Multiple Tails
By GEN, March 22, 2024
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Episode 13 (March 15, 2024): This week, the GEN editors discussed business news from NanoString, Curio, and Cellares.
Featuring Alex Philippidis (Senior Business Editor, GEN), Uduak Thomas (Senior Editor, GEN), Jonathan Grinstein, PhD, (Senior Editor, GEN), and moderated by Corinna Singleman, PhD, (Managing Editor, GEN and IPM).
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base:
The State of Omics 2024 Registration
GEN Summit
NanoString Agrees to be Acquired by Investment Firm for $220M
By GEN, March 11, 2024.
Curio Begins Testing Commercial Spatial Barcoding Technology for Single Cell Sequencing
By GEN, March 12, 2024
Cellares Unveils Clinically-Compliant Cell Therapy Manufacturing Platform
By Jonathan D. Grinstein, PhD, GEN, March 12, 2024
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Episode 12 (March 8, 2024): Featuring Julianna LeMieux (Deputy Editor-in-Chief, GEN), Uduak Thomas (Senior Editor, GEN), and Alex Philippidis (Senior Business Editor, GEN), moderated by Fay Lin (Senior Editor, GEN Biotechnology)
This week, the GEN editors cover a recent interview with the Lost Women of Science, advances in delivery with lipid nanoparticles, Novo Nordisk’s expansion in the Boston area, and how organoids derived from amniotic fluid show promise for understanding fetal diseases.
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base:
At Lost Women of Science, the Unsung Are Celebrated
By Julianna LeMieux, GEN, March 7, 2024.
To Mark International Women’s Day, C-Suite Women Share Leadership Insights
By GEN, March 7, 2024.
Lipid Nanoparticles Engineered to Target Lung Cells Reduce Tumor Size in Mice
By GEN, March 4, 2024.
Novel Thio-lipids Developed Capable of Reaching Eyes and Lungs in Animals
By GEN, March 5, 2024.
Novo Nordisk Expands Boston Area Research and Early Development
By Alex Philippidis, GEN, March 2, 2024.
Metal-Organic Nanoparticles Enable Better Vaccine Delivery, Stronger Immune Response
By GEN, March 6, 2024.
Organoids Originating from Cells in Amniotic Fluid Could Illiminate Congential Conditions
By GEN, March 5, 2024.
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Episode 11 (March 1, 2024): After being diverted by the SARS-CoV-2 pandemic to develop and manufacture COVID-19 vaccines, Moderna gets back to advancing rare disease mRNA therapeutics; a look at rare autoimmune diseases that fly below the public radar; Form Bio announced a partnership with Ginkgo Bioworks to bring their AI out of the computer and into gene therapy production by optimizing genetic payloads.
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base:
Rare Disease Day: Moderna Gets Back to Its Roots
By Jonathan D. Grinstein, GEN, February 28, 2024
Taming the Immune System When Rare Diseases Strike
By Kathy Liszewski, GEN, February 27, 2024
Form Bio’s AI Ensures Gene Therapies Pass Muster, with Ginkgo’s Help
GEN, February 28, 2024
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Episode 10 (February 23, 2024): Researchers from Francis Collins’ lab developed an efficient CRISPR prime editing protocol to generate isogenic-induced pluripotent stem cell (iPSC) lines carrying heterozygous or homozygous alleles for putatively causal single nucleotide variants. An RNA-based system known as PRINT can create and introduce site-specific, safe, and stable transgenes into the human genome. Astellas Pharma and Kelonia announced a nearly $800 million research collaboration and license agreement to develop innovative universal, off-the-shelf in vivo CAR T cell therapies. Fourth-quarter earnings and revenue fell short of expectations as Biogen worked to eliminate 1,000 jobs (11.5% of its workforce), among other cost-cutting actions, and restructured its pipeline after a slow start.
Plus, an interview with Andrea Choe, founder and chief executive officer at Holoclara.
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base:
Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing
The CRISPR Journal, February 14, 2024
Addressing Scientific Misconduct: An Interview with Elisabeth Bik
By Uduak Thomas, GEN Biotechnology, February 15, 2024
StockWatch: Biogen’s Q4 Results Disappoint Analysts
By Alex Philippidis, GEN Edge, February 18, 2024
Astellas and Kelonia Partner for $800M In Vivo CAR T Cell Therapies
By Jonathan D. Grinstein, PhD, GEN Edge, February 20, 2024
PRINT: Precise RNA-Mediated Insertion of Transgenes
GEN, February 21, 2024
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Episode 9 (February 16, 2024): Using CRISPR-Cas9 technology, British animal genetics firm Genus has generated a population of pigs that are resistant to the deadly porcine reproductive and respiratory syndrome (PRRS) virus. Exscientia has fired its founder, CEO, and principal executive officer Andrew Hopkins, PhD, and removed him from the company’s board, after it concluded that he engaged in “inappropriate” relationships with two employees. Julianna LeMieux, PhD, Deputy Editor in Chief at GEN, provides a recap of her time at AGBT 2024.
Plus, an interview with Christian Henry, president and chief executive officer at PacBio.
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base:
CRISPRed Pigs: Precision Porcine Gene Editing Combats PPRS Virus Threat
By Uduak Thomas, GEN, February 14, 2024
Exscientia Fires CEO for “Inappropriate” Relationships with Two Employees
GEN, February 13, 2024
Sun, Spatial, and Sequencing: A Report from the First Day of AGBT
By Julianna LeMieux, PhD, and Jonathan D. Grinstein, PhD, GEN, February 7, 2024
NanoString CSO Joe Beechem Insists the Company “Not Going Anywhere”
By Julianna LeMieux, PhD, GEN, February 8, 2024
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Episode 8 (February 9th, 2024): Intellia and Ultragenyx gave updates on their clinical trials for gene therapies for inherited rare diseases. Novo Holdings, which manages the assets of the foundation that controls Novo Nordisk, agreed to buy Catalent for $16.5 billion to keep up with the high demand for its hit drugs Wegovy and Ozempic. Spatial biology tools developer NanoString Technologies filed for bankruptcy, blaming the $31 million jury award assessed against it last November in a patent infringement case filed by rival 10x Genomics. Plus, an interview with Simon Barnett, research director at Dimension.
Listed below are key references to the GEN stories, media, and other items discussed in this episode of Touching Base:
Gene Therapy for Hereditary Angioedema Shows Success in Patients
· GEN, February 5, 2024
Ultragenyx’s Gene Therapy Ameliorates Pediatric Neurodegenerative Disorder
· By Jonathan Grinstein, GEN Edge, February 7, 2024
CRISPR-Repaired T Cells May Treat Fatal Inflammatory Diseases
· GEN, February 5, 2024
NanoString Files for Chapter 11 Bankruptcy, Launches Strategic Review
· By Alex Philippidis, GEN, February 5, 2024
Novo Holdings Buys Catalent for $16.5B; Sells Three Sites to Novo Nordisk for $11B
· By Alex Philippidis, GEN, February 5, 2024
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Episode 7 (February 2, 2024): Simplify Genomics launches genome interpretation platform, COUR’s nanoparticles for autoimmunity, gene replacement therapy for heart condition, CG Oncology and ArriVent IPOs; an interview with Nautilus Biotechnology co-founders, Sujal Patel and Parag Mallick.
Listed below are key references to the GEN stories, media and other items discussed in this episode of Touching Base:
Human Longevity Spin-Out Aims to Tap into Variant Interpretation Market
By Uduak Thomas, GEN, January 31st, 2024
Light My Fire: COUR Raises $105M Series A to Advance Tolerogenic Nanoparticles for Autoimmunity
By Jonathan Grinstein, GEN Edge, January 30th, 2024
Gene Replacement Therapy Halts Fatal Arrhythmogenic Condition in Mice
GEN, January 30th, 2024
StockWatch: IPO Revival? CG Oncology, ArriVent Raise a Combined $555M
By Alex Philippidis, GEN Edge, January 28th, 2024
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Episode 6 (January 26, 2024): 11-year-old regains hearing after gene therapy; Kyverna uses blood draw instead of apheresis for CAR T manufacturing; DNA production technology with GSK and Elegen, StockWatch with Nvidia and Recursion; an interview with renowned cardiologist, Eric Topol, MD
Listed below are key references to the GEN stories, media and other items discussed in this episode of Touching Base:
Gene Therapy Restores Hearing in 11-Year-Old After Just One Month
GEN, January 24th, 2024
GSK and Elegen Team Up to Develop DNA-Based Medicines and Vaccines
By Jonathan Grinstein, GEN Edge, January 24th, 2024
Blood Brothers: Kyverna Reinvents Autologous CAR T Manufacturing from Blood Draw
By Jonathan Grinstein, GEN Edge, January 24th, 2024
StockWatch: Nvidia Jumps 24% on Recursion, Amgen AI Partnerships
By Alex Philippidis, GEN Edge, January 21st, 2024
Five Deaf Children Have Hearing Restored by AAV-Based Gene Therapy
GEN, January 25th, 2024
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Episode 5 (January 19, 2024); RNAs to address Alzheimer’s disease; monkey cloned via somatic cell nuclear transfer; Cytokinetics stock roller coaster; an interview with founder and CEO of 1910 Genetics, Jen Nwankwo, PhD.
Listed below are key references to the GEN stories, media and other items discussed in this episode of Touching Base:
· Alzheimer’s Disease Linked to Toxic Short RNAs
GEN, January 18, 2024.
· Rhesus Monkey Cloned via Somatic Cell Nuclear Transfer
GEN, January 16, 2024.
· StockWatch: M&A Talk Fuels Cytokinetics Stock Roller Coaster
By Alex Philippidis, GEN Edge, January 16th, 2024.
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Episode 4 (January 12, 2024): Takeaways from the J.P. Morgan Health Care conference: Illumina, Danaher, 10x, Empress Therapeutics; an interview with Liberate Bio’s Shawn Davis and Walter Strapps.
Listed below are references to relevant GEN stories discussed in this episode of Touching Base:
JPM: Illumina’s new CEO spells out 2024 priorities, presents preliminary Q4 2023 resultsBy Alex Philippidis, GEN, January 10, 2024.
JPM: Prime Medicine eyes 2024 IND for first prime editing therapyBy Alex Philippidis, GEN, January 9, 2024
JPM 2024: Veracyte’s C2i genomics acquisition adds AI readouts to liquid biopsy testingBy Jonathan D. Grinstein, GEN, January 8, 2024
JPM: More M&A “firepower” in store for 2024, EY predictsBy Alex Philippidis, GEN, January 8, 2024
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Episode 3 (January 5, 2024): Interview with Co-founder and CEO of Moonwalk Biosciences and former CTO of Illumina, Alex Aravanis; Neuro gene therapy with Novartis and Voyager; GEN reporters look forward to the 2024 J.P. Morgan Healthcare Conference
Listed below are key references to the GEN stories, media and other items discussed in this episode of Touching Base:
Novartis, Voyager Ink Up-to-$1.3B Expansion of Neuro Gene Therapy CollaborationBy Alex Philippidis, GEN, January 2, 2024.
Moonwalk Biosciences Raises $57M to Edit the EpigenomeBy Uduak Thomas, GEN, January 4, 2024.
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Episode 2 (December 22, 2023): Interview with President and CEO of Tome Biosciences, Rahul Kakkar; intelligent lab partner using LLMs; AI for antimicrobials; mRNA vaccine production in Africa; Moderna’s positive cancer vaccine data.
Listed below are key references to the GEN stories, media and other items discussed in this episode of Touching Base:
The Next Chapter in Genome Editing? Tome Emerges from Stealth with $213M By Alex Philippidis, GEN, December 19, 2023.Artificial Intelligence-Based Lab Partner Designs, Runs Experiments in the Lab GEN, December 20, 2023.BioNTech Advances Plans for mRNA Vaccine Production in Africa by 2025 GEN, December 19, 2023.Explainable AI Directs Small Molecule Structural Class Drug Discovery By Jonathan Grinstein, GEN, December 20, 2023.StockWatch: Positive Cancer Vaccine Data Wows Moderna Investors By Alex Philippidis, GEN Edge, December 18, 2023.Hosted on Acast. See acast.com/privacy for more information.
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Episode 1 (Week ending December 8, 2023): Nevan Krogan (UCSF) mapping autism pathways; Nvidia’s latest AI partnership; CAR-T regulations; epigenome editing; mRNA therapeutics.
References to the GEN stories, media and other items discussed in this episode of Touching Base:
· Autism’s Molecular Mechanisms Uncovered through Protein-Protein Interaction Network
By Julianna Lemieux, GEN, December 5, 2023.
· Rhapsody in B: Tune Therapeutics Presents Data for Hepatitis B Epigenetic Silencer
By Jonathan Grinstein, GEN Edge, December 6, 2023.
· Nvidia Looks to Genentech for its Next Leap in AI Drug Discovery
By Alex Philippidis, GEN Edge, November 28, 2023.
· StockWatch: CAR-T Shares Mostly Flat as FDA Probes Risk of New Cancers
By Alex Philippidis, GEN, December 1, 2023
· Perfect Pitch: Genome Editing Pioneer Fyodor Urnov on Commercializing CRISPR Therapies and Epigenomic Tuning {VIDEO}
GEN Edge, August 30, 2023
· Press release: John Crowley appointed President & CEO of BIO
Biotechnology Innovation Organization
· BIO CEO Rachel King Outlines Industry’s Challenges on “Close to the Edge”
GEN multimedia, April 26, 2023
· The First CRISPR Drug: Vertex Pharmaceuticals’ Casgevy Wins U.K. Approval for Sickle Cell Disease
GEN, November 16, 2023
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