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In this episode of the Oncology Brothers podcast, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Nicholas Hornstein, a GI medical oncologist from Northwell Health, to discuss the recent FDA approval of nivolumab and ipilimumab for metastatic colorectal cancer with MSI-high or MMR-deficient disease, based on the CheckMate 8HW study.
Join us as we delve into:• The significance of MSI-high status in colorectal cancer and its prevalence.• The study design and key findings of CheckMate 8HW, including the impressive progression-free survival rates.• The comparison of dual checkpoint inhibitors versus single-agent therapies and chemotherapy.• Important side effects associated with the combination therapy and how to manage them.• Insights on patient selection for immunotherapy, including considerations for age and comorbidities.• The potential future of immunotherapy in treating not just MSI-high but also MSS colorectal cancer.
Whether you're a healthcare professional or simply interested in the latest advancements in oncology, this episode provides valuable insights into the evolving landscape of cancer treatment.
YouTube: https://youtu.be/wJRlECiY2VA
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Don't forget to like, subscribe, and check out our previous episodes for more discussions on FDA approvals, conference highlights, and treatment algorithms. We look forward to seeing you at ASCO 2025!#OncologyBrothers #CancerPodcast #Immunotherapy #ColorectalCancer #FDAApproval #CheckMate8HW
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Welcome to the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain are joined by Dr. Gilberto Lopes, a thoracic medical oncologist from the Sylvester Cancer Center. Together, they dived into the latest updates on anti-EGFR drugs used in non-small cell lung cancer (NSCLC) with EGFR mutations.
In this informative discussion, they covered:• The evolution of EGFR inhibitors, including Afatinib, Osimertinib, Amivantamab, and Lazertinib.• Common side effects associated with these treatments, such as diarrhea, skin toxicity, and infusion-related reactions.• Strategies for managing these side effects to improve patient quality of life and treatment adherence.• Insights from recent studies, including the SKIPirr trial and the MARIPOSA study, highlighting the benefits of new combinations and treatment approaches.
Youtube: https://youtu.be/v6fb6nx0YY4
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Join us as we explore how proactive management of side effects can maximize the effectiveness of these therapies and enhance patient outcomes. Don't forget to check out our other ToxCheck discussions, treatment algorithms, and conference highlights!
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Join us in this episode of the Oncology Brothers podcast as we dive deep into the rapidly evolving treatment landscape for small-cell lung cancer. Hosted by community oncologists Drs. Rahul and Rohit Gosain, we are thrilled to welcome Dr. Ticiana Leal, a thoracic medical oncologist from the Winship Cancer Institute - Emory University.
In this episode, we covered:• Current treatment paradigm of small cell lung cancer, in localized setting and extensive stage.
• We covered the recent approval of durvalumab in limited stage setting post chemoRT.
• We touched on the role of growth factors, and how they get rarely utilized, and covered use of Trilaciclib.
• Stressed the importance of immunotherapy in extensive stage with choices of Atezolizumab and Durvalumab, and touched on extended survival data with Atezolizumab
• Talked about logistical issues and uptake of Tarlatamab post approval.• Stressed the importance of clinical trials to move the field ahead.
Whether you're a practicing oncologist or simply interested in the latest advancements in cancer treatment, this episode is packed with valuable information to help guide your practice.
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Join us in this episode of the Oncology Brothers podcast as we dive deep into the rapidly evolving treatment landscape for metastatic non-small cell lung cancer (NSCLC) with actionable mutations in frontline therapy. Hosted by community oncologists Drs. Rahul and Rohit Gosain, we are thrilled to welcome Dr. Susan Scott, a thoracic medical oncologist from the Johns Hopkins Hospital.
In this episode, we covered:• Common EGFR mutations and the latest treatment options, including osimertinib, amivantamab, and chemotherapy combinations.• The importance of comprehensive NGS testing and the need for retesting at progression.• Insights into managing side effects associated with various therapies, including the proactive management of cutaneous toxicities.• Treatment strategies for less common mutations such as ALK, ROS1, BRAF, and RET, along with their respective targeted therapies.• The role of immunotherapy in specific mutations and the importance of patient choice and preferences in treatment decisions.
Whether you're a practicing oncologist or simply interested in the latest advancements in cancer treatment, this episode is packed with valuable information to help guide your practice.
YouTube: https://youtu.be/LMYDAjZcn5w
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Welcome to the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain are joined by Dr. Mark Awad, a world-renowned thoracic medical oncologist from Memorial Sloan Kettering. Together, they dived deep into the treatment landscape for metastatic non-small cell lung cancer (NSCLC) without actionable mutations in frontline settings.
Episode Highlights:• The importance of next-generation sequencing (NGS) and PD-L1 levels in treatment decision-making.• Current treatment options for patients with high PD-L1 scores, including single-agent immunotherapy.• Strategies for patients with low or intermediate PD-L1 scores, including chemotherapy combined with immunotherapy.• Discussed KRAS G12C and HER2 positive disease in second-line settings, including the latest approved therapies.• Insights into the potential side effects and considerations when transitioning from immunotherapy to targeted therapies.
Join us as we explored the complexities of treating metastatic NSCLC and the ongoing need for clinical trials and biomarker discovery. Don't forget to check out our other episodes for more insights on treatment algorithms and recent FDA approvals!
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In this episode of the Oncology Brothers podcast, Drs. Rahul & Rohit Gosain wrap up their three-part CME series on HER2-positive biliary tract cancer. Joined by Dr. Rachna Shroff, they delved into the critical topic of managing adverse events associated with treatments like TDXD and Zanidatamab.
The discussion covered:• Overview of the treatment landscape for biliary tract cancer• Common side effects of TDXD, including interstitial lung disease, nausea, and fatigue• Management strategies for adverse events, including dose reductions and supportive care• Insights on Zanidatamab, its side effects, and infusion-related reactions• The importance of biomarker testing and patient-centered care in treatment decisions
Tune in to gain valuable insights on how to improve patient quality of life while navigating the complexities of HER2-positive biliary tract cancer treatments.
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Welcome to another episode of the Oncology Brothers podcast! In this episode, we dived into the recent FDA approval of Durvalumab combined with chemotherapy for resectable muscle-invasive bladder cancer, based on the NIAGARA trial.
Join us as we chat with Dr. Thomas Powles, a GU medical oncologist and the lead author of the NIAGARA trial. We discussed the study design, the significant improvements in overall survival, and the implications of this new treatment approach. Dr. Powles shared insights on the use of immunotherapy in the perioperative setting, the importance of pathological complete response, and the safety of combining Durvalumab with chemotherapy.
Key topics covered in this episode:• Overview of the NIAGARA trial and its findings• Comparison of Durvalumab and cisplatin-based chemotherapy outcomes• The significance of event-free survival and overall survival rates• Insights on managing side effects and treatment sequencing• The evolving role of ctDNA in determining treatment strategies
YouTube: https://youtu.be/s_tXoX5yhV8
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Tune in to learn how these advancements are changing the landscape of bladder cancer treatment and improving patient outcomes. Don't forget to like, subscribe, and check out our other episodes for more insights on oncology and FDA approvals!#OncologyBrothers #BladderCancer #Dervalumab #FDAApproval #NiagaraTrial #Immunotherapy #CancerResearch #OncologyPodcast
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Welcome to another episode of the Oncology Brothers podcast! In this episode, Drs. Rohit and Rahul Gosain, both practicing community medical oncologists, continue their discussion on HER2-positive biliary tract cancer. They are joined by Dr. Shubham Pant from MD Anderson, who shares his expertise on this rapidly evolving field.
In this episode, we cover:• The importance of HER2 testing in biliary tract cancers, including intrahepatic and extrahepatic cholangiocarcinomas and gallbladder cancers.• Who should be tested for HER2 positivity and how to classify HER2-positive disease.• The role of next-generation sequencing (NGS) and immunohistochemistry (IHC) in determining HER2 status.• Current treatment options for HER2-positive biliary tract cancer, including the latest clinical trials and approved therapies like trastuzumab deruxtecan and zanidatamab.• The significance of patient-centered decision-making and managing side effects associated with these treatments.• Insights into the potential for brain metastases in biliary tract cancer and the importance of ongoing surveillance.
Join us as we delve into the latest data and strategies for managing HER2-positive biliary tract cancer, and stay tuned for our next episode where we will discuss side effects and management of these therapies.
Accreditation/Credit DesignationPhysicians’ Education Resource®, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Physicians’ Education Resource®, LLC designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Acknowledgment of Commercial SupportThis activity is supported by an educational grant from Jazz Pharmaceuticals, Inc.
Link to gain CME credits from this activity:https://www.gotoper.com/courses/from-bench-to-bedside-paradigm-shifts-in-her2-metastatic-btc-treatment
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This is the second episode of a two-part series on the HER2 diagnostic and treatment landscape in non-small cell lung cancer (NSCLC), hosted by the Oncology Brothers, Drs Rohit and Rahul Gosain. In this episode, Dr Isabel Preeshagul and Dr Eric Singhi provide the benefit of their experience when discussing how to approach different treatment scenarios in HER2-mutant NSCLC. The conversation unfolds to cover:• Ways to distinguish HER2 alterations from other alterations on biomarker reports • The latest efficacy and safety data of currently approved and emerging treatments for HER2-altered NSCLC • The potential CNS activity of these treatments in patients with HER2-mutated NSCLC • How the treatment pathway may look in the near future Clinical takeaways• In NSCLC, HER2-positivity includes mutations, amplifications and overexpression. It's important to distinguish HER2 alterations from EGFR mutations, particularly exon 20 insertions, when interpreting next-generation sequencing (NGS) results • Trastuzumab Deruxtecan (T-DXd) is currently the only approved targeted agent for HER2-altered NSCLC in the 2nd-line setting. It shows promising efficacy, especially in HER2-mutant cases, but has limited brain penetration and is associated with notable side effects, including pneumonitis, which requires close monitoring • Emerging TKIs, such as zongertinib, BAY 2927088 (sevabertinib), and NVL-330, target HER2-mutations and have shown high response rates and CNS activity in early studies, without ILD/pneumonitis. These treatments come with unique side effects like diarrhoea and rash, which can be managed with supportive care • CNS metastases are common, with up to 30% of HER2-altered NSCLC patients presenting with or quickly developing CNS metastases. Current large molecule therapies (like T-DXd) have limited brain penetration, making small-molecule TKIs, like zongertinib, BAY 2927088 (sevabertinib), and NVL-330, promising for their potential CNS activity• Current standard 1st-line care for HER2-mutant NSCLC remains platinum-based chemotherapy ± immunotherapy. Targeted agents (like T-DXd) are generally reserved for 2nd-line use, but ongoing trials are evaluating the move toward frontline therapy
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Welcome to the Oncology Brothers podcast! In this episode, Drs. Rohit and Rahul Gosain are joined by Dr. Ghassan Abou-Alfa, a medical oncologist specializing in the hepatobiliary space at Memorial Sloan Kettering. Together, they explored the current treatment landscape of biliary tract cancer, focusing on the advancements in HER2-driven therapies.
Key topics discussed included:
• The evolution of treatment options for biliary tract cancer, including chemotherapy and immunotherapy.
• The significance of genetic testing, including IDH1 mutations, FGFR alterations, and HER2 status.
• The role of multidisciplinary collaboration in managing hepatobiliary cancers.
• Insights into the latest clinical trials and emerging therapies for HER2-positive biliary tract cancer.
Join us as we delve into the complexities of biliary tract cancer and the promising developments in HER2-targeted treatments. Don't forget to check out our next episode, where we will take a deeper dive into the data surrounding HER2 therapies and discuss management strategies for common side effects.
YouTube: https://youtu.be/pGiU7JJGNOc
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#OncologyBrothers #BiliaryTractCancer #HER2 #CancerTreatment #MedicalOncology #CME #Podcast
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Join us for an insightful episode of the Oncology Brothers podcast as we dive into the fast-evolving landscape of HER2-positive non-small cell lung cancer (NSCLC). In this first part of the two-part series, Drs. Rahul and Rohit Gosain were joined by Dr. Devika Das, a thoracic medical oncologist, and Dr. Fernando Lopez-Rios, a pathologist, to discuss the critical importance of testing and identifying HER2 alterations in lung cancer patients.
In this episode, we covered:• The significance of HER2 alterations in NSCLC and how they differ from breast and gastric cancers.• The complexities of biomarker testing, including NGS, IHC, and FISH amplification.• Patient characteristics and phenotypes associated with HER2-positive disease.• The current testing workflows in clinical practice and the role of liquid biopsies.• Insights into the treatment landscape for HER2-positive NSCLC, including recent FDA approvals and ongoing clinical trials.
Whether you're a healthcare professional or simply interested in the latest advancements in oncology, this episode provides valuable information on the integration of precision medicine in lung cancer treatment.
YouTube: https://youtu.be/gMi-sflQyQo
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Don't forget to subscribe for the next episode, where we will explore treatment options for HER2-positive non-small cell lung cancer in greater detail!
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Welcome back to the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain are joined by Dr. Joshua Sabari, a thoracic medical oncologist from NYU, to discuss the latest findings from the European Lung Cancer Conference (ELCC) 2025.
We dived into several key studies that are shaping the future of lung cancer treatment, including:• KEYNOTE-799: Exploring the combination of concurrent chemotherapy and radiation with the PD-1 inhibitor pembrolizumab for unresectable non-small cell lung cancer (NSCLC).• LAURA: The impact of osimertinib in patients with EGFR mutations post-chemoradiation therapy.• MARIPOSA: The promising results of amivantamab and lisertinib in the metastatic setting for EGFR-mutated NSCLC.• KRYSTAL-7: Investigating the use of KRAS G12C inhibitors in frontline therapy.
Join us as we discuss the implications of these studies, the importance of next-generation sequencing (NGS), and how to manage side effects associated with these new therapies.
YouTube: https://youtu.be/akoXXAUEl_8
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#Oncology #LungCancer #ELCC2025 #EGFR #KRAS #CancerResearch #Podcast
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Welcome to another episode of the Oncology Brothers podcast! In this episode, Drs. Rohit and Rahul Gosain are joined by Dr. Aman Chauhan, a medical oncologist specializing in neuroendocrine tumors from Sylvester Comprehensive Cancer Center in Miami.As of April 2025, the oncology landscape has seen 10 new FDA approvals, including the recent approval of cabozantinib for neuroendocrine tumors based on the CABINET study. The discussion dived deep into the implications of this approval, the study design, and how cabozantinib fits into the treatment landscape for both pancreatic and extra-pancreatic neuroendocrine tumors.
Key topics covered in this episode include:• The evolution of treatment options for neuroendocrine tumors• Insights into the CABINET study design and results• Sequencing treatment options for patients with neuroendocrine tumors• Side effects and management strategies for cabozantinib• The importance of personalized treatment approaches in oncology
Join us as we explore the exciting advancements in neuroendocrine tumor management and what they mean for patients and oncologists alike. Don't forget to like, subscribe, and check out our other discussions on FDA approvals, toxicity management, and conference highlights!
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Join us in this insightful episode of the Oncology Brothers podcast as we dive deep into the current treatment landscape of pancreatic cancer. Drs. Rohit and Rahul Gosain are joined by Dr. Emil Lou, a medical and neuro-oncologist from the University of Minnesota, to discuss the challenges and advancements in managing this complex disease.
In this episode, we covered:• The importance of a multidisciplinary approach in treating early-stage pancreatic cancer.• The role of neoadjuvant and adjuvant therapies, including the latest insights on chemotherapy regimens like FOLFIRINOX, nal-IRI and gemcitabine.• The significance of germline and next-generation sequencing (NGS) testing in personalizing treatment plans.• The current state of clinical trials and emerging therapies, including PARP inhibitors for BRCA mutations and the implications of ctDNA testing.• Prognostic discussions around metastatic pancreatic cancer and the importance of managing side effects to improve patient quality of life.
Key takeaways include the necessity of balancing treatment efficacy with adverse events, the critical role of genetic testing, and the need for vigilance regarding venous thromboembolism (VTE) in pancreatic cancer patients.
Don't miss this comprehensive discussion that aims to shed light on the ongoing efforts to improve outcomes for patients battling pancreatic cancer.
YouTube: https://youtu.be/HCKQxmOqRTI
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Welcome to another episode of the Oncology Brothers! In this episode, Drs. Rahul and Rohit Gosain are joined by their brother, Dr. Timothy Brown from UT Southwestern, to discuss the latest treatment paradigms for upper gastrointestinal (GI) malignancies, specifically focusing on esophageal and gastroesophageal junction adenocarcinoma, as well as gastric cancer.
Episode Highlights:• Early Disease Management: perioperative FLOT versus concurrent chemoradiation.• Adjuvant Nivolumab: Insights from the Checkmate 577 trial and its implications for patients with residual disease post-chemoradiation.• Biomarker Testing: The importance of testing for MSI, HER2, Claudin 18.2, and PD-L1 to guide treatment decisions in metastatic settings.• Patient-Centered Care: Emphasizing the significance of shared decision-making and multidisciplinary approaches in managing complex cases.
Join us as we unpack the nuances of upper GI malignancies and share key takeaways from recent studies and clinical practices.
YouTube: https://youtu.be/UNyi71u2wIw
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Welcome to another episode of the Oncology Brothers podcast! In this episode, hosts Drs. Rahul and Rohit Gosain continue their ToxCheck series, focusing on the management of side effects associated with treatments for pancreatic cancer.
Join us as we dive deep into the use of key drugs such as 5-FU, oxaliplatin, irinotecan, liposomal irinotecan, and the combination of gemcitabine and nab-paclitaxel. We are joined by esteemed guests Dr. Rachna Shroff from the University of Arizona and Dr. Midhun Malla from the University of Alabama, who share their insights and clinical pearls on managing the challenging side effects of these therapies.
Key topics discussed include:• The utility of 5-FU bolus and leucovorin in treatment regimens• Managing common side effects like diarrhea, mucositis, and neuropathy• The importance of preemptive strategies in side effect management• Insights on liposomal irinotecan and its tolerability• The impact of gemcitabine and nab-paclitaxel on quality of life
Whether you're a healthcare professional or someone interested in oncology, this episode provides valuable information on optimizing treatment while maintaining patient quality of life.
YouTube: https://youtu.be/KByOGRpzFMQ
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Don't forget to check out our other ToxCheck episodes on antibody drug conjugates, CAR-T, and anti-EGFR drugs used in colorectal cancer.
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Join us in this insightful episode of the Oncology Brothers podcast as we dive deep into the current treatment landscape of prostate cancer with Dr. Alan Bryce, Chief Clinical Officer and GU Medical Oncologist from City of Hope.
In this episode, we explore:• The treatment paradigm for early-stage prostate cancer, including the role of active surveillance and the use of abiraterone based on the STAMPEDE trial.• The importance of understanding risk factors and treatment options for low, intermediate, and high-risk patients.• The implications of PET-PSMA imaging versus conventional CT modalities in staging and treatment decisions.• The management of biochemical recurrent disease and the significance of PSA doubling time in treatment planning.• The role of PARP inhibitors in patients with HRR mutations and the nuances of selecting appropriate therapies.• Strategies for managing metastatic disease, including the use of Lutetium-177 (Pluvicto) and cabazitaxel.
Dr. Bryce provides a masterclass on navigating the complexities of prostate cancer treatment, emphasizing the need to balance between over-treatment in early disease and under-treatment in metastatic cases.
YouTube: https://youtu.be/Zfu-yGmH0rg
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If you find this episode helpful, please share it with your colleagues and leave us a review! Don't forget to check out our other episodes in the GU treatment algorithm series, including discussions on renal cell carcinoma and bladder cancer.
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Join us for an insightful episode of the Oncology Brothers podcast as we dive deep into the world of renal cell carcinoma (RCC) with Dr. Katy Beckermann, the Medical GU Director of Cancer Research at Tennessee Oncology.
In this episode, hosts Drs. Rahul & Rohit Gosain, practicing medical oncologists, discuss the latest advancements in RCC treatment, including:• The role of Pembrolizumab in the adjuvant setting based on the Keynote 564 study and its implications for early-stage disease.• Current treatment paradigms for metastatic RCC, including dual checkpoint inhibitors, TKI with immunotherapy, and single-agent options.• The importance of patient characteristics and IMDC risk categorization in treatment decisions.• Insights into sequencing therapies, including the use of Belzutifan for refractory disease and the management of side effects.• The role of ctDNA, PD-L1 testing, and NGS in RCC.
Whether you're a community oncologist or simply interested in the latest in cancer care, this episode is packed with valuable information to help you stay informed and provide the best care for your patients.
YouTube: https://youtu.be/Bbv9N7-YKIM
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Don't forget to like, subscribe, and leave a review to let us know how we're doing and how we can continue to support you in the community!
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Join Drs. Rahul & Rohit Gosain in this insightful episode of the Oncology Brothers podcast as they continue their treatment algorithm series, focusing on the rapidly evolving landscape of bladder cancer. They are joined by Dr. Joaquim Bellmunt, a medical oncologist and director of bladder cancer at the Dana-Farber Cancer Institute, who shares his expertise on the latest treatment paradigms for both muscle invasive and non-muscle invasive bladder cancer.
In this episode, you'll learn about:• The distinction between muscle invasive and non-muscle invasive bladder cancer and their respective treatment approaches.• The role of BCG treatment and emerging options for BCG-refractory disease.• The significance of the NIAGARA trial and its implications for neoadjuvant chemotherapy and perioperative immunotherapy.• Current strategies for managing muscle invasive bladder cancer, including the use of cisplatin-based therapies and the introduction of immunotherapy.• Insights into the metastatic space, including the use of enfortumab vedotin (EV) and pembrolizumab, and the importance of next-generation sequencing (NGS) in treatment decisions.• Key side effects to monitor with various treatments and the importance of maintaining quality of life for patients.
Whether you're a healthcare professional or simply interested in the latest advancements in oncology, this episode is packed with valuable information.
YouTube: https://youtu.be/apUp2-BkgWQ
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Welcome to the Oncology Brothers podcast! In this episode, Drs. Rahul and Rohit Gosain are joined by Dr. Anwaar Saeed, Chief of GI Medical Oncology at UPMC, to discuss the recent approval of Tislelizumab, a new checkpoint inhibitor for upper GI malignancies, including esophageal squamous cell cancer, GE junction, and gastric cancer.
We dive deep into the studies that led to Tislelizumab’s approval, including the Rationale 302, 305, and 306 trials. Dr. Saeed explains the unique mechanism of action of Tislelizumab, its higher binding affinity to PD-1, and how it compares to other PD-1 inhibitors like nivolumab and pembrolizumab.
Key topics covered in this episode:• Overview of Tislelizumab and its mechanism of action• Insights from the Rationale 306 trial and its implications for frontline treatment• Discussion on the Rationale 305 trial focusing on adenocarcinoma• The importance of PD-L1 testing and biomarker-driven treatment decisions• Side effect profiles of Tislelizumab compared to other immunotherapies• Future directions in the use of immunotherapy for upper GI malignancies
Join us for this informative discussion that highlights the evolving landscape of cancer treatment and the importance of precision oncology. If you find this episode helpful, please share it with your colleagues and leave us a review!
YouTube: https://youtu.be/hQeLdpSzGCk
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