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We may be on the cusp of a revolution in medicine, thanks to tools like AlphaFold, the technology for Google DeepMind, which helps scientists predict and see the shapes of thousands of proteins. How does AlphaFold work, what difference is it actually making in science, and what kinds of mysteries could it unlock? Today’s guest is Pushmeet Kohli. He is the head of AI for science at DeepMind. We talk about proteins, why they matter, why they’re challenging, how AlphaFold could accelerate and expand the hunt for miracle drugs, and what tools like AlphaFold tell us about the mystery of the cosmos and our efforts to understand it.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guest: Pushmeet Kohli
Producer: Devon Baroldi
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Are conspiracy theories more popular than ever? Are Americans more conspiratorial than ever? Are conservatives more conspiratorial than liberals? Joseph Uscinski is a political scientist at the University of Miami and one of the nation's preeminent experts on the psychology of conspiratorial thinking and the history of conspiracy theories in America. He has some counterintuitive and surprising answers to these questions. Today, he and Derek discuss—and debate—the psychology and politics of modern conspiratorial thinking.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guest: Joseph Uscinski
Producer: Devon Baroldi
Links
Uscinski's research page: https://people.miami.edu/profile/60b5fb062f4f266afb6739ec21657c74
"The psychological and political correlates of conspiracy theory beliefs" https://www.nature.com/articles/s41598-022-25617-0
"Fake news on Twitter during the 2016 U.S. presidential election" https://pubmed.ncbi.nlm.nih.gov/30679368/
"Right and left, partisanship predicts (asymmetric) vulnerability to misinformation" https://misinforeview.hks.harvard.edu/article/right-and-left-partisanship-predicts-asymmetric-vulnerability-to-misinformation/
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Exercise is a conundrum. On the one hand, physical activity is clearly one of the best interventions for preventing physical disease and mental suffering. On the other hand, scientists don't really understand how it works inside the body or what exactly running, jumping, lifting, and squatting do to our tissues and organs. That's finally changing. Euan Ashley, a professor of genomics and cardiovascular medicine and the chair of the Stanford Department of Medicine, is a member of a new research consortium that studies rats and humans to understand the molecular changes induced by exercise. Today we talk about the earliest findings from this new consortium, how exercise might have disparate effects in men versus women, why nature’s most effective cardiovascular intervention also seems to be nature’s most effective mental health intervention, as well as whether it will one day be possible to identify the molecular basis of exercise precisely enough to develop exercise pills that give us the benefits of working out without the sweat.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guest: Euan Ashley
Producer: Devon Baroldi
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Derek offers a short but sweet review of the Democratic National Convention, the science of post-convention bounces, and the reality of the 2024 polling: It's still a toss-up.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Producer: Devon Baroldi
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Today's episode is about how we change our minds—and what political science tells us about the best ways to change the minds of voters. Our guest is David Broockman, a political scientist at the University of California Berkeley, and the coauthor, with Josh Kalla, of a new essay in Slow Boring on Kamala Harris, Donald Trump, and the most persuasive arguments and messages to decide this election. Today, David and I talk about the four biggest myths of political persuasion—and in the process, David will attempt to do something that I’m not entirely sure is possible: He’ll try to change my mind about how persuasion works.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guest: David Broockman
Producer: Devon Baroldi
Links:
"What's Better Than Calling Donald Trump 'Weird'?" https://www.slowboring.com/p/whats-better-than-calling-trump-weird
"Consuming cross-cutting media causes learning and moderates attitudes: A field experiment with Fox News viewers" https://osf.io/preprints/osf/jrw26
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Laurie Santos is a superstar in the crowded field of happiness research. She is a cognitive scientist at Yale University whose course on the psychology of happiness was the most popular class in the school's history. She is the host of the immensely popular ‘Happiness Lab’ podcast. Today, she and Derek talk about her favorite lessons from modern happiness research, lessons on striving and anxiety from existential philosophy, our relationship to time, the science of cognitive time travel, temporal mind tricks to reduce anxiety like "psychological distancing," and more.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guest: Dr. Laurie Santos
Producer: Devon Baroldi
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In a special emergency-ish episode, Bloomberg's Conor Sen joins the show to discuss a buffet of economic and financial fears, including a disappointing jobs report, a meltdown in global stocks, the "carry trade" heard round the world, the smartest criticisms of (and smartest defense of) the Federal Reserve's decision not to raise interest rates, and more.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guest: Conor Sen
Producer: Devon Baroldi
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Derek offers his thoughts on Kamala Harris, the new 2024 reality, and gender polarization in the "boys vs. girls" election. Then we talk about the spam apocalypse. The average American receives one spam call or text every single day, adding up to tens of billions of robocalls and texts per year. Derek welcomes Joshua Bercu, the executive director of Industry Traceback Group, to talk about the history and technology behind robocalls and texts, why it’s been so hard to hold robocallers accountable, how spammers do that thing where they make a call look like it’s coming from a local friend, how we've managed to crush certain kinds of robocalls, and what it would take to finally win the war on spam.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guest: Joshua Bercu
Producer: Devon Baroldi
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It is a general rule of thumb that richer societies are happier societies. This is true across countries, as GDP and life satisfaction are highly correlated. And it is true across time. Countries get happier as they get richer. But there is a caveat to this general principle. Which is that the United States is not nearly as contented as its gross national income would predict.
In fact, the U.S. is, as we’ve covered on this show, in a bit of a gloom rut. It has now been nearly two decades since a majority of Americans have told pollsters at NBC that they’re satisfied with the way things are going. This hope drought has no precedent in modern polling. NBC itself reported that “We have never before seen this level of sustained pessimism in the 30-year-plus history of the poll.”
Polls show that faith in government, business, and other institutions is in free fall—especially among conservatives. But they also show that conservatives are generally happy with their life and in their relationships. If conservatives have happiness without trust, American progressives seem to have trust without happiness.
In a recent paper called “The Politics of Depression,” published by the journal Social Science & Medicine–Mental Health, the epidemiologist Catherine Gimbrone and several coauthors showed that young progressives are significantly more depressed than conservatives, have been for years, and the gap is growing over time. Other studies, including the General Social Survey, show the same.
Why are young progressives so sad? Today’s guest is Greg Lukianoff, the president and CEO of the Foundation for Individual Rights and Expression (FIRE) and coauthor of ‘The Coddling of the American Mind.’ He has written intelligently, critically, and emotionally about happiness, depression, politics, and progressivism.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guest: Greg Lukianoff
Producer: Devon Baroldi
Links:
"People in Richer Countries Tend to Be Happier" https://ourworldindata.org/happiness-and-life-satisfaction
"The Politics of Depression" by Catherine Gimbrone et al https://www.sciencedirect.com/science/article/pii/S2666560321000438
"How to Understand the Well-Being Gap Between Liberals and Conservatives" by Musa al-Gharbi https://americanaffairsjournal.org/2023/03/how-to-understand-the-well-being-gap-between-liberals-and-conservatives/
"The Coddling of the American Mind" The Atlantic essay by Jonathan Haidt and Greg Lukianoff https://www.theatlantic.com/magazine/archive/2015/09/the-coddling-of-the-american-mind/399356/
‘The Coddling of the American Mind’ [book] https://www.amazon.com/Coddling-American-Mind-Intentions-Generation/dp/0735224897
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On today's episode: the state of American politics and the future of America's economy. Derek discusses a media myth in the aftermath of the failed Trump assassination attempt and reviews three basic truths about Joe Biden's doomed presidential bid. Then, Chicago Fed president Austan Goolsbee joins the show to answer Derek's blunt question, "Are you going to cut rates next month?" Plus, they discuss the Federal Reserve, how it works, how he sees the economy, whether high rates are constraining housing production, and whether Trump's signature economic policy idea—high tariffs in an age of global inflation—would help the U.S. economy. (TLDR: No.)
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guest: Austan Goolsbee
Producer: Devon Baroldi
Links:
“Stop Pretending You Know How This Will End,” Derek Thompson, The Atlantic
“Hit or Miss? The Effect of Assassinations on Institutions and War,” by Benjamin Jones and Benjamin Olken
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Skyrocketing rates, shrinking affordability: The U.S. housing market is a mess. It's also a bit of a mystery. Why are prices still sky-high, even though many measures of demand are weak? If the supply of new homes is nearing a historic high, how come the inventory for existing homes is close to a historic low? Today's guests agree that this is one of the weirdest housing markets in recent history. Mike Simonsen, president founder of Altos Research, and Lance Lambert, cofounder and editor-in-chief of Residential Club, join to talk about the state of the U.S. housing market—what makes it ugly, what makes it weird, and what would have to happen to make it better.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guests: Mike Simonsen & Lance Lambert
Producer: Devon Baroldi
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Joe Biden's disastrous debate performance has created a crisis for the Democratic Party and a set of interlocking debates about whether the White House—or the White House media—covered up his cognitive decline. The Atlantic’s Mark Leibovich, who first wrote that Biden should drop out of the race two years ago, joins to discuss Biden campaign strategy and the hypocrisy of many Democrats who refused to state publicly what they knew privately: that Biden's age-related blunders were getting more serious. Then we are joined by the busiest man in media, Alex Thompson, political correspondent of Axios, who has absolutely dominated this story in the past week. As a group, we talk about Biden’s age, the Democratic campaign strategy—Project "Bubble Wrap"—that is blowing up in their faces, the failures of the political press and Democratic operatives to see what’s in front of their noses, and the chances that Kamala Harris will imminently replace Joe Biden as the Democratic presidential nominee.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guests: Mark Leibovich & Alex Thompson
Producer: Devon Baroldi
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In the first five decades of the 20th century, the number of serial killers in the U.S. remained at a very low level. But between the 1950s and 1960s, the number of serial killers tripled. Between the 1960s and 1970s, they tripled again. In the 1980s and 1990s, they kept rising. And then, just as suddenly as the serial killer emerged as an American phenomenon, he (and it really is mostly a he) nearly disappeared. What happened to the American serial killers? And what does this phenomenon say about American society, criminology, and technology?
Today's guest is James Alan Fox, the Lipman Family Professor of Criminology, Law, and Public Policy at Northeastern University. The author of 18 books, he has been publishing on this subject since before 1974, the year that the FBI coined the term "serial killer."
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guest: James Alan Fox
Producer: Devon Baroldi
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We've done several podcasts on America's declining fertility rate, and why South Korea has the lowest birthrate in the world. But we've never done an episode on the subject quite like this one.
Today we go deep on the psychology of having children and not having children, and the cultural revolution behind the decline in birthrates in America and the rest of the world. The way we think about dating, marriage, kids, and family is changing radically in a very short period of time. And we are just beginning to reckon with the causes and consequences of that shift. In the new book, 'What Are Children For,' Anastasia Berg and Rachel Wiseman say a new "parenthood ambivalence" is sweeping the world. In today's show, they persuade Derek that this issue is about more than the economic trends he tends to focus on when he discusses this issue.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guests: Anastasia Berg & Rachel Wiseman
Producer: Devon Baroldi
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Today’s episode is about the science of breathing—from the evolution of our sinuses and palate, to the downsides of mouth breathing and the upsides of nasal breathing, to specific breath techniques that you can use to reduce stress and fall asleep fast. Our guest is James Nestor, the author of the bestselling book 'Breath: The New Science of a Lost Art.'
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guest: James Nestor
Producer: Devon Baroldi
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What do most people not understand about the news media? I would say two things. First: The most important bias in news media is not left or right. It’s a bias toward negativity and catastrophe. Second: That while it would be convenient to blame the news media exclusively for this bad-news bias, the truth is that the audience is just about equally to blame. The news has never had better tools for understanding exactly what gets people to click on stories. That means what people see in the news is more responsive than ever to aggregate audience behavior. If you hate the news, what you are hating is in part a collective reflection in the mirror. If you put these two facts together, you get something like this: The most important bias in the news media is the bias that news makers and news audiences share toward negativity and catastrophe. Jerusalem Demsas, a staff writer at The Atlantic and the host of the podcast Good on Paper, joins to discuss a prominent fake fact in the news — and the psychological and media forces that promote fake facts and catastrophic negativity in the press.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guest: Jerusalem Demsas
Producer: Devon Baroldi
Links:
"The Maternal-Mortality Crisis That Didn’t Happen" by Jerusalem Demsas https://www.theatlantic.com/ideas/archive/2024/05/no-more-women-arent-dying-in-childbirth/678486/
The 2001 paper "Bad Is Stronger Than Good" https://assets.csom.umn.edu/assets/71516.pdf
Derek on the complex science of masks and mask mandates https://www.theatlantic.com/newsletters/archive/2023/03/covid-lab-leak-mask-mandates-science-media-information/673263/
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Plastic is a life-saving technology. Plastic medical equipment like disposable syringes and IV bags reduce deaths in hospitals. Plastic packaging keeps food fresh longer. Plastic parts in cars make cars lighter, which could make them less deadly in accidents. My bike helmet is plastic. My smoke detector is plastic. Safety gates for babies: plastic.
But in the last few months, several studies have demonstrated the astonishing ubiquity of microplastics and the potential danger they pose to our bodies—especially our endocrine and cardiovascular systems. Today’s guest is Philip Landrigan, an epidemiologist and pediatrician, and a professor in the biology department of Boston College. We start with the basics: What is plastic? How does plastic become microplastic or nanoplastic? How do these things get into our bodies? Once they’re in our bodies what do they do? How sure are we that they’re a contributor to disease? What do the latest studies tell us—and what should we ask of future research? Along the way we discuss why plastic recycling doesn’t actually work, the small steps we can take to limit our exposure, and the big steps that governments can take to limit our risk.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guest: Philip Landrigan
Producer: Devon Baroldi
Links:
"Plastics, Fossil Carbon, and the Heart" by Philip J. Landrigan in NEJM https://www.nejm.org/doi/full/10.1056/NEJMe2400683
"Tiny plastic shards found in human testicles, study says" https://www.cnn.com/2024/05/21/health/microplastics-testicles-study-wellness/index.html
Consumer Reports: "The Plastic Chemicals Hiding in Your Food" https://www.consumerreports.org/health/food-contaminants/the-plastic-chemicals-hiding-in-your-food-a7358224781/#:~:text=BEVERAGES,in%20this%20chart
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In an age of cults, sports are the last gasp of the monoculture—the last remnant of the 20th century mainstream still standing. Even so, the new NBA media rights deal is astonishing. At a time when basketball ratings are in steady decline, the NBA is on the verge of signing a $70-plus billion sports rights deal that would grow its annual media rights revenue by almost 3x. How does that make any sense? (Try asking your boss for a tripled raise when your performance declines 2 percent a year and tell us how that goes.) And what does this madness tell us about the state of sports and TV economics in the age of cults and cord-cutting? John Ourand, sports correspondent with Puck News, explains.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guest: John Ourand
Producer: Devon Baroldi
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The news media is very good at focusing on points of disagreement in our politics. Wherever Democrats and Republicans are butting heads, that's where we reliably find news coverage. When right and left disagree about trans rights, or the immigration border bill, or abortion, or January 6, or the indictments over January 6, you can bet that news coverage will be ample. But journalists like me sometimes have a harder time seeing through the lurid partisanship to focus on where both sides agree. It's these places, these subtle areas of agreements, these points of quiet fusion, where policy is actually made, where things actually happen.
I’m offering you that wind up because I think something extraordinary is happening in American economics today. Something deeper than the headlines about lingering inflation. High grocery prices. Prohibitive interest rates. Stalled out housing markets.
Quietly, and sometimes not so quietly, a new consensus is building in Washington concerning technology, and trade, and growth. It has three main parts: first, there is a newly aggressive approach to subsidizing the construction of new infrastructure, clean energy, and advanced computer chips that are integral to AI and military; second, there are new tariffs, or new taxes on certain imports, especially from China to protect US companies in these industries; and third, there are restrictions on Chinese technologies in the U.S., like Huawei and TikTok. Subsidies, tariffs, and restrictions are the new rage in Washington.
Today’s guest is David Leonhardt, a longtime writer, columnist, and editor at The New York Times who currently runs their morning newsletter, The Morning. he is the author of the book Ours Was the Shining Future.
We talk about the history of the old economic consensus, the death of Reaganism, the demise of the free trade standard, the strengths and weaknesses of the new economic consensus, what could go right in this new paradigm, and what could go horribly wrong.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guest: David Leonhardt
Producer: Devon Baroldi
Links:
David Leonhardt on neopopulism: https://www.nytimes.com/2024/05/19/briefing/centrism-washington-neopopulism.html
Greg Ip on the three-legged stool of new industrial policy: https://www.wsj.com/economy/the-u-s-finally-has-a-strategy-to-compete-with-china-will-it-work-ce4ea6cf
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The game of basketball has changed dramatically in the last 40 years. In the early 1990s, Michael Jordan said that 3-point shooting was "something I don’t want to excel at," because he thought it might make him a less effective scorer. 20 years later, 3-point shots have taken over basketball. The NBA has even changed dramatically in the last decade. In the 2010s, it briefly seemed as if sharp-shooting guards would drive the center position out of existence. But the last four MVP awards have all gone to centers.
In his new book, ‘Hoop Atlas,’ author Kirk Goldsberry explains how new star players have continually revolutionized the game. Goldsberry traces the evolution of basketball from the midrange mastery of peak Jordan in the 1990s, to the offensive dark ages of the early 2000s, to the rise of sprawl ball and "heliocentrism," and finally to emergence of a new apex predator in the game: the do-it-all big man.
Today, we talk about the history of paradigm shifts in basketball strategy and how several key superstars in particular—Michael Jordan, Allen Iverson, Manu Ginóbili, Steph Curry, and Nikola Jokic—have served as tactical entrepreneurs, introducing new plays and skills that transform the way basketball is played.
If you have questions, observations, or ideas for future episodes, email us at [email protected].
Host: Derek Thompson
Guest: Kirk Goldsberry
Producer: Devon Baroldi
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