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Is the future of medicine sweetened by the study of glycans? As GlycanHub rounds off its season, we've brought back the insights of 11 eminent scientists spanning from neuroscience to nanotechnology. Each guest delves into their vision of how glycans could shape medical advancements in their respective fields. Join Rina, our host, for a grand finale that paints a holistic picture of the promising horizon glycobiology is steering us towards.
Answers to the question: What role do you think glycans will play in the future of medicine relevant to your area of study?
Salome Pinho [01:21] Olga Zaytseva [03:04] Peter Joshi [03:51] Hudson Freeze [05:11] Samia Mora [06:11] Anna Halama and Karsten Suhre [08:09] Ronald Schnaar [12:03] Gordon Lauc [14:49] Louise Newson [17:35] Vered Padler-Karavani [18:47]View the Show Notes Page for this Episode
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Could your steak dinner be tricking your immune system? In this episode we shed light on the connection between specific foods and colorectal cancer. Explore xeno-autoantigens, grasp the nuances of immunotherapy, and question the reliability of animal-derived heart valves. Vered Padler-Karavani is the principal investigator in the Department of Cell Research and Immunology at Tel Aviv University. Her research combines glycobiology, immunology, bio-nanotechnology, cancer research and xenotransplantation. Tune in to uncover the hidden connections between glycans, our diet, and the potential health repercussions.
We discuss:
Why study Glycobiology [01:35]Xeno-autoantigens & Xenosialitis [03:16]Where Does Neu5Gc Accumulate? [06:33]Red Meat & Colorectal Cancer [10:28]Tumor-associated Carbohydrate Antigens [11:54]Immunotherapy: Potential & Limitations [13:22]Animal-derived Heart Valves: Safety & Efficacy [20:02]Navigating Safety Regulations for Biologic Therapies [31:27] Neu5Gc in Foods: The Gcemic Index [34:14]Does Prof. Vered Padler-Karavani Still Eat Red Meat? [37:23]Neu5Gc as Biomarkers [38:08]Follow Vered on social media:
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Does menopause hold implications beyond reproductive health? This episode reveals that the shift in hormonal balance affects inflammatory patterns, mediated by complex carbohydrates called glycans. We unravel the overlooked role of perimenopause in chronic disease onset and debunk common myths. Exploring hormone replacement therapy, we discuss its wider health impact, beyond mere symptom management. Louise Newson, a distinguished GP and Menopause Specialist, is the founder of the Balance App, The Menopause Charity, and the Newson Health Menopause Society. An active member of the UK Government Menopause Taskforce, she continually works to elevate menopause understanding and care.
Listen in as we discuss the potential of glycans as biomarkers for menopause, surpassing existing diagnostic tests in their predictive capacity.
We discuss:
Menopause Specialisation: Why Choose It? [02:11]Menopause: Myths vs. Facts [04:12]What Exactly Is Menopause? [05:33]Testosterone's Role in Female Health [08:04]Sex Hormones and Immune Regulation [09:18]Menopause and the Rise of Chronic Illness [12:36]Viewing Menopause as a Hormone Deficiency [15:22]Menopause and Metabolic Syndrome [16:57]Menopause and the Gut Microbiome [18:20]Oestrogen's Role in the Cardiovascular System [24:03]Is Perimenopause Contributing to Chronic Disease? [26:59]Limitations of Current Menopause Tests [30:53]Introducing the Balance App [32:00]Glycan-Based Menopause Tests [34:05]Addressing the Lack of Menopause Education in Medicine [35:36]Common Questions About Hormone Replacement Therapy [38:50]A Look at the Newson Clinic [41:26]Follow Louise on social media:
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In an era defined by COVID-19, understanding the intricacies of our immune response and the profound role our lifestyle choices play in shaping our resilience or vulnerability to future pandemics is of great importance. In this episode, we unravel the influence of glycans, complex carbohydrates instrumental in immune response regulation, on our understanding of COVID-19 susceptibility and severity. We explore the role of lifestyle in disease prevention, particularly focusing on diet and obesity. Gordan Lauc is a Professor of Biochemistry and Molecular Biology at the University of Zagreb Faculty of Pharmacy and Biochemistry and founder and CEO of Genos Ltd. Listen in as he shares valuable insights into pandemic regulations, the spread of misinformation, and vital lessons for the future.
We Discuss:
The Role of Glycans in Promoting and Suppressing Inflammation [03:11]Biological Age as a Predictor of COVID-19 Severity [09:48]Behind the Scenes of Study Design: Stratifying COVID-19 Patients [12:17]The Role of Proinflammatory Glycans in COVID-19 Severity [16:24]Impact of Lifestyle Choices on Disease Risk [22:22]Glycan Biomarkers in Disease Prediction [28:58]Biobanking: A Vital Tool in Pandemic Preparedness [41:39]COVID-19 Regulations and Responses: A Croatian Perspective [43:48]Vaccine Mandates and Universal Masking: Is It Too Much? [50:13]Lessons for Future Pandemics [53:51]Follow Gordan on Social Media:
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The longer lifespans we enjoy come shadowed by age-related diseases, notably Alzheimer's. This episode shines a light on the often-overlooked glycans, complex carbohydrates that play a pivotal role in healthy brain function. Our understanding of Alzheimer's causation has evolved, moving beyond just 'trash accumulation' to include problems with 'trash clearance.' Discover the potential of glycans in healing spinal cord injuries, the hurdles in identifying early biomarkers and delivering drugs to the brain. We delve into the essential role of gangliosides, a unique class of glycolipids, and separate science from media hype around Alzheimer's prevention. Ronald Schnaar is the Professor and Interim Director of the Department of Pharmacology and Molecular Sciences and a Professor of Neuroscience at Johns Hopkins University School of Medicine. Listen in as he unpacks his extensive research in neuro glycobiology and the practical hurdles in the path of Alzheimer's research and prevention.
We Discuss:
Why Study Glycobiology? What Drew Ronald to Glycobiology [02:41]Understanding the Crucial Role of Glycans in Cell-to-Cell Interaction [05:18]Study on Gangliosides in Context of Nerve Cell Insulation [06:29]Congenital Disorders of Ganglioside Biosynthesis: Symptoms and Treatment Options [12:03]The Potential Role of Glycans in Repairing Spinal Cord Injuries [18:17]The Evolution in Our Understanding of Alzheimer's Disease [20:45]Challenges of Studying Alzheimer’s Disease [27:23]International Research Collaboration for Study of Alzheimer’s Disease [31:09]Dual Causes of Alzheimer's: A New Perspective [32:37]Are Mice Good Models for Neurodegenerative Diseases? [34:42]The Challenge of Translating Research into Clinical Application [38:40]Challenges of Drug Delivery to the Brain [40:45]The Future of Glycan Biomarkers of Alzheimer's Disease [42:23]Alzheimer’s Prevention: Sifting Fact from Fiction in Media Coverage [45:58]Ronald’s Future Research Plans and Focus [51:27]Ronald’s Final Message to Our Listeners [54:44]Follow Ronald on Social Media:
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Please be advised that this show is for information only and should not be considered as a replacement or equal to medical advice.
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Are you ready to journey through the intricate layers of Omics, a rapidly developing field that's reshaping our understanding of biological systems? From genomics to proteomics and metabolomics, the multi-omics approach intertwines these layers, offering a rich, multidimensional view of human biology. Today's conversation unravels the fascinating complexity within our bodies, spotlighting the current advancements in multi-omics research and its transformative potential in disease diagnosis and treatment. You'll also discover why glycans, despite often being overlooked in multi-omics studies, are in fact promising biomarkers due to their role as intermediate phenotypes. In this conversation, we are joined by two scientists from Weill Cornell Medicine in Qatar. Karsten Suhre, the Professor of Physiology and Biophysics and the Director of Bioinformatics Core and Dr. Ania Halama, who is an Assistant Professor in Research of Physiology and Biophysics. Tune in, as we unravel the enigmas of this complex and transformative field of research.
We Discuss:
Anna and Karsten's Collaborative Journey [02:27]Metabolism and Metabolomics [04:40]Linking the Dots: The Interconnected Nature of Omics Layers [07:44]Glycomics: The Underrated Player in Multi-Omics Research [09:26]Qatar Metabolomics Study on Diabetes and the Molecular Human [11:52]Unveiling a New Platform: An Introduction to the Comics Server [23:41]Intermediate Phenotypes [28:04]The advantages of a multi-omic approach to research [33:12]Overcoming the Hurdles: Current Challenges in the Multi-Omics Landscape [36:18]How Much Can Genomic Sequencing Inform Prevention and Diagnosis? [45:17]From Lab to Clinic: Karsten and Anna's Pursuit of Translating Research into Practice [50:21]Follow Anna on Social Media:
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It is a widely known fact that cardiovascular diseases are the leading cause of mortality and morbidity in both men and women, which puts an urgency on gaining a better understanding of them. One interesting lens to look at CVDs is through glycans. However, in order to do so, we need to uncover the answer to which came first, the chicken or the egg? Do glycans change in response to the disease? Or are they actively involved in disease development? To figure this out, we welcomed Prof. Samia Mora to the podcast. Samia is a Professor of Medicine at Harvard Medical School and Director of the Centre for Lipid Metabolomics at the Brigham and Women’s Hospital in Boston, Massachusetts. Her research focuses on risk factors and prevention of cardiovascular diseases (CVDs). Listen in as she introduces us to a number of modifiable risk factors and the cumulative effect both positive and negative behaviours have on future disease risk.
We Discuss:
Introduction to Cardiovascular Diseases [01:15]The Key Role of Inflammation in Cardiovascular Disease Development [02:41]The 'Good vs Bad Cholesterol' Perspective: Is It Outdated? [04:05]Glycans: Their Role in Predicting Cardiovascular Disease Risk [08:09]A Look Back: What We Can Learn from the GlycA Biomarker from the 1980s [10:41]Unravelling the Impact of Obesity and Weight Loss on Cardiovascular Disease [15:03]The Glycan Dilemma: Do They Change in Response to Disease or Are They Partake in Disease Development? [21:47]Risk Factors for Cardiovascular Disease: Modifiable vs Non-Modifiable [25:55]Lifestyle Changes: A Proactive Approach to Prevention [31:38]The Effect of Weight Loss on Inflammation Levels [40:14]How Often Should Blood Lipid Levels Be Measured? [43:17]Glycans and Sex-Specific Cardiovascular Risk [48:18]Pregnancy and Menopause as Risk Factors for Cardiovascular Disease [50:02]Glycans: Effective Biomarkers of Cardiovascular Disease? [58:44]Follow Samia on social media
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Glycosylation, a biological process vital to life, is likely something you’ve never heard of before. It involves the addition of sugar molecules, known as glycans, to proteins and lipids which enable a number of crucial physiological functions, from immune regulation to cell-to-cell communication. This episode explores what happens when genetic mutations disrupt the glycosylation pathway as well as the detective work and collaboration required to diagnose and treat the resulting conditions. Hudson Freeze is the Director of the Sanford Children’s Health Research Centre and the Human Genetics Programme at Sanford Burnham Prebys Medical Discovery Institute, his research focuses on Congenital Disorders of Glycosylation, or CDG for short. Listen in as he reflects on the adventurous road to discovery of these rare conditions, the unlikely therapeutic options, the knowledge gap within the medical and scientific communities, and how a single discovery at Yellowstone National Park changed the course of history.
We Discuss:
Hudson’s Background [02:11]Glycosylation vs. Glycation [03:37]Congenital Disorders of Glycosylation (CDG) [06:10]The Accelerating Pace of CDG Research [15:50]Hudson’s Groundbreaking Discovery [21:02]Utilising Animal Models for Glycosylation Research [25:36]Including Families and Patients in CDG Research [34:51]The Future of Diagnostic Options [40:55] The Role of Dietary Supplementation in CDG Treatment [45:37]Overcoming Funding Challenges [57:11]View the Show Notes Page for This Episode
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The concept of biological age might sound like a new notion, but it’s something researchers have been looking at for 35 years. A person’s biological age can tell us more about them than chronological age because it includes genetics, lifestyle and environmental factors. Since it’s such an individualised metric, it’s important to find a reliable way of measuring it. In the episode, Rina and her guest Dr Peter Joshi describe 11 different biological ageing clocks, the research behind them and why GlycanAge is such a great tool for providing not just an accurate measurement of your biological age, but also actionable tips you can incorporate to promote healthy ageing. Our guest is a Chief Scientist for Humanity Health, a company using digital biomarkers to measure and improve the rate of ageing.
We Discuss:
How has our understanding of ageing changed [02:43] What are the hallmarks of ageing [11:15] Explaining the term biological age [14:25] Multi-omics analysis of biological age [20:50]Are biological clocks predictive of chronological age [26:21]The benefit of measuring biological age [43:36]How to improve the biological clocks [46:45]Follow Peter on social media
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How much control do we have over our health? The study of epigenetics made us aware of the remarkable malleability of our phenotype, prompting closer investigation on how lifestyle and environment impact our health and longevity. In this context, glycans - a class of historically understudied biological polymers may hold the key to a better understanding of the interplay between genetic and epigenetic factors contributing to disease development. Olga Zaytseva is a post-doctoral researcher at Genos Glycoscience Research Laboratory in Croatia, her research focuses on the relationship between human diseases and the regulation of antigen-specific IgG glycans. Listen in as she unravels the latest research on genetic and epigenetic regulation of IgG glycosylation and introduces us to the role of environmental factors in common diseases, from obesity to depression.
We Discuss:
Genetics versus Epigenetics: Understanding the Differences [02:22]Epigenetic Changes in Disease: Exploring the Example of Depression [07:37]Good vs. Bad Glycans: Debunking the Myths [12:31]Measuring Glycans on IgG: Benefits and Applications [15:40]GWAS and Glycosylation: Unravelling the Genetic Regulation [21:21]The Role of Environment in Epigenetic Changes: Examining the Learning Process Example [24:46]Mutations make sense in the Context: A Closer Look at Obesity [30:08]Environmental Impact on IgG Glycome: Insights from Smoking and Diet [32:44]Behaviour and IgG Glycome: Is There a Connection? [34:46]Pleiotropy and Poor Hearing in White Cats: What's the Link? [36:18]Glycan Changes and Disease: Causative or Consequential? [40:59]IgG Glycans and Country Development: Investigating the Association [47:51]Glycans as Biomarkers: Challenges and Opportunities [51:51]Exciting Questions Yet to Be Answered: Future Directions in Glycan Research [57:46]Follow Olga on social media
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Glycans have a great capacity to fine-tune the inflammatory response and often determine how successfully the immune system distinguishes between friend and foe. While cancer cells build a glycan shield to hide from immune surveillance, pathogens can mimic our glycans in order to evade immune detection and perpetuate infection. Salomé Pinho is the Immunology, Cancer and GlycoMedicine Group leader at the Institute for Research and Innovation in Health at the University of Porto, her research focuses on cancer and inflammatory conditions. Listen in as she introduces us to the intricacies of immune regulation and the potential of glycans as diagnostic and prognostic biomarkers as well as immunotherapeutic targets.
We Discuss:
The role of glycans in immunological tolerance [4:51] Why has glycobiology been neglected for so long? [10:28]Cancer and immune tolerance [12:08] Glycans as cancer biomarkers and immunotherapeutic targets [20:00] Glycan mimicry in autoimmune diseases [23:48] Glycans as biomarkers of inflammatory bowel disease (IBD) [27:49] GlycanSwitch Project [35:33]Follow Salomé on social media
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Is it enough to conduct medical research only on white men? Why are women more affected by autoimmune diseases? Do menopause and pregnancy trigger different ailments? Is there such a thing as a male and a female hormone?
In this episode of The Age of You - a sweet secret to longevity, we discuss male-centric medicine and the effects created by the exclusion of women in medical research.
Our guests are DR Alka Patel, a TEDx speaker, GP, lifestyle doctor, longevity coach, author, podcaster, the founder of Lifestyle First, a platform that helps people change their lifestyles for the better and DR Julia Jurić - a Senior Researcher at Genos Glycoscience Laboratory.
Watch this episode on YouTube
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Please be advised that this video is for information only and should not be considered as a replacement or equal to medica -
Menopause is no laughing matter, but having humour about it might be the key to breaking down the stigma.
In order to celebrate World Menopause Day, we’re bringing you an uplifting interview with Suzzane Parkes - a person near and dear to all of us in GlycanAge. Suzanne is a consultant that spent her career in the fitness industry and has always prioritized a holistic approach to her health.
Suzanne is passionate about sharing her menopause journey in order to prevent future generations from suffering the way she has. Her vulnerability has helped us prepare an amazing episode which will answer the most common questions we receive about menopause.
The episode will cover
Menopause symptomsHow men can support their partners through menopauseThe process of getting diagnosed with menopauseThe shame associated with menopauseHRT and alternative methods of alleviating symptoms How GlycanAge can help monitor the changes caused by menopauseAs always, if you have any questions, you can leave them as comments on our social media which are listed below.
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For more information on managing your menopause, check out the Balance appPlease be advised that this video is for information only and should not be considered as a replacement or equal to medical advice.
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Despite the buzz around novel cancer therapies, the harsh reality is that most only extend life expectancy by a few months. Dr Azra Raza, a Professor of Medicine, and the Director of the MDS Centre at Columbia University, has a different approach. Azra argues that the key to defeating cancer lies in early detection, and she has dedicated over 35 years of her career to collecting samples and researching myelodysplastic syndromes (MDS) with the goal of catching cancer at its earliest stage. Listen in as she discusses her ground-breaking work and her belief that we are entering a new cancer parading. Dr Raza is leading the charge with a coalition of 8 leading institutions in the USA.
Azra’s first patient [5:56] The impact of losing her husband to cancer on Azra as an oncologist [9:49] Ageing is the most potent carcinogen [13:34] Azra’s new cancer model [17:06] Azra’s revolution – coalition of 8 institutions [24:45] Mice are the real elephants in the room [30:51] Who pays the cost of cancer treatment? [39:21] Azra’s tissue repository – 35 years in the making [43:20] Why is early detection the way forward? [48:42] In search for the giant cell [53:34] The First Cell Centre [1:00:52] Advice for young scientists and clinicians [1:07:16] Azra’s final message [1:11:42]
We Discuss:You can find our guest, Dr Azra Raza, via these links:
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Why do women age faster during menopause? Should menopause be rebranded as a hormone deficiency? Is it ever too late to start HRT? Listen to this episode to find out the answers to these questions and many more!
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Doctor Louise Newson is the Founder of Newson Health Menopause & Wellbeing Centre as well as Balance App and The Menopause Charity. She’s a renowned menopause specialist and is dedicated to helping women of all ages understand that menopause doesn’t have to be a terrible experience. If you’re interested in learning more about her work and tips for anyone in perimenopause or menopause, you can find it in her book - Preparing for Perimenopause and Menopause.
Tim Spector is a professor of Genetic Epidemiology at King's College London and the scientific cofounder of ZOE - a health science company committed to helping people understand how their bodies respond to food. Professor Spector wrote two insightful books grounded in latest research that dive deeper into nutrition and the myths of dieting - Spoon Fed and The Diet Myth.
Gordan Lauc is the leading scientist in the field of glycobiology and the founder of Genos, the world’s largest glycan analysis facility in the world.
All of our listeners are invited to use the code WOMENSDAY at the checkout page and get a 20% discount on a GlycanAge test.
Watch the video recording of this podcast on YouTube.
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t’s not often you get to listen to inspirational yet grounded people. However, today we bring you just that. Meet Anastasis Tzanis — A yoga and breathing instructor, and a nutritional therapist. He shared his struggles with IBS, the effects of yoga, and his experience with GlycanAge. Find out why he doesn’t believe in the one-solution-fits-all approach and why he’s not a fan of restrictive diets. As he and Rina discuss trends in the alternative health industry, Anastasis shares his tips on how to spot the right people to work with.
Find out more about Anastasis via the following links:
Breathing for Yoga course: https://oxygenadvantage.com/breathing-for-yoga-online-course/
Website: www.atzanis.com
Linkedin: https://www.linkedin.com/in/anastasistzanis/Listen to the whole episode and share any comments or questions for future guests via our social media:
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Dear listener, are you interested in learning how to live healthier and take advantage of the latest scientific research? If the answer is yes, you’ll love our first episode in which we dive into understanding longevity.
Tune in as our host Rina interviews Professor Gordan Lauc on the importance of glycans and how these sugars will shape the future of medicine. Other topics we discuss in the episode are - chronic illness, interesting research into the best diet, modern medicine and more.
Find out more information about GlycanAge on our website https://glycanage.com/
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Watch the video recording of this podcast on YouTube.
Engage with us on social media:Please be advised that this video is for information only and should not be considered as a replacement or equal to medical advice.
