Episódios

  • 力,是物理学中一个抽象的概念,然而,它却实在地存在于我们所处的宇宙空间。大到星体的运行轨迹,小到细胞的分裂方向,它像一个隐形的雕刻师,无时无刻不在塑造着客观世界的形态。


    片头:《SAGA》 ---Hurray for the Riff Raff

    片尾:《Cancel the party》 ---Julie Doiron


    文献:


    Green, P. B. & Stanton, F. W. Turgor Pressure: Direct Manometric Measurement in Single Cells ofNitella.Science155, 1675–1676 (1967).



    Maeda, S.et al.The Conflict Between Cell Proliferation and Expansion Primarily Affects Stem Organogenesis in Arabidopsis.Plant and Cell Physiology55, 1994–2007 (2014).



    LeGoff, L. & Lecuit, T. Mechanical Forces and Growth in Animal Tissues.Cold Spring Harb Perspect Biol8, a019232 (2016).



    Elliott, L.et al.A self-regulatory cell-wall-sensing module at cell edges controls plant growth.Nat. Plants10, 483–493 (2024).



    Hamant, O. & Haswell, E. S. Life behind the wall: sensing mechanical cues in plants.BMC Biol15, 59 (2017).



    Landrein, B. & Ingram, G. Connected through the force: mechanical signals in plant development.Journal of Experimental Botany70, 3507–3519 (2019).



    Trinh, D.-C.et al.How Mechanical Forces Shape Plant Organs.Current Biology31, R143–R159 (2021).



    Mechanical forces in plant tissue matrix orient cell divisions via microtubule stabilization.Developmental Cell



    A self-regulatory cell-wall-sensing module at cell edges controls plant growth.Nature Plants


  • 降低胆固醇有各种各样的办法,如果不改变DNA序列只改变DNA的表观修饰会不会更加安全可控呢 ?一个细胞也要像一支队伍,生物电的传递让他们拥有了多样的行走模式。更多精彩内容尽在本期的paperbee。


    更安全可控的降胆固醇方案:PCSK9的抑制性表观标签加载

    Durable and efficient gene silencing in vivo by hit-and-run epigenome editing


    游仆虫:一个细胞也要像一支队伍

    Cell motility: Bioelectrical control of behavior without neurons


    腺毛也系了一条领带

    Novel lignin-based extracellular barrier in glandular trichome


    非哺乳动物的哺乳行为

    Milk provisioning in oviparous caecilian amphibians


    小贴士:加入KU复合物,提高同源重组的基因打靶效率

    Redirecting DNA repair for efficient CRISPR-Cas-based gene targeting in tomato





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  • 说到痤疮杆菌,你可能想到了可怕的痘痘,然而,说不定,它经过改造也可以称为我们的朋友。你大概玩过植物大战僵尸,但你可能不知道,一些凶狠的寄生者会把寄主变成僵尸。更多精彩内容,尽在本期的paper bee,欢迎您的收听。


    化敌为友:改造痤疮杆菌减少皮脂产生

    Delivery of a sebum modulator by an engineered skin microbe in mice


    煤气灯操纵者:绿僵菌 和 斯德哥尔摩综合症患者: 阿根廷蚁

    Fungal infection alters collective nutritional intake of ant colonies


    分布了几百个着丝粒的染色体在联会后怎么进行交换?

    Meiotic recombination dynamics in plants with repeat-based holocentromeres shed light on the primary drivers of crossover patterning


    空气污染阻隔了夜行昆虫的觅食路

    Pollution disrupts nighttime pollination by degrading scents


    小贴士

    pA-regulator的更安全的基因调控方法

    pA regulator: a system for controlling mammalian gene expression via the modulation of polyA signal cleavage





  • 当给类脑器官插上电极,连上AI,人类是否开启了创造智慧生物的大门?植物的神奇总是超乎我们的想象。时间能让很多东西湮灭,却也能让很多东西重获新生。


    片头曲:《很多鹅》 —旺福乐队


    插曲:《休息》 —以莉.高露


    《It start out so nice》 —Rodriguez 《相思河畔》 —顾媚


    片尾曲:《Annika》 —Björn Olsson


    人脑连接AI:

    Biocomputer’ combines lab-grown brain tissue with electronic hardware

    verve101:

    first in vivo base editing lowers cholesterol

    蛛丝纤维:

    Bioengineered spider silk without critters

    老碳新用的红杉:

    After fire, coast redwoods use decades-old carbon reserves to recover

    生物结皮:

    Biocrusts protect the Great Wall of China from erosion


  • 大家好,这里是paper bee 。我是林海七。


    如果可以用你的细胞造一个机器人,你想用它来做什么呢?听说,帽带企鹅一天要打盹10000次,上课走神的你是不是觉得小巫见大巫。原来,在很久很久以前,有一种雄蚊子也会吸血?更多精彩内容,尽在本期paperbee ,欢迎您的收听。


    片头曲:《很多鹅》 —旺福乐队


    插曲:《休息》 —以莉.高露


    《It start out so nice》 —Rodriguez 《相思河畔》 —顾媚


    片尾曲:《Annika》 —Björn Olsson



    人类来源的细胞机器人(anthrobot)


    打盹10000次/天的帽带企鹅(chinstrap penguin micro-snap)


    章鱼机械臂(octopus arm)


    会吸血的雄蚊子化石(the earliest fossil of mosquito)


    神经肽作为明确的信号分子(wireless nerve signal)


    病毒作为构建trangene-free的载体


    因为喜马拉雅放不了链接,所以只放了关键词,有兴趣可以自行查阅。