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Professor Kevin Brindle joins Ellie Wolmark to discuss his life's work in imaging research as he reaches retirement. Kevin is particularly interested in metabolic imaging. His research group has developed novel magnetic resonance-based molecular imaging techniques to detect the early responses of tumours to therapy, with a view to translating these into clinical application. He talks about how he got into this topic in the first place, his amazing contributions to the field over the past four decades, and about how his techniques can be translated into the clinic to impact patient treatment.
Kevin is Emeritus Professor of Biomedical Magnetic Resonance in the Department of Biochemistry and a Senior Group Leader in the CRUK Cambridge Institute at the University of Cambridge, UK. He is also a Fellow of the Academy of Medical Sciences and of the Royal Society. -
Dr Ines Machado, Dr Gabriel Funingana, Thomas Buddenkotte and Amied Shadmaan talk about the research they are undertaking within the collaborative project between GE Healthcare, the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust. They also provide an update on the development of the Oncocare platform.
Ines is a Research Associate in the Crispin Lab at the CRUK Cambridge Institute, University of Cambridge, UK.
Gabriel is a Clinical Fellow and PhD student in the Department of Oncology, University of Cambridge, UK.
Thomas is a consultant to the Crispin Lab. He obtained his PhD at the University of Cambridge, UK, working at the Department of Applied Mathematics and Theoretical Physics and the Department of Radiology. He is now affiliated with the Department of Diagnostic and Interventional Radiology and Nuclear Medicine at the University Medical Center Hamburg-Eppendorf, Germany, and the Hamburg-based company Jung Diagnostics.
Amied is Director of AI & Clinical Collaborations at GE Healthcare. -
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This week, Ellie Wolmark is joined by Dr Claire King, Cherry May Sanchez and Dr Rhys Grant to discuss some of the amazing engagement, involvement and inclusion initiatives that we run here at the CRUK Cambridge Centre at the University of Cambridge, UK. They share how and why we engage and involve patients and the public in our research, and focus on the importance of championing equality, diversity and inclusion (EDI) in all aspects of our work. You will also hear about some of our projects for working with hard-to-reach communities, including how our Nursing and Allied Health Professionals Programme are helping to tackle health inequalities for people experiencing homelessness.
Claire is a Programme Manager for the Advanced Cancer Imaging and Cancer Immunology Programmes and an EDI Champion at the CRUK Cambridge Centre.
Cherry May is the CRUK Senior Research Nurse and co-Lead for the Nursing and Allied Health Professionals Programme at the CRUK Cambridge Centre.
Rhys is the Engagement Lead and an EDI Champion at the CRUK Cambridge Centre. -
In today's episode, Marika Reinius and Maria Delgado Ortet talk about the multidisciplinary 3D mould guided radiogenomics project in ovarian cancer. They highlight how the process works and why it is potentially game changing in the treatment of a cancer where the standard of care has not really changed in over 20 years.
Marika is a clinical research fellow at the CRUK Cambridge Centre, University of Cambridge, UK.
Maria is a PhD Student in the Department of Radiology and the Department of Engineering at the University of Cambridge, UK. -
Professor Jason Carroll speaks about his research in molecular oncology, with a focus on the work underpinning the PIONEER breast cancer trial and the outcomes of this clinical trial.
Jason is Professor of Molecular Oncology and Senior Group Leader at the CRUK Cambridge Institute, University of Cambridge, UK. He is also co-lead for the Precision Breast Cancer Virtual Institute at the CRUK Cambridge Centre, UK. -
In today's episode, Ellie Wolmark is joined by Professor George Vassiliou to talk about his research on clonal haematopoiesis and a new clinic that he has recently set up. We'll uncover what clonal haematopoiesis is and how it can sometimes lead to the development of blood cancer.
George is a CRUK Senior Clinical Fellow and Professor of Haematological Medicine at the University of Cambridge, UK. He is also a member of Faculty at the Wellcome-MRC Cambridge Stem Cell Institute and a Consultant Haematologist at Cambridge University Hospitals NHS Foundation Trust. -
In this episode, Professors Grant Stewart and Stephen Price discuss what it means to be both a cancer surgeon and a clinical researcher. They talk about how they can improve surgery for brain and kidney cancer patients, how they can identify cancer as quickly as possible through screening, and how they can improve on the outcomes of surgery by augmenting it with other treatments such as radiotherapy and drugs.
Grant is co-lead of both the Institute for Integrated Cancer Medicine and the Urological Malignancies Virtual Institute at the CRUK Cambridge Centre, UK, and is Professor of Surgical Oncology in the Department of Surgery at the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust.
Stephen is co-lead of the Brain Cancer Virtual Institute at the CRUK Cambridge Centre, UK, and is Professor of Neurosurgical Oncology and Honorary Consultant Neurosurgeon at the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust. -
Dr Raj Jena talks about his research on analysis of the images used for radiotherapy planning and for modelling the effects and outcomes of radiotherapy treatment. As a clinician, he uses radiotherapy and drug treatments on patients with tumours in the brain or spine. He also talks about the InnerEye Project, a collaboration with Microsoft Cambridge, which uses algorithms to map and segment tumours from CT/MRI scans.
Raj is a Clinical Consultant and Radiation Oncologist at Cambridge University Hospitals NHS Foundation Trust, UK, and is a member of the CRUK Cambridge Centre at the University of Cambridge, UK. -
Ellie Wolmark introduces part four of our Integrated Cancer Medicine: Research in Focus series. She talks to members of the CRUK Cambridge Centre about a diverse range of topics, including Dr Raj Jena to hear about his ground-breaking research, specifically the InnerEye project and how this amazing collaboration with Microsoft Cambridge has been brought into the clinic to benefit patients. Other topics include combining being a surgeon and a clinical researcher, Professor George Vassiliou talking about his research on clonal haematopoiesis and a new clinic that he has recently set up, as well as much, much more. As always you will hear discussions about research and research collaborations, the techniques that are being developed and how they translate to the clinic to affect patient treatments and outcomes.
Ellie is Communications Manager for Integrated Cancer Medicine at the University of Cambridge, UK, and the CRUK Cambridge Centre, UK. -
In this special episode of our podcast, we bring you a recording of a live 'Ask Me Anything (AMA)' event held by our Pancreatic Cancer Programme for World Pancreatic Cancer Day on 16 November 2023. The AMA webinar saw specialists from across different disciplines answering questions submitted by members of the public and discussing topics related to day-by-day living with pancreatic cancer.
In alphabetical order, the AMA panel consisted of:
Dr Bristi Basu, an Academic Consultant in Medical Oncology specialising in experimental cancer therapeutics at the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, and the clinical co-lead of the CRUK Cambridge Centre Pancreatic Cancer Programme.
Yvonne Cartwright, a Consultant in Palliative Medicine at Cambridge University Hospitals NHS Foundation Trust.
Dr Paulo Fidalgo, a Gastroenterologist at the Digestive Unit of the Champalimaud Clinical Centre in Portugal, and head of their Risk Assessment and Early Diagnosis Programme.
Kirsty Hoare, a Cancer Support Specialist at Maggie's.
Dr Asif Jah, a Consultant Surgeon in hepato-pancreatico-biliary (HPB) and transplant surgery at Cambridge University Hospitals NHS Foundation Trust, and Clinical Lead of the Department of HPB Surgery and Associate Lecturer at the University of Cambridge.
Jeni Jones, a Pancreatic Cancer Specialist Nurse at Pancreatic Cancer UK.
Laura McGeeney, a Pancreatic Cancer Specialist Dietician at Cambridge University Hospitals NHS Foundation Trust.
Sally Pascall, a 13-year survivor of pancreatic cancer, and one of our patient representatives who advises the Pancreatic Cancer Programme on issues that are relevant to patients.
Abigail Redman, an HPB Oncology Clinical Nurse Specialist at Cambridge University Hospitals NHS Foundation Trust. -
In this special episode of our podcast, Hui-Ling Ou is joined by Isobel Turbin to talk about inherited pancreatic cancer, genetic testing, and genetic counselling. They also discuss which genetic tests are currently available, why these genes are important, and how testing results may help pancreatic cancer patients.
Dr Hui-Ling Ou is the Programme Manager for the Pancreatic Cancer Programme at the CRUK Cambridge Centre at the University of Cambridge, UK.
Isobel Turbin is a Principal Genetic Counsellor within the East Anglia Regional Genetics Service, UK. She currently holds cancer genetic, general genetic, and prenatal genetic clinics at Addenbrooke's Hospital in Cambridge, UK, as well as monthly general genetic clinics in King's Lynn, UK. Isobel is also the Education and Training Co-lead in the East Anglian Genetic Counselling Team.
Useful links mentioned in this podcast episode:
National Genomic Test Directory: www.england.nhs.uk/publication/national-genomic-test-directories
EUROPAC: www.europactrial.com
Genetic Alliance UK: www.geneticalliance.org.uk
Genetic and Genomic Testing (NHS webpage): www.nhs.uk/conditions/genetic-and-genomic-testing
Clinical Genetics at Cambridge University Hospitals NHS Foundation Trust: www.cuh.nhs.uk/our-services/clinical-genetics -
In today's episode, Ellie Wolmark is joined by Natalie Ellis, Ellen Nowak and Lauren Gardiner Walton to talk about the development of the Arts Strategy for the Cambridge Cancer Research Hospital (CCRH). They also discuss the benefits of the arts in cancer care and in supporting patient treatment and recovery.
If you would like to get involved in the CCRH project by joining any of the groups that Ellen mentions in this episode, further information can be found at: www.cambridgecancer.org.uk/our-community/get-involved
Natalie is Head of Arts at Cambridge University Hospitals NHS Foundation Trust.
Ellen is an Arts Programme Manager at Cambridge University Hospitals NHS Foundation Trust.
Lauren is a member of the CCRH Environment Design Working Group as well as being Curator of the Cambridge University Herbarium, and was recently treated for cancer.
About CUH Arts:
CUH Arts is Cambridge University Hospitals' arts-in-health programme, dedicated to shaping care through creativity. They strive to promote wellbeing, distract from illness, and improve the hospital experience by providing excellent creative and cultural opportunities for patients, staff, visitors and the wider community. Embedded within one of the world's leading hospital trusts, their diverse, person-centred, multi-disciplinary programme of live, participatory and visual arts is facilitated and managed by an expert team of arts professionals in collaboration with artists and cultural partners. -
In this episode, Professor Charlotte Coles talks about her work on the personalisation of radiation techniques to give patients with cancer the best chance of cure with the least side effects.
Charlotte is Professor of Breast Cancer Clinical Oncology and Deputy Head of the Department of Oncology at the University of Cambridge, UK. She is also the Director of CRUK RadNet Cambridge. -
In this week's episode, Professor Florian Markowetz talks about his work and recent publication on chromosomal instability. Chromosomal instability is a dynamic process of DNA change, which leads to some DNA being present multiple times and some being lost altogether. Some cancers are dominated by this process of genomic disruption; ovarian, pancreatic and triple-negative breast cancer for example. These chaotic DNA changes mean that there are not good biomarkers present to guide treatment decisions. Florian's laboratory has found a structure underlying chromosomal instability and has identified genomic fingerprints which enable them to read out the fundamental reasons for the DNA changes.
Florian is a group leader at the Cancer Research UK Cambridge Institute at the University of Cambridge, UK. -
Dr Marcel Gehrung talks about how his research at the CRUK Cambridge Centre led him to co-found the start-up Cyted with Rebecca Fitzgerald, Professor of Cancer Prevention and Director of the Early Cancer Institute at the University of Cambridge, UK, and Maria O'Donovan, lead pathologist for upper gastrointestinal cancer and diagnostic cytology at Cambridge University Hospitals NHS Foundation Trust.
Cyted combines innovative AI-driven diagnostics with a new sample collection method to detect and prevent oesophageal cancer, developed at Cambridge University. -
In this week's fascinating episode, Ellie Wolmark is joined by Dr Dario Bressan to discuss how the Cancer Grand Challenges team IMAXT has brought cancer researchers together with astronomers and video game designers to build the world's first virtual reality map of a tumour. By developing this entirely new way to study cancer, team IMAXT could revolutionise the diagnosis and treatment of people with the disease.
Dario is Head of the IMAXT Laboratory at the CRUK Cambridge Institute at the University of Cambridge.
Cancer Grand Challenges is a funding initiative co-founded by Cancer Research UK and the National Cancer Institute in the US. -
In the first episode of part three, podcast host Ellie Wolmark is joined by Professor Robert Rintoul and Lauren Wallis to talk about biological sampling. They discuss what biosamples and biobanks are, how they are collected and used, and why they are so important for both patient treatment and cancer research.
Robert is Professor of Thoracic Oncology in the Department of Oncology at the University of Cambridge, and Honorary Consultant Respiratory Physician at Royal Papworth Hospital.
Lauren is Translational Research Manager in the Urological Malignancies Programme at the CRUK Cambridge Centre, University of Cambridge. -
Ellie Wolmark introduces part three of our Integrated Cancer Medicine: Research in Focus series. In the coming episodes, the net continues to be spread a little wider to include conversations about biosampling, the IMAXT project, the company Cyted, personalised radiotherapy, and much, much more. As always you will hear discussions about research and research collaborations, the techniques that are being developed, and how they translate to the clinic to affect patient treatments and outcomes.
Ellie is Communications Manager for Integrated Cancer Medicine at the University of Cambridge and the CRUK Cambridge Centre. -
In the final episode of this series, we are joined by a special guest, Robert Chuter, a researcher from the Christie Hospital. Robert shares with us his research into the impact radiotherapy has on climate change. We are all aware of the effects that we have on the world around us, and the way in which we minimise our impact on the environment is crucial for the future of the planet. Neil, a member of our Patient and Public Involvement and Engagement (PPIE) Group, joins us this week to discuss radiotherapy, the environment, and what can be done to reduce our carbon footprint.
Robert works with the Clinical Radiotherapy Physics Team at the Christie Hospital in Manchester, UK, and the Radiotherapy-Related Research (RRR) Group at the University of Manchester. Whilst his main focus is on the Magnetic Resonance Linear Accelerator (MR-Linac), he is also the Chair of the Institute of Physics and Engineering in Medicine's (IPEM) Environmental Sustainability Group, which he set up in February 2020. As part of this, he has written many articles and presented at numerous meetings on this critically-important topic. He was also successful in being awarded nearly £10,000 by the North-West Greener NHS Innovation Fund to estimate the carbon footprint of the radiotherapy treatment pathway. -
Today, Andrew Robinson talks to us about adaptive radiotherapy, where we are with it now, and the potential it has for the future. Adaptive radiotherapy has been around for many years, but it is not currently standard practice. Essentially, there are different ways in which we can adapt radiotherapy treatment, which Andrew explains during this episode. Helene, a member of our Patient and Public Involvement and Engagement (PPIE) Group, asks questions about what this may mean for radiotherapy practice and how the workforce may manage some of the associated challenges.
Andrew is the Head of Radiotherapy Physics in the Radiotherapy Department at Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, UK. He is a Health and Care Professions Council (HCPC)-registered Clinical Scientist, Medical Physics Expert, and Higher Specialist Scientist. Andrew has experience across many areas of radiotherapy physics including quality control, dosimetry, prostate brachytherapy, stereotactic radiotherapy planning, and equipment replacement projects. - Mehr anzeigen
