Episodes
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Managing hypoglycemia remains a persistent, high-stakes challenge for both clinicians and the patients they support. What are the updates to the Diabetes Canada Clinical Practice Guidelines for Hypoglycemia and how can these be integrated into daily practice immediately?
Our host, Dr. Jeremy Gilbert, an Endocrinologist at Sunnybrook Health Sciences Centre and Associate Professor at the University of Toronto, discusses standardizing hypoglycemia safety with Dr. Akshay Jain, a Clinical Endocrinologist and Medical Director for Research at Unity Healthcare based in Surrey, British Columbia.
Together, our experts explore the complex clinical realities and systemic gaps surrounding hypoglycemia management. They discuss the practical implications of the updated Diabetes Canada guidelines, detailing the new three-level classification of hypoglycemia, and the symptoms associated with each level. They highlight the importance of prevention, strategies for monitoring, and important conversations to have with patients about hypoglycemia. Tune in to hear practical, actionable tips for managing hypoglycemia to better support individuals living with diabetes.
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The views and opinions expressed in this episode are those of the speakers, and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Jeremy Gilbert:
Direct financial relationship, including receipt of honoraria: CPD Network, LMC Canada Inc., CSEM, S+L Solutions, Liv Agency, Unik Agency, STA. Membership on advisory boards or speaker’s bureaus: Abbott, Amgen, Bayer, Insulet, Tandem, Boehringer Ingelheim, Eli Lilly, GSK, HLS Therapeutics, Novartis, Novo Nordisk.Dr. Akshay Jain:
Direct financial relationship, including receipt of honoraria: Abbott, Abbvie, AstraZeneca, Amgen, Antibody, Bausch Healthcare, Bayer, Boehringer Ingelheim, Care to Know, CCRN, Connected in Motion, CPD Network, Dexcom, Diabetes Canada, Eli Lilly, Embecta, EOCI, GSK, HLS Therapeutics, Janssen, Liv, Master Clinician Alliance, MDBriefcase, Merck, Medtronic, Moderna, NP Circle, Novartis, Novo Nordisk, Partners in Progressive Medical Education, Pfizer, Roche, Six Degrees, Timed Right, Unik, WebMD. Membership on advisory boards or speaker’s bureaus: Abbott, AstraZeneca, Amgen, Bausch Healthcare, Bayer, Boehringer Ingelheim, Dexcom, Eli Lilly, Embecta, Gilead Sciences, GSK, HLS Therapeutics, Industrii, Insulet, Janssen, Medtronic, NP Circle, Novartis, Novo Nordisk, Partners in Progressive Medical Education, Pendopharm, PocketPills, Roche, Sandoz, Takeda, Ypsomed. Funded grants, research, or clinical trials: Abbott, Amgen, Argenx, Astra Zeneca, Novo Nordisk, Roche, Sanofi.MAT-CA-2600837
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What is the role of early detection of type 1 diabetes and how can it be integrated into clinical practice?
In this episode, our host, Dr. Maha Lebbar, discusses the practical aspects of screening for type 1 diabetes (T1D) with Dr. Rémi Rabasa-Lhoret, endocrinologist at Centre Hospitalier de L’Université de Montréal (CHUM), professor and researcher at the Montréal Clinical Research Institute (IRCM).
Join our experts as they discuss the clinical benefits of early T1D identification and the transformative potential of early interventions in improving long-term health outcomes and preventing severe complications. Learn about the practical steps and options for T1D screening, gaining in-depth insights into various screening pathways, existing programs, and promising research initiatives driving innovation in this field. Tune in as we explore how studies such as FEDERATE Can are actively bridging the critical gap between research and its practical application in clinical settings.
Discover concrete recommendations for healthcare providers to integrate early detection of T1D into their everyday practice, including workflow considerations for screening, monitoring, and follow-up.
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The opinions and views expressed in this episode are those of the speakers and do not necessarily reflect the position of the entities they represent.
Declaration of conflict of interest:
Dr Maha Lebbar:
Direct financial links, including receipt of fees: Sanofi. Receipt of grants or funding for research projects or clinical trials: Sanofi.Dr Rémi Rabasa-Lhoret:
Direct financial links, including receipt of fees: Abbott, CPD Network, Dexcom, Eli Lilly, Janssen, Medtronic, Merck, Novo Nordisk, Sanofi, Tandem Diabetes Care, Vertex Pharmaceuticals. Advisory Committee or Speaker Bureau Members: 35Pharma Inc., Abbott, Bayer, Boehringer Ingelheim, Dexcom, Eli Lilly, GlaxoSmithKline Inc., HLS Therapeutics, INESSS, Insulet, Medtronic, Merck, Novo Nordisk, Sanofi, Ypsomed. Receipt of grants or funding for research projects or clinical trials: Diabetes Canada, Cystic Fibrosis Canada, Canadian Institutes of Health Research (CIHR), Diabetes Research Foundation (JDRF), Novo Nordisk, Société francophone du diabetes, Medtronic, Merck, Sanofi. Patents relating to a medicine, product or medical device: Eli Lilly.MAT-CA-2200968
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How can T1D screening programs be effectively established in the clinic, and what are the considerations to get started?
Our host, Dr. Alice Cheng, explores this topic with James Stainer, a Registered Nurse and Certified Diabetes Educator at Windsor-Essex Community Health Centre.
Join our experts for a foundational discussion detailing the initiation of the first community-based T1D screening program in Canada at Windsor-Essex Community Health Care Centre. Learn about important considerations throughout the planning and screening process including strategies to garner awareness, share results, and facilitate continued monitoring. Hear about how the multidisciplinary screening team collaborates and is setting the stage for additional programs towards the proactive detection of T1D.
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The views and opinions expressed in this episode are those of the speakers, and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Alice Cheng:
· Direct financial relationship, including receipt of honoraria: Abbott, Amgen, Astellas, AstraZeneca, Bayer, Biomea Fusion, Boehringer Ingelheim, Dexcom, Eli Lilly, GSK, Insulet, HLS Therapeutics, Medtronic, MSD, Novo Nordisk, Pfizer, Sandoz, Sanofi, Vertex, CPD Network, Canadian Collaborative Research Network, Master Clinical Alliance, Canadian Medical & Surgical Knowledge Translation Research Group, Sea Courses, Alliance of Best Practices in Health Education, Partners in Progressive Medical Education, MD Briefcase, LMC Physician Inc., Medscape, Humber River Health, Timed Right, The ACADEMY, International Atherosclerosis Society, Canadian Cardiovascular Society, Diabetes Canada, ADA. Membership on advisory boards or speaker’s bureaus: Abbott, Amgen, Astellas, AstraZeneca, Bayer, Biomea Fusion, Boehringer Ingelheim, Dexcom, Eli Lilly, GSK, Insulet, HLS Therapeutics, Medtronic, MSD, Novo Nordisk, Pfizer, Sandoz, Sanofi, Vertex. Funded grants, research, or clinical trials: Applied Therapeutics, Novo Nordisk, Sanofi.
James Stainer:
· Direct financial relationship, including receipt of honoraria: Sanofi, Dexcom, Abbott, Eli Lilly, Novo Nordisk, Janssen. Membership on advisory boards or speaker’s bureaus: Sanofi, Abbott, Eli Lilly. Funded grants, research, or clinical trials: AstraZeneca.
MAT-CA-2600205
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How can healthcare providers best navigate the unique complexities of diabetes in an aging population?
Our host, Dr. Jeremy Gilbert, explores the multifaceted nature of type 2 diabetes management in the elderly with Dr. Peter Lin, Director of Primary Care Initiatives at the Canadian Heart Research Centre and contributing author to the Diabetes Canada Clinical Practice Guidelines.
In this episode, our experts delve into crucial considerations for managing diabetes in older people, including comorbidities, cognition, frailty, hypoglycemia risk, and the use of basal insulins. Hear our experts share their practical strategies for prioritizing care goals, personalizing treatment approaches, fostering multidisciplinary teamwork, and ensuring patient safety and well-being in this vulnerable population.
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The views and opinions expressed in this episode are those of the speakers, and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Jeremy Gilbert:
Direct financial relationship, including receipt of honoraria: CPD Network, LMC Canada Inc., CSEM, S&L Solutions, liV Agency, Unik Agency, STA. Membership on advisory boards or speakers’ bureaus: AstraZeneca, Abbott, Amgen, Bayer, Insulet, Tandem, Boehringer Ingelheim, Eli Lilly, GSK, HLS Therapeutics, Novartis, Novo Nordisk, Sanofi.Dr. Peter Lin:
Direct financial relationship, including receipt of honoraria: AstraZeneca, Boehringer Ingelheim, Bayer, Eli Lilly, Merck, Sanofi, Amgen, MDBriefCase, Canadian Heart Research Centre, CCRN, CHIEF, LMC Diabetes & Endocrinology Group, Diabetes Canada, Novo Nordisk, HLS Therapeutics, Medexus Pharmaceuticals, Pri-Med Canada, liV Agency, MEDUCOM Health, The Rounds, Medscape. Membership on advisory boards or speakers’ bureaus: AstraZeneca, Boehringer Ingelheim, Bayer, Eli Lilly, Merck, Sanofi, Amgen, MDBriefCase, Canadian Heart Research Centre, CCRN, CHIEF, LMC Diabetes & Endocrinology Group, Diabetes Canada, Novo Nordisk, HLS Therapeutics, Medexus Pharmaceuticals, Pri-Med Canada, liV Agency, MEDUCOM Health, The Rounds, Medscape.MAT-CA-2500991
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How can early identification transform type 1 diabetes (T1D) care and what groundbreaking advances are on the horizon?
Our host, Dr. Alice Cheng, explores this topic with Dr. Karen McAssey, a pediatric endocrinologist, researcher, educator, and advocate for people living with T1D at McMaster Children's Hospital in Hamilton, Ontario.
Join our experts for a compelling conversation that delves into the profound impact of diabetic ketoacidosis (DKA) and unveils how early intervention can change the course of T1D. Discover why preventing DKA at diagnosis is paramount, learn about the latest consensus guidance for monitoring early-stage T1D, and hear about exciting Canadian research developments shaping the future of T1D screening, monitoring, and prevention.
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The views and opinions expressed in this episode are those of the speakers, and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Alice Cheng:
· Direct financial relationship, including receipt of honoraria: Abbott, Amgen, Astellas, AstraZeneca, Bayer, Biomea Fusion, Boehringer Ingelheim, Dexcom, Eli Lilly, GSK, Insulet, HLS Therapeutics, Medtronic, MSD, Novo Nordisk, Pfizer, Sandoz, Sanofi, Vertex, CPD Network, Canadian Collaborative Research Network, Master Clinical Alliance, Canadian Medical & Surgical Knowledge Translation Research Group, Sea Courses, Alliance of Best Practices in Health Education, Partners in Progressive Medical Education, MD Briefcase, LMC Physician Inc., Medscape, Humber River Health, Timed Right, The ACADEMY, International Atherosclerosis Society, Canadian Cardiovascular Society, Diabetes Canada, ADA. Membership on advisory boards or speaker’s bureaus: Abbott, Amgen, Astellas, AstraZeneca, Bayer, Biomea Fusion, Boehringer Ingelheim, Dexcom, Eli Lilly, GSK, Insulet, HLS Therapeutics, Medtronic, MSD, Novo Nordisk, Pfizer, Sandoz, Sanofi, Vertex. Funded grants, research, or clinical trials: Applied Therapeutics, Novo Nordisk, Sanofi.
Dr. Karen McAssey:
· Direct financial relationship, including receipt of honoraria: Dexcom, Medtronic, Tandem. Membership on advisory boards or speaker’s bureaus: Abbott, Dexcom, Insulet, Eli Lilly, Medtronic, Sanofi. Funded grants, research, or clinical trials: DRF, NIH-NIDDK, Medtronic.
MAT-CA-2500921
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What are the most effective ways for a diabetes care team to tackle the complexities and challenges of insulin management for patients?
Our host, Dr. Alice Cheng, discusses practical approaches in coordinating multidisciplinary diabetes care with Dr. Michelle Long, a Primary Care Physician based in Port Hope, Ontario, with more than 30 years in clinical practice, and Ms. Susie Jin, a Pharmacist and Certified Diabetes Educator based in Cobourg, Ontario, recognized for her national leadership in diabetes.
Together, our experts explore the importance of a connected care team—including endocrinologists, general practitioners, pharmacists, and diabetes educators—in optimizing insulin use for patients with diabetes. They discuss strategies for initiating insulin conversations, dispelling misconceptions, and leveraging the expertise of the entire care team. Tune in to hear practical tips for improving communication and collaboration among healthcare providers to better support individuals living with diabetes, especially in resource-limited settings.
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The views and opinions expressed in this episode are those of the speakers, and do not necessarily reflect the views or positions of any entities they represent.
Additional resource for healthcare providers:
‘Insulin Pen Start Checklist’
Available at: https://guidelines.diabetes.ca/reduce-complications/insulin-checklist
Declaration of conflict of interest:
Dr. Alice Cheng:
Direct financial relationship, including receipt of honoraria: Abbott, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Dexcom, Eli Lilly, GSK, Insulet, HLS Therapeutics, Medtronic, Novo Nordisk, Pfizer, Sanofi, CPD Network, Canadian Collaborative Research Network, Master Clinical Alliance, Canadian Medical & Surgical Knowledge Translation Research Group, Sea Courses, Alliance of Best Practices in Health Education, Partners in Progressive Medical Education, MD Briefcase, LMC Physician Inc., Medscape, Humber River Health, Timed Right, The ACADEMY, International Atherosclerosis Society, Canadian Cardiovascular Society, Diabetes Canada, ADA. Membership on advisory boards or speaker’s bureaus: Abbott, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Dexcom, Eli Lilly, GSK, Insulet, HLS Therapeutics, Medtronic, Novo Nordisk, Pfizer, Sanofi. Funded grants, research, or clinical trials: Applied Therapeutics, Novo Nordisk, Sanofi.Dr. Michelle Long:
None.Ms. Susie Jin:
Direct financial relationship, including receipt of honoraria: Abbott, AbbVie, Boehringer Ingelheim, Dexcom, Sol-M, Canadian Association of Pharmacy Technicians, Canadian Pharmacists Association, Diabetes Canada, Manitoba Pharmacists Association, Ontario Pharmacists Association, Sun Life, Wounds Canada. Membership on advisory boards or speaker’s bureaus: AbbVie, Dexcom, Kenvue, Eli Lilly. Funded grants, research, or clinical trials: Boehringer Ingelheim.MAT-CA-2500670
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Curious about how primary care practitioners are managing the complexities of type 2 diabetes (T2D) in their practice?
Join our host Dr. Alice Cheng as she delves into this topic with Dr. James Kim, Clinical Assistant Professor in the Department of Family Medicine at the University of Calgary, lead editor for the Primary Care section of the Canadian Journal of Diabetes, and a key contributor within Diabetes Canada.
Our experts examine the critical role that primary care plays in the early diagnosis of T2D, personalizing and implementing treatment plans, and facilitating regular screening for potential complications. They stress the importance of managing both the physical and mental health of people living with diabetes, and provide practical strategies for organizing care and for maximizing the use of community resources.
Don’t miss the conversation!
The views and opinions expressed in this episode are those of the speakers, and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Alice Cheng:
Direct financial relationships, including receipt of honoraria: Abbott, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Dexcom, Eli Lilly, GSK, Insulet, HLS Therapeutics, Medtronic, Novo Nordisk, Pfizer, Sanofi, CPD Network, Canadian Collaborative Research Network, Master Clinical Alliance, Canadian Medical & Surgical Knowledge Translation Research Group, Sea Courses, Alliance of Best Practices in Health Education, Partners in Progressive Medical Education, MDBriefCase, LMC Physician Inc., Medscape, Humber River Health, Timed Right, The ACADEMY, International Atherosclerosis Society, Canadian Cardiovascular Society, Diabetes Canada, American Diabetes Association. Membership on advisory boards or speakers’ bureaus: Abbott, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Dexcom, Eli Lilly, GSK, Insulet, HLS Therapeutics, Medtronic, Novo Nordisk, Pfizer, Sanofi. Funded grants, research, or clinical trials: Applied Therapeutics, Novo Nordisk, Sanofi.Dr. James Kim:
Direct financial relationships, including receipt of honoraria: Abbott, AbbVie, AstraZeneca, Boehringer Ingelheim, Eisai, embecta, Eli Lilly, GSK, Janssen, Novo Nordisk, Pfizer, Sanofi, Takeda, Searchlight, Otsuka, Teva. Membership of advisory board or speakers’ bureaus: Abbott, AbbVie, ALK, AstraZeneca, Bayer, Boehringer Ingelheim, Eisai, embecta, Eli Lilly, GSK, Novo Nordisk, Sanofi, Teva, Takeda, Searchlight, Valeo. Funded grants, research, or clinical trials: Novo Nordisk. All other investments or relationships: MDBriefCase, CPD Network, Academy for Continued Advancement in Healthcare Education, EOCI, Family Physician Airway Group of Canada, Liv Agency, PPME, CCRN.MAT-CA-2401556
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How is our understanding of autoimmunity in type 1 diabetes (T1D) shifting the way it’s detected and treated?
Our host, Dr. Alice Cheng, discusses this topic and more with Dr. Bruce Perkins, Professor, Endocrinologist, Epidemiologist, and Clinician-Scientist in the Faculty of Medicine and the Institute for Health Policy Management and Evaluation at the University of Toronto.
In this episode, the stages of T1D development and the role of autoimmunity are summarized, before examining the clinical benefits and challenges of autoantibody testing for the early detection of T1D. Current practices are discussed, as well as who should be prioritized for screening. Finally, our experts explore future directions of population-wide screening initiatives with the hopes of delaying or preventing clinical onset in those at high risk of developing T1D.
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The views and opinions expressed in this episode are those of the speakers, and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Alice Cheng:
Direct financial relationship, including receipt of honoraria: Abbott, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Dexcom, Eli Lilly, GSK, Insulet, HLS Therapeutics, Medtronic, Novo Nordisk, Pfizer, Sanofi, CPD Network, Canadian Collaborative Research Network, Master Clinical Alliance, Canadian Medical & Surgical Knowledge Translation Research Group, Sea Courses, Alliance of Best Practices in Health Education, Partners in Progressive Medical Education, MD Briefcase, LMC Physician Inc., Medscape, Humber River Health, Timed Right, The ACADEMY, International Atherosclerosis Society, Canadian Cardiovascular Society, Diabetes Canada, ADA. Membership on advisory boards or speakers’ bureaus: Abbott, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Dexcom, Eli Lilly, GSK, Insulet, HLS Therapeutics, Medtronic, Novo Nordisk, Pfizer, Sanofi. Funded grants, research, or clinical trials: Applied Therapeutics, Novo Nordisk, Sanofi.Dr. Bruce Perkins:
Direct financial relationship, including receipt of honoraria or in-kind compensation: Abbott, Sanofi, Insulet, Medtronic, Novo Nordisk. Membership on advisory boards or speakers’ bureaus: Abbott, Insulet, Sanofi, Novo Nordisk, Vertex. Funded grants, research, or clinical trials: Novo Nordisk, Bank of Montreal. Patents on a drug, product, or device: Boehringer Ingelheim.MAT-CA-2401456 Nov 2024
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What do we know about the developmental stages of type 1 diabetes (T1D), and how can this understanding ultimately lead to improved patient outcomes?
Our host, Dr. Alice Cheng, explores these questions with Dr. Bruce Perkins, Professor, Endocrinologist, Epidemiologist, and Clinician-Scientist in the Faculty of Medicine and the Institute for Health Policy Management and Evaluation at the University of Toronto.
Our experts kick off the discussion by identifying the key differentiators between type 1 and type 2 diabetes, before diving into the presence and involvement of autoantibodies in the development of T1D. Dr. Perkins details the stages of T1D, and explains how identification of early stages has the potential to improve patient outcomes and prevent serious illness.
Don’t miss the conversation!
The views and opinions expressed in this episode are those of the speakers, and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Alice Cheng:
Direct financial relationship, including receipt of honoraria: Abbott, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Dexcom, Eli Lilly, GSK, Insulet, HLS Therapeutics, Medtronic, Novo Nordisk, Pfizer, Sanofi, CPD Network, Canadian Collaborative Research Network, Master Clinical Alliance, Canadian Medical & Surgical Knowledge Translation Research Group, Sea Courses, Alliance of Best Practices in Health Education, Partners in Progressive Medical Education, MD Briefcase, LMC Physician Inc., Medscape, Humber River Health, Timed Right, The ACADEMY, International Atherosclerosis Society, Canadian Cardiovascular Society, Diabetes Canada, ADA. Membership on advisory boards or speakers’ bureaus: Abbott, Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Dexcom, Eli Lilly, GSK, Insulet, HLS Therapeutics, Medtronic, Novo Nordisk, Pfizer, Sanofi. Funded grants, research, or clinical trials: Applied Therapeutics, Novo Nordisk, Sanofi.Dr. Bruce Perkins:
Direct financial relationship, including receipt of honoraria or in-kind compensation: Abbott, Sanofi, Insulet, Medtronic, Novo Nordisk. Membership on advisory boards or speaker’s bureaus: Abbott, Insulet, Sanofi, Novo Nordisk, Vertex. Funded grants, research, or clinical trials: Novo Nordisk, Bank of Montreal. Patents on a drug, product, or device: Boehringer Ingelheim.MAT-CA-2401455 Nov 2024
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As technology advances, what are the current and future digital innovations that can best serve patients with diabetes and improve diabetes management?
Our host, Dr. Ilana Halperin, discusses these innovations with Dr. Peter Lin, Director of Primary Care Initiatives at the Canadian Heart Research Centre, and a contributing author of the 2013 and 2018 Canadian Diabetes Guidelines.
Our experts delve into the evolving role of continued glucose monitoring and how its increased usage can lead to positive patient behaviour change. Advances in insulin delivery are also discussed, and how connected innovations can lead to decreasing the burden on patients and healthcare providers. Finally, our speakers touch on the potential role for AI in diabetes management.
Don’t miss the conversation!
The views and opinions expressed in this episode are those of the speakers, and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Ilana Halperin:
Direct financial relationship, including receipt of honoraria: Sanofi, Novo Nordisk, Dexcom, Abbott. Membership on advisory board: Sanofi, DexcomDr. Peter Lin:
Direct financial relationship, including receipt of honoraria: AstraZeneca, GlaxoSmithKline, Medexus, Moderna, Pfizer, Amgen, Novo Nordisk, Eli Lilly, Boehringer Ingelheim. Membership on advisory board or speaker’s bureaus: AstraZeneca, GlaxoSmithKline, Medexus, Moderna, Pfizer, Amgen, Novo Nordisk, Eli LillyMAT-CA-2400907
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Why does the timely addition of basal insulin remain an important issue in practice, despite the increasing use of glucagon-like peptide-1 receptor agonists (GLP1-RA) seen in recent years?
Our host, Dr. Ronald Goldenberg, takes a deeper look into this topic with Dr. Meera Luthra, an endocrinologist at St. Joseph’s Healthcare Hamilton and Clinician Educator at McMaster University.
The episode discusses clinical inertia and approaches you may use in practice for treatment intensification to improve glycemic control, particularly around initiating basal insulin, for patients with type 2 diabetes (T2D). The importance of real-world studies is discussed, namely, the RESTORE-G and DELIVER-G studies, in the context of the efficacy behind adding basal insulin to GLP1-RA therapy to optimize glycemic control.
The RESTORE-G study examined treatment intensification approaches to adding basal insulin for patients with T2D already on a GLP1-RA therapy. The DELIVER-G study looked at the impact of the addition of second-generation basal insulin, glargine U300 for patients with T2D on GLP1-RA therapy. Our experts also dive into the relevance and applicability of some practical approaches for treatment intensification to improve glycemic control in clinical practice.
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The views and opinions expressed in this episode are those of the speakers, and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Ronald Goldenberg:
Direct financial relationship, including receipt of honoraria: Abbott, Amgen, Bayer, Boehringer Ingelheim, CCRN, CMSKTRG, Eli Lilly, EOCI, Hamilton Academy of Medicine, HIT Global, HLS, Insulet, Janssen, LiV, LMC Physician Inc., MD Briefcase, Novartis, Novo Nordisk, Sanofi, SL Solutions, Unik, Virtual Hallway Consults Inc. Membership on advisory boards or speakers’ bureaus: Abbott, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, HLS, Janssen, Novo Nordisk, Sanofi. Funded grants, research, or clinical trials: Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, Novo Nordisk, Sanofi.Dr. Meera Luthra:
Direct financial relationship, including receipt of honoraria: Amgen, Bayer, Boehringer Ingelheim, Dexcom, Eisai, Pfizer, Eli Lilly, Novo Nordisk, Sanofi. Membership on advisory boards or speakers’ bureaus: Dexcom, HLS Therapeutics, Novo Nordisk, Sanofi. Funded grants, research, or clinical trials: NoneMAT-CA-2400799
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Hypoglycemia associated with commonly used diabetes medications can be distressing and potentially lethal. What are the latest recommendations on prevention and treatment of hypoglycemia from the Diabetes Canada Clinical Practice Guidelines (CPG)?
Our host, Dr. Alexandria Ratzki-LeeWing, takes a deeper look into this topic together with Dr. Stewart Harris, a family doctor and professor at Western University in London.
This episode discusses highlights from the 2023 CPG chapter updates on hypoglycemia in adults. Our speakers explore how guidance on hypoglycemia has evolved in these new recommendations, and its impact on diabetes care for both people living with diabetes and clinicians.
They also touch on practical strategies to reduce hypoglycemia risk, and offer their perspectives on topics that may be expanded on in future CPG iterations.
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The views and opinions expressed in this episode are those of the speakers and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Ratzki-LeeWing
Direct financial relationship including receipt of honoraria: Eli Lilly, Novo Nordisk, American Diabetes Association. Funded grants, research, or clinical trials: Sanofi Global.Dr. Harris:
Direct financial relationship including receipt of honoraria or in-kind compensation: Abbott, AstraZeneca, Bayer Inc., Dexcom, Eli Lilly, HLS Therapeutics, Janssen, Novo Nordisk, Sanofi Aventis. Membership on advisory boards: Abbott, AstraZeneca, Bayer Inc., Dexcom, Eli Lilly, HLS Therapeutics, Janssen, Novo Nordisk, Sanofi Aventis. Funded grants, research, or clinical trials: Abbott, Applied Therapeutics Inc., AstraZeneca, Boehringer Ingelheim, Eli Lilly, Novartis, Novo Nordisk, Sanofi Aventis.MAT-CA-2400059
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Diabetes remission is a concept that has been gaining attention as new treatments and interventions become available in the Diabetes Canada Clinical Practice Guidelines. How do we define diabetes remission, and what strategies can we employ to sustain it once it has been attained?
Our host, endocrinologist Dr. Hertzel Gerstein, professor of medicine at McMaster University and Hamilton Health Sciences, takes a deeper look into this topic with Dr. Kaberi Dasgupta, a physician scientist and professor of medicine at McGill University and the McGill University Health Centre.
This episode explores the latest updates from the Diabetes Canada Clinical Practice Guidelines on remission of type 2 diabetes (T2D) and other new approaches in development.
In their discussion, they detail the definition of remission in diabetes and what it means for the patient, before explaining the importance of early intervention in T2D. Together, they review two approaches included in the Canadian clinical practice guidelines to achieving remission: bariatric surgery and low-energy diets. They also discuss the importance of sustaining weight loss by continuing to adhere to the same healthy diet and lifestyle modifications that were implemented to attain remission.
Ongoing research efforts focused on prevention, treatment, and remission of diabetes continue to emerge, with more discoveries expected in the future.
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The views and opinions expressed in this episode are those of the speakers and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Gerstein
Membership on advisory board or speakers’ bureaus: Sanofi, Lilly, Merck, AstraZeneca, DKSH, Zuellig, Novo Nordisk, Abbott, Pfizer, Kowa, Hanmi, Carbon Brand, Jiangsu Hanson Pharma. Funded grants, research, or clinical trials: Eli Lilly, Merck, AstraZeneca, Novo NordiskDr. Dasgupta:
Funded grants, research, or clinical trials: CIHR, The Lawson Foundation, The JR McConnell Foundation.MAT-CA-2300840
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Numerous challenges afflict patients with type 1 diabetes (T1D) throughout their disease journey. How can newer, more innovative management approaches help patients overcome these challenges?
This episode discusses the challenges that regularly burden patients with T1D, and how recent technological breakthroughs, such as automated insulin pumps and continuous glucose monitoring (CGM), have been transformative in diabetes management.
Our host, Dr. Ronald Goldenberg, takes a deeper look into this topic with Dr. Bruce Perkins, Professor, Endocrinologist, Epidemiologist, and Clinician Scientist in the Faculty of Medicine and the Institute for Health Policy Management and Evaluation at the University of Toronto, and Director of Leadership at the Sinai Centre for Diabetes. Together, they provide practical advice for patients and their healthcare team in managing T1D and discuss emerging developments that have the potential to shift the treatment paradigm in diabetes care.
Don’t miss the conversation!
The views and opinions expressed in this episode are those of the speakers, and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Ronald Goldenberg:
Direct financial relationship including receipt of honoraria: Abbott, Agora, Amgen, Antibody, AstraZeneca, Bayer, Boehringer Ingelheim, CCRN, CMSKTRG, Eli Lilly, EOCI, HIT Global, HLS, Inceptus, Janssen, LiV, Master Clinician Alliance, MD Briefcase, Merck, Mylan, Novo Nordisk, Sanofi, Script Medical, Servier, STA, Takeda, Toronto Knowledge Translation Working Group, Unik, Valeant. Membership on advisory boards or speakers’ bureaus: Abbott, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, HLS, Janssen, Merck, Novo Nordisk, Sanofi. Funded grants, research or clinical trials: Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, Novo Nordisk, Sanofi.Dr. Bruce Perkins:
Direct financial relationship including receipt of honoraria: Novo Nordisk, Sanofi, Abbott, Insulet, Medtronic. Membership on advisory boards: Abbott, Insulet, Novo Nordisk, Sanofi, Vertex. Funded grants, research, or clinical trials: Bank of Montreal, Novo Nordisk. Patent on a drug, product, or device: Boehringer Ingelheim.MAT-CA-2300841
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With the abundance of various glucose monitoring technologies, how can healthcare providers guide patients with type 2 diabetes (T2D) toward the most appropriate choice?
Our host, Dr. Ronald Goldenberg, takes a deeper look into this topic with Dr. Ilana Halperin, Endocrinologist at Sunnybrook Health Sciences Centre and Assistant Professor at the University of Toronto.
This episode discusses the limitations of previous-generation glucose monitoring devices and highlights the advantages of continuous glucose monitoring (CGM) with an emphasis on the most important parameters, namely time-in-range (TIR), time-below-range (TBR), and coefficient of variation (CV). The importance of clinical trials is discussed, namely, the IMMEDIATE and two-part MOBILE studies in the context of CGM for T2D.
The IMMEDIATE study examined the efficacy of intermittently scanned CGM in patients with T2D using non-insulin therapies. The MOBILE Phase 1 study explored the impact of CGM discontinuation after 8 months of use in adults with T2D treated using basal insulin without bolus insulin. Similarly, the MOBILE Phase 2 study assessed the effectiveness of CGM in adults with T2D treated with both basal insulin and bolus insulin in primary care practices. Our experts also dive into the relevance and applicability of these recent study findings to clinical practice.
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The views and opinions expressed in this episode are those of the speakers and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Ronald Goldenberg:
Direct financial relationship including receipt of honoraria: Abbott, Agora, Amgen, Antibody, AstraZeneca, Bayer, Boehringer Ingelheim, CCRN, CMSKTRG, Eli Lilly, EOCI, HIT Global, HLS, Inceptus, Janssen, LiV, Master Clinician Alliance, MD Briefcase, Merck, Mylan, Novo Nordisk, Sanofi, Script Medical, Servier, STA, Takeda, Toronto Knowledge Translation Working Group, Unik, Valeant. Membership on advisory boards or speakers’ bureaus: Abbott, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, HLS, Janssen, Merck, Novo Nordisk, Sanofi. Funded grants, research or clinical trials: Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, Novo Nordisk, Sanofi.Dr. Ilana Halperin:
Direct financial relationship including receipt of honoraria or in-kind compensation: Abbott, Dexcom, Novo Nordisk, Sanofi. Membership on advisory boards: Dexcom, Sanofi.MAT-CA-2300748
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Hypoglycemia is a major concern for people living with diabetes; however, there are numerous myths and misconceptions surrounding its role in diabetes management. What are the common misunderstandings about hypoglycemia in diabetes care?
Our host, Dr. Alexandria Ratzki-LeeWing, takes a deeper look into this topic together with Dr. Stewart Harris, a family doctor and professor at Western University in London.
This episode explores the impact of hypoglycemia on individuals with diabetes, and examines its consequences and associated risks in everyday life. In the past decade, real-world evidence has emerged, with long-term prospective studies indicating an alarmingly high burden of severe hypoglycemia.
Our speakers today cover practical strategies for preventing and managing hypoglycemia in patients with diabetes, such as patient education on identifying low blood glucose symptoms and promoting effective self-management. Other approaches discussed include employing newer therapies with reduced hypoglycemia risk or safer long-acting basal insulin, and leveraging technology such as continuous glucose monitors (CGMs) combined with regular consultations for optimal use.
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The views and opinions expressed in this episode are those of the speakers and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Ratzki-LeeWing
Direct financial relationship including receipt of honoraria: Eli Lilly, Novo Nordisk, American Diabetes Association. Funded grants, research, or clinical trials: Sanofi Global.Dr. Harris:
Direct financial relationship including receipt of honoraria or in-kind compensation: Abbott, AstraZeneca, Bayer Inc., Dexcom, Eli Lilly, HLS Therapeutics, Janssen, Novo Nordisk, Sanofi Aventis. Membership on advisory boards: Abbott, AstraZeneca, Bayer Inc., Dexcom, Eli Lilly, HLS Therapeutics, Janssen, Novo Nordisk, Sanofi Aventis. Funded grants, research, or clinical trials: Abbott, Applied Therapeutics Inc., AstraZeneca, Boehringer Ingelheim, Eli Lilly, Novartis, Novo Nordisk, Sanofi Aventis.MAT-CA-2300744
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Titration is a crucial element for individuals with diabetes taking basal insulin to achieve their glycemic targets, so how do we ensure we’re doing it optimally?
Our host, Dr. Ronald Goldberg, takes a deeper look into this topic with Dr. Irene Hramiak, a Professor of Medicine at Western University, and the current Department of Medicine Site Chief and Endocrinologist at St. Joseph’s Hospital.
This episode discusses the history of basal insulin titration and how standard protocols have changed over time, with new advances brought on by clinical evidence from trials like the INSIGHT study, and patient empowerment. Our experts also take a deeper look into the recent LixiLan ONE CAN study, of which Dr. Hramiak was the primary investigator: Comparing a daily versus weekly titration algorithm in people with type 2 diabetes switching from basal insulin to iGlarLixi in the LixiLan ONE CAN randomized trial.
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The views and opinions expressed in this episode are those of the speakers and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Goldenberg:
Direct financial relationship including receipt of honoraria: Abbott, Agora, Amgen, Antibody, AstraZeneca, Bayer, Boehringer Ingelheim, CCRN, CMSKTRG, Eli Lilly, EOCI, HIT Global, HLS, Inceptus, Janssen, LiV, Master Clinician Alliance, MD Briefcase, Merck, Mylan, Novo Nordisk, Sanofi, Script Medical, Servier, STA, Takeda, Toronto Knowledge Translation Working Group, Unik, Valeant. Membership on advisory boards or speaker’s bureau: Abbott, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, HLS, Janssen, Merck, Novo Nordisk, Sanofi. Funded grants, research or clinical trials: Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, Novo Nordisk, Sanofi.
Dr. Hramiak:
Membership on advisory boards or speaker’s bureau including receipt of honoraria: CCRN, Canadian Medical & Surgical Knowledge Translation Research Group, Boehringer Ingelheim/Eli Lilly (BI-LILLY joint venture), Eli Lily & Co, Insulet Corp, Medtronic, Merck & Co Inc, Novo Nordisk, Sanofi-Aventis, Western University. Membership on advisory boards or speaker’s bureau: CCRN, Canadian Medical & Surgical Knowledge Translation Research Group, Boehringer Ingelheim/Eli Lilly (BI-LILLY joint venture), Eli Lily & Co, Insulet Corp, Medtronic, Merck & Co Inc, Novo Nordisk, Sanofi-Aventis. Funded grants, research or clinical trials: Eli Lilly, Novo Nordisk, Sanofi.
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Exercising with diabetes requires extra preparation, so how can healthcare providers best guide those living with type 1 diabetes in exercising safely to maintain a healthy lifestyle?
Our host, Dr. Ronald Goldenberg, takes a deeper look into this topic with Dr. Mike C. Riddell, a Professor at York University’s School of Kinesiology and Health Science and Muscle Health Research Centre, and a Senior Scientist at the LMC Diabetes and Manna Research in Toronto. He is a leading authority on exercise and diabetes, having published numerous peer-reviewed articles, book chapters, international guidelines, and a patient guidebook on the effects of exercise and stress on diabetes and metabolism.
This episode discusses the different types of exercises recommended and the practical considerations surrounding blood glucose monitoring, carbohydrate intake, and insulin dosing adjustments when staying active for those living with diabetes.
Our experts also touch on some new and exciting clinical data recently presented at the ADA 2022 Scientific Sessions related to diabetes and exercise. They discuss key findings from the Type 1 Diabetes Exercise Initiative (T1DEXI) study, which assessed the effect of exercise type on time in range by comparing continuous glucose monitoring data on active vs. sedentary days, of which Dr. Riddell was a co-author. Our experts also discuss key takeaways from the ULTRAFLEXI-1 study, which compared second-generation basal insulin analogues glargine 300 U/mL (Gla-300) and degludec 100 U/mL (IDeg-100) flexibility around spontaneous exercise sessions in adults with type 1 diabetes.
Don’t miss the conversation!
The views and opinions expressed in this episode are those of the speakers and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Goldenberg:
Direct financial relationship including receipt of honoraria: Abbott, Agora, Amgen, Antibody, AstraZeneca, Bayer, Boehringer Ingelheim, CCRN, CMSKTRG, Eli Lilly, EOCI, HIT Global, HLS, Inceptus, Janssen, LiV, Master Clinician Alliance, MD Briefcase, Merck, Mylan, Novo Nordisk, Sanofi, Script Medical, Servier, STA, Takeda, Toronto Knowledge Translation Working Group, Unik, Valeant. Membership on advisory boards or speaker’s bureau: Abbott, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, HLS, Janssen, Merck, Novo Nordisk, Sanofi. Funded grants, research or clinical trials: Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, Novo Nordisk, Sanofi.
Dr. Riddell:
Direct financial relationship including receipt of honoraria: Dexcom, Novo Nordisk, Sanofi, Lilly Diabetes. Membership on advisory boards or speaker’s bureau: Zucara Therapeutics, Zealand Pharma, Indigo Diabetes. Funded grants, research or clinical trials: Insulet Canada, Dexcom, Verily, Glyconet, JAEB Center for Health Research, Natural Sciences and Engineering Research Council of Canada (NSERC), Zucara Therapeutics, Mitacs Canada. Other financial relationships/investments: investments (shares) in Supersapiens and Zucara Theraputics.
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Do second-generation basal insulin analogues really offer any advantages over their first-generation counterparts?
Our host, Dr. Ronald Goldenberg, takes a deeper look into this topic with Dr. Alice Cheng, an endocrinologist at Credit Valley Hospital in Mississauga and St. Michael's Hospital in Toronto. She is also an Associate Professor in the Department of Medicine at the University of Toronto and the current the Chair of the Professional Section of Diabetes Canada and an Associate Editor for the Canadian Journal of Diabetes.
This episode focuses on second-generation basal insulin analogues, and the clinical benefits they confer compared to previous generations. Dr. Cheng discusses how the design of next-generation basal insulin analogues allow flatter and longer time-action profiles, which translate to less hypoglycemia for those using it. Given that fear of hypoglycemia is a significant barrier for both physicians and patients, choosing therapies that limit those episodes can be an important consideration. Our experts also touch on the topics of biosimilars, populations for which second-generation basal insulin analogues may be most appropriate, and how different basal insulins can offer more dosing flexibility.
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The views and opinions expressed in this episode are those of the speakers and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Goldenberg:
Direct financial relationship including receipt of honoraria: Abbott, Agora, Amgen, Antibody, AstraZeneca, Bayer, Boehringer Ingelheim, CCRN, CMSKTRG, Eli Lilly, EOCI, HIT Global, HLS, Inceptus, Janssen, LiV, Master Clinician Alliance, MD Briefcase, Merck, Mylan, Novo Nordisk, Sanofi, Script Medical, Servier, STA, Takeda, Toronto Knowledge Translation Working Group, Unik, Valeant. Membership on advisory boards or speaker’s bureau: Abbott, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, HLS, Janssen, Merck, Novo Nordisk, Sanofi. Funded grants, research or clinical trials: Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, Novo Nordisk, Sanofi.
Dr. Cheng:
Direct financial relationship including receipt of honoraria: Abbott, Astra Zeneca, Bayer, Boehringer Ingelheim, Dexcom, Eli Lilly, Insulet, HLS Therapeutics, Janssen, Novo Nordisk, Sanofi, Takeda, Antibody, EOCI, Six Degrees, Liv, CPD Network, Canadian Collaborative Research Network, Master Clinical Alliance, Canadian Medical & Surgical Knowledge Translation Research Group, Sea Courses, Alliance of Best Practices in Health Education, Partners in Progressive Medical Education, Agence Unik, MD Briefcase, LMC Physician Inc., Meducomm, Humber Hospital, Timed Right, The ACADEMY. Membership on advisory boards or speaker’s bureau: Abbott, Amgen, Astra Zeneca, Bayer, Bausch, Boehringer Ingelheim, Dexcom, Eli Lilly, GSK, HLS Therapeutics, Insulet, Janssen, Merck, Medtronic, Novo Nordisk, Pfizer, Sanofi, Takeda. Funded grants, research or clinical trials: Applied Therapeutics, Sanofi.
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Diabetes Canada updated their recommendations for the pharmacologic glycemic management of type 2 diabetes in adults in 2020, but how can clinicians interpret and implement these guidelines in their everyday practice?
Our host, Dr. Ronald Goldenberg, takes a deeper look into this topic with Dr. Peter Lin, the Director of Primary Care Initiatives at the Canadian Heart Research Centre and a Family Physician based in Toronto. He has been heavily involved in physician education, serving as an Associate Editor for the Elsevier WebPortal – Practice Update Primary Care, and was a contributing author to the 2013 and 2018 Diabetes Canada Clinical Practice Guidelines on Cardiovascular Protection in People With Diabetes.
This episode discusses how the newly updated recommendations by Diabetes Canada have shifted the focus of pharmacologic management of type 2 diabetes, to now include consideration of other clinically relevant outcomes such as cardiovascular and renal benefits. Our experts take a comprehensive, in-depth walkthrough of the treatment algorithms presented in these updated guidelines. They also discuss practical considerations when selecting an antihyperglycemic agent at various points throughout the type 2 diabetes patient journey: at diagnosis; when reviewing, adjusting, or advancing therapy; and when starting or advancing insulin.
Don’t miss the conversation!
The views and opinions expressed in this episode are those of the speakers and do not necessarily reflect the views or positions of any entities they represent.
Declaration of conflict of interest:
Dr. Goldenberg:
Direct financial relationship including receipt of honoraria: Abbott, Agora, Amgen, Antibody, AstraZeneca, Bayer, Boehringer Ingelheim, CCRN, CMSKTRG, Eli Lilly, EOCI, HIT Global, HLS, Inceptus, Janssen, LiV, Master Clinician Alliance, MD Briefcase, Merck, Mylan, Novo Nordisk, Sanofi, Script Medical, Servier, STA, Takeda, Toronto Knowledge Translation Working Group, Unik, Valeant. Membership on advisory boards or speaker’s bureau: Abbott, AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, HLS, Janssen, Merck, Novo Nordisk, Sanofi. Funded grants, research or clinical trials: Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Janssen, Merck, Novo Nordisk, Sanofi.
Dr. Lin:
Direct financial relationship including receipt of honoraria: Astrazeneca, BoehringerIngelheim, Bayer, Eli Lilly, Merck, Sanofi, Amgen, mdBriefCase, Canadian Heart Research Center, Bayer, Lincorp Medical Inc., CCRN, CoreCare, CHIEF, LMC Diabetes & Endocrinology Group, Diabetes Canada, Novo Nordisk, Humber River Hospital, Canadian Medical & Surgical Knowledge Translation Research Group, HLS, Medexus, Pri-med Canada, liV Agency, Meducomm, The Rounds, Peterborough Medical Society, the Peterborough Regional Health Centre Foundation and Peterborough Public Health, WebMD, Medscape, Moderna, LifeLabs, Acino. Membership on advisory boards or speaker’s bureau: Astrazeneca, Boehringer Ingelheim, Bayer, Eli Lilly, Merck, Sanofi, Amgen, mdBriefCase, Canadian Heart Research Center, Lincorp Medical Inc., CCRN, CoreCare, CHIEF, LMC Diabetes & Endocrinology Group, Diabetes Canada, Novo Nordisk, Humber River Hospital, Canadian Medical & Surgical Knowledge Translation Research Group, HLS, Medexus, Pri-medCanada, liV Agency, Meducomm, TheRounds, Peterborough Medical Society, the Peterborough Regional Health Centre Foundationand Peterborough Public Health, WebMD, Medscape, Moderna, LifeLabs, Acino.
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