Episodi
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If you’ve ever read the little instructions pamphlet included in a box of tampons, you probably came across a paragraph calling attention to a condition called toxic shock syndrome (TSS). It describes the association between TSS and tampon use, symptoms of TSS, and guidance on how to reduce risk. This legally mandated warning label has formed an indelible link connecting tampons and TSS, and indeed, tampons form a large part of the story of TSS. But they are not the entire story. In this episode, we delve into that full story, examining what TSS actually is, the pathogens it’s associated with, and how it was first identified. If you’ve had TSS questions ever since you first heard of it in health class or on your box of tampons, this is the episode for you!
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This week, we’re coming at you with a classic TPWKY episode on one of the most notorious poisons out there: strychnine. Although strychnine might not flash across too many headlines these days, it was once imported by the ton in certain regions of the world. What did people want with so much strychnine? Depends on who you ask. Maybe it was for a revitalizing tonic, maybe a rat poison, or maybe it was to murder the founder of a famous university. Tune in to learn how this deadly poison acts on the body and keep listening for a very special musical treat.
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Episodi mancanti?
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For the past few months, measles has been in regular rotation in the news cycle here in the US, with outbreaks occurring across the country in regions with low vaccine uptake. These outbreaks represent a worrying trend in the rejection of scientific and medical expertise, with long-term consequences not only for those individuals refusing vaccines but also the communities to which they belong. In this TPWKY book club episode (recorded March 14, 2025), Dr. Adam Ratner joins us to discuss his book Booster Shots: The Urgent Lessons of Measles and the Uncertain Future of Children's Health. With his firsthand experience treating children with measles and other vaccine-preventable diseases, Dr. Ratner provides a powerful perspective on the dangers of the measles virus and vaccine hesitancy. What can we learn from the history of measles and the measles vaccine rollout? Why is measles such a dangerous virus? Where do we go from here? Tune in for all this and more.
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Last week, we started this two-parter with a big picture view of pasteurization and the raw milk movement. In this episode, we address the alleged health claims made by proponents of raw milk and dive into the very real risks carried by its consumption. Is raw milk actually better for you? Does it have more vitamins or prevent allergies? What deadly pathogens does it harbor? How much does drinking raw milk increase your chance of contracting a milk-related disease? (Spoilers: A LOT). We tackle these questions with reliable data that paint a very different picture of raw milk than that shown by many raw milk influencers. Tune in for all this and more.
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Seriously, what’s the deal? Lately, it seems like raw milk has started to pop up more and more frequently in our feeds, with influencers touting the alleged health benefits of raw milk over pasteurized milk. In this and next week’s episode, we explore the raw milk phenomenon as it has grown over the past few decades. We start this two-parter with a look at the dangers of milk in a pre-pasteurization world, how Pasteur developed the life-saving process that bears his name, the subsequent rise of anti-pasteurizers, and how the anti-science sentiment surrounding raw milk today reveals a larger and more troubling agenda.
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Tuberculosis, or consumption as it was once known, might conjure up images of huge sanitoriums or writers and artists from the late 1800s (Moulin Rouge, anyone?). But this deadly disease is far from an illness of the past. In many parts of the world, tuberculosis remains an insidious killer, despite the fact that we’ve had effective drugs to treat the infection for decades. In this week’s TPWKY book club episode, we’re thrilled to be joined by the one-and-only John Green to chat about his latest book, Everything Is Tuberculosis. Tune in for a fascinating conversation that tours the past, present, and uncertain future of this devastating illness.
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After last week’s episode, we all know about each of the diseases that we’re protected against thanks to our childhood vaccine schedule here in the US. And after this week’s episode, we’ll understand more about the schedule itself - why it might look different from other schedules around the world, how it gets made, and who makes the recommendations. We’ll also review some of the current outbreaks of vaccine-preventable diseases before leaving you with some of our thoughts on how to talk about vaccines and vaccine hesitancy.
Updates:
At the time of recording, the ACIP meeting originally scheduled in Feb 2025 had not been rescheduled. It is now rescheduled for April 15-16 and the agenda is posted here: https://www.cdc.gov/acip/meetings/index.html
Additionally, the case numbers of current measles outbreaks in the US have grown substantially since the time of our recording. Updated case numbers are reported every Friday here: https://www.cdc.gov/measles/data-research/index.html and at the time of episode release there have been 712 cases reported in the US and 3 deaths.Support this podcast by shopping our latest sponsor deals and promotions at this link: https://bit.ly/3WwtIAu
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We’re already back with our first episode of season 8! This week and next, we’re exploring childhood vaccine schedules - what diseases they protect us from, how the schedule is arranged, and who decides on the vaccines to include and the timing of vaccinations. In this first episode, we start with a refresher on how vaccines work before running through the entire schedule we have here in the US, vaccine by vaccine, comparing pre- and post-vaccine mortality rates. We close out the episode by discussing why vaccination is so important, not just for personal protection but for our communities. Stay tuned for more childhood vaccine schedule talk next week!
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Content Warning: This episode includes mentions of miscarriage, pregnancy loss, pregnancy complications, traumatic birth experiences, and other potentially disturbing topics related to childbirth, pregnancy, and the postpartum period.
We close out our pregnancy series with a big picture view of how the childbirth experience has changed over the past century - both for the better and for the worse. From home to hospital, what have we lost and what have we gained? We also delve into the period known as the fourth trimester, examining the physiological changes that can occur after childbirth as well as one of the most common (but not commonly discussed) conditions that people develop during this time: postpartum depression. Tune into this info-packed episode, and don’t forget to send us your recommendations for future topics!
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Content Warning: This episode includes mentions of miscarriage, pregnancy loss, pregnancy complications, traumatic birth experiences, and other potentially disturbing topics related to childbirth, pregnancy, and the postpartum period.
In Act 3 of our pregnancy series, we arrive at the big moment: childbirth. We begin the episode with a closer look at one of the most commonly performed surgeries around the world: the cesarean section. Exploring how this procedure went from rare to everywhere reveals some of the larger medical trends shaping the childbirth experience in nuanced ways. Then, we take a step back to ask “what is actually happening in labor?” Journeying through the labor and delivery process contraction by contraction gives us the opportunity to examine what is happening in our bodies during this crucial time and how things might not go according to plan.
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Content Warning: This episode includes mentions of miscarriage, pregnancy loss, pregnancy complications, traumatic birth experiences, and other potentially disturbing topics related to childbirth, pregnancy, and the postpartum period.
The second episode in our pregnancy series kicks off with a tribute to one of the most amazing organs: the placenta. We trace the evolutionary origins of the human placenta and examine how this organ allows for such an intimate and delicately balanced relationship between mother and fetus, as well as what can happen if that balance is disrupted. We then turn towards the pregnant person, exploring the broad physiological changes that happen body system by body system throughout pregnancy. Why do you pee so much? Feel nauseous? Have high blood pressure? We get into it all.
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Content Warning: This episode includes mentions of miscarriage, pregnancy loss, pregnancy complications, traumatic birth experiences, and other potentially disturbing topics related to childbirth, pregnancy, and the postpartum period.
With this and the next three episodes, we’re delivering a four-part series on pregnancy, trimester by trimester. We start our series with a tour through the history of the pregnancy test: how and when did these sticks with the two blue lines become the everyday at-home medical device they are today? How has their introduction changed the knowledge that women have about their bodies and who has access to that knowledge? Then we explore the biology of what happens at the very beginning of pregnancy with some light embryology, exploring the earliest steps of implantation, placentation, and what could happen if this process doesn’t go as expected.
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Check out Advances In Care, a podcast that showcases the latest medical breakthroughs by physicians at NewYork-Presbyterian hospital. Our very own Erin Welsh just started a hosting role on the pod! Available wherever you get your podcasts: https://go.pddr.app/advances-in-care-host
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For much of history, female reproductive anatomy has been studied only in the context of or in comparison to male reproductive anatomy. This shows in clinical trial design, in healthcare disparities, in the research questions we ask (or fail to ask), it’s even apparent in our language - the word “vagina” means “sheath”, as if vaginas only exist to sheathe penises. Only recently have researchers begun to close this gap in our knowledge when it comes to half the humans on this planet. In Vagina Obscura: An Anatomical Voyage, award-winning journalist and author Rachel Gross takes readers through the origins of this information gap, examining how preconceived notions about sex and gender underlie the bias that still exists today. She then delves into the fascinating research that seeks to confront this bias and address the vast health inequities that limit care for so many. Tune in for a truly enlightening odyssey through the only recently charted world of female anatomy.
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Has a name brand prescription medication ever shot to notoriety as quickly as Viagra did? Within a few months of its arrival on the market, it seems like everyone knew about the little blue pill, whether through commercials featuring celebrity spokespeople or from endless jokes on late night talk shows. But while everyone understood that this medication promised to treat erectile dysfunction, what most people didn’t know was the wild story leading to its development. Or how this medication (and similar medications) actually works. Or the tremendous impact this blockbuster drug would have on the ways that medications are advertised and developed. In this episode, we bring you those stories (and many more).
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In forests, in lawns, in city parks across the world lurks a small, pale, unassuming mushroom whose inconspicuous appearance belies its deadly nature. For within this mushroom dwelsl one of the deadliest poisons known to humans: amatoxin. It’s because of this toxin that the aptly-named ‘death cap mushroom’ (Amanita phalloides) is responsible for the vast majority of mushroom-related deaths around the globe each year. What makes this poisonous mushroom so very deadly, and is there anything we can do about it? In this episode, we take a journey through this legendary mushroom’s story, exploring its destructive biology, its murderous history, and its worrying yet hopeful future. Tune in to learn more about these mushrooms that show death can come in small packages.
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Okay everyone, think about your tongue. Maybe move it around a bit, check in with it, consider what it means to you. Now imagine that your tongue suddenly shriveled up and fell off and that in its place is a tongue-sized isopod aka rollie pollie aka pillbug. Just there, hanging out, forever. How are you feeling? Horrified? Disgusted? Hey, we get it. But at least you’ll never be alone again. Believe it or not, this is not some bad creative writing exercise. This is a very real parasite. In fact, it’s not just one but a whole group of them. Fortunately for us humans, these tongue-replacing isopods don’t target mammals but rather various fish species (unfortunately for the fish). And in this week’s episode, we’re getting up close and personal with these bizarre (and dare we say cute?) organ-replacing parasites. If you’re wondering why on earth you should care about a niche parasite like this one or why it might be a bad idea to get rid of all of earth’s parasites, then we warmly invite you to sit back, relax, and enjoy this parasite appreciation hour.
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Hemorrhagic virus? Check. Deadly disease? Check. Mosquito-borne? Check. Affected by animal movement, human activity, and environmental change? Check. Rift Valley Fever has all the markings of a classic TPWKY episode. This week, we’re doing a deep dive on this deadly virus, taking a One Health approach to explore the intricate relationships between animals, humans, and the environment to understand how this virus moves across the landscape. We trace the various paths this virus takes: through the organisms it infects, across the globe as it spreads, and over time as it appears to be evolving to be deadlier. Tune in to learn more about Rift Valley fever and what we might see with this pathogen in the years to come.
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We are coming at you with our very first live episode from Perth, Australia! Here at the 2024 Australian Institute of Occupational Hygienists Annual Scientific Conference and Exhibition, occupational hazards and exposures get top billing. And one of the most ubiquitous hazards, experienced by nearly every industry is fatigue, specifically fatigue caused by circadian rhythm disruption. In this very special episode, we explore how our circadian rhythms work and some of the consequences that can emerge when we work against those rhythms, whether that’s because we’re traveling across many time zones or switching to night shift work. We then dig into the history of circadian rhythm research, from how we first learned about these daily patterns to when their disruption became a routine occurrence. Helping us to navigate some of the alarmist headlines (“your screens are ruining your sleep!”) and biohacker claims (“avoid jet lag with this one simple trick!”) is Ian Dunican, PhD. Dr. Dunican is the Director and Chief Adviser of Melius Consulting, a scientific consultancy undertaking research, consulting, and education, and he also hosts and produces the Sleep4Performance podcast. We also bring on Dr. John Iliff, Emergency Physician and Aeromedical Consultant to share his frightening experience with fatigue after a long shift during his training as a physician. Tune in for a fascinating discussion about the rhythms that drive our lives!
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Everyone’s got a favorite disease movie. What’s yours? Does it feature zombies like 28 Days Later (2002), or is it more grounded in reality, like Contagion (2011)? Does it end with a glimmer of hope or with a dose of despair? Who are the bad guys and who are the good guys? From the early days of disease movies like Panic in the Streets (1950) to more recent films like Little Joe (2019), these movies have provided endless entertainment, excitement, and opportunities to examine society itself. In this TPWKY book club episode, Robert Alpert, Dr. Merle Eisenberg, and Dr. Lee Mordechai join us to discuss their book Diseased Cinema: Plagues, Pandemics, and Zombies in American Movies. Diseased Cinema approaches the genre of disease-themed movies with the goal of understanding what these movies say about our hopes, our fears, our anxieties, and how these perspectives have shifted over the decades. When did faith in our government’s problem solving give way to rugged self-reliance? Why did people start to view science as the bad guy rather than the source of salvation? Tune in for a fascinating discussion that will stay on your mind long after your next movie night. And also check out Merle and Lee’s excellent podcast Infectious Historians!
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Yes, the world may be out to get us with allergens around every corner, but we’ve got some tricks up our sleeve to help us cope. Our allergy treatment toolkit includes an impressive suite of tools, and in the second episode of our two-part series on allergies, we focus on three in particular: antihistamine medications, allergy shots, and the epinephrine auto-injector (aka the EpiPen). We take you through how exactly each of these work, trace their development from concept to product, and highlight some of the most promising areas of allergy treatment research today. Have you ever wondered why we have so many different types of antihistamines? Or thought about what the Cold War has to do with the EpiPen? Then this is the episode for you.
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