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It's always exciting to see flashy headlines about the next revolutionary drug approved by the FDA or how a biotech startup is making millions for a diagnostic test. However, it's equally important to not lose sight of what gets us to the most important discoveries in the first place: basic research. Today, we're interviewing Dr. Marc Kirschner, a renowned cell biologist and biochemist known for his research on the cytoskeleton, cell cycle, and embryo signaling. Join us to hear his thoughts on how scientific disciplines have become more intertwined over time, the crucial role of technological advancements such as electron microscopy in the field of biochemistry, and the dire need for approaching scientific discovery with curiosity instead of going straight for the money.
Dr. Marc Kirschner is the founding chair of the Department of Systems Biology at Harvard Medical School and is known for major discoveries in cell and developmental biology. He has also coauthored 2 books on the biological basis of evolution and helped launch the peer-reviewed journal PLOS (Public Library of Science) Biology. -
It's always interesting to think about how many technologies that we take for granted today, such as genome sequencing and bioengineering, were completely unheard of just a few decades ago. This episode, we're going back to the roots of these applications with Dr. James Collins, who is widely regarded as one of the founders of the field of synthetic biology. Tune in to hear his thoughts on the importance of leveraging the tools we have today for pandemic prevention and readiness, how to reframe thinking around biosecurity when it comes to applications of these technologies, and how AI can help us outrun antibiotic resistance with rapid drug discovery.
Dr. James Collins is a professor of medical engineering and science at MIT, a core faculty member at the Wyss Institute of Harvard University, and a member of the Broad Institute of MIT and Harvard. He is a member of the National Academies of Engineering, Science, and Medicine, and his technologies have been licensed by over 25 biotech and medical device companies. -
If something like the COVID-19 pandemic ever happened again, how would we deal with it? Would it be any different from last time? Through our experiences from 2020 to now, it's important to remember how crucial vaccine development and preventative research efforts are in matters of public health. Today, we're joined by Dr. Barney Graham, who has made major contributions to vaccines for HIV/AIDS, Zika, RSV, and ultimately SARS-CoV-2. Tune in to hear Dr. Graham's firsthand experiences with discovering virus spike proteins, working on various teams to develop vaccines for different epidemics, and advocating for global health policy reform.
Dr. Barney Graham is the former deputy director and one of the founding members of the Vaccine Research Center, which is part of the National Institutes of Health (NIH). He was elected a member of the National Academy of Sciences in 2022 and currently serves as the director of the David Satcher Global Health Equity Institute at the Morehouse School of Medicine. -
Some of the biggest scientific discoveries and biotechnology companies today were born out of skepticism. But what is it actually like to have participated in building this work from the group up? Today, we're hearing a first-hand perspective in this from Dr. Robert Langer, billionaire cofounder of Moderna and widely renowned biotechnologist. Join us in a riveting discussion about how the ups and downs of his career taught him to advocate for himself through research, how his lab is collaborating with The Gates Foundation to create more efficient treatments for developing countries with novel drug delivery systems, and the importance of having a creative mindset to find solutions in unusual places.
Dr. Robert Langer is currently an Institute Professor at MIT and a faculty member of the Harvard–MIT Program in Health Sciences and Technology. Having authored over 1,500 scientific papers, he is the most cited engineer in history and one of the 10 most cited individuals in any field. Dr. Langer has participated in founding 40+ biotechnology companies including Moderna and holds over 1,500 granted or pending patents. -
Many of us have early memories of visits to the pediatrician, which are often underscored by fear of the dreaded needle. Being poked and prodded is never fun regardless of your age, but it's especially important to consider that a lot of this discomfort is unnecessary. And, traumatizing experiences in young patients can foster distrust for healthcare workers during their formative years. Today, we're chatting with Dr. Stefan Friedrichsdorf about palliative care, advocating for pain management in pediatrics, and how taking a bit of extra time for a simple, evidence-backed procedure to reduce anxiety during vaccinations can help kids develop positive associations with the healthcare system through adulthood.
Dr. Stefan Friedrichsdorf is a pediatric pain and palliative medicine specialist. Through his roles as a professor of pediatrics at UCSF and the medical director of the Stad Center for Pediatric Pain, Palliative and Integrative Medicine, he is helping to make pain management for kids a #1 priority through their care. -
From a privileged perspective, it can be easy to consider good mental health as an additional benefit on top of the precursor of physical health. However, it turns out that we need to reframe this mindset, especially in the context of social communities and developing countries. Today, we're chatting with Sean Mayberry about StrongMinds, a global nonprofit treating hundreds of thousands of people each year, mostly in Africa, with depression. Tune in to hear about the surprisingly controversial label of mental health, the sustainability of group therapy approaches for depression, and how mental health care targeted at caregivers improves many other factors in the household.
Sean Mayberry is the CEO of StrongMinds, a TEDx speaker, and a renowned humanitarian addressing health outcomes in poverty-stricken communities. Prior to founding this organization, he worked as a diplomat and social marketer implementing programs for malaria and HIV/AIDS prevention in Africa.
See the work at StrongMinds: strongminds.org/ -
From asbestos to PFAS to microplastics, nowadays it seems like harmful chemicals are present everywhere we turn. Though there are certainly many hazardous chemicals in our environment, there's also a large amount of misinformation about how these findings are communicated and in what capacity they become toxic. To clear up the air, we're joined today by Dr. Michal Freedhoff, head of the Office of Chemical Safety and Pollution Prevention (OCSSP). Tune in to hear her unique perspective on how safety regulations became more rigorous since 2016 under the revised Toxic Substances Control Act (TSCA), how we still see impacts of historical ignorance around chemical safety in today's chemical regulations, and the dire need to prevent science from turning into a weapon of uncertainty through accusatory claims against scientists.
Michal Freedhoff is the Assistant Administrator for the Office of Chemical Safety and Pollution Prevention (OCSPP). She has a PhD in physical chemistry from the University of Rochester and has over 20 years of government experience, including serving on scientific research and development committees of the United States Senate and House of Representatives. -
Wouldn't it be amazing to have a long weekend every week and still get paid full time? It turns out that this isn't just a magical fantasy, but rather a reality for employees at hundreds of companies across the globe. And not only is it fun to have Fridays off, but it's also an evidence-proven method of reducing burnout, increasing revenue with higher overall productivity, and retaining existing employees as well as attracting new talent. Today, we're interviewing Dale Whelehan, who is spearheading the initiative to convince skeptics and create a million new years of free time through 4 Day Week Global. Join us to hear important insights about the science of tunnel vision resulting from burnout, the 100-80-100 rule of work output, and making this a widespread reality through a fundamental culture shift around work.
Dale Whelehan is the CEO of 4 Day Week Global and has a PhD in Behavioral Science from Trinity College Dublin. He is on the 2024 Forbes 30 Under 30 list, a member of the Forbes Business Council, and an Advisory Council Member of the Harvard Business Review.
See the 4 Day Week Global website: www.4dayweek.com/ -
As we continue to build our knowledge about gender differences healthcare, an important part of the scene is femtech, which refers to a wide range of solutions applying technology to serve women's health. But what does femtech truly mean in its execution, and how does it affect concerns about health equity today? To tackle these questions, we're joined by Amy Keenan on behalf of FemHealth Insights, an organization empowering stakeholders in women's health through data and community building. Tune in to hear all about the underrepresentation of female patients in clinical trials and the future of joint advocacy efforts in shaping more equitable healthcare.
Amy Keenan is a leader in women's health as a 2024 fellow for FemHealth Insights. She is leading the campaign for Dr. Brittany Baretto, Chief Information Officer of FemHealth Insights, as she launches the book Unlocking Women's Health: FemTech and the Quest for Gender Equity.
Tune into the FemTech Focus podcast: www.femtechfocus.com/
Check out Dr. Brittany Baretto's new book: www.amazon.com/Unlocking-Womens-Health-FemTech-Gender/dp/1961347911 -
When a pharmaceutical company first develops a novel drug or therapeutic, it is protected by a patent. While this ensures that the company can profit off of their creation, it also creates a monopoly as the sole patent holder can charge higher prices without worrying about competition. But this is being changed by the Medicines Patent Pool (MPP), a UK-based organization that has signed agreements with 22 patent holders so far to distribute the much cheaper, generic version of life-saving products for low and middle income countries. Join us and Charles Gore, the Executive Director of MPP, in a discussion about the importance of manufacturing capacity for drug distribution, the need to advocate for federal funding in healthcare, and other unexpected regulatory challenges through this line of work.
Prior to his current role at MPP, Charles Gore brought 2 decades of work in advocating for hepatitis C patients through his role as president of The World Hepatitis Alliance, cofounder and chief executive of The Hepatitis C Trust, and the inaugural president of the European Liver Patients Association. He is also a member of the 2024 TIME100 Health list.
Check out MPP: medicinespatentpool.org/ -
We often hear the term "women's health" when discussing things such as breast cancer, menstruation, and pregnancy. But, can we only chalk it up to visits to the gynecologist? (Spoiler alert - definitely not.) Today, we're joined by Dr. Lori Frank, president of WHAM (Women's Health Access Matters), an organization dedicated to increasing awareness and funding for women's health. Tune in to hear about reframing women's health into a more expansive definition, the importance of intersectionality in feminism, and how the gaping disparity in money for women's health research continues to affect healthcare today.
Dr. Lori Frank is the inaugural president of WHAM and brings a background of biopsychology with a master's degree from Johns Hopkins University. She also currently serves a senior advisor for The New York Academy of Medicine, a board member of the Personalized Medicine Coalition, and a member of the Memory Screening Advisory Board of the Alzheimer's Foundation of America.
Check out WHAM: whamnow.org/ -
Chronic illness affects an estimated 130 million people in the United States, and that number continues climbing with infectious diseases resulting in conditions such as long COVID. Today, we're specifically focusing on ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome), a genetically-linked chronic illness that isn't talked about enough. Join us with Jaime Seltzer, a researcher and advocate for ME/CFS through #MEAction, to hear about what it was like to be diagnosed with this condition, the need for a personalized approach when working towards institutional reform, and lessons learned through leading the #MEAction's Teach ME, Treat ME campaign.
Jaime Seltzer is the scientific director at #MEAction, a nonprofit healthcare organization focusing on advocacy efforts for infection-associated chronic illness. Along with representing #MEAction at many institutions including the CDC and NIH, she is a research scientist at the Stanford University Genome Technology Center and Snyder Lab.
Check out #MEAction: www.meaction.net/ - Показать больше
