Эпизоды
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TWiV reviews multi-country outbreak of Mpox, first face covering ban in Nassau County NY, case of polio in India, more in US accept vaccine misinformation, other wartime diseases in Gaza besides polio, a new scientist run virus genome database, Mpox epidemiology and vaccine effectiveness in England, and metabolic immaturity and breastmilk bile acid metabolites determine heightened newborn vulnerability to norovirus diarrhea.
Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker
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Links for this episode MicrobeTV Discord Server Multi-country Mpox outbreak (WHO) Face covering ban in Nassau County (NBC) Polio case in India (Business Standard) More acceptance of vaccine misinformation (EurekAlert) War in Gaza not just causing polio (Jerusalem Post) Scientist run virus genome database (Science) Mpox epidemiology and vaccine effectiveness (Emerg Inf Dis) Newborn vulnerability to norovirus diarrhea (Cell Host Microbe) Timestamps by Jolene. Thanks! Weekly PicksBrianne – Viral adaptation to climate change
Rich – “Understanding the biology of monkeypox virus to prevent future outbreaks” by B. Moss
Vincent – We can now watch Grace Hopper’s famed 1982 lecture on YouTubeIntro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
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In his weekly clinical update, Dr. Griffin discusses seasonal influenza vaccine recommendations from the CDC, polio vaccine campaign securing mpox vaccine for Africa, and donating to reduce food insecurity in mpox affected areas before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, when to use convalescent plasma, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, how fibrin drives thromboinflammation and neuropathology in COVID-19, and an evidence based approach to long COVID.
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Links for this episode Recommendations for seasonal influenza prevention and vaccines (MMWR) Gaza: poliovirus RNA in sewage water (Reuters) Success of the polio vaccination campaign in Gaza (Reuters) UNICEF-Gavi-WO-Africa CDC securing mpox vaccines (Gavi) mpox vaccine tender (CIDRAP) What about vaccines? (Bavarian Nordic) Resolving food insecurity (UNICEF USA) Semaglutide and the SELECT trial(Journal of the American College of Cardiology) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Optimal duration of systemic corticosteroids treatment (OFID) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Does vaccination prevent long COVID (LANCET: Respiratory Medicine) Fibrin drives thromboinflammation & neuropathology in COVID-19(Nature) Postacute sequelae of COVID: an evidenced based approach, Dr. Daniel Griffin (OFID) Letters read on TWiV 1146 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
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Пропущенные эпизоды?
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TWiV reviews a case of polio in Gaza, more Mpox, COVID-19 boosters, effectiveness of Ebola virus vaccine, measles cases across the US, an endogenous retroviral envelope protein that regulates human cardiomyocyte development, and submergence of an encephalitic alphavirus caused by receptor shifts.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode MicrobeTV Discord Server Gaza baby has polio (Times Israel) Monkeypox virus clade Ib in Thailand (CIDRAP) Updated COVID-19 vaccines (FDA) Effectiveness of Ebola virus vaccine (Lancet Inf Dis) Measles cases in Georgia, Oregon (CIDRAP) Retrovirus protein regulates cardiomyocyte development (Cell Stem Cell) Receptor shifts govern submergence of encephalitis arbovirus (Nature) Letters read on TWiV 1145 Timestamps by Jolene. Thanks! Weekly PicksKathy – Googlegangers and AWWW clip
Rich – RP FLIP (floating instrument platform)
Alan – Big labs are bad for careers
Vincent – So You’re Underwater: Why Do You See That Circle of Light Above You?Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
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In his weekly clinical update, Dr. Griffin discusses Dr. Fauci’s case of West Nile virus, polio vaccine campaign develops in Gaza, disease that associates with Oropouche virus, mpox: vaccines, clinical trial for mpox antiviral and the WHO strategic preparedness and response plan before reviewing the recent statistics on SARS-CoV-2 infection, how to obtain free COVID tests, EUA for updated Novavax COVID vaccine, ISDA support of and where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if nirmatrelvir/ritonavir is effective at preventing hospitalization of high risk patients, incidence of mental illness in the vaccinated and unvaccinated, the effect of amubarvimab/romlusevimab on long COVID outcome, having an evidence based approach to long COVID and how fibrin drives thromboinflammation and neuropathology in COVID-19.
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Links for this episode Fauci recovering at home from West Nile Virus infection (STAT News) Gaza: poliovirus RNA in sewage water (GPEI) Bombs and polio…..cease fire, Oh my! (Guardian) The variant type 2 poliovirus in Gaza (United Nations: The Question of Palestine) 25 years polio free? (Facebook) 2 doses of nOPV2= 1.2M vaccines=640,000 children (CNN) More polio……India, two-year-old child in Tikrikilla, Meghalaya (Business Standard) Sloth fever……Oropouche virus (USA Today) Oropouche virus disease import into US (MMWR) Gabon’s first case of mpox (CIDRAP) Declaration of mpox (Gabonese Republic Ministry of Health and Social Affairs) What about vaccines? (Bavarian Nordic) LC16 replicating smallpox vaccine (WHO) Historical smallpox vaccination against mpox clade II (Eurosurveillance) FDA approves Emergent Bio’s smallpox vaccine for mpox (Reuters) Mpox: epidemiology and vaccinology (Emerging Infectious Disease) Tecovirimat for MPOX? (STOMP) UGH! The WHO has a strategic preparedness and response plan to contain mpox outbreak (WHO) WHO preparedness plan prepares to lunch (CIDRAP) Working blindly against new mpox isolate (Reuters) CDC monkey pox response: TRANSMISSION ? (CDC Newsroom) The mpox (Africa CDC: Centers for Disease Control and Prevention) Evidence for mpox respiratory transmission(LANCET Microbe) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Four free COVID tests! (ASPR: Administration for Strategic Preparedness & Response) Great, more SARS-CoV-2 testing! (CIDRAP) EUA for updated Novavax COVID-19 vaccine (FDA) Infectious Disease Society guidelines for treatment and management (ID Society) IDSA suggests new preventive COVID-19 agent (IDSA) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Breakthrough from pemivibart/permgarda (bioRxiv) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Effectiveness of nirmatrelvir/ritonavir preventing hospitalization of high risk patients (Current Therapeutic Research) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) COVID-19, mental illness vaccinated and unvaccinated (JAMA Psychiatry) Post acute COVID- 19 outcomes amubarvimab/romlusevimab versus placebo (eClinical Medicine) Postacute sequelae of COVID: an evidenced based approach, Dr. Daniel Griffin (OFID) Fibrin drives thromboinflammation & neuropathology in COVID-19 (Nature) Letters read on TWiV 1144 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
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TWiV discusses WHO declaration of Mpox as a public health emergency of international concern, Sweden reports first case of clade 1b outside of Africa, can household pets be productively infected with monkeypox virus, widespread exposure to SARS-CoV-2 in wildlife communities, and modulation of plant defenses by insect salivary GAPDH benefits viral transmission.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode MicrobeTV Discord Server Mpox outbreak is PHEIC (WHO) Tecovirimat not great against monkeypox virus clade I (NIH) Case of Mpox Clade I in Sweden (PHAS) Mpox and pets in USA (Emerg Inf Dis) SARS-CoV-2 widespread in wildlife communities (Nat Comm) Salivary GAPDH benefits plant virus transmission (Nat Comm) Letters read on TWiV 1143 Timestamps by Jolene. Thanks! Weekly PicksDickson – NASA Confirms Evidence That Liquid Water Flows on Today’s Mars
Listener Pick
Kathy – TBP for PCR internal control
Rich – xmACIS2 compares the data in the ACIS database to that in GHCN-Daily
Alan – Larry, the world’s most highly cited cat
Vincent – The Viral Paleontologist Who Unearths Pathogens’ Deep HistoriesRyan – Mpox emergencies AP News one and two
Rona – Up in smoke
David – Ode to Joy (YouTube, TikTok)Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
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In his weekly clinical update, Dr. Griffin discusses global transmission of mpox, the different clades of the virus and associated pathogenesis, vaccination vs antiviral therapy against mpox and the US’s aid response for controlling the African outbreak before reviewing the recent statistics on SARS-CoV-2 infection, authorization and approval of updated COVID vaccines, the economic benefit of an annual COVID vaccine and if the first updated vaccines against XBB.1.5 were effective, where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and how long COVID differs in children and adolescents.
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Links for this episode mpox epidemic caused by monkeypox clade I in affected African countries (European Centre for Disease Prevention and Control) mpox in Pakistan (Reuters) mpox imported into Pakistan (UNMC Global Center for Health Security) mpox domesticated in Taiwan (Focus Taiwan: CAN English News) clade IIb not Ib in Taiwan (bne Intellinews) WHO: mpox public health emergency of global care (NY Times) Vaccines didn’t turn back mpox…..people did (NY Times) Deadlier mpox version in Thailand (NY Times) Antiviral tecovirimat….not so much (NIH News) What about vaccines? (Bavarian Nordic) Invest or not to invest Barvaian Nordic pox vaccine manufacturer? (Yahoo! Finance) US to support Africa’s mpox response (CIDRAP) $35M to support mpox outbreak response in central and eastern Africa (USAID From the AMERICAN PEOPLE) COVID-19 deaths (CDC) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) FDA approves and authorizes updated mRNA COVID-19 vaccines (FDA) Novavax still working on updated COVID-19 vaccine (novavax) COVID-19 variant update (CDC & IDSA) Economic benefit of annual COVID-19 vaccination (JID) Early COVID-19 XBB.1.5 vaccine effectiveness (Influenza and other respiratory viruses) Uptake of COVID-19 vaccines and associated hospitalization due to COVID-19 in pregnancy (Vaccine) Novavax heterologous booster demonstrates lower reactogenicity (JID) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Breakthrough from pemivibart/permgarda (bioRxiv) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Long COVID differs in children and adolescents (JAMA Network) Letters read on TWiV 1142 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
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TWiV discusses the spread of monkeypox virus clade 1b in Africa, COVID drops to tenth leading cause of death in the US, response to detection of poliovirus in Gaza, mechanism of MIS-C after SARS-CoV-2 infection, neonatal Fc receptor is a pan-arterivirus receptor, and antiviral immunity in plants mediated by protein arginine methyltransferase 6.
Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker
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Links for this episode MicrobeTV Discord Server Mpox widespread in Africa (CIDRAP) Africa declares Mpox emergency (Science) COVID drops to 10th leading cause of US deaths (MMWR) Response to detection of poliovirus in Gaza (WHO) Molecular mimicry in MIS-C (Nature) Neonatal Fc receptor is pan-arterivirus receptor (Nat Comm) Antiviral immunity in plants by protein arginine methytransferase 6 (Cell Host Micr) Letters read on TWiV 1141 Timestamps by Jolene. Thanks! Weekly PicksBrianne – Kate Douglass: Olympian and Statistician (Swimming in Data)
Dickson – Women of recent note: Kamala Harris (Democratic Party presidential candidate); Katie Ladecky (10,000 meters); Sydney McLaughlin-Levrone (400 meter hurdles); Gabby Thomas, Sha’Carri Richardson, Melissa Jefferson, and Twanisha Terry (4 x 100 relay); women’s basketball team
Rich – Texas State University Forensic Anthropology Research Facility
Vincent – Sea lion ‘camera crews’ capture new footage of ocean floorIntro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
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In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID.
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Links for this episode Measles transmission after secondary vaccination failure (Emerg Inf Dis) Mpox public health emergency of international concern (WHO) First case of new mpox strain outside of Africa (Reuters) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Where to get pemgarda (Pemgarda CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) Individual monoclonal antibodies against SARS-CoV-2 should be used (CID) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Long COVID science, research and policy (Nature Medicine) Measurements of prior SARS-CoV-2 infection and postacute sequelae by the clinical laboratory (Annals of Internal Medicine) Risk factors for long COVID syndrome in postmenopausal women with previous SARS-CoV-2 infections (Annals of Epidemiology) New studies estimate long-COVID rates, identify risk factors (CIDRAP) Monitoring long COVID via telemedicine (PLoS One) Letters read on TWiV 1140 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
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Vincent travels to the Karolinska Institute in Stockholm on 31 May 2024 to meet with Dr. Judith Bruchfeld and discuss her research on the etiology and treatment of Long COVID.
Hosts: Vincent Racaniello
Guest: Judith Bruchfeld
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Links for this episode MicrobeTV Discord Server Immune system perturbations in Long COVID (J Immunol) Post-COVID immune system perturbations (J Immunol) Systems disregulation in Long COVID (Sci Rep) Clincal standards for diagnosing, treating, and preventing Long COVID (Intl J Tuberc Lung Dis) Timestamps by Jolene. Thanks!Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
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In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID.
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Become a patron of TWiV!
Links for this episode Harms of the lab leak hypothesis (Journal of Virology) Lab leak mania (PaulOffit, Substack) This is a special message: pandemic started in nature! (TWiV) RSV vaccine recommendations August 6 2024 (MMWR) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Where to get Pemgarda (Pemgarda) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Long COVID defined (NEJM) Contribute to our Floating Doctors fundraiser Lenacapavir on Puscast #60 Letters read on TWiV 1138 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
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TWiV discusses a twice-yearly antiviral for prevention of AIDS, the WHO pandemic plan, West Nile resurgence in the US, the BANAL SARS-CoV-2 related viruses reproduce in human cells but do not transmit among animal hosts, and an amino acid change in dengue virus that enhances midgut replication in mosquitoes but reduces pathogenicity in humans.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode MicrobeTV Discord Server PrEP with HIV-1 capsid inhibitor (NEJM) WHO pandemic plan (pdf) West Nile virus resurgence in US (NY Times) Properties of BANAL SARS-CoV-2 like viruses (Nat Micro) BANAL viruses on TWiV 809 Different effect of dengue virus amino acid change in humans and mosquitoes (Sci Transl Med) Eng Ong Ooi on TWiV 633 Letters read on TWiV 1137 Timestamps by Jolene. Thanks! Weekly PicksKathy – Using big data to improve traffic light timing
Listener Pick
Rich – Dillo Dirt
Alan – Dueling Banjos on banjo and kora
Vincent – The world’s most expensive dinosaur and moreMike – Science through a glass darkly
Lisa – On A Mission“ Season FourIntro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
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In his weekly clinical update, Dr. Griffin discusses how the pandemic may have effected our trust in physicians and hospitals and if waiting longer to make strain selection for the seasonal influenza vaccine would be advantageous before reviewing the recent statistics on SARS-CoV-2 infection, how different CVODI-19 vaccines effect the cardiovascular system, if the a third of either COVID-19 mRNA vaccine is effective, where to find PEMGARDA, if convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and the long term consequences of a SARS-CoV-2 infection on human health including incidences of diabetes, respiratory problems, hearing loss and maternal-fetal health.
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Links for this episode In physicians and hospitals, we trust (JAMA Network) Are there benefits for delaying seasonal influenza vaccine selections (JID) Personal protective effect for wearing surgical face masks in public spaces (the BMJ) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Cardiovascular safety of different COVID-19 vaccination(Nature Comm) Effectiveness of a third dose of mRNA-1273 versus BNT162b2 among older adults (Vaccine) Where to get pemgarda (Pemgarda) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Incidence of diabetes after SARS-CoV-2 infection (The Lancet Diabetes & Endocrinology) Post-COVID-19 respiratory sequelae two years after hospitalization (The Lancet Regional Health) Incidence of hearing loss following COVID-19 among young adults (eClinical Medicine) The effect of long-term COVID-19 infection on maternal and fetal complications (Scientific Reports) Contribute to our Floating Doctors fundraiser Letters read on TWiV 1136 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
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TWiV reviews whats going on with measles and its global resurgence, poliovirus found in Gaza, vaccine hesitancy in a community, 14 year old dies of Nipah, selection of SARS-CoV-2 viruses resistant to nirmatrelvir, and protective but non-neutralizing antibodies from survivors of Crimean-Congo hemorrhagic fever virus.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli
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Links for this episode MicrobeTV Discord Server What’s going on with measles? (J Virol) Poliovirus in Gaza (Science) Sanitation concerns in Gaza (AP) Community vaccine beliefs (PLoS One) 14 year old dies of Nipah in India (Hindustan Times) Selection of nirmatrelvir resistance mutants (Sci Adv) CCHFV monoclonal antibodies (Cell Rep) CCHFV vaccine (TWiV 565) Prometheus Project (TWiV 578) TWiV at USAMRIID (TWiV 1015) Letters read on TWiV 1135 Timestamps by Jolene. Thanks! Weekly PicksAngela – Animal research is not always king
Listener Pick
Brianne – Why the US has more tornadoes than any other country
Dickson – Earth’s core has slowed so much it’s moving backward
Alan – Article about the Smithsonian’s forensic ornithology lab, led by Carla Dove
Vincent – Seventh patient ‘cured’ of HIV: why scientists are excitedCharles – An Inquiry into Morals by Robert M. Pirsig and My Beloved Monster by Caleb Carr
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
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In his weekly clinical update, Dr. Griffin discusses Merck’s RSV preventative monoclonal antibody Clesrovimab before reviewing the recent statistics on SARS-CoV-2 infection, if previous SARS-COV-2 infections predict the outcome of subsequent infections, if using COVID rapid diagnostic tests is cost effective, if the protein based vaccine NVX-CoV2327 elicits a durable immune response, if combination treatment of vaccine and antiviral drugs effectively protect against hospitalization, where to find PEMGARDA, what do when healthcare workers succumb to SARS-CoV-2 infection, and how COVID-19 may alter the cognitive trajectories of older patients.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, emailBecome a patron of TWiV!
Links for this episode Clesrovimab, RSV preventative monoclonal antibody for infants (Merck) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Characterizing SARS-CoV-2 reinfections and long COVID (Communications Medicine) Cost-effectiveness of COVID rapid diagnostic tests (PLoS Medicine) NVX-CoV2373 against pre-Delta and Delta strains of COVID-19 little evidence of waning immune response (CID) Combined Protection of Vaccination and Nirmatrelvir-Ritonavir Against Hospitalization(CID) Pemgarda infusion center locator (Pemgarda) Respiratory virus guidance (CDC) Early phase of SARS-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection(Nature Aging) Contribute to our Floating Doctors fundraiser Letters read on TWiV 1134 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
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TWiV reviews cases of measles in Brooklyn NY and Washington DC, stalling of global childhood vaccination, licenses H5N1 vaccines protect against circulating strains, viruses traveling without passports. OC43 SARS-CoV- 2 spike replacement virus as an improved BSL-2 proxy virus for SARS-CoV-2 neutralization assays, and deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode MicrobeTV Discord Server Measles in Brooklyn NY (ABC) Measles in Washington DC (DC Health) Global childhood immunization stalls (WHO) Licensed H5N1 vaccines protect against circulating strains (Nat Med) Viruses moving without passports (European CDC) OC42-SARS-CoV-2 replacement spike virus (PNAS) Deep mutational scanning of Lassa virus glycoprotein (Immunity) Letters read on TWiV 1133 Timestamps by Jolene. Thanks! Weekly PicksDickson – Elemental sulfur found on Mars
Kathy – Lennette Lectures at ASV, including Gail Wertz, ASV 2024
Rich – Electricity maps (Opinions: Nuclear Waste Is Misunderstood; Should We Be Worried About Nuclear Waste?)
Alan – Nature sent an investigative reporter to a predatory conference
Vincent – Coal-filled trains are likely sending people to the hospitalIntro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
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In his weekly clinical update, Dr, Daniel Griffin reviews President Biden’s case of COVID, reviews recent statistics on SARS-CoV-2 infection, discusses post-acute sequelae after infection during pregnancy, the use of nirmatrelvir-ritonavir for post-exposure prophylaxis, where to find Pemgarda, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment, effectiveness of Ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment in patients hospitalized with COVID-19, CDC update of Long COVID Basics page, postacute sequelae of SARS-CoV-2 infection in the pre-delta, delta, and omicron eras, Long COVID risk has dropped over time but remains substantial, efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID, and the interplay between diet and the gut microbiome: implications for health and disease.
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Links for this episode President Biden has COVID (CNN, USA Today) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Post–acute sequelae of COVID after infection during pregnancy (OB & Gyn) Oral nirmatrelvir–ritonavir as postexposure prophylaxis for Covid-19 (NEJM) Pemgarda infusion center locator (Pemgarda) Unable to access pemgarda, gotta call Daniel (microbeTV) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Combined treatment of COVID reduces molnupiravir-induced mutagenicity (J Inf Dis) Effectiveness of ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19 (Inf Dis Therapy) Comparative effectiveness of combination therapy with nirmatrelvir–ritonavir and remdesivir versus monotherapy (Lancet) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) Isolation guidance (CDC) Managing healthcare staffing shortages (CDC) Steroids, dexamethasone at the right time (OFID) Anticoagulation guidelines (hematology.org) Long COVID is defined (National Academies) Long COVID: the ANSWERS! (longcovidtheanswers.com) The FACTS: post COVID-19=long COVID? (WHO) The BASICS of long COVID-19 (CDC) Postacute sequelae of SARS-CoV-2 infection in the pre-delta, delta, and omicron eras (NEJM) Long Covid risk has dropped over time but remains substantial (CNN) Efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID (Clin Micro Inf) Diet and the gut microbiome: implications for health and disease (Nat Rev Micro) Contribute to our Floating Doctors fundraiser Letters read on TWiV 1132 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
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TWiV reviews the potential impact on science of the Supreme Court ruling in the Chevron decision, measles in New Hampshire and Vermont, new who proposed terminology for respiratory pathogen transmission, and pathogenicity and transmission of bovine H5N1 influenza virus.
Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit
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Links for this episode MicrobeTV Discord Server Articles on Chevron decision (one, two, three) Measles in New Hampshire and Vermont (NH DHHS) Pathogenicity and transmission of bovine H5N1 virus (Nature) Letters read on TWiV 1131 Timestamps by Jolene. Thanks! Weekly PicksDickson – Stockholm Wood City
Listener Picks
Rich – “The Wide Wide Sea” by Hampton Sides
Vincent – Tour de France stage 12Amy – Earth Forced from the Protective Heliosphere: What Do We know?
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
Content in this podcast should not be construed as medical advice.
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In his weekly clinical update, Dr. Griffin discusses H5N1 influenza in the bird and cow communities of Colorado and Michigan and dengue in New York and the US before reviewing the recent statistics on SARS-CoV-2 infection, the absence of association with proton pump inhibitors and COVID-19 severity in children, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, a resource of long COVID answers, how the WHO and CDC define long COVID and how it compares to ME/CSF.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, emailBecome a patron of TWiV!
Links for this episode H5N1: birds and cows oh, my…..Michigan and Colorado (CIDRAP) Flu pandemic for the Colorado chicken (Colorado Sun) It’s a disaster: Avian flu in Weld county (Colorado.gov) More 9.7 million dengue cases in US this year: CDC issues warning (Patch.com) Long Island has DENGUE! (Long Island News12) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Association between proton pump inhibitors and COVID-19 susceptibility or severity in children? (Journal of Pediatrics) Where to get pemgarda (Pemgarda) Unable to access pemgarda, gottacall Daniel (microbeTV) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Benefits of desamethasone, reversal of monocyte dysfunction for severe COVID-19 (Cell) Anticoagulation guidelines (hematology.org) Long COVID: the ANSWERS! (longcovidtheanswers.com) The FACTS: post COVID-19=long COVID? (WHO) The BASICS of long COVID-19 (CDC) Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness (CDC) Contribute to our Floating Doctors fundraiser Letters read on TWiV 1130 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
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TWiV reviews measles in Kenya, a trial for a intranasal COVID vaccine, dengue in the Florida Keys and in Central/South America, Spain connecting government with scientists, T cell activation and viral RNA fragments persist for up to 2 years after SARS-CoV-2 infection, and durable cross-reactive and protective antibodies against avian N2 neuraminidases elicited by A(H2N2) and A(H3N2) influenza pandemics.
Hosts: Vincent Racaniello and Alan Dove
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email
Become a patron of TWiV!
Links for this episode MicrobeTV Discord Server Measles in Kenya (WHO) Intranasal COVID vaccine trial (NIH) Dengue in Florida Keys (Florida Health) Dengue rising in Central/South America (NPR) Spain to connect scientists with government (Science) Persistence of T cells and viral RNA after SARS-CoV-2 infection (Sci Transl Med) Influenza pandemics induce cross-reactive antibodies against avian N2 (Nat Comm) Letters read on TWiV 1129 Timestamps by Jolene. Thanks! Weekly PicksAlan – The first few minutes of this video by Roger Barnes
Listener Picks
Vincent – Billy & Molly: An Otter Love StoryFernando – A City on Mars
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
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In his weekly clinical update, Dr. Griffin discusses the fourth US case of H5N1 human infection and reminds the audience of the definition of “pasteurization” before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, how an EEG can be used to look for signatures of cognitive decline after SARS-CoV-2 infection and what we observed 2 years following SARS-CoV-2 infection for tissue-resident T cell and viral RNA persistence.
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, emailBecome a patron of TWiV!
Links for this episode Fourth case human infection associated with an ongoing multistate outbreak of A(H5N1) (CDC) Human H5N1 in Colorado and thedefinition of pasteurization (CIDRAP) Is “raw” milk more risky than pasteurized (Annenberg Public Policy Center) COVID-19 national trend (CDC) COVID-19 deaths (CDC) Winter, spring, summer and fall COVID-19 surges? (CDC) Where to get pemgarda (Pemgarda) Unable to access Pemgarda, gotta call Daniel (microbeTV) CDC Quarantine guidelines (CDC) Early phase of SARs-CoV-2 infection (COVID.gov) NIH COVID-19 treatment guidelines (NIH) Infectious Disease Society guidelines for treatment and management (ID Society) Drug interaction checker (University of Liverpool) Molnupiravir safety and efficacy (JMV) Molunpiravir works: reduces hospitalizations and deaths due to COVID-19 and all-cause mortality (CID) Convalescent plasma recommendation for immunocompromised (ID Society) What do when your heathcare provider is infected with SARS-CoV-2 (CDC) Managing healthcare staffing shortages (CDC) Steroids,dexamethasone at the right time (OFID) Benefits of dexamethasone, reversal of monocyte dysfunction for severe COVID-19 (Cell) Anticoagulation guidelines (hematology.org) EEG signatures for cognitive decline after SARS-CoV-2 infection (BMC Medicine) Tissue resident T-cells and viral RNA 2 years after SARS-CoV-2 infection (Science Translational Medicine) Contribute to our Floating Doctors fundraiser Letters read on TWiV 1128 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene. Thanks!Intro music is by Ronald Jenkees
Send your questions for Dr. Griffin to [email protected]
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