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In this episode, we discuss eye-tracking as an early biomarker for Autism. Eye-tracking, on infants, improve assessment outcomes at young ages, as young as 14-months-old. Adding biomarkers to the assessment process is valuable, and Autism research is beginning to offer more biomarkers. We've covered biomarkers in cellular respiration, serotonin, two studies on 6-week-olds- 1) predicted profound Autism with brain cortical organoids and 2) salience network connectivity. Today, we review four scientific papers on eye-tracking being added to the assessment process.
A valuable consideration is the roles our eyes have on brain development, which we cover as well.
Pierce et al 2019 https://pubmed.ncbi.nlm.nih.gov/31034004/
Wen et al 2022 https://www.nature.com/articles/s41598-022-08102-6
Keehn et al 2024 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2818669
Early Autism Evaluation (EAE) https://medicine.iu.edu/expertise/indiana-health/access-to-care/autism/care
Rudling et al 2024 https://journals.sagepub.com/doi/full/10.1177/13623613231203037
The Roles of Oxytocin and Vasopressin in the Autistic Phenotype https://www.youtube.com/watch?v=DAtmC-s1_e0
0:00 Intro; 2 studies on 6-week-olds; Eye Development and Brain Development, Opsins
5:23 OCT (Optical Coherence Tomography) scans and Brain predictors, Melanopsin and Choroid Plexus
7:06 Melanin and Melanopsin through the body and biochemistry
8:39 Fruit Tree Example from Dr. Kruse
9:29 Eye-tracking and Autism as a Biomarker; Neuroplasticity- Human's capacity to think; Autism is NEW in human evolution
14:05 Social Attention; Oxytocin- magnocellular and parvocellular; Objects over People; Gaze Following
17:21 Gaze Attention
18:02 Joint Attention
19:12 Studies on Infants; Pierce et al, 2019
25:00 Wen et al, 2022
27:03 Keehn et al, 2024 and Early Autism Evaluations (EAE)
29:25 Rudling et al, 2024
32:15 Wrap-Up/Final Thoughts
34:55 Reviews/Ratings, Contact Info
X: https://x.com/rps47586
Hopp: https://www.hopp.bio/fromthespectrum
email: [email protected]
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For this episode, we discuss the roles and sensitivity of mitochondria with Dr. Richard Frye, MD, PhD. Dr. Frye received an MD and a PhD in Physiology and Biophysics from Georgetown University. He is board certified in Pediatrics, Neurology with special competence in Child Neurology, and as a Certified Principal Investigator. In addition, he has a Masters in Biomedical Sciences and Biostatistics from Drexel University. Dr. Frye has over 300 publications in leading journals and book chapters.
He currently sees patients as a Neurologists and Director of Research at Rossingnol Medical Center and at Neurodevelopmental Precision Medicine. In 2022, Dr. Frye co-founded the Autism Discovery and Treatment Foundation where they are dedicated to discover biomarkers, metabolic endophenotypes, and treatments for neurodevelopemental disorders.
Dr. Frye shares many figures during the conversation so the listener can follow along.
Dr, Richard Frye https://drfryemdphd.com
CV https://wparticles.seek2understand.org/wp-content/uploads/2023/02/DrFryeCVJan2023.pdf
Rossingnol Medical Center Facebook https://www.facebook.com/RossignolMedicalCenter
Neurobiology of Disease 2024 paper https://www.sciencedirect.com/science/article/pii/S0969996124001190?via%3Dihub
Autism and GI, and exploring how changes in Light have major implications (Apple) https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000664349495
0:00 Dr. Richard Frye
6:13 Intro into mitochondria & energy production, various disease & dysfunction
11:16 Mitochondrial DNA, sensitivity, and the roles with epigenetics
16:16 Biomarkers of mitochondrial dysfunction, delicate delivery (space and time) into the electron transport chain
20:58 Cytochrome C Oxidase (complex IV); Carnitine, Fat, and Creatine
26:57 Molecules connected to aging & cellular respiration, environemental signals implicating mitochondria
30:26 Terrible Trio: oxidative stress, mitochondria dysfunction, immune/inflammation, DAMPS & inflammation
34:29 Environmental risks for the Embryo, overreactivity of mitochondria (200%) and physiological insults and regression
42:50 Tryptophan (aromatic amino acid), NAD, and Gastrointestinal biosynthesis
45:52 Light as an environmental change factoring into the Autistic Phenotype, Infant Tree and Adult Tree examples; Vitamin D (skin & brain are connected through Neuroectoderm)
54:54 Future Research
59:58 Wrap up, Reviews/Ratings
X: https://twitter.com/rps47586
Hopp: https://www.hopp.bio/fromthespectrum
email: [email protected]
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In this episode, we discuss the mitochondria. You know mitochondria as the "powerhouse" of the cell, but this biological process is biophysics meeting biochemistry. We discuss glycolysis, the TCA cycle (or Citric Acid cycle or Krebs cycle), and Oxidative Phosphorylation. This discussion goes deep inside the atomic molecular level with electrons and protons. Hang in there with the discussion and topic of Autism and understanding of the generational link to a loss of electrons.
Jack Kruse https://www.patreon.com/DrJackKruse/posts
Glycolysis https://www.ncbi.nlm.nih.gov/books/NBK470170/#:~:text=Glycolysis%20is%20a%20central%20metabolic,use%20in%20other%20metabolic%20pathways.
Citric Acid cycle https://en.wikipedia.org/wiki/Citric_acid_cycle
Oxidative Phosphorylation https://en.wikipedia.org/wiki/Oxidative_phosphorylation
0:00 Intro; Light, water, magnetism; The "powerhouse" and understanding of healthy living organisms and different cell types; Photosynthesis and Cell Respiration
4:11 Prokaryotes, Eukaryotes, and Cytochrome C Oxidase (CCO)
6:53 Mitochondria and Cellular Respiration 1) Glycolysis, 2) Citric Acid cycle, and 3) Oxidative Phosphorylation (OXPHOS)
8:25 Glycolysis
10:03 Citric Acid cycle
12:02 OXPHOS
13:51 Cytochrome I
15:07 Cytochrome II
16:08 Cytochrome III
17:10 Cytochrome IV and creating water
19:56 Not all water is equal/same; Aging; Light and Melanin and Rates of Autism
29:20 Cytochrome V and ATPase; Chromophores
33:56 Evolution and losing electrons; Autism and modern health complications
37:50 Environmental signals due DNA sequencing; Autism research and Genetic studies
40:23 Reviews/Ratings and contact info
X: https://twitter.com/rps47586
Hopp: https://www.hopp.bio/fromthespectrum
email: [email protected]
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In this episode, we challenge the modern trend of Autism and ADHD comorbid diagnosis. We will use children from Kanner and Asperger to show these so-called ADHD symptoms are simply parts of the Autistic Phenotype. However, society finds it easier to lump these two conditions together, and we question why. We review both, the inattentive criteria and the hyperactivity and impulsivity of ADHD and explain when the Autistic phenotype exhibit these conditions.
The criteria for ADHD are downstream behaviors seen across multiple reasons and act as a collect-all. I did not say ADHD does not exist, but I do say Autism and ADHD existing simultaneously seems unlikely if you really understand the phenotypes. Might it just be easier for society to lump these together instead of challenging the differences?
B.3 and Inattention are complete opposites. Hyperactivity and Impulsivity can show up when anyone is in the wrong or horrible environment.
Autism and ADHD https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8918663/
Leo Kanner http://www.autismtruths.org/pdf/Autistic%20Disturbances%20of%20Affective%20Contact%20-%20Leo%20Kanner.pdf
Hans Asperger https://psycnet.apa.org/record/1992-97284-002
0:00 Intro; Brief Note on how environmental signals such as electromagnetic fields (EMF, i.e., Light) informs the genes on how to respond, and how disease manifests
2:51 Autism and ADHD; Neurodiversity; and some problems in society
7:58 Core of Autism- B.3, and Donald Triplett example; B.2 and Social Communication
13:27 Autistic Phenotypes
19:01 ADHD Phenotypes
21:41 Specifiers and Lumping Contrasting Phenotypes
33:18 Medication and ODD (Oppositional Defiant Disorder) Rant
35:42 Autism conundrum with ADHD
38:45 Reviews/Ratings and Contact Info
Hopp: https://www.hopp.bio/fromthespectrum
X: https://twitter.com/rps47586
email: [email protected]
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My guest today is Jonathan Mitchell. Jonathan is a senior citizen Autistic, Author of numerous novels and blogs, and stands up for the purpose of Autism. His blog, Autism Gadfly, provides perspectives of Autism otherwise not considered by the lay-public or researchers in Autism. Jonathan's views have been mentioned in Newsweek, NPR, Autism Daily Newscast, and HuffPost.
Jonathan was born in 1955 in Los Angeles. We discuss his experience at an early age including psychoanalytic therapy, psychological assessment, and troubles through education. Eventually, Jonathan and his family learned about Autism while on a trip to the East. Jonathan faced many challenges through his education in different schools beginning in kindergarten. However, Jonathan graduated from UCLA with a bachelors of arts in psychology.
We also discuss challenges in professional and personal life as an adult where he faced various barriers. In the early 2000s, when the internet allowed for different communication platforms, Jonathan began to call out things wrong in Autism. In addition, he carries a loud voice for a cure/treatment for Autism. Recently, you can find him on X as he continues to be a voice for the Autistic community.
The Mu Rhythm Bluff https://www.amazon.com/Mu-Rhythm-Bluff-Jonathan-Mitchell-ebook/dp/B00BQN84GM/ref=sr_1_1?crid=2UHATAWKAT5YA&dib=eyJ2IjoiMSJ9.eocnp6hSIjLZqAuzxnIcPw.vv03H-Vx-BeqtHx4_dYo4W6QomZdOkuZ4JEBPgbA-IQ&dib_tag=se&keywords=the+mu+rhythm+bluff&qid=1724157644&sprefix=the+mu+rhy%2Caps%2C104&sr=8-1
X: https://twitter.com/autismgadfly
Jonathan Mitchell website http://www.jonathans-stories.com
Wikipedia https://en.wikipedia.org/wiki/Jonathan_Mitchell_(writer)
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Hans Asperger called the children "little professors"- This is Autism.
In this episode, we explore criteria B.3, which is the core of Autism. Donald Triplett's father's first sentence to Leo Kanner- He seems self-satisfied.
Leo Kanner http://www.autismtruths.org/pdf/Autistic%20Disturbances%20of%20Affective%20Contact%20-%20Leo%20Kanner.pdf
Hans Asperger https://psycnet.apa.org/record/1992-97284-002
Erwin Schrödinger https://en.wikipedia.org/wiki/Erwin_Schrödinger
0:00 Intro, Erwin Schrödinger and Leo Kanner; Light gives Life to Cells
2:29 B.3
5:15 Hans Asperger, Autist
7:19 Leo Kanner
8:31 Paths to Superpowers; Autism and Education; Medicine and Charles Sidney Burwell
13:50 Personal Experiences; Vietnam War; B.2 complications with B.3
15:22 Baseball Game and Probability
16:52 Adult Examples
17:55 1950s and Novel- example of Abnormal B.3; Thinking in Pictures and Supplementing Relationships
21:29 Disruptions from unplanned or outside interference; Medication Approach and Warning
23:36 Unusual Objects; ADHD prep; Finding interests in Life
26:31 Check-Out lanes and Autism; Self-Satisified- This is Autism
28:53 Circumscribed
31:36 Perseverative; The Nervous System
35:44 Bible; Inner-focus using B.3 as a Superpower and directing focus
39:16 Dogs and Snakes
39:50 Autistic Phenotype and B.3 at the Center
40:30 Reviews/Ratings and Contact Info
X: https://twitter.com/rps47586
Hopp: https://hopp.bio/fromthespectrum
email: [email protected]
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In this episode, we explore typical topics with Autism research and try to understand the purpose. Autism research is confounding, and maybe, lacks direction. We offer a research suggestion based on the most plausible cause of Autism- the new modern day environmental factor- Artificial Light. Remember, Autism just shows up, so it makes sense to send the mother and father back to an environment pre-Autism.
Quantum Biology https://www.patreon.com/DrJackKruse/posts
Photobiological Implications of Folate https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862485/
B9 (folate) and B12 (cobalamin) are Photoreceptors, too.
0:00 Autism Research Direction and missing the beginning; Is it Click-Bait?; Confounding
3:30 Changes in Light and the Full Spectrum; the number of Genes involved with Autism Research
5:07 Genetic Variants, Copy Number, Duplications, Deletions
7:04 Gene-Envrionment Interaction; MTHFR; Methylation, Myelin
13:03 Brain Connectivity and Neurobiology
13:55 Socio-Environmental/Socioeconomic; Robert Sapolsky
14:25 Early Diagnosis and Bio-markers
14:47 Comorbid Conditions
16:05 Personalized Interventions
16:27 Medications and the PROFIT MILL
18:36 Today's Purpose; Parental Melanin, Artificial Light, and nnEMF
19:30 Research Idea with 3 Groups and Returning the Environment before Autism magically shows up
25:17 Shift-Work Warning
26:20 Back to Autism; Amish
29:07 Reviews/Ratings, Contact Info
X: https://twitter.com/rps47586
Hopp: hopp.bio/fromthespectrum
email: [email protected]
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In the episode, we will explore a common problem with Autism- the Gastrointestinal Tract. The one consistent finding with Autism and GI is a problem exists. However, research on complicated in these complicated and complex areas of human biology despite what appears to be tight controls in the studies. However, one crucial component is missing- Light. In this episode, we will cover how biology structures order from the light input and the chaos from the environment.
Major Areas include Enterochromaffin Cells, Serotonin, Aromatic Amino Acids, Vitamin D, Enteric Nervous System, the endocrine systems, and the Hypothalamic-Pitutary-Adrenal Axis.
Cause of Autism: https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496
Su study: https://www.nature.com/articles/s41564-024-01739-1
Sunlight and Vitamin D: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897598/
Multi-Axis-Meta-Analysis https://www.nature.com/articles/s41598-022-21327-9
Quantum Engineering 33, 54, and 55 https://www.patreon.com/DrJackKruse/posts
(0:00) Autism and the GI Tract; inconsistent research; Order versus Chaos- Light and Environment and Health Conditions
(3:10) The GI Tract; Gut-Brain Axis; Gut Microbiome and Various Nervous Systems
(6:22) POMC; HPA; Stress example
(8:19) Common Autism problems in the GI
(9:23) Enterochromaffin Cells; Serotonin; Immune and Inflammation
(14:09) Melanin/POMC; Clock-Timing; Omentum
(16:31) Real-life Acute GI Fix; Bacteria makes Dopamine in the Gut
(19:04) Vitamin D Receptors and more Clock-Timing
(22:13) Obesity and Autism connection? (uncoupled systems); Biosynthesis of Vit D and specific Wavelength of Light with Shared Biological Processes- DNA, RNA, Aromatic Amino Acids
(24:33) Avoiding UV Light implications
(26:18) Scientific Literature; Archaea, Bacteria, Fungi, Virus; "confounding" data
(30:03) Ubiquinol-7, COQ10, Thiamine Diphosphate; TCA cycles
(32:38) Controls (plural) in Research and lack of Control (singular); LIGHT is GREATER than FOOD
(38:27) Reviews/Ratings and Contact Info
X: https://x.com/rps47586
Facebook: https://www.facebook.com/fromthespectrum.podcast
Email: [email protected]
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In this episode, we explore Autism developing in the embryo. We will review a couple Scientific papers discussing specific time frames of development within the embryo based on each trimester and specific cellular abnormal processes occurring. We will connect previous biological and environmental components and how it influences the creation of Autism and previous episodes of From the Spectrum podcast.
Remember in the Cause of Autism episode- Light, Water, Magnetism, Periodic Elements, Vitamins, and Proteins because they are involved. During the episode, we review risk-genes and how this could be the wrong direction for Autism research. As a counter, I provide where research and funding needs to focus- pregnancy.
Cause of Autism https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000662271496
Eric Courchesne https://profiles.ucsd.edu/eric.courchesne
Prenatal Origins of ASD: The When, What, and How of ASD Development https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(20)30051-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0166223620300515%3Fshowall%3Dtrue
The ASD Living Biology: from cell proliferation to clinical phenotype https://www.nature.com/articles/s41380-018-0056-y
Leukocytes and Melanin Pigmentation https://core.ac.uk/download/pdf/81931995.pdf
mTOR and PTEN https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9743803/
Cancer Drug for "Autism" https://neurosciencenews.com/asd-cognition-cancer-pharmacology-26481/
0:00 Autism and the Embryo; Review of previous developmental milestones, and the processes and "ingredients" used in our Biology
5:45 Cellular processes; ASD Living Biology; becoming the complex living organism
8:17 1st Trimester: Proliferation, neurogenesis, migration
8:46 2nd Trimester: Neurite overgrowth, synaptogenesis and synaptic function
9:12 3rd Trimester: Neural networks
9:33 Epoch 1 and 2
13:04 Scientific Literature; risk-genes; send research and funding to pregnancy
17:57 Abnormal brain development in the embryo
21:39 Excitation and the risk-genes and consequences to the Nervous System
24:36 Be cautious of research direction; MEDICATION and MEDICAL PARADIGM RANT
29:32 Connecting Light and Abnormal Development across the Body- Example Melanin and Leukocytes
33:12 Recap on the Past 3 episodes
36:00 Reviews/Ratings and Contact Info
X: https://twitter.com/rps47586
Facebook: https://www.facebook.com/fromthespectrum.podcast
Email: [email protected]
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In this episode, we explore some critical dates and understanding of Autism. We will time travel from 1911 to 2024 with a goal of understanding why the sharp increase in Autism diagnosis of late. We review the closeness of schizophrenia and the separation from schizophrenia. In addition, we will review Autism becoming a separate diagnosis in the DSMs from the 1980s and review the closeness of Vaccines and Assessment Standardization that parallels this time. Hopefully, some consideration about the rates of Autism are presented.
Top Revenue Business Types- Not good. https://www.ibisworld.com/united-states/industry-trends/biggest-industries-by-revenue/
Bayh-Dole Act https://www.govinfo.gov/content/pkg/USCODE-2011-title35/html/USCODE-2011-title35-partII-chap18.htm
How Autism became Autism https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757918/#bibr56-0952695113484320
Eugon Bleuler DEMENTIA PRAECOX OR THE GROUP OF SCHIZOPHRENIAS https://philpapers.org/archive/BLEDPO-2.pdf
Dr. Catherine Lord https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000659246090
(0:00) Intro, Classifications, Symptoms, Schizophrenia, DSM, Assessments, Vaccines and Bayh-Dole Act
(3:21) 1911; Twilight Peaks; Psychoanalysis; Eugon Bleuler; Early Autism
(10:37) 1959- Separating from Schizophrenia; Generational Lineage; Visual Imagery; Communication Problems are noticed
(14:21) The DSM and the Development of Autism Diagnosis
(17:32) Assessments becoming Standardized
(20:22) Vaccines and the Bayh-Dole Act of 1980; Vaccine Schedule and Centralized Medicine and Revenue
(25:06) 1980s-2000 emergence of Diagnosis and Assessments; Rates of Autism and Explainations
(30:03) Reviews/Ratings and Contact Info
X https://twitter.com/rps47586
Facebook https://www.facebook.com/fromthespectrum.podcast
Email [email protected]
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Autism just magically shows up.
In this episode, we explore neuroplasiticity in our biology for one common environmental change- Light. Please consider 1) Critical Thinking and 2) Curiosity as we travel upstream in the biological implications causing Autism. In addition, we will explore other common health conditions related to Light. These health conditions are dementia, type 1 diabetes, obesity, type 2 diabetes, cancer, and cardiovascular diseases.
The episode will discuss light as an electromagnetic strip and how our biology uses this energy. We discuss the embryo, neuroectoderm (brain and skin), proteins being wide-band gap semiconductors, photoelectric effect, cytochromes and mitochondria, chromophores, and related topics.
"... I realized that all biochemistry is the bridesmaid to physics. I then realized that physics are how the business of cells gets completed. Light is the biophysical levers that control substrate level biochemistry in cells." - Dr. Jack Kruse
(Start here) Regenerative Health with Dr. Max Guhlane and Dr. Jack Kruse https://www.youtube.com/watch?v=Ln3WszTq0uA
Tetragrammaton with Rick Rubin, Jack Kruse, and Bill Gifford https://www.youtube.com/watch?v=EHe78j9UrMI
Tetragrammaton with Rick Rubin, Jack Kruse, and Andrew Huberman https://www.youtube.com/watch?v=oK9_j6fa2P4
Decentralized is the way (The Status Quo is NO GOOD) https://www.youtube.com/watch?v=VO4JwdXuXXs
Tryptophan Biosynthesis https://faseb.onlinelibrary.wiley.com/doi/epdf/10.1096/fj.04-2079rev
Autism and Vit Bs and Serotonin https://www.patreon.com/posts/quantum-19-74498277
Autism and Melanin https://www.patreon.com/posts/quantum-45-83724567
Regions of Interest:
Atoms,
Aromatic Amino Acids,
Artificial Light,
Chromophores,
Cytochromes,
Electromagnetic,
Embryo,
Folate Acid (and Folic Acid)
Sunlight,
Melanin (Neuromelanin),
Melanocytes,
Melanogenesis,
Melanopsin,
Mitochondria,
Neuroectoderm,
Neuroplasticity,
Periodic Elements,
Photoelectric Effect,
Pro-opiomelanocortin (POMC)
Proteins (wide-band gap semiconductors),
Serotonin,
Tryptophan Hydroxylase 1 and 2,
Vitamins A, b9 (Folate/Folic Acids), B12, and D,
Water
X: https://twitter.com/rps47586
Facebook: https://www.facebook.com/fromthespectrum.podcast
Email: [email protected]
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In this episode, we discuss Autism with Dr. Leanna Hernandez. Dr. Hernandez is an Assistant Professor in the Department of Psychiatry and Biobehavioral Sciences at UCLA and director of the Hernandez Lab. She is a member of UCLA’s Center for Autism Research and Treatment, Center for Neurobehavioral Genetics, and the Brain Research Institute, and serves as Co-Director of the Genetics, Genomics, and Informatics Core for UCLA’s Intellectual and Developmental Disabilities Research Center.
Hernandez Lab https://www.hernandezlabucla.org
Additive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism https://www.nature.com/articles/mp2016209
Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity https://www.nature.com/articles/s41398-020-0750-9
Oxytocin and Vasopressin and the Autistic Phenotype https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000660031273 https://www.youtube.com/watch?v=DAtmC-s1_e0
(0:00) Intro; Dr. Leanna Hernandez
(2:24) Autistic Phenotypes
(4:13) Dr. Hernandez education journey into Autism and the Hernandez Lab
(9:03) 2017 Paper Oxytocin Receptor Gene, Common Genetic Variance, Single Nucleotide Polymorphisms (SNP), and Reward and Social Processing and the Nucleus Accumbens (NAc)
(15:10) Differences in Brain Connectivity between Autistics and Non-Autistics
(20:06) Social Cognition, Boy Bias in Autism; GENDAAR Consortium and Sex- and Diagnosis-Differences
(21:48) GENDAAR
(22:45) Boys versus Girls Connectivity involving the NAc with and without Autism
(25:38) Different Connectivity correlated with Different ADOS scores for Repetitive Behaviors
(26:35) Female Protective Effect for Autism; Camouflaging/Masking
(30:19) The Assessment process for Girls and the Oxytocin Receptor Gene Sex Differences and Socialness and understanding the Boy Bias
(32:48) Current Research and a Genome Wide approach and Polygenic Risk Scores
(35:10) Oxytocin and Excitation/Inhibition
(37:08) Sharing Information and Current Research
(41:45) The Future of Autism Research
(45:48) Reviews/Ratings and Contact Info
email: [email protected]
X: https://twitter.com/rps47586
Facebook: https://www.facebook.com/fromthespectrum.podcast
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We expand on a critical network discussed in the Autism and Adaptive Responses episode. The biology that gives us Autism, gives us a condition the outside world is chaotic. The trade off is our inner world is comfortable. See criteria B.3.
The Salience Network is used to determine what we send our attention to as we orient ourselves with the outside world. You can see this in Autism versus Non-Autism. Autistics orient to single objects or single interests more than multiple objects or interests. That's Criteria B of Autism- Restricted, Repetitive Interests, Behaviors, or Activities.
In Autism, the Salience Network connects to different regions compared to Non-Autism, and this is shown at Six-Weeks-Old. And, this implicates our Social Attention and Social Motivation. Remember Hans Aspergers called the children "little professors" because Autism provides a path of Superpowers based on those fixated interests that are "abnormal in intensity or focus."
Covered Here. Also, we prepare for another discussion with a leading scientist from UCLA.
Study on Six-Week-Old https://www.nature.com/articles/s42003-024-06016-9
GENDAAR https://pubmed.ncbi.nlm.nih.gov/34050743/
(0:00) Intro; Human's Capacity to Think; the Salience Network and the NAc
(2:56) Insula
(4:47) Defining the Salience Network and Salience Detection; getting "hijacked" and metabolic bank account
(7:42) the Biology that gives us Autism causes a Chaotic outside world
(9:00) Returning to Six-week-olds and the Salience Network
(10:28) The Prefrontal Cortex and Human Cortex quiets things so we can properly evaluate things
(13:52) Salience Connections of six-week-olds; social attention at 3-12 months; Autistic traits at 12 months
(17:40) Sex-and-Diagnosis Differences; GENDAAR study using 8-17 year olds; Salience Network and Sensorimotor and Repetitive Behaviors
(20:47) Second Key Finding and possible cause of Boys Bias with Autism
(21:30) The Nucleus Accumbens- Reward Hub; Two Parts; shell and core
(25:20) Preparing for a future episode
(30:27) Reviews/Ratings and Contact Info
Facebook https://www.facebook.com/fromthespectrum.podcast
Email: [email protected]
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In this episode, we explore Oxytocin and Vasopressin's vast roles in Human Biology. We time travel to cover the evolution of the two molecules and learn about their functions with developing and socializing. Oxytocin and Vasopressin are dynamic molecules whereby they are Peptides and Hormones. In addition, we cover previously discussed brain regions and how the molecules work alongside key Neuromodulators like Serotonin and Dopamine.
Social Reward https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214365/
Social Reward Requires Oxytocin and Serotonin in Nucleus Accumbens (Parvo Path) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091761/
Magnocellular and Parvocellular social Information Processing https://www.cell.com/neuron/fulltext/S0896-6273(20)30770-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627320307704%3Fshowall%3Dtrue
Magnocellular and Parvocellular https://onlinelibrary.wiley.com/doi/10.1111/jne.12284
Meta-Analysis of Intranasal https://pubmed.ncbi.nlm.nih.gov/?term=intranasal+oxytocin+autism&sort=pubdate&filter=pubt.meta-analysis
https://pubmed.ncbi.nlm.nih.gov/33400920/
Intranasal Review https://pubmed.ncbi.nlm.nih.gov/38579916/
(0:00) Intro; Oxytocin and Vasopressin; Episode Objectives
(2:46) Oxytocin and Vasopressin; 700 million year time travel (Phylogeny)
(4:12) Peptides and Hormones; Modes of Transmission- Endocrine, Paracrine, Synaptic
(6:35) Proteins and Peptides; Amino Acids and Aromatic Amino Acids and Light
(8:58) Magnocellular and Parvocellular
(12:33) Roles of Oxytocin and Vasopressin and connections to various Brain Regions
(22:20) Scientific Literatures
(27:12) Oxytocin and Serotonin; 1) Reward Processing, 2) Fear Response, 3) Social-Emotional Processing
(30:07) Oxytocin and Dopamine
(31:08) Dopamine Receptors
(31:37) GABA
(33:57) Intranasal Oxytocin
(36:08) Take aways from Intranasal Literature
(37:24) Biggest Take Away (Magnocellular versus Parvocellular and Intranasal Administration)
email: [email protected]
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In this episode, we discuss Autism with Dr. Catherine Lord. Dr. Lord is a Distinguished Professor of Psychiatry and Education at UCLA and one of the foremost researchers in Autism. Dr. Lord provides tremendous insights into her roles in Autism and Autism Assessment.
Dr. Lord discusses her journey into Autism, the evolution of the Assessment including the ADOS growing from her basement and being overran by demand to the Gold Standard, the Challenges with understanding the Spectrum, updates on the Lancet Commission and Profound Autism, and Barriers in the Medical and Educational Systems.
Dr. Catherine Lord:
https://www.semel.ucla.edu/autism/team/catherine-lord-phd
https://childmind.org/bio/catherine-lord-phd/
https://labs.dgsom.ucla.edu/lord/pages/our_team
The Lancet Commission https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01541-5/abstract
The Lancet https://pubmed.ncbi.nlm.nih.gov/30078460/
Nature Reviews Disease Primers https://pubmed.ncbi.nlm.nih.gov/31949163/
Autism and Education https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000656055638
https://music.amazon.com/podcasts/d948fecc-8cfa-4203-8493-a12d2c9c92ed/episodes/bf7ce843-0dd2-4fe8-b800-82ea9cace96d/from-the-spectrum-finding-superpowers-with-autism-autism-and-education
The mention of a recent article on Predicting Profound Autism and Cell Biology and me shying away from saying "Organoids" in real-time https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11127428/
(0:00) Intro
(3:22) Dr. Lord's journey into Autism and Recognizing a Spectrum
(11:25) The Evolution of Autism Assessment and Discussion on the ADI and ADOS- from making the ADOS in her Basement and being Overran by Demand to the Gold Standard; Revisions of Assessment Instruments
(16:36) Gaps in the Autism Assessment
(23:15) The Challenges with Understanding the Spectrum of Autism
(29:32) Updates on the Lancet Commission and Profound Autism
(35:19) Barriers with Autism and the Medical Field
(39:29) Barriers with Autism and Education- Four Strikes against the Autistic Phenotype: Sensory-Processing, Speech and Language, Social Communication/Interaction, and Subject Switching (understand B3: Fixated Interests)
(44:25) The Future of Autism and Helping Autistics Across the Life Span
(51:03) Reviews/Ratings and Contact Info
email: [email protected]
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In this episode, we explore three regions associated with social awareness- the medial Prefrontal Cortex, the Anterior Cingulate Cortex, and the Insula. We review the functions of each, the interactions between each region, and the inputs and bi-directional connections to some crucial areas of the brain. In large part, we will review adaptive responses and cover some scientific literature on these regions and the implications to Autism.
https://molecularautism.biomedcentral.com/articles/10.1186/s13229-024-00593-6
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354837/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766703/#:~:text=Schematic%20structure%20of%20different%20regions,and%20infralimbic%20cortex%20(IL).
https://www.cell.com/neuron/fulltext/S0896-6273(12)01108-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627312011087%3Fshowall%3Dtrue
https://www.nature.com/articles/s42003-024-06016-9
https://www.sciencedirect.com/science/article/pii/S0149763409000815?via%3Dihub#aep-section-id15
https://www.tandfonline.com/doi/full/10.1080/17470919.2023.2242095
https://www.sciencedirect.com/science/article/abs/pii/S0006322308011578
(0:00) Intro; mPFC, ACC, and Insula
(3:26) mPFC, Excitation / Inhibition; CNTNAP2, SHANK3, Neuroligin, and PTEN
(7:42) Functions of mPFC and a primary dive into Adaptive Responses; Neuromodulators
(13:52) ACC
(15:23) the mPFC and ACC lead the way
(19:29) Scientific Studies on Theory of Mind Task and Sensory Processing
(21:52) Insula
(26:49) Scientific Study: Eye Gaze, Social Attention, Social Cognition, Observational Learning
(30:11) Social and Nonsocial Studies- different areas for Autistics versus Non-Autistic
(32:38) A study using 6-week-old Infants, attentional biases and sensorimotor and different brain areas
(35:05) Wrap Up
email: [email protected]
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In this episode, we discuss biology of anxiety, responses from anxiety, and common situations causing anxiety with Autism. The stress response system of the body is very finite and the nervous system reflexively responds based on what it knows. A few biological components of anxiety include the amygdala, bed nucleus of the stria terminalis (BNST), and the spine. Common responses to anxiety include avoidance, shifts in physiology, and valance, or how we feel about the situation. To end, we have a lengthy discussion on some common sources of anxiety.
Biology and Anxiety https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690364/
Deisseroth on Anxiety https://www.youtube.com/watch?v=UtCeIefq_PM
Deisseroth on Autism and Anxiety https://www.youtube.com/watch?v=4oiKOX2lCmE
Physiological Sighs https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00474-8
Jack Feldman https://bioscience.ucla.edu/people/jack-feldman/
David Spiegel https://med.stanford.edu/profiles/david-spiegel
Joseph LeDoux https://as.nyu.edu/faculty/joseph-e-ledoux.html
(0:00) Intro; Comorbid Tendency and the DSM
(2:56) Anxiety's role
(3:42) Biology and responses of Anxiety; Amygdala and Bed Nucleus of the Stria Terminalis; Avoidance, Physiology, Valance
(7:48) Avoidance (Action)- Hypothalamus
(9:11) Brief notes on Cortex
(11:36) Back to the Hypothalamus
(12:27) Physiology/Breathing (Body)- Parabrachial Nucleus; Physiological Sigh; Brainstem, Spine, and Body
(17:48) Valance (Feelings)- Ventral Tegmental Area; direct or indirect exposure- it doesn't matter
(20:00) Dopamine, Neuroplasticity, Side note on Testosterone, Multiple words have the same meaning
(24:58) Common situations for Anxiety and Autism
(35:58) Wrap Up, Reviews and Ratings, Contact Info
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In this episode, we cover Autism and employment- some Superpowers and some Superdeficits. We discuss different types of work that are easier and fit our abilities and cover some challenges in the workplace. Some challenges include the social dynamic and being misunderstood, which are driving forces and sources of burnout and avoidance. Remember the metabolic "bank" account and the Excitation/Inhibition discussion.
Brain Science and Sir Simon Baron-Cohen https://www.youtube.com/watch?v=gMxfq_QLuUU
Brain Science Podcast https://www.youtube.com/@BrainSciencePodcast
Pattern Seekers by Sir Simon Baron-Cohen https://www.amazon.com/Pattern-Seekers-Autism-Drives-Invention/dp/1541647149
Autistic Brain by Temple Grandin https://www.amazon.com/Autistic-Brain-Temple-Grandin/dp/0544227735
(0:00) Intro; Clip of Sir Simon Baron-Cohen on Brain Science with Dr. Ginger Campbell; Society's trap and time perception
(6:20) Autism and awareness; Do others see or understand our abilities
(9:12) The applying process and the interview- we hate look at me; Superdeficits are easier to remember; Honesty and accuracy and Employers don't have an accurate comparison
(12:39) Understanding the Autistic Brain
(14:25) Autistic Traits - some Superpowers
(21:20) Autistic Traits - some Superdeficits
(28:43) Good and Bad: Perfectionism- a tough balance
(30:42) Do things that you can do, you will do, and you love to do; The Nervous System just does; See Temple Grandin and Sir Simon Baron-Cohen on types of employment for different types of Autistic Brains
(31:38) Reviews and Ratings; Contact Information
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In this episode, we discuss Autism and Education. We explore some current condition within education and some personal experiences. Specifically, the school day is in complete conflict with Autism- both Criteria A and B. This is the primary factor with the challenges of Autism in Education. The classroom requires a Social Dynamic, a Speech and Language Dynamic, and Sensory-Processing Dynamic, which is 3 strikes against Autism. In addition, the subject switching throughout the school day complicates our path of learning- Our learning style prefers spending extended times on a single subject. Autism gives us the ability to be comfortable within ourselves and this accelerates our learning, our Superpowers. School and the world mostly requires the social communication and interaction.
Antipsychotics https://www.marketresearchfuture.com/reports/antipsychotic-drugs-market-2784#:~:text=The%20antipsychotic%20drugs%20market%20size,period%20(2023%20%2D%202030).
Pediatrician and Psychologists on the Medical Paradigm https://podcasts.apple.com/us/podcast/radically-genuine-podcast-with-dr-roger-mcfillin/id1573253801?i=1000624733618
Autism and Education https://www.fhautism.com/shop/autism-and-education-the-way-i-see-it-what-parents-and-teachers-need-to-know/
Thinking in Pictures https://www.grandin.com/inc/visual.thinking.html
Autism and Intelligence and an Explanation https://www.youtube.com/watch?v=pxNg0xcadsM&t=316s
(0:00) Intro; Autism and Education; Are Educators educated on Autism?; Biases from others towards the environment
(7:00) The Prescription Era; Medication first Paradigm
(10:32) The School Day- Conflicts with Criteria A and B; Limits a Capacity to Think; Underlying thoughts and feelings of agitation and frustration when learning;
(13:15) Autism gives us the ability to be comfortable within ourselves; Are we like the so-called normal people, or not?
(13:39) The Classroom- Social Dynamic, Speech and Language Dynamic, Sensory-Processing Dynamic, 3 strikes against Autism;
(14:39) Subject Switching and Criteria B conflict
(17:14) If you have met one child with Autism, you have met one child with Autism
(17:49) Elementary School, 2 reasons why Reading is HARD, Social dynamic experience;
(23:07) 4th Grade personal experience- easy task from the outside, tremendous difficulty for Autistics;
(27:00) Art was fine, other subjects were not fine; Details to General versus General to Details;
(27:58) High School personal experiences; Pathway to Success > General Education;
(29:52) Did I graduate, or Not?
(31:56) SAT
(32:43) Assessment Superpowers and Superdeficits- Very Superior to Severe/Impaired; Schools simply cannot accommodate to all- within group (Autistic to Autistic) or between group (Autistic to Masses)
(36:34) Education Arrangement; Taking Notes is challenging
(39:16) Wrap Up, Reviews, Ratings, Feedback, Contact Information
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There is no question Mothers that have children with Autism are incredible. You are loved and appreciated.
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