Episodes
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If you have been thinking about buying a LED mask, the hardest part is knowing what actually matters. The price range is all over the place, every brand seems to have some version of “FDA cleared” on the page, and a lot of the buying advice sounds scientific enough to trust. But none of that automatically tells you whether the device is strong enough to do anything meaningful for your skin.
That is why we wanted to take a closer look at an Allure post called So You Wanna Buy a LED Mask. The guide brings up the same things people usually look at before buying one: price, number of bulbs, FDA clearance, clinical trials, and how often you have to use it. Some of those details can be useful, but they can also distract from the real questions: how much light does the device actually deliver, what wavelengths does it use, and is the coverage strong enough to create meaningful stimulation?
That matters if you are about to spend a few hundred dollars on a device and you are using the wrong signals to decide. A high price, FDA clearance, or a small clinical study can make a mask sound more credible, but those details do not always answer the question you actually care about: Will this device give my skin enough stimulation to be worth using?
What’s Discussed:
(04:22) Why we are reacting to Allure’s LED mask buying guide.
(05:12) Why the $100 to $1000 LED mask price range is not very helpful.
(07:31) Why diode count matters, but output matters more.
(08:33) Whether you actually need to use a LED mask every day.
(10:55) What FDA clearance does and does not tell you.
(13:35) Why a five-subject clinical trial is not strong proof.
(15:45) The wavelengths that matter for red light therapy.
Listen to this episode of Biohacking Beauty to understand what actually matters before buying a LED mask, and why the most scientific-sounding claims are not always the ones that tell you if a device will work.
Resources Mentioned:
Age-Associated Changes in Oxidative Stress and NAD+ Study: journals.plos.org/plosone/article/
FASEB study on how methylene blue delays cellular senescence cells: faseb.onlinelibrary.wiley.com/doi/
Find more from Young Goose:
Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
Instagram: @young_goose_skincare
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We have been getting the same question in our DMs for months now. Peptides are everywhere. Everyone is talking about them. But what actually has evidence behind it, what is hype, and where do hormones fit into all of this? So we went and found someone who has been living this conversation for 35 years, not just talking about it.
Dr. Jennifer Berman is a urologist, New York Times bestselling author, and one of the leading voices in female sexual and menopausal health. She pioneered the field at UCLA, runs the Berman Women's Wellness Center in Beverly Hills, and has been her own first patient through every transition she now treats. She is the kind of doctor who was doing things a decade before they became mainstream and has the clinical receipts to back all of it up.
In this episode we get into why peptides are the missing piece of the menopause puzzle, what hormones are really doing to your skin from the inside out, and how treatments that were written off as fringe became the new gold standard for longevity.
What's Discussed:
(01:42) Why peptide production declines with age and what that actually means for how women look and feel in perimenopause.
(04:04) The regulatory reality around peptides right now and why medical grade from a 503B pharmacy is the only route worth taking.
(06:07) The specific peptides with the strongest evidence for skin, muscle, fat loss, recovery, and cognitive function.
(13:12) Why your mid to late 30s is already perimenopausal by definition and why that changes when you start.
(15:02) C-Link, C-Max, and PE22-28 for mood, neuroplasticity, and cognitive protection and why Dr. Berman stacks them together.
(39:17) The exact point where topical skincare stops being enough and what hormone imbalance is doing to skin that no cream can fix.
(53:08) Why cycling your peptides matters, what receptor attenuation actually is, and why the protocol on your feed is not a clinical protocol.
By the end of this episode you will know which peptides have actual evidence behind them, where topical skincare stops working without hormonal support, and what an inside-out longevity protocol looks like from a doctor who has lived every transition she treats.
Resources Mentioned:
Age-Associated Changes in Oxidative Stress and NAD+ Study: journals.plos.org/plosone/article/
FASEB study on how methylene blue delays cellular senescence cells: faseb.onlinelibrary.wiley.com/doi/
Find more from Young Goose:
Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
Instagram: @young_goose_skincare
Find more from Dr. Jennifer Berman:
Website: bermansexualhealth.com/
Instagram: @jenbermanmd
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Creatine has been boxed in as a gym-bro supplement for decades, but the latest research shows it's doing far more than building muscle. It buffers brain energy under sleep deprivation, supporting bone density and mood stability through perimenopause, and freeing up methyl groups for detoxification and DNA repair.
We dive deeper into this in the Biohacking Beauty Podcast with Dr. Dan Pardi. We also chat about why the bloating myth is backwards, how creatine and NAD work synergistically to support mitochondrial energy, and what topical creatine could mean for the future of skincare.
Dr. Dan Pardi is a researcher whose first study in the 1990s focused on creatine, and he has spent three decades following the science as it expanded from sports performance into brain health, healthspan, and women's physiology. He is the Chief Health Officer at Qualia Life Sciences, where the team has earned recognition from the Nutrition Business Journal for science and innovation.
His work focuses on translating peer-reviewed research into formulations that support cellular energy, methylation, and longevity.
Let's dive in.
Use code YOUNGGOOSE at https://www.qualialife.com/ for a special discount.
What's Discussed:
(4:32) Why creatine went from a niche Olympic edge to a billion-dollar category after the 1992 Games.
(11:18) The sloping-surface analogy that explains why 5 grams saturates muscle but barely touches the brain.
(15:47) How creatine buffers cognitive performance under sleep deprivation, with no decrement at baseline.
(22:05) Why the bloating myth is backwards and what intracellular hydration actually feels like.
(28:40) Topical creatine, the dermal layer, and why molecule size matters for skin delivery.
(36:22) The decade of creatine in women: bone density, mood, and energy fluctuations through menopause.
(42:15) Where the hair loss rumor really came from, and why creatine took the blame.
(51:08) Why 40% to 70% of your body's methylation goes to making creatine, and what that means for NAD stacking.
Find more from Young Goose:
Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
Instagram: @young_goose_skincare
Find more from Dr. Dan Pardi:
Instagram: @drdanpardi
Substack: @drdanpardi
Find more from Qualia:
Website: qualialife.com
Instagram: @qualialife
Qualia Creatine: qualialife.com/shop/qualia-creatine
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When summer skin starts looking dull, congested, tired, or slower to recover, it is easy to blame the obvious things: heat, sweat, sunscreen, long days outside, or the wrong moisturizer. So the conversation usually stays on the surface. Use SPF. Cleanse better. Switch to lighter products. Add antioxidants. But before we treat summer skin like another product problem, there is a deeper question worth asking: what is the sun doing to the cell before you ever see the damage in the mirror?
In this episode of Biohacking Beauty, I want to take the sun conversation past burns, wrinkles, and dark spots. I’m walking through what UV exposure does to the systems your skin depends on to keep up with summer: cellular energy, NAD, mitochondrial function, and DNA repair. Because the skin does not only need protection from the sun. It also needs enough repair capacity to deal with the damage that gets through.
Young Goose's Skin Under the Sun campaign is active from June 15 through June 28 at younggoose.com
What’s Discussed:
(01:50) The light-activated repair tool humans lost.
(06:10) Why NAD matters for skin energy and repair.
(10:15) How UV exposure increases oxidative stress and disrupts NAD supply.
(16:44) What UV-induced DNA lesions are and why CPDs matter.
(22:21) Why L.A.D.R. serum was built around light-activated repair-inspired science.
(31:52) Why the sun is one of the biggest controllable inputs into biological skin aging.
(35:43) The five protocol-level moves for supporting skin through summer.
Listen to this episode of Biohacking Beauty to understand what UV is doing under the surface and how to build a smarter summer protocol around protection, energy, and repair.
Resources Mentioned:
Age-Associated Changes in Oxidative Stress and NAD+ Study: journals.plos.org/plosone/article/
FASEB study on how methylene blue delays cellular senescence cells: faseb.onlinelibrary.wiley.com/doi/
Find more from Young Goose:
Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
Instagram: @young_goose_skincare
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Every fibroblast inside your dermis right now is asking 200 to 2,000 mitochondria to power its work in real time, and those mitochondria are descendants of a free-living bacterium swallowed by a larger cell 2 billion years ago. As you age, those mitochondria run slower and your cells build fewer of them to replace the ones that fail.
In this solo episode, Young Goose co-founder Amitay Eshel breaks down the two sides of mitochondrial decline that drive skin aging and explains why the science-led skincare category has spent the last decades addressing only one of them.
The first side of skin aging is where most skincare brands have built their products around. The other side is the one almost no skincare on the market is formulating for, and it is where the next chapter of skin longevity is being written.
If you have outgrown the antioxidant-and-peptide era of skincare and want to understand what is actually happening underneath your skin as it ages, this episode is for you.
What's Discussed:
(01:35) The 2-billion-year-old contract inside every skin cell that is now fraying.
(04:10) Why skin is one of the most mitochondria-dense organs in your body.
(08:20) The 2012 paper that showed NAD drops by half between 35 and 70.
(13:15) How a refugee fired in 1933 figured out the chemistry your cream still runs on.
(16:30) The second half of the decline almost no skincare addresses.
(19:45) The master regulator that decides whether your cells can hire.
(24:00) The two columns of mitochondrial biology and why most brands only work in one.
(32:10) Why this is a ten-year strategy, not a two-week one.
Resources Mentioned:
Download the Cellular Energy Protocol: https://www.younggoose.com/pages/the-mitochondrial-skin-stack
Age-Associated Changes in Oxidative Stress and NAD+ Study: journals.plos.org/plosone/article/
FASEB study on how methylene blue delays cellular senescence cells: faseb.onlinelibrary.wiley.com/doi/
Find more from Young Goose:
Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
Instagram: @young_goose_skincare
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Roughly 25% to 30% of the population carries slow variants in the MAOA or COMT genes, the two enzymes responsible for clearing adrenaline, dopamine, and serotonin from the brain.
For these individuals, common polyphenols marketed for inflammation and longevity, including curcumin, act as weak MAOA inhibitors that further slow neurotransmitter breakdown. The result is a quiet buildup of stimulation that gets misread as anxiety, insomnia, or unexplained agitation, with no obvious connection to the supplement bottle that caused it.
In this episode of Biohacking Beauty, Dr. Tyler Panzner joins us to translate exactly this kind of pharmacological nuance into protocols people can actually use. He is a PhD pharmacologist with research in neuropharmacology and breast cancer metastasis, and has worked with over 900 clients, particularly highly sensitive people, to identify their genetic weak points and remove the supplements quietly working against them.
If you are stacking longevity supplements, feel wired without explanation, or want to understand why your body responds differently than the marketing promises, this episode is for you.
What's Discussed:
03:15 Why supplements are the "Wild West" of holistic health.
08:42 The hidden problem with curcumin, resveratrol, and EGCG for sensitive people.
15:30 The four gas pedals of the brain: adrenaline, histamine, glutamate, and sulfur.
22:18 Stress vs. anxiety and how the brain builds narratives around physiological activation.
29:45 Why your meditation practice may be failing because of a supplement.
37:20 NMN degradation, the NAMPT "toll booth," and topical vs. systemic delivery.
46:08 The future of multi-omics testing and personalized protocols.
Find more from Young Goose:
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at younggoose.com
Instagram: @young_goose_skincare
Find more from Dr. Tyler Panzner:
Website: drtylerpanzner.com
Instagram: @drtylerpanzner
Facebook: Dr. Tyler Panzner
Linkedin: Tyler Panzner, Ph.D.
YouTube: @drtylerpanzner
FREE Guides: drtylerpanzner.com/free-guides
1:1 Genetic Coaching: https://drtylerpanzner.com/startyourjourney
Quieting an Overactive Mind Webinar: https://overstimulated.drtylerpanzner.com/webinar-registration-page
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Your skin has a biological age and for most people, it's not the same as their chronological one. Mayo Clinic published the SkinSpan framework this year specifically to quantify it, and the 12 Hallmarks of Aging now have a direct application to dermal tissue.
This raises an uncomfortable question: if you're already optimizing everything below the neck with NAD IVs, peptides, and red light, why is the skincare on your face still operating on a paradigm from 1987?
In this new episode of the Biohacking Beauty Podcast, we give you a preview of the keynote we're delivering at Dave Asprey's Beyond Conference and walk you through the 3-pillar framework that replaces traditional anti-aging skincare with longevity science in mind.
Because the results you can feel today and results you can measure in ten years are not the same thing. And we think you deserve both.
Let's dive in.
What's Discussed:
(2:29) The gap no one in longevity talks about.
(3:06) Why your moisturizer is 38 years behind your supplements.
(6:21) The 12 Hallmarks of Aging, decoded.
(9:42) Pillar 1: The master pathway of skin aging.
(12:18) Why NAD in a jar doesn't work (and what does).
(14:22) The cellular housekeeping system that quietly shuts down with age.
(15:17) The peptide that affects 32% of your skin's genome.
(16:55) Pillar 2: The software updates your cells stop sending.
(20:09) The PRP lineage that changed regenerative aesthetics.
(22:54) Pillar 3: The pillar our community doesn't want to hear about.
(29:09) The protocol, tiered by where you're starting.
(37:55) How Young Goose fits into what you're already doing.
(40:32) The two tests we're building to measure skin longevity.
Find more from Young Goose:
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincareHead to younggoose.com/products/youth-body-cream for 20% off
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The melanocytes giving pigment to your skin right now might be older than your car. They have been sitting in your dermis for decades, and unlike the cells on your skin's surface, they do not get replaced. They have to keep themselves clean which happens through autophagy.
In Part 2 of our autophagy deep dive, we get specific about how skin handles autophagy differently from other parts of the body. We unpack why long-lived cells like fibroblasts and melanocytes depend on this cleanup process, what happens when it fails, and how it ties directly to gray hair, hyperpigmentation, sagging skin, and that brownish dullness no serum seems to fix.
We also introduce one of the most overlooked players in this entire conversation, and explain why we believe it is the next NAD. If you want to understand what is actually happening underneath your skin as it ages, and what tools we have to intervene at the cellular level, this episode is for you.
What's Discussed:
(01:06) Why skin needs autophagy more than almost any other organ(03:07) The cells on your face that may be older than your car(04:25) The 2013 paper that linked autophagy failure to dermatitis(08:44) Zombie mitochondria and why photo-aged skin makes bad collagen(12:25) Senescent cells, SASP, and how a few bad cells poison the dermis(18:38) The 2019 Drexel rapamycin trial that proved this works in humans(23:22) The 2024 spermidine study that changes how we think about autophagy(29:51) Why your skin barrier collapses without this one moleculeResources Mentioned:
Biohacking Beauty Podcast with Dr. Scott Sherr: Stress & Light on Your Skin Are Aging Your Entire Body Podcast/dr-scott-sherr-stress-light-on-your-skin-are-aging/
2024 Study on endogenous spermidine as essential for rapamycin-induced autophagy and longevity: pubmed.ncbi.nlm.nih.gov/39212197/
Young Goose Companion Booklet: younggoose.com/pages/autophagy-skin-activate-your-bodys-anti-aging-system
Find more from Young Goose:
Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare
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What if your skin could literally rebuild itself from the inside out? In this episode, we break down one of the most powerful and misunderstood biological processes in the human body: autophagy.
From its Nobel Prize-winning discovery to the molecular machinery that drives it, we walk you through exactly what autophagy is, how it works at the cellular level, and why it matters far more than most people realize for skin aging.
We explore the two master switches that control autophagy, mTOR and AMPK, and how the constant tug of war between them determines whether your cells are in build mode or cleanup mode. We also explain why most people in the modern world are stuck in permanent mTOR activation, and what that means for how their skin ages over time.
This is Part 1 of our deep dive. In Part 2, we go skin-specific and break down exactly how autophagy renews your skin at the tissue level.
What's Discussed:
(0:19) The "phoenix process": the cellular mechanism rebuilding your skin from the inside out
(3:14) What autophagy actually means, and why the science world ignored it for 30 years
(4:47) How baker's yeast cracked the code that won the 2016 Nobel Prize
(7:14) Inside a single skin cell: the step-by-step breakdown of how autophagy actually works
(10:22) Why autophagy is not destruction, and what this means for your collagen supplements
(16:44) The two master switches controlling whether your cells build or clean
(20:10) The everyday habit silencing your body's most powerful anti-aging system
(26:17) Why aging skin isn't broken, it has just never been told to clean
Resources Mentioned:
Biohacking Beauty Podcast: Ben Azadi: Why 93% of Americans Are Aging Too Fast + What to Do About It: podcasts.apple.com/us/podcast/ben-azadi
Find more from Young Goose:
Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
Instagram: @young_goose_skincare
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Most of what the supplement and skincare industry sells for aging targets one pathway at a time. But your biology does not age that way. It declines across 12 interconnected processes simultaneously, and by the time one of them shows up on your skin, the others have already been running for years.
We at Young Goose believe that skin longevity is not a topical problem. It is a whole biology problem, and the ingredients you choose, how they interact, and whether anyone has actually tested them together matters more than any single molecule ever could.
In this episode, we are joined for the second time around by Chris Mirabile, founder of NOVOS which is the first biotech company to target all 12 biological causes of aging. Chris collaborates with leading researchers at Harvard and MIT and has built his work around one premise: that real interventions require real testing on real humans, not just promising ingredients.
Let's dive in.
What's Discussed:
(2:14) Why single ingredient marketing is a commercial story, not a scientific one.(9:56) The three hallmarks hitting skin hardest and how they feed each other.(12:02) How UV damage depletes 90% of NAD in the skin from a single exposure event.(22:14) Why stacking molecules requires human testing, not just ingredient research.(33:48) The NOVOS cardiovascular study and results that surprised the researchers.(48:12) Why spending more on your biology does not make your protocol safe.(1:02:18) What omics testing reveals that epigenetics alone cannot tell you.(1:09:45) Where skin longevity is heading in the next five years.Find more from Young Goose:
Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincareFind more from Chris Mirabile & Slow My Age:
Instagram: @slowmyage
YouTube: @slowmyage
TikTok:@slowmyage
X: @slowmyage
Personal Blog: slowmyage.com
Find more from NOVOS:
Website: NOVOSlabs.com
Instagram: @NOVOSlabs
Facebook: NOVOS
Youtube: @NOVOSlabs
TikTok: @NOVOSlabs_
X: @NOVOSLabs
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Most of what goes viral on SkinTok is missing one thing. The part where someone actually checks if it works.
In this bonus episode, Amitay and Anastasia break down three of the most viral skincare trends circulating today, red light therapy wands, at-home dermarolling, and tretinoin, and run each one through a biohacker's lens. Not to dismiss them outright. But to ask the questions the original videos never do.
What is actually happening at the cellular level? What are the real risks? And where does the marketing stop and the science start?
What’s Discussed:
(2:03) Why red light therapy wands are closer to a flashlight than a treatment.(4:26) What photon accumulation actually means and why moving a wand around your face defeats the purpose.(10:42) Why "sold out" is a marketing claim, not proof that something works.(14:00) What dermarolling actually does to the skin and where the real risks are.(15:21) Why elastin claims in skincare are almost always wrong.(17:06) The difference between at-home dermarolling and professional microneedling.(19:51) How to use a dermaroller safely if you choose to.(28:32) Why tretinoin makes skin worse before it gets better and what that actually means.(32:58) The half-life of vitamin A and why twice a week use barely moves the needle.(34:06) How retinoids accelerate cellular turnover but also drive senescence.(35:44) What can counteract the long-term tradeoffs of tretinoin use.Check out our Mother’s Day Special:
Explore the Mother’s Day gift sets at younggoose.com/pages/mothers-day
Find more from Young Goose:
Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.comInstagram: @young_goose_skincare
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Mothers sacrifice so much of themselves to carry another human being in their body for nine months. Even after childbirth, there's a phase called the fourth trimester because babies are still heavily dependent on moms for their survival.
Motherhood looks different for every woman. For Anastasia, who is a first-time mom, motherhood looked particularly different since her family is overseas and she's also running Young Goose with Amitay. Yet, there's something unique when a biohacker becomes a mom that new moms can learn from.
In this Young Goose Mother's Day Special, we celebrate every mother who gives selflessly to their family. We also take a peek into Anastasia's life as a new mom, what changed in her body and mindset, and how she maintained her self-care while taking care of the family and the business.
This episode will make you realize that it takes a village to raise a kid, but it takes a great mom to raise a kid and still come back to herself. Because the only way she can show up fully for others is when she can show up for herself first.
What's Discussed:
(3:11) Who Anastasia was before motherhood: the risk-taker who crossed the world.(6:03) Why Anastasia loves a small circle and how she protects it.(10:09) Why Anastasia went back to work early, and the regret she wants other new moms to avoid.(12:00) Why motherhood is the hardest thing she has ever done, more than building a company.(15:49) How motherhood flipped the dynamic: why the assertive co-CEO becomes the soft parent.(25:26) Postpartum breakouts, cortisol, and why her skin told the story before anything else did.(29:25) What her early postpartum self-care actually looked like.(30:33) The non-negotiables: PEMF mat, lymphatic drainage suit, and red light therapy.(34:04) Anastasia's postpartum bounce-back stack: spermidine, NAD+, and PC.(1:58) How a biohacker reconnects with a body that no longer feels like her own.(4:05) The self-massage course that changed everything.(5:42) What self-care actually looks like in this season of motherhood.(10:02) Redefining energy as a mother: capacity, limits, and the cost of burnout.(16:01) Mindfulness as a skincare tool: why lowering cortisol shows up on your face.(26:06) The 20-minute practice that can stand in for hours of lost sleep.(27:45) The 4-7-8 breathing technique for moms who do not have 20 minutes.(43:28) Advice for new moms who feel self-care is unrealistic in this season.(43:45) The reframe that changes what self-care means for a new mom forever.Check out our Mother’s Day Special:
Explore the Mother’s Day gift sets at https://www.younggoose.com/pages/mothers-day
Find more from Young Goose:
Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at https://younggoose.comInstagram: @young_goose_skincare
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Most of the NAD+ skincare on shelves right now is built on a misunderstanding. And if you've been trusting niacinamide to do the heavy lifting, this episode is going to change how you read a label.
This episode is Part 2 of our NAD+ deep dive. Here, we get into what actually works to raise NAD+ in the skin, the real precursors, the delivery technology that gets them where they need to go, and the mitochondrial support system most brands leave out. We also walk through the lifestyle levers that move the needle, and why one of them becomes non-negotiable for women after a certain age.
If Part 1 explains what steals your NAD+, this episode is where the science gets practical and eye-opening.
What's Discussed:
(5:07) What the clinical data actually says about topical niacinamide(7:21) Why most niacinamide products on your shelf are underdosed(8:16) The roundabout pathway that makes niacinamide a poor NAD+ precursor(9:03) Niacinamide is a brightening agent, not an NAD+ booster(10:15) Why NMN can't cross the skin barrier alone(11:19) CD38 and blocking the enzyme that destroys NAD+(13:03) NAD+ alone is potential energy, not usable energy(13:45) Liposomal encapsulation and how real precursors get into the skin(17:02) The five mitochondrial pathways your skin actually needs(18:53) Senescent cells and the next telomeres conversation(25:17) Why NAD Apex targets NAD+ in three dimensions(26:39) Lifestyle strategies: fasting and the AMPK pathway(28:47) How to get 30 to 50% more NAD+ from caloric restriction through fasting(30:37) The fun fact behind why 16:8 fasting became the standard(33:02) HIIT and its compounding effect on baseline NAD+(34:51) Sleep is an NAD+ dependent repair session, not just rest(39:15) Your skin does 8x more renewal at night(41:38) Sun protection as an NAD+ strategy(44:49) Why you should expose your back more than your face(45:29) Contrast therapy, heat shock proteins, and cold-driven biogenesis(50:32) Why stacking NAD+ boosting activities at 50% beats maxing out one modality(52:49) The perimenopause problem no one is talking about(56:29) Why niacinamide creates homework for the body(1:01:46) You recycle more NAD+ daily than you can ever supplement(1:02:19) 5-Amino-1MQ, the peptide that recycles NAD+(1:05:35) Mitophagy, autophagy, and the role of spermidine(1:06:44) Ergothioneine, the only antioxidant with a direct mitochondrial transporter(1:07:46) Fermented resveratrol and activating SIRT1Check out resources mentioned:
Part 1 of our NAD+ deep dive: The NAD+ Thief Your Skin Can't Escape: CD38, Zombie Cells, and the Decline
Check out our NAD+ Guide: NAD+ & SKIN AGING - The Cellular Energy Connection
Sleep is Skincare episode: How Timing Unlocks Your Body’s Best Skincare Repair
Find more from Young Goose:
Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at https://younggoose.comInstagram: @young_goose_skincareVampire Exosomes: Professional Exosome Serum for Regeneration and Post-Treatment Recovery https://younggoose.com/products/vampire-exosomes
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A lot of us treat hair loss the way skincare treats wrinkles, as a cosmetic problem to cover up. But almost every case of thinning, recession, or shedding has something deeper driving it, and by the time it shows up in the mirror, a significant amount of density is already gone.
We at Young Goose believe that beauty is whole body care, and hair is one of the most metabolically active tissues in the body. It is also one of the first places systemic stress, hormone shifts, nutrient deficiencies, and inflammation show up.
In this episode, Dr. Alan Bauman joins us to break down the biology of hair aging and the protocols that actually move the needle. Dr. Bauman is the founder of Bauman Medical in Boca Raton and one of the pioneers of modern hair restoration, with nearly three decades of clinical practice and more than 35,000 patients treated.
His core message is simple and urgent: time equals follicles. Every week of delay is density you do not get back. And most people have no idea it is happening until the loss is already visible.
We go deeper into this in the latest episode of Biohacking Beauty: The Anti-Aging Skincare Podcast. We also cover the hidden hair loss risks of GLP-1s and testosterone optimization, the precision diagnostics replacing guesswork, and the red light therapy details almost no one talks about.
Let's dive in!
What's Discussed:
(2:20) How Dr. Bauman became a hair restoration pioneer and the patient who changed everything.(9:50) Why hair is an emotional organ and a biomarker for systemic health.(12:14) Time equals follicles: why every week of delay costs you density.(13:38) The mechanism of androgenetic alopecia and how DHT miniaturizes the follicle.(16:30) Why DHT is not the only driver: stress, inflammation, nutrient deficiency, and GLP-1s.(18:55) The hidden hair loss risks of weight loss peptides and caloric deficits.(21:06) Precision diagnostics: AI-powered microscopy, DNA testing, and preservation first.(23:36) What genetic testing actually tells us about your DHT metabolism pathways.(29:40) Minoxidil and finasteride explained, and why oral microdose is the modern approach.(32:20) Dutasteride, topical finasteride, and when to escalate.(39:41) Copper tripeptide, zinc thymulin, and the peptides with real hair growth data.(42:18) The hair loss side effect of TRT and hormone optimization nobody warns you about.(48:09) Red light therapy for hair: the science, the studies, and what actually works.(52:00) Wavelength precision, power density, and why most devices will not move a follicle.(59:06) Why movement destroys the premise of photobiomodulation.(1:04:36) PRP and modern dual spin protocols for hair regeneration.(1:08:28) Autologous hair follicle stem cell banking and the future of restoration.Find more from Young Goose:
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincareVampire Exosomes: Professional Exosome Serum for Regeneration and Post-Treatment Recovery https://younggoose.com/products/vampire-exosomesFind more from Dr. Alan Bauman:
Instagram: @dralanbauman
Youtube: @AlanBaumanMD
X: @DrAlanBauman
Facebook: Bauman Medical Group
Shop: https://dralanbauman.com/
Website: https://www.baumanmedical.com/
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Most people know NAD+ as a supplement trend. But very few understand what's actually happening inside their skin cells when it runs out or what's stealing it in the first place.
By the time you're 45, you've lost half of the molecule that powers virtually every function keeping your skin young. Sadly, it only gets worse from there.
The enzyme your skin uses for DNA repair can wipe out up to 90% of what's left after a single afternoon in the sun. This isn't a slow, graceful decline. It's a collapse happening beneath the surface long before the wrinkles appear.
In this episode, we will nerd out and break down exactly why NAD+ disappears, who the thieves are, and what the science actually says about getting it back. From the sirtuin-PARP-CD38 trifecta to the zombie cell feedback loop that accelerates the drain with age, this is the most complete picture of NAD+ and skin aging we've put together to date.
We also cover the real differences between NMN, NR, and niacin, why the precursor you choose actually matters, and what to stack with it to protect your methylation pathways.
Ready to nerd out in this with us?
Let's dive in!
What's Discussed:
(4:00) The number that changes how you think about skin aging.(6:03) What NAD+ actually does and why "rechargeable battery" undersells it.(8:18) The three enzyme families consuming your NAD+ as a substrate.(8:23) Sirtuins: the police of your cells and what they cost you.(9:42) PARPs: the fire brigade and why one sunburn nearly wipes you out.(11:16) CD38: the NAD+ Pac-Man that gets worse with age.(15:10) The five-fold decline: what the 2012 tissue study actually found.(16:15) CD38 and the zombie cell feedback loop driving the decline.(19:39) What the depletion actually looks like in the mirror.(28:04) Why NAD+ decline is reversible & supplementation deep dive.(28:41) NMN: how it works and what the studies actually show.(31:50) NR: the most clinically studied precursor and who it's best for.(33:27) Niacin: the $5 option and why most people can't tolerate it.(38:14) Why timing your NAD+ to your circadian rhythm matters.(38:35) TMG and methylation: what to stack and the two-to-one ratio.Learn more about NAD from our previous podcasts and videos:
Previous NAD YouTube Videos:
NAD+, Skincare Science + The Future of Skincare: https://www.youtube.com/watch?v=ZmwYLywwcsA Biohack Your Way to Better Skin - Benefits of NAD Boosting Supplementation for Skincare & Anti-Aging: https://www.youtube.com/watch?v=KIz5MvW7X1M Why Your NAD+ Supplement Isn't Helping Your Skin | The Truth: https://www.youtube.com/watch?v=euIj0eLt4Aw The Science Behind NAD+, Link Between NAD+ Skin Aging, Importance of Precursors: https://www.youtube.com/watch?v=wmsUeQklYY0 The NAD+ Protocol That Could Reverse Skin Aging (Doctors Won't Tell You) | Dr. Scott Sherr: https://www.youtube.com/watch?v=iYJgVSoj_XMPrevious NAD Podcasts:
NAD 101: Unlocking The Secrets To Youthful Skin: https://podcasts.apple.com/us/podcast/nad-101-unlocking-the-secrets-to-youthful-skin/id1552026927?i=1000652231123 The Relationship Between NAD+ and Your Skin, NAD+ Depletion, Bioavailability, Precursors, Sirtuins, and More: https://podcasts.apple.com/us/podcast/22-the-relationship-between-nad-and-your-skin/id1552026927?i=1000568088462 The Science Behind NAD+, the Link Between NAD+ and Skin Aging, and the Importance of Precursors: https://podcasts.apple.com/us/podcast/the-science-behind-nad-the-link-between-nad-and/id1552026927?i=1000615122098 Ben Azadi: How NAD+ Helps Reverse Aging + Skin Problems Connected to Deeper Health Issues: https://podcasts.apple.com/us/podcast/ben-azadi-how-nad-helps-reverse-aging-skin-problems/id1552026927?i=1000662495945 Turn Back the Clock: NAD and Skin Biohacking: https://podcasts.apple.com/us/podcast/turn-back-the-clock-nad-and-skin-biohacking/id1552026927?i=1000681105344Research Studies Mentioned:
Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042357 CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30225-7 Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages: https://www.nature.com/articles/s42255-020-00305-3 Enhanced SIRT1 Activity Mitigates UVB-Induced Senescence in Dermal Fibroblasts: https://pubmed.ncbi.nlm.nih.gov/39401943/ Slc12a8 is a nicotinamide mononucleotide transporter: https://www.nature.com/articles/s42255-018-0009-4 The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: https://link.springer.com/article/10.1007/s11357-022-00705-1 Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD+ synthesis via enterohepatic circulation: https://www.science.org/doi/10.1126/sciadv.adl5154 Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults: https://www.nature.com/articles/s41467-018-03421-7Find more from Young Goose:
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincareHead to younggoose.com/products/youth-body-cream for 20% offBody Cream: Head to younggoose.com/products/youth-body-cream for 20% off
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Most people treat their skin like a surface problem. But almost every persistent skin issue, from rosacea to eczema to accelerated aging, has something deeper driving it.
That deeper driver is almost always the gut, the liver, or a backed-up detox pathway. We at Young Goose, always believe that skincare is whole body care and we want our community to identify the deeper causes of skin issues that products alone can’t fix.
In this episode, functional nutrition practitioner Dani Conway joins us to break down why the skin is not the origin of the problem but the exit sign. When the body cannot eliminate toxins efficiently, they take the path of least resistance. For a lot of women, that path is the skin on their faces.
Dani brings nearly 20 years of clinical practice to this conversation, along with a sharp, evidence-grounded perspective on why fixing hormones first is often the wrong starting point and what to address instead.
We go deeper into this in the latest episode of Biohacking Beauty: The Anti-Aging Skincare Podcast. We also cover how to deal with food sensitivities, common misconceptions around hormones and blood sugar testing, and the use of GLP-1 and peptide use.
Let’s dive in!
What's Discussed:
(0:57) How poor detoxification shows up on the skin.
(2:09) The foundational actions to support detox.
(5:44) The lymphatic system explained.
(6:33) Why Dani stopped addressing hormones first.
(8:01) Microplastics, endocrine disruptors, and chemicals women apply to their skin.
(11:40) The gut-skin axis: How gut symptoms always end up on your face.
(13:55) NAD, CD38, and why a bacterial infection in your gut affects cell energy.
(16:59) Why peptides and NAD supplements don't work if the foundation isn't dialed in first.
(21:26) Can you actually fix hormones or just manage them?
(25:12) Real-world food sensitivity examples and how to figure out your personal triggers. (29:41) How to run an elimination diet correctly.
(34:39) The big picture nobody talks about: it's not the food, it's the immune system.
(36:06) The new science on acne: The bacteria and immune system response.
(38:06) Hot take: Why immune optimization is the next mitochondria.
(39:49) CGMs and skin aging: Why Dani actually pulls clients back from data obsession.
(42:09) Fasting insulin ranges: Why the lab's "normal" range is dangerously wide.
(43:35) The role of GLP-1s and how to use them as a therapy instead of a crutch.
(45:12) Dani's hot take on berberine and leptin resistance.
Find more from Young Goose:
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincareFind more from Dani Conway:
Instagram: @DaniConwayOfficialWebsite: https://nutritionthenaturalway.com/The Wellness Collective: https://nutritionthenaturalway.com/drop-the-weight-shred-the-fat/Weight Loss Accelerator Program: https://go.nutritionthenaturalway.com/wlaFree Complimentary Guide: https://go.nutritionthenaturalway.com/hhh
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Most people think that the stinging feeling, redness or tightness are always good signs of skin detoxification. Tricky enough, it can look like ‘glass skin’ or skin renewal. However, almost always the temporary tight and bright skin is a skin barrier issue in disguise.
Skin barrier damage is one of the most misread signals in skincare. It looks like purging but it is actually your skin telling you it has been pushed past its limit.
It’s easy to think there’s no damage at all because overexfoliation can temporarily give a satisfying baby skin at the cost of long-term skin wellness.
One of the best ways to distinguish normal skin stimulation versus barrier damage is to understand your skin biology. As Anastasia always says, "We're not chasing a 10-day glow. We're chasing a 10-year outcome."
We go deeper into this in the latest episode of Biohacking Beauty: The Anti-Aging Skincare Podcast. We also cover what real skin barrier repair should feel like, the pillars of skin wellness, and how to listen better to your skin to train it to become more resilient.
Resources mentioned:
Barrier Protocol: https://www.younggoose.com/pages/barrier-protocol
What's Discussed:
(04:20-05:11) Why a weak skin barrier makes every other skincare step stop working
(05:11-06:16) The four signs of barrier damage that looks like progress
(06:16-08:29) What is a skin barrier and what happens when the lipid ratio breaks down
(08:29-10:10) How barrier disruption can disguise as purging
(10:10-13:00) A case study of laser-induced barrier damage and the cycle of over-treatment
(13:00-15:11) The three pillars of skin wellness: performance, resilience, and longevity
(15:11-16:52) What your skin should be able to do before you add any heavy stimulation
(16:52-18:30) The three-step barrier reset protocol
(18:30-20:30) Morning versus nighttime barrier: defense vs. repair
(20:30-25:09) The truth about exfoliation culture and the glass skin trend
(25:09-27:00) How to build an exfoliation schedule that works for your skin type
Find more from Young Goose:
VAMPIRE EXOSOMES → Professional Exosome Serum for Regeneration and Post-Treatment RecoveryUse code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincare
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Did you know that the most powerful anti-aging protocol isn't about how long you sleep? It's about when. Getting eight hours of sleep for skincare feels like a tough feat to achieve especially when life gets in the way.
By understanding how your skin begins its optimal repair time, it’s still possible to achieve the best skin results without the guilt of not sleeping enough.
In our quest in finding the best skincare ingredient for our products, we discovered that hours of sleep do matter, but best skin results happen by following the skin’s optimal program sequences for deep repair.
We go deeper into this in the latest episode of Biohacking Beauty: The Anti-Aging Skincare Podcast. We also cover how melatonin onset, circadian rhythm, growth hormones, and inflammation play a huge role in giving your skin the environment it needs to do its best work.
What's Discussed:
(1:54-5:09) Why sleep timing matters more than sleep hours for skin repair(07:01-15:19) The three repair windows your skin depends on every night: melatonin onset, growth hormone pulse, and barrier recovery(05:09-5:55) Why dull skin, slow healing, and crepey eyes are often a timing problem — not a product problem(13:28-17:10) How to build a recovery-first nighttime routine before adding any stimulation(37:47-40:47) The silk vs. cotton pillowcase: Which fabric choice is part of your skincare(43:29-47:36) Supplements that support skin repair at night(17:17-17:30) Red light therapy as the only exception to the no-stacking ruleResources mentioned:
Sleep protocol: https://www.younggoose.com/pages/sleep-protocol
Episode with Anastasia (BeautyFascia): https://podcasts.apple.com/us/podcast/anastasia-beauty-fascia-facial-fascia-and-massage
Episode on Face Taping with Olga from Natural Face Bible: https://podcasts.apple.com/us/podcast/real-japanese-face-taping-explained-with-olga
Find more from Young Goose:
The Elastin Action Protocol → Engineered for Skin Navigating Elasticity ChangeThe Winter Skin Protocol → Build for How Skin Actually Behaves in WinterVAMPIRE EXOSOMES → Professional Exosome Serum for Regeneration and Post-Treatment RecoveryUse code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincare
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Molecular hydrogen is often described as a selective antioxidant, but that framing is incomplete. In this episode, we explore hydrogen as a mitochondrial hormetic signal that can influence redox balance, inflammatory regulation, and adaptive stress pathways. The key distinction is that delivery route changes mechanism. Oral, inhaled, and topical hydrogen act differently in the body, with different kinetics, tissue distribution, and biological implications.
We dive deeper into this in the Biohacking Beauty Podcast with Alex Tarnava. We discuss why topical hydrogen is gaining attention for skin outcomes, how gut-mediated signaling may drive systemic effects, and why interpreting evidence requires understanding study design, delivery method, and real-world product variability.
WHAT’S DISCUSSED:
(04:52) Why hydrogen is not a traditional antioxidant and what that actually means biologically
(06:17) How different delivery routes change tissue targeting and systemic signaling
(10:09) Why skin aging and inflammatory conditions behave more like a systems problem than a single pathway
(15:10) How mild oxidative stress can activate endogenous antioxidant production
(16:05) The hidden risk of reductive stress from excessive antioxidant use
(17:59) Why inflammation must be regulated rather than suppressed for long-term tissue repair
(28:52) The gut-driven mechanisms that may influence visible skin outcomes
(29:42) How corporate-owned research and investigator-led studies shape the hydrogen evidence landscape
(37:25) Why exaggerated longevity claims distort innovation and erode trust
(50:49) The growing issue of counterfeit hydrogen products and what it signals about market maturity
Find more from Young Goose:
The Elastin Action Protocol → Engineered for Skin Navigating Elasticity Change Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincareFind more from Alex Tarnava:
Website: https://hydrogenwatertablets.com
https://alextarnava.com
Instagram: https://www.instagram.com/alextarnava
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Chronic stress isn’t just a mental or emotional burden. It creates a biological cascade that disrupts mitochondrial function, accelerates inflammation, and shows up visibly in the skin long before deeper symptoms appear.
We dive deeper into this in the Biohacking Beauty Podcast with Dr. Scott Sherr. We also talk about the sympathetic spiral of doom, why skin reflects mitochondrial decline before other symptoms appear, and why sequencing interventions matter more than intensity.
Dr. Scott Sherr is a board-certified internal medicine physician certified in Health Optimization Medicine (HOMe) and a specialist in Hyperbaric Oxygen Therapy. He is the COO of Troscriptions and focuses clinically on mitochondrial health, stress physiology, and advanced recovery protocols.
What's Discussed:
(01:52) Why chronic stress is not just mental and directly impacts cellular energy(05:17) How modern life keeps the nervous system stuck in chronic fight or flight(07:25) Cortisol and stress hormones disrupting mitochondria and accelerating skin aging(11:16) Why skin aging is often the first visible sign of mitochondrial decline(24:16) The sympathetic spiral of doom explained through energy loss and stress signaling(27:14) Why stress reduction and mitochondrial support must happen at the same time(46:22) Why aggressive skincare and biohacking fail without mitochondrial resilience(50:35) Hyperbaric oxygen therapy, sequencing, and why timing matters more than intensityFind more from Young Goose:
The Elastin Action Protocol → Engineered for Skin Navigating Elasticity Change The Winter Skin Protocol → Build for How Skin Actually Behaves in Winter VAMPIRE EXOSOMES → Professional Exosome Serum for Regeneration and Post-Treatment RecoveryUse code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at https://younggoose.comInstagram: @young_goose_skincareFind more from Dr. Scott Sherr:
Website: https://troscriptions.com
LinkedIn: @troscriptions
Instagram: @drscottsherr @troscriptions
Facebook: @Troscriptions
Youtube: @troscriptions
Tiktok: @troscriptions
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