Reproduzido
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That little bottle of retinol serum sitting on your bathroom counter - what do you know about its history? This week, we’re digging deep into the man behind the medicine, renowned dermatologist Dr. Albert Kligman, and the unethical research he conducted at Holmesburg Prison in the mid-20th century. Kligman’s research program at Holmesburg spanned decades, involved dozens of experiments (including tretinoin) and thousands of individuals, received ample funding from public universities and many pharmaceutical companies, and was generally praised until it all came crashing down in the early 1970s. But, as we’ll discover, the unethical behavior persisted even after the program’s closure as Kligman fought to get tretinoin to market. The murky history of retinoids might be a bit too long to include on the label, but this episode forces us to consider the human cost of a household product and the importance of acknowledging that history.
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Episode Notes
Edwin- Todd HollowGummy- KingdekuComputer- ScarletVideo Editing: Violetlegacy
Video Version [Includes Captions]
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Our heroes learn a long-buried secret. The transcript for this episode can be found on our website. Want to support the Inn? Visit our Patreon, follow us on Twitter, or leave us a review on Apple Podcasts. The next episode will be up October 10th. See you then!
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Our heroes set out an a long journey into unfamiliar territory. Or do they? The transcript for this episode can be found on our website. Want to support the Inn? Visit our Patreon, follow us on Twitter, or leave us a review on Apple Podcasts. The next episode will be up on September 26th. See you then!
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Our heroes suffer a disappointment. Some handle it better than others. The transcript for this episode can be found on our website. Want to support the Inn? Visit our Patreon, follow us on Twitter, or leave us a review on Apple Podcasts! The next episode will be up on September 12th. See you then!
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Our heroes quibble over their next move. There are no good options. The transcript for this episode can be found on our website. Want to support the inn? Visit our Patreon, follow us on Twitter, and leave us a review on Apple Podcasts! The next episode will be up on August 29th. See you then!
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Our heroes...probably should have had a plan. The transcript for this episode can be found on our website. Want to support the inn? Visit our Patreon, follow us on Twitter, and leave us a review on Apple Podcasts! The next episode will be up on August 15th. See you then!
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Our heroes are none too pleased with Friar Velune. The transcript for this episode can be found on our website. Want to support the inn? Visit our Patreon, follow us on Twitter, and leave us a review on Apple Podcasts! The next episode will be up on August 1st. See you then!
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Our heroes get back from a nasty close encounter and relax through the time-honored practice of mocking each other. The transcript for this episode can be found on our website. Want to support the inn? Visit our Patreon, follow us on Twitter, and/or leave us a review! The next episode will be up on July 18th. See you then!
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Our heroes become one in purpose. More or less. The transcript for this episode can be found on our website. Like what you hear? Follow us on Twitter, and leave a review! The next episode will be up July 4th. See you then!
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Our heroes meet in a tavern. As you do. The transcript for this episode can be found on our website. Like what you hear? Follow us on Twitter, and leave a review! The next episode will be up on June 20th. See you then!
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On the night of December 2, 1984, a deadly gas leak at the Union Carbide pesticide plant in Bhopal, India led to what has been described as the world’s worst industrial disaster. In the immediate aftermath of the gas leak, thousands of people died and hundreds of thousands were injured from exposure to the toxic gas methyl isocyanate. But long after the international headlines and news reports dwindled to silence, long after Union Carbide paid a paltry settlement to survivors, long after the disaster faded from much of the world’s memory, the gas leak continues to haunt the residents of Bhopal. In this episode, we trace the path of methyl isocyanate from initial discovery to the night of the disaster and the years that followed. We then explore what about this gas makes it so very deadly before assessing how the contamination still present at the site is causing health problems for residents decades after the gas leak.
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Does it seem like the supplement section of your grocery store gets bigger every time you go in? Or that all television commercials these days seem to be advertising dietary supplements that promise to improve your concentration, help you lose weight, make you happier, healthier, smarter, stronger, cooler, poop better or some mix of those? You’re not imagining things. The explosion of the US dietary supplement industry over the past few years is very real, and when you’re inundated with ads for supplements everywhere you turn, it can be very difficult to navigate whether these things actually do what they say and how much they’re allowed to say without actually doing anything. That’s where this episode comes in. We take you through what supplements actually are, how their regulation in the US has changed over the past century, what dietary supplements can and cannot claim on their label, and how the supplement market has fared since the Covid pandemic (spoilers: it’s thriving).
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For life on this planet, iron is not optional. It is essential. When our iron levels are low, we can get sick, and when they get really really low, we can even die. But you know what they say, too much of a good thing can be a bad thing. In the case of iron, the genetic condition hemochromatosis is often to blame for iron overload, but why is too much iron a bad thing? In this episode, we explore that question and many others, starting with why iron is a biological non-negotiable and how a lack of iron regulation in hemochromatosis can lead to severe tissue damage. Then we’re going Deep Time™ to suss out the origins of our dependence on iron, a journey that eventually leads us to the Neolithic Revolution and the 20th century realization that a certain ancient medical practice is not as obsolete as previously thought. Tune in to catch us ironing out the details of this incredibly common genetic disorder.
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“Throbbing, pulsating pain.” “Like a drill boring into your head.” “As though your head is gripped by a vise.” “Stabbing pain hammering through your brain.” There is no shortage of metaphors used to describe the horrific, incapacitating pain of migraines. But try as we might, can any of them truly convey what it feels like to be at the mercy of such pain? In many ways, migraines reveal our shortcomings: with language that fails to accurately describe pain, with empathy when we continue to dismiss migraines as “just really bad headaches”, with medicine as we struggle to find reliable treatments and preventatives, and with biology as we fail to understand the complete pathology of this condition. In this episode, we do our best to explore these shortcomings by deep diving into what we do know about the biology and history of migraines. Why do some people get migraines and others don’t? How do certain medications work? What the heck is going on with aura? Have migraines always been around? How have people dealt with them or perceived them historically? What’s on the horizon for migraines in the future? As always, we’ve got lots of questions and lots of answers for you, so tune in today!
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Malevolent follows Arkham Investigator Arthur Lester as he unravels the mysterious circumstances that have befallen him. In the Twentieth part of Malevolent the final confrontation is here. Compelled to find out if his daughter is in the Dreamlands, Arthur and the Entity head within the walls of an unknown City in hopes of finding her. Here they will encounter a truly unexpected truth as well as gain the tools to confront the King in Yellow once and for all... If you are enjoying this Podcast, please consider becoming a Patreon supporter to receive all Chapters as they are completed as well as the choices that you, the listener, get to make. Find out more here: https://www.patreon.com/TheINVICTUSStream
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The search for my cat leads me halfway up the High Street, where the writhing tentacles of the Leviathan tower over us all.
transcript: https://thelostcatpodcast.tumblr.com/post/184135236497/the-lost-cat-podcast-transcripts-s01-ep03-the
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Wilma. Purring.
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More purring. Lots of purring.
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There’s a gang of Cattle Rustlers coming to town to rustle up the cattle.
Weather: “Dark Skies“ by Danny Schmidt
Original episode art by Jessica Hayworth
UNLICENSED Season 2 arrives October 31, only on Audible
The Welcome to Night Vale Roleplaying Game is coming! Crowdfunding launch begins OCT 1!Sign up for the Night Vale newsletter for good news and recommendations.
Patreon is how we exist! If you can, please help us keep making this show.
Music: Disparition
Logo: Rob Wilson
Written by Joseph Fink, Jeffrey Cranor & Brie Williams
Narrated by Cecil Baldwin
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Check out our books, live shows, store, membership program, and official recap show at welcometonightvale.com
A production of Night Vale Presents.
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