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Artificial intelligence is revolutionizing what we once thought impossible. But how can we distinguish genuine breakthroughs from mere hype? In this episode of Science Changing Life, we welcome Eric Topol, MD—renowned physician, scientist, and author. As executive vice president at Scripps Research and founder of the Scripps Research Translational Institute, Dr. Topol shares his thoughts on how AI is transforming science and medicine today and offers a glimpse into what the future may hold. His advice to listeners? 'Be open to change.'
Twitter: https://twitter.com/EricTopol
LinkedIn: https://www.linkedin.com/in/eric-topol-md-b83a7317/
Ground Truths podcast: erictopol.substack.com
Scripps Research Magazine: magazine.scripps.edu/ -
Thanks to revolutionary technologies like CRISPR, we’re now living in an age where it’s becoming possible to rewrite the very building blocks of life itself—our DNA. We sit down with Scripps Research Fellow and CRISPR expert Shannon Miller, PhD, to discover how these gene editing technologies are poised to reverse a range of diseases. Listen in as we explore Shannon’s unique journey into science—beginning not with a single eureka moment, but instead with a passion for creativity and discovery.
Twitter: https://twitter.com/_shannonmmiller
Miller lab: https://www.millerlabresearch.com/team
Scripps Research Magazine: https://magazine.scripps.edu/ -
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Four years after the onset of the COVID-19 pandemic, another virus threatens to reach pandemic potential: the H5N1 bird flu. We sit down with Arnab Chatterjee, vice president of medicinal chemistry at Calibr-Skaggs, who explains the need to invest in the best science to make sure we’re more prepared than we were for the SARS-CoV-2 outbreak.
Chatterjee breaks down how likely it is for H5N1 to become transmitted between humans, and the steps we can take now to better protect ourselves in the future.
LinkedIn: linkedin.com/in/arnab-chatterjee-b024661/
Scripps Research Magazine: magazine.scripps.edu/ -
Galileo’s telescope revolutionized our modern understanding of the universe. Assistant neuroscience professor Xin Jin, PhD, wants to do just that—except for the brain. By building new tools that enable her and other neuroscientists to peer into the inner workings of the mind, Jin is uncovering the cells, genes and other complex drivers behind neurological diseases. Listen in as we explore the galaxy of the brain.
Twitter: https://x.com/xinjin
Jin lab: https://www.jin.scripps.edu/
Scripps Research Magazine: magazine.scripps.edu/ -
More than 90% of drugs fail to make it from the lab bench to approval. How, then, has a physician-scientist like Hugh Rosen found so much success in developing medicines? Rosen, who’s the chair of molecular and cellular biology at Scripps Research, co-invented the drugs ozanimod (approved for multiple sclerosis and ulcerative colitis) and navacaprant (in Phase 3 trials for major depressive disorder).
In this episode of Science Changing Life, listen in as Rosen unveils the success stories behind these groundbreaking treatments—shedding light on the challenges and triumphs shaping modern medicine.
Rosen Lab: https://www.scripps.edu/rosen/index.html
Scripps Research Magazine: magazine.scripps.edu/ -
Donna Blackmond never thought her career would lead to solving how life first formed on the prebiotic Earth. But as she points out in this episode of Science Changing Life, does any scientist start out knowing where their research will take them? Blackmond, who is a professor and the John C. Martin Endowed Chair in Chemistry at Scripps Research, shares how her wide-ranging background across chemistry and chemical engineering is helping answer some of today’s biggest questions in science and medicine.
Episode transcript: https://www.scripps.edu/_files/images/2024_images/donna-blackmond-podcast-episode-45-transcript.pdf
Blackmond Lab: https://www.scripps.edu/blackmond/
Blackmond’s recent PNAS and Nature papers: https://www.scripps.edu/news-and-events/press-room/2024/20240228-blackmond-molecules.html
Scripps Research centennial: 100.scripps.edu/
Scripps Research Magazine: magazine.scripps.edu/ -
Dr. Jay Pandit is a director of digital medicine at the Scripps Research Translational Institute and an assistant professor in the Department of Molecular Medicine at Scripps Research, where he combines medicine and technology to improve patients’ clinical outcomes. Listen in as we explore how biosensors and wearable technologies are enabling users to take control of their own health data and usher in a new era of personalized medicine.
Episode transcript: https://www.scripps.edu/_files/images/2024_images/jay-pandit-transcript.pdf
X: https://twitter.com/JayPandit
LinkedIn: www.linkedin.com/in/jay-pandit-9489008
Scripps Research centennial: https://100.scripps.edu/
Scripps Research Magazine: https://magazine.scripps.edu/ -
Ahmed Badran is an assistant professor of chemistry at Scripps Research, where his lab harnesses synthetic biology to address some of biggest global problems. Listen in as we discuss reengineering plant enzymes to capture carbon, plastic-eating bacteria and new classes of antibiotics that spare our gut microbiome.
Episode transcript: https://www.scripps.edu/_files/images/2023_images/ahmed-badran-transcript.pdf
Badran lab website
https://badranlab.com/
Twitter
@AhmedHBadran
Scripps Research Magazine
https://magazine.scripps.edu/ -
Professor Mia Huang is based in the Department of Molecular Medicine at Scripps Research, where her lab explores how vital sugar molecules in the body orchestrate complex biological events. Listen in as we discuss deciphering cancer cell signals to develop new therapies, engineering red blood cells for transfusions and how to become a master of strategy.
Episode transcript: https://www.scripps.edu/_files/images/2023_images/mia-huang-transcript.pdf
Huang lab website
https://www.huangresearch.com/
Q&A with Mia
https://magazine.scripps.edu/profiles/2020/fall/science-with-a-view-understanding-how-natures-biomolecules-tick-with-mia-huang/
Twitter
@HuangMia
Scripps Research Magazine
https://magazine.scripps.edu/ -
Professor Ram Krishnamurthy is based in the Department of Chemistry at Scripps Research, where his lab investigates the reactions that could have first given way to life on Earth. Listen as we discuss finding biological building blocks on meteorites, NASA’s search for life on other planets, and staying grounded with philosophy and meditation.
Episode transcript
https://www.scripps.edu/_files/images/2023_images/ram-krishnamurthy-transcript.pdf
Ram’s faculty profile
https://www.scripps.edu/faculty/krishnamurthy/
Astrobiology at NASA
https://astrobiology.nasa.gov/news/new-nasa-research-consortium-to-tackle-lifes-origins/
Scripps Research Magazine
https://magazine.scripps.edu/ -
Professor Sumit Chanda is an infectious disease expert and immunologist, where he works both in the Department of Immunology and Microbiology and at Calibr, Scripps Research’s nonprofit drug discovery and development division. He has devoted his career to understanding how the immune system responds to numerous viruses, such as influenza, Dengue virus and SARS-CoV-2. Listen as we discuss everything from pandemic preparedness to drug discovery, as well as his unrelenting drive to uncover new treatment options—including for COVID-19.
Episode transcript
https://www.scripps.edu/_files/images/2023_images/sumit-chanda-transcript.pdf
Infectious disease sleuth Sumit Chanda, PhD, joins Scripps Research and its Calibr drug discovery division
https://www.scripps.edu/news-and-events/press-room/2021/20210915-chanda-calibr.html
Center for Antiviral Medicines & Pandemic Preparedness
https://www.campp.org/
Chanda lab website
https://linktr.ee/thechandalab
Twitter/Instagram
@thechandalab -
Professor Ali Torkamani is the Director of Genome Informatics at the Scripps Research Translational Institute, where his team mines population-level genetic data to make predictions about future disease risk. Listen in as we discuss smartphone apps that could help predict the risk of a heart attack, the addition of genetic data to biosensors of the future and the use of video games as an introduction to data science.
Show notes:
Episode transcript: coming soon….
MyGeneRank app
https://mygenerank.scripps.edu/
Ali’s faculty profile
https://www.scripps.edu/faculty/torkamani/
Twitter
@ATorkamani
Scripps Research Magazine
https://magazine.scripps.edu/ -
Are the mitochondria truly the powerhouses of the cell? In this episode, assistant professor Danielle Grotjahn shares why she thinks “the stress sensors of the cell” may be a more appropriate name for this cellular organelle–and more. Dr. Grotjahn works in the Department of Integrative Structural and Computational Biology at Scripps Research, where her lab is answering how mitochondrial networks change shape in response to genetic, pharmacological or environmental stress. Listen as we talk about the links between mitochondrial dysfunction and disease, cell death, and the cutting-edge imaging technologies that are enabling Grotjahn and her team to peer into the mysteries of the mitochondria.
Show notes:
Episode transcript: https://www.scripps.edu/_files/images/2023_images/danielle-grotjahn-transcript.pdf
Grotjahn lab website
https://grotjahnlab.org/
Twitter
@nani_grotjahn
Scripps Research Magazine
https://magazine.scripps.edu/ -
Dr. Stuti Jaiswal is an assistant professor of molecular medicine at Scripps Research and an internist at Scripps Clinic. Listen in as we discuss the health issues associated with insufficient sleep, the best time to go to bed and what the latest wearables can tell us about our sleep patterns.
Show notes:
Episode transcript: https://www.scripps.edu/_files/images/2023_images/stuti-jaiswal-transcript.pdf
REFRESH sleep study at Scripps Research
https://refresh.scripps.edu/
The Digital Trials Center current research
https://digitaltrials.scripps.edu/about/
Scripps Research Magazine
https://magazine.scripps.edu/ -
Dr. Evert Njomen is a postdoctoral researcher in the lab of Professor Ben Cravatt, based in the Department of Chemistry. Listen as we talk about the autophagy process to cleanse cells, new ways of dealing with antibiotic resistance and cooking with homegrown herbs.
Show notes:
Episode transcript: https://www.scripps.edu/_files/images/2022_images/podcast-images/Evert-Njomen-transcript.pdf
Evert awarded prestigious fellowship from the Howard Hughes Medical Institute
https://www.scripps.edu/news-and-events/press-room/2021/20210304-njomen-howard-hughes-medical-institute-fellowship.html
Cravatt lab website
https://www.scripps.edu/cravatt/index.html
Tweet @EvertNjomen
Explore the Scripps Research Magazine
https://magazine.scripps.edu/
Subscribe to receive our monthly e-newsletter
https://signup.e2ma.net/signup/1879047/1890109/
@scrippsresearch on Twitter -
Professor Andrew Su is based in the Department of Integrative Structural and Computational Biology, where his lab develops digital tools to draw conclusions from the vast streams of medical data generated each day. Listen to us discuss gaming as a way of being a scientist, the replacement of doctors with machine-learning and your Netflix watching history.
Show notes:
Episode transcript: https://www.scripps.edu/_files/images/2022_images/podcast-images/Andrew-Su-transcript.pdf
Andrew’s TEDx talk: Building the knowledgebase of biology using citizen science
https://www.youtube.com/watch?v=hT_pj1cB0Q8
Su lab website
https://sulab.org/
Tweet: @andrewsu
Citizen science initiatives:
https://www.zooniverse.org/
https://fold.it/
https://stallcatchers.com/main
Explore the Scripps Research Magazine
https://magazine.scripps.edu/
Subscribe to receive our monthly e-newsletter
https://signup.e2ma.net/signup/1879047/1890109/
@scrippsresearch on Twitter -
Dr. Travis Young is the Vice President of Biologics at Calibr, the drug discovery and development division of Scripps Research. Travis and the team have created a new type of immunotherapy called “switchable” chimeric antigen receptor (CAR) T-cell therapy, which is already delivering precise and powerful therapies to patients with the most difficult to treat cancers. Listen as we talk about reengineering an individual’s immune T cells, promising clinical trials in leukemia and lymphoma patients, and using similar approaches to treat autoimmune diseases.
Show notes:
Episode transcript: https://www.scripps.edu/_files/images/2022_images/podcast-images/Travis-Young-transcript.pdf
Travis and his colleagues discuss ongoing therapies being developed at Calibr during the Front Row lecture series
https://www.youtube.com/watch?v=WRzQniqUlHo&t=2625s
Preliminary results of switchable CAR-T cells in lymphoma patients
https://www.scripps.edu/news-and-events/press-room/2021/20211208-calibr-announces-clinical-data-car-t-cells.html
Tweet: @CARTCellTherapy
Explore the Scripps Research Magazine
https://magazine.scripps.edu/
Subscribe to receive our monthly e-newsletter
https://signup.e2ma.net/signup/1879047/1890109/
@scrippsresearch on Twitter -
Part three of our mini-series centered on brain health. Professor Frederick Barrett is based in the Department of Psychological & Brain Sciences at Johns Hopkins School of Medicine and Associate Director at the Center for Psychedelic and Consciousness Research. Fred and his colleagues investigate the therapeutic effects of psychoactive substances in intractable patient populations, including those with depression, opioid use disorder and cognitive impairments. Listen as we talk about the different types of hallucinogenic mushrooms, whether psychedelics could one day treat neurodegeneration and the remedial value of a bad “trip.”
Show notes:
Episode transcript: https://www.scripps.edu/_files/images/2022_images/podcast-images/Frederick-Barrett-transcript.pdf
Fred’s TEDMED talk: The neuroscience of psychedelic drugs, music and nostalgia
https://www.ted.com/talks/frederick_streeter_barrett_the_neuroscience_of_psychedelic_drugs_music_and_nostalgia?language=en
Center for Psychedelics and Consciousness Research
https://hopkinspsychedelic.org/barrett
Tweet: @FredBarrettPhD
Explore the Scripps Research Magazine
https://magazine.scripps.edu/
Subscribe to receive our monthly e-newsletter
https://signup.e2ma.net/signup/1879047/1890109/
@scrippsresearch on Twitter -
The second part of our three-part mini-series on brain health. Professor Ryan Shenvi is based in the Department of Chemistry at Scripps Research, where his lab reconstructs useful molecules typically found in remote corners of the world. Listen as we talk about traditional remedies of indigenous cultures, formulating medicines from industrial waste and Charles Dickens’ drinking habits.
Show notes:
Episode transcript: https://www.scripps.edu/_files/images/2022_images/podcast-images/Ryan-Shenvi-transcript.pdf
Shenvi finds a quick way to synthesize novel neuroactive compounds found in rainforest tree
https://www.scripps.edu/news-and-events/press-room/2022/20220317-shenvi-neuroactive-compounds-in-rainforest-tree.html
Q&A with Ryan
https://magazine.scripps.edu/profiles/2022/online-exclusive/channeling-ethnomedicine-to-address-mental-health/
Shenvi lab website
https://www.shenvilab.org/
Tweet: @Shenvi_Lab
Explore the Scripps Research Magazine
https://magazine.scripps.edu/
Subscribe to receive our monthly e-newsletter
https://signup.e2ma.net/signup/1879047/1890109/
@scrippsresearch on Twitter -
We kick off the Summer 2022 podcast season with the first of a three-part mini-series dedicated to brain health. Professor Sandra Encalada is based in the Department of Molecular Medicine at Scripps Research, where her lab investigates the transport of cargo within brain cells and its role in health and disease. Listen as we talk about new therapeutic agents to stop and reverse neurodegeneration, environmental neurotoxins and when to listen to your gut feeling.
Show notes:
Episode transcript: https://www.scripps.edu/_files/images/2022_images/podcast-images/Sandra-Encalada-transcript.pdf
Encalada illuminates how brain cells die in prion diseases
https://www.scripps.edu/news-and-events/press-room/2021/20211222-encalada-brain-cells-prion-diseases.html
Encalada lab website
https://www.encalada.scripps.edu/
Tweet: @EncaladaLab
Explore the Scripps Research Magazine
https://magazine.scripps.edu/
Subscribe to receive our monthly e-newsletter
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