Episódios
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TWiN explains a study showing that while groups of neurons, form the basis for memory, astrocytes are key components of the adaptive reponse to learning experiences, and regulate the flow of information during circuit plasticity and memory recall.
Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung
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Links for this episode MicrobeTV Discord Server Write your Senator, oppose RFK Jr nomination Astrocytes and memory (Nature) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
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TWiN explains the identification of a brain circuit and periodic branch-specific neurotransmitter deployment that regulates organismal adaptation to photoperiod change.
Hosts: Vincent Racaniello, Jason Shepherd, and Tim Cheung
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Links for this episode MicrobeTV Discord Server Brain circuit for photoperiod adaptation (Nature) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
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TWiN explores how pregnancy leads to modifications in brain structure and function that may prepare the mother for parenting.
Hosts: Vincent Racaniello, Jason Shepherd, and Vivianne Morrison
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Links for this episode MicrobeTV Discord Server Pregnancy transforms the brain (Nature) Hormone-mediated neural remodeling during pregnancy (Science) Effects of pregnancy on brain activity (Nature Comm) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
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Joseph Paton and Felipe Rodrigues join TWiN to explain how they used temperature manipulation to alter the speed of neuronal dynamics in the dorsal striatum of rats, a manipulation that selectively slowed down or sped up time perception, illuminating the mechanisms of time-based decisions.
Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison
Guest: Joseph J. Paton and Felipe Rodrigues
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Links for this episode MicrobeTV Discord Server Using temperature to analyze the neural basis of a time-based decision (Nat Neurosci) Hot times for the dorsal striatum (Nat Neurosci) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
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Mauro Costa-Mattioli returns to TWiN to discuss the results of a placebo controlled, double blind clinical trial of a probiotic which improved social behavior but not autism severity in children with ASD.
Hosts: Jason Shepherd, Timothy Cheung, and Vivianne Morrison
Guest: Mauro Costa-Mattioli
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Links for this episode MicrobeTV Discord Server Probiotics for autism spectrum disorder (Cell Host Microbe) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
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TWiN reviews altered somatosensory reactivity, which is frequently observed among individuals with autism spectrum disorders (ASD), and in mouse models the developmental timing of aberrant touch processing can predict the manifestation of ASD-associated behaviors in mouse models.
Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison
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Links for this episode MicrobeTV Discord Server Mouse models of autism spectrum disorder (Nature Neuroscience) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
Send your neuroscience questions and comments to [email protected]
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TWiN reviews experiments which show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential in cerebral organoids, organotypic culture of human brain explants and post-mortem brain samples from individuals with COVID-19.
Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison
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Links for this episode MicrobeTV Discord Server SARS-CoV-2 perturbs synaptic homeostasis (Nature Micro) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
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TWiN welcomes mice to the elite club of ‘self-aware’ animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling visual self-recognition.
Hosts: Vincent Racaniello, Timothy Cheung, and Vivianne Morrison
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Links for this episode MicrobeTV Discord Server Mice are self-aware (Neuron) Mirror self-recognition in mice (Neuron) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
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TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury.
Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung
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Links for this episode MicrobeTV Discord Server Activation of endogenous retroviruses in TBI oligodendroglia (Cell Rep) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
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TWiN explains an amazing study of a man who was paralyzed after a spinal cord injury and regained the ability to walk after implantation of a brain-spinal cord interface.
Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung
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Links for this episode MicrobeTV Discord Server Walking naturally after spinal cord injury (Nature) The paralyzed rat that walked (YouTube) Mike the headless chicken (Wikipedia) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
Send your neuroscience questions and comments to [email protected]
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TWiN explains research showing that interaction between glioma cells and neurons in the brain shares mechanistic features with synaptic plasticity that contributes to memory and learning in the healthy brain.
Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung
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Links for this episode MicrobeTV Discord Server Glioma synapses recruit mechanisms of adaptive plasticity (Nature) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
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TWiN discusses research showing that sciatic nerve activation with electroacupuncture at the sciatic nerve controls systemic inflammation and rescues mice from polymicrobial peritonitis, by inducing vagal activation of aromatic L-amino acid decarboxylase, leading to the production of dopamine in the adrenal medulla.
Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung
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Links for this episode MicrobeTV Discord Server Electroacupuncture modulates the immune system (Nat Med) Electroacupuncture drives the vagal–adrenal axis (Nature) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
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TWiN reviews a mouse model of ADHD to characterize hypersensitivity to pain, and that sensitization is further amplified in a pathological inflammatory state.
Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung
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Links for this episode MicrobeTV Discord Server Pain hypersensitivity in ADHD model (PNAS) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
Send your neuroscience questions and comments to [email protected]
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TWiN discusses a study of on the pathways that control opioid analgesic tolerance, a root cause of opioid overdose and misuse, which can develop through an associative learning.
Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung
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Links for this episode MicrobeTV Discord Server Associative opioid analgesic tolerance (Sci Adv) Pavlovian-conditioned opioid tolerance (Sci Adv) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
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TWiN explains how psychedelic drugs such as LSD, psilocybin, and MDMA, which are being explored for treating a wide range of neuropsychiatric diseases, reopen the social reward period for critical learning.
Hosts: Vincent Racaniello, Jason Shepherd, and Timothy Cheung
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Links for this episode MicrobeTV Discord Server Psychedelic drugs open critical period (Nature) Psychedelics reopen critical periods (News-Med) LSD microdosing doesn’t work (U Chicago Med) Timestamps by Jolene. Thanks!
Download TWiN 042 (34 MB .mp3, 57 min)
Subscribe (free): Apple Podcasts, Google Podcasts, RSSMusic is by Ronald Jenkees
Send your neuroscience questions and comments to [email protected]
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Vivianne explains how early in Alzheimer’s disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and that melanin-concentrating hormone, produced during sleep, is involved in this protective response.
Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison
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Links for this episode MicrobeTV Discord Server Melanin-concentrating hormone and Alzheimer’s disease (Nat Neurosci) Alzforum Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
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Tim takes TWiN through two studies on the role of dopamine: that syllables are natural units of spontaneous behavior used by the brain to structure action, and that mesolimbic dopamine release conveys causal associations but not reward prediction errors, thereby challenging the dominant theory of reward learning.
Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison
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Links for this episode MicrobeTV Discord Server Spontaneous behavior without explicit reward (Nature) Dopamine release conveys causal associations (Science) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
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Junjie from Jason’s lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibodies which underlie paraneoplastic syndrome.
Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Junjie Xu
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Links for this episode MicrobeTV Discord Server Virus-like capsids in paraneoplastic disease (bioRxiv) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
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TWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A.
Hosts: Vincent Racaniello, Ori Lieberman, Timothy Cheung, and Vivianne Morrison
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Links for this episode MicrobeTV Discord Server Immunity to the microbiota promotes sensory neuron regeneration (Cell) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
Send your neuroscience questions and comments to [email protected]
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TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions.
Hosts: Vincent Racaniello, Jason Shepherd, Timothy Cheung, and Vivianne Morrison
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Links for this episode Microglia states and nomenclature (Nature) Timestamps by Jolene. Thanks!Music is by Ronald Jenkees
Send your neuroscience questions and comments to [email protected]
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