Episodios
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In this episode, my guest is Robert Greene, multiple New York Times bestselling author and expert on human psychology and behavior both at the individual and group levels and in the context of relationships, careers, and society. We discuss how to find, pursue and achieve oneâs unique life purpose, and how to best learn from good and hard experiences along that journey. We discuss power dynamics in relationships, the different types of human communication and the interplay between seduction and vulnerability. We discuss how to find the right romantic partner, improve healthy self-awareness, the link between anxiety and creativity, and pick ideal mentors and role models. Robert also discusses his recent stroke and what he has learned from his near-death experience about motivation, urgency and appreciation for life. Listeners of all ages will benefit from Robertâs insights on navigating the process of building a deeply purposeful life and enhancing oneâs relationship with the self, others and society. For show notes, including referenced articles and additional resources, please visit hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanROKA: https://roka.com/hubermanHelix Sleep: https://helixsleep.com/hubermanWaking Up: https://wakingup.com/hubermanInsideTracker: https://insidetracker.com/hubermanMomentous: https://www.livemomentous.com/hubermanTimestamps(00:00:00) Robert Greene(00:01:58) Sponsors: ROKA, Helix Sleep & Waking Up(00:05:56) Mastery (The Book), Purpose(00:08:26) Finding Purpose, Childhood, Learning & Emotional Engagement(00:18:00) Early Interests, Delight & Discovery(00:22:50) Love vs. Hate Experiences & Learning(00:28:25) Self-Awareness, Frustration, Excitation(00:31:47) Sponsor: AG1(00:33:18) Sublime Experiences, Real vs. False; Authenticity & Time(00:43:57) Power & Relationships; Purpose & Mastery(00:55:51) Seduction, Vulnerability, Childhood(01:07:04) Sponsor: InsideTracker(01:08:05) Power Dynamics & Romance; Equality, Love Sublime & Connection(01:18:42) Vulnerability in Relationships, Creativity; Social Media, Justice(01:29:45) Outrage, Control, âArt of Ignoreâ(01:33:50) Masculinity & Femininity(01:42:16) Picking Role Models; Purpose & Mentor Relationship(01:51:07) âAliveâ Thinking; Anxiety & Creativity(01:58:55) Convergent Interests & Romantic Relationships(02:07:19) Self-Awareness, Core Values & Romantic Relationships(02:15:27) Non-Verbal Communication & Relationships(02:24:58) Eyes, Voice, Intuition & Seduction(02:28:38) Virtual World, Social Skills, Non-Verbal Communication(02:32:19) Self-Awareness & Intelligence, Artificial Intelligence (AI), Nuance(02:41:43) Human Brain, Plasticity(02:45:18) Stroke & Near-Death Experiences, Self, Time(02:55:49) Appreciation & Near-Death Experience, Urgency(03:01:36) âDeath Groundâ & Urgency(03:09:13) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network NewsletterDisclaimer
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Welcome to a preview of the 13th Ask Me Anything (AMA) episode, part of Huberman Lab Premium.
Huberman Lab Premium was launched for two main reasons. First, it was launched in order to raise support for the main Huberman Lab podcast — which will continue to come out every Monday at zero-cost. Second, it was launched as a means to raise funds for important scientific research. A significant portion of proceeds from the Huberman Lab Premium subscription will fund human research (not animal models) selected by Dr. Huberman, with a dollar-for-dollar match from the Tiny Foundation. Read our Annual Letter 2023.
If you're an existing Premium member, you can login to access the full episode.
If you're not a member, you can join Huberman Lab Premium to enjoy exclusive content, including monthly Ask Me Anything (AMA) episodes, AMA transcripts, podcast episode transcripts, early access to live events and help advance human scientific research.
Timestamps
(00:00:00) Introduction
(00:01:46) Does Cold Weather Make You Sick?
(00:21:58) Huberman Lab Premium
In the full AMA episode, we discuss:
Wim Hof Breathing and Sickness
Articles
Association of oral breathing with dental malocclusions and general health in children
Title Card Photo Credit: Mike Blabac
Disclaimer -
¿Faltan episodios?
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In this episode, my guest is Dr. Adam Grant, Ph.D., a professor of organizational psychology at The Wharton School of the University of Pennsylvania, an expert in the science and practical steps for increasing motivation, maximizing and reaching our potential, and understanding how individuals and groups can best flourish. He is also an avid public educator, having written five bestselling books, delivered several top-ranking TED Talks and is the host of two psychology podcasts. We discuss how to overcome procrastination, how to increase intrinsic motivation (even for dreaded tasks), identify blind spots and rethink our assumptions, and how we can build a persistent growth mindset. We also explain tools to improve creativity and discuss the surprising relationship between creativity and procrastination. We then explore how to effectively solicit useful feedback and grow from constructive criticism and how you can improve your level of focus and attention using science-supported methods. We also discuss mental tools to get out of negative thought spirals, how to nurture potential in yourself or others, and the dark side of perfectionism. The discussion delivers more than a dozen science-supported protocols that are readily applicable to anyone seeking to live a more productive, fulfilling, and creative life.For show notes, including referenced articles and additional resources, please visit hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanEight Sleep: https://eightsleep.com/hubermanLevels: https://levels.link/hubermanWaking Up: https://www.wakingup.com/hubermanInsideTracker: https://insidetracker.com/hubermanMomentous: https://www.livemomentous.com/hubermanTimestamps(00:00:00) Dr. Adam Grant(00:01:37) Sponsors: Eight Sleep, Levels & Waking Up(00:05:56) Procrastination & Emotion; Curiosity(00:14:06) Creativity & Procrastination; Motivation(00:20:48) Intrinsic Motivation & Curiosity(00:27:59) Tool: Tasks & Sense of Purpose(00:30:52) Sponsor: AG1(00:32:34) Extrinsic Rewards, Choice; Social Media(00:42:24) Tool: âQuiet Timeâ Protocol, Chronotypes(00:49:20) Tool: Creativity: Mornings, Movement, Stillness(00:57:05) Sponsor: InsideTracker(00:58:14) Tools: Ideas & Filtering, Feedback & Opinions, Advice(01:07:15) Tool: Constructive Criticism, âSecond Scoreâ; Verbs(01:14:40) Tool: Growth Mindsets, Scaffolding; Job Innovation(01:21:50) Tools: Task Sequencing & Intrinsic Motivation; Tapering & Frame of Reference(01:30:03) Tools: Momentum, Confidence & Domains; Negative Thought Spirals(01:36:16) Tool: Phone & âTo Donâtâ List; Writing Ideas(01:39:54) Tool: Bias Blindspot, Reflected Best-Self Portrait(01:45:36) Helping Others, Synthesizing Information(01:50:24) Modes of Thinking, Blind Spots & Assumptions(01:56:10) Thinking Like a Scientist: Hypothesis-Testing & Discourse, Social Media(02:05:150 Tool: Authenticity, Sincerity & Etiquette, âSnapshotâ & Online Presence(02:12:49) Realizing Potential: Motivation, Opportunity & Process(02:21:53) Skills to Realize Potential, Perfectionism(02:27:52) Tool: Early Success & Performance Cycle, âFailure Budgetâ(02:31:56) Future Projects, Complex Issues & Challenging Ideas(02:40:10) Artistic Hobbies, Magicians(02:45:55) Science Communication, Interest & Self-Relevance(02:52:16) Languishing, Descriptive Language & Emotions(03:00:09) Tool: Nurture Potential in Children, âCoach Effectâ(03:10:16) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network NewsletterDisclaimer
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In this episode, I explain a specific writing protocol shown in hundreds of scientific studies to significantly improve immediate and long-term health. I explain how to implement this specific protocol, which takes only four days and 15-30 minutes per day. I also explain the mechanism for how the four-day writing protocol affects neuroplasticity (brain rewiring) and brain function in the short and long term. I explain how these brain changes positively impact our physical health, including our system's immune function and thus our ability to combat infections, improve sleep, reduce feelings of physical and emotional pain, lower anxiety, and bring about healing from traumas. This episode ought to be of interest to anyone seeking better mental and/or physical health through the use of brief yet highly effective science-supported protocols.For show notes, including referenced articles and additional resources, please visit hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanLMNT: https://drinklmnt.com/hubermanEight Sleep: https://eightsleep.com/hubermanWaking Up: https://wakingup.com/hubermanInsideTracker: https://insidetracker.com/hubermanMomentous: https://livemomentous.com/hubermanTimestamps(00:00:00) Journaling Protocol for Mental & Physical Health(00:03:06) Sponsors: LMNT, Eight Sleep & Waking Up(00:07:16) Journaling & Confronting Traumatic Events(00:11:25) Tool: Expressive Writing(00:14:38) Morning Notes, Gratitude Journaling, Diary Journaling(00:18:00) Tool: Consecutive Writing Bouts; Trauma Definition(00:24:38) Low Expressors vs. High Expressors(00:29:29) Tools: Language, Vocabulary & Emotion; Analyzing Writing(00:35:02) Tool: Writing Session Tips(00:39:31) Sponsor: AG1(00:41:02) Positive Mental & Physical Benefits(00:46:45) Expressive Writing & Immune Function; Brain-Body Connection (00:57:02) Sponsor: InsideTracker(00:58:10) Neuroplasticity, Prefrontal Cortex & Subcortical Structures(01:05:00) Structured Writing, Trauma & Narratives; Truth-Telling(01:08:56) Neuroplasticity, Truth-Telling & Relief from Trauma(01:15:32) Honesty, Brain Activity & Narratives(01:22:01) Overcoming Trauma & the Brain; Stress, Emotions & Honesty(01:26:41) Expressive Writing Protocol & Benefits(01:36:16) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network NewsletterTitle Card Photo Credit: Mike BlabacDisclaimer
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Recently I had the pleasure of hosting a live event in Toronto, ON. This event was part of a lecture series called The Brain Body Contract. My favorite part of the evening was the question & answer period, where I had the opportunity to answer questions from the attendees of each event. Included here is the Q&A from our event in Toronto, ON.
We'll be hosting four live events in Australia in February 2024. Limited tickets remain for our show in Melbourne on February 10, 2024, and Brisbane on February 24, 2024. Our show in Sydney at the Sydney Opera House sold out quickly, so we've added a second show at the Aware Super Theatre on February 18, 2024. For tickets and event details, please visit https://www.hubermanlab.com/events.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
Eight Sleep: https://eightsleep.com/huberman
Timestamps
(00:00:00) Introduction
(00:02:41) What Motivated You to Do the Guest Series With Dr. Paul Conti?
(00:08:07) Enhancing Emotional Resilience in Triggering Situations: Protocols and Best Practices
(00:12:46) Understanding and Fostering Sudden Inspiration in the Brain
(00:16:36) How Can Canadians Fight the Season Depression?
(00:22:45) How Do You Increase Neuroplasticity After 30?
(00:28:46) What Type of Movement Protocol Do You Recommend for Someone Working From Home?
(00:33:02) What Does Your Morning Meditation Consist Of?
(00:38:05) Conclusion
Title Card Photo Credit: Mike Blabac
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In this episode, my guest is Natalie Crawford, MD, a double board-certified physician specializing in obstetrics and gynecology, fertility and reproductive health and host of the âAs a Womanâ podcast. We discuss female hormones, nutrition, supplementation, reproductive health, and fertility, including how the timing and duration of puberty impact a womanâs long-term hormone cycles and menopause. We also discuss the pros and cons of various birth control methods and how hormonal vs. non-hormonal birth control each affects fertility. We cover the factors that impact egg and sperm quality and how to leverage timing for conception. We also discuss procedures to assess female fertility, including egg count and hormone testing, the process of egg freezing, in vitro fertilization (IVF) and other reproductive options. This episode represents fairly comprehensive coverage of female hormones and reproductive health, highlighting important tests and screening, behavioral, nutritional, supplement and prescription-based tools that women of any age can use to improve their fertility, hormone function and overall health. For the full show notes, please visit hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanMaui Nui: https://mauinuivenison.com/hubermanHelix Sleep: https://helixsleep.com/hubermanInsideTracker: https://insidetracker.com/hubermanMomentous: https://www.livemomentous.com/hubermanTimestamps(00:00:00) Dr. Natalie Crawford(00:01:40) Sponsors: Maui Nui Venison & Helix Sleep; The Brain Body Contract(00:04:59) Female Puberty & Growth Characteristics, Height(00:13:27) Eggs & Ovulation, Harvesting Eggs, In Vitro Fertilization (IVF)(00:17:31) Endocrine Disruptors, Fetal Development(00:21:39) Lavender, Tea Tree & Evening Primrose Oils, Scents, Diapers(00:25:13) Breast Milk vs. Formula & Fertility(00:26:04) Menstruation Cycle & Hormones, Timing(00:34:08) Sponsor: AG1(00:35:59) Estrogen, Progesterone & Menstrual Cycle(00:38:08) Hormonal Birth Control & Ovarian Reserve, AMH Testing, Fertility(00:42:42) Spermatogenesis & Testosterone; Heat: Ovaries vs Testes(00:46:11) Period & Pregnancy, Conception Window(00:48:56) Estrogen, Libido & Ovulation; Mittelschmerz(00:51:33) Tool: Intercourse Timing & Conception; Artificial Insemination, IVF(00:55:03) Egg/Sperm Quality, Cigarettes, Vaping, Cannabis & Alcohol (01:02:20) Sponsor: InsideTracker(01:03:29) Intrauterine Device (IUD), Depo-Provera & Fertility(01:10:00) Birth Control Risks & Benefits, Cancers, Polycystic Ovarian Syndrome (PCOS)(01:19:39) Blood Clotting & Birth Control Pill; Health Screening (01:24:50) Tool: AMH Testing, Ovarian Reserve, Antral Follicle Count Ultrasound(01:29:55) IVF, In Vitro Maturation (IVM); Early Ovarian Reserve Screening(01:35:40) Tools: Egg Freezing, IVF; Age & Egg Quality(01:43:37) Egg Freezing & IVF Procedures, Maternal Age, Success Rates(01:51:30) Tool: Sperm Freezing & Paternal Age, Vasectomy(01:55:01) Hormones, Egg Freezing & IVF(02:00:42) Three-Parent IVF, Mitochondrial DNA(02:05:21) IVF Embryo Storage & Donation; Donor Education & Consent(02:14:29) Autism, Developmental Disorders, IVF Babies, Age (02:20:36) Tools: Sleep, Nutrition & Fertility; Dietary Fat(02:27:32) Protein, Meat, Tofu, Fish; Sugar, Artificial Sweeteners; Weight & Miscarriage(02:37:38) Tools: Supplements; Prenatal Vitamins, Omega 3s, Vitamin D, Coenzyme Q10(02:42:26) L-Carnitine & Male Fertility; PCOS & Myo-inositol; Metformin(02:47:11) Egg Retrieval, Ovarian Hyperstimulation Syndrome, Minimal Stimulation(02:57:56) INVOcell(03:03:12) Egg Freezing, Intracytoplasmic Sperm Injection (ICSI), Sperm Fragmentation(03:11:45) Genetic Testing, IVF Transfer & Success Rate, Embryo Banking(03:15:10) Menopause(03:19:47) Hormone Replacement Therapy & Menopause(03:22:25) Early-signs of Menopause(03:25:18) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network NewsletterDisclaimer
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In this episode, my guest is Dr. Michael Eisenberg, MD, a urologist and professor specializing in male sexual function and fertility at Stanford University. Based on his clinical work and research, he is considered a top world expert on male sexual and reproductive health. We discuss testosterone levels and what really impacts them, testosterone therapy, sperm quality and counts, penile and testicular health and function, pelvic floor and prostate and urinary tract health, erectile function and dysfunction and the various causes and treatments for common male sexual, hormonal and reproductive challenges. We also address post-finasteride syndrome and trends in penile length. This episode is rich in actionable information about menâs sexual and reproductive health, including key tests and at-home evaluations, and the behavioral, nutritional, exercise and prescription-based tools that can support male sexual and reproductive health.For show notes, including referenced articles and additional resources, please visit hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanROKA: https://roka.com/hubermanEight Sleep: https://eightsleep.com/hubermanLMNT: https://drinklmnt.com/hubermanMomentous: https://www.livemomentous.com/hubermanTimestamps(00:00:00) Dr. Michael Eisenberg(00:01:49) Sponsors: ROKA & Eight Sleep(00:04:20) Sperm Quality, Geographic & Environmental Factors (00:12:00) Fertility & Sperm Quality; Testosterone, Cell Phones & Heat(00:19:26) Testosterone, Age, Obesity(00:26:49) Tool: Optimize Sperm Quality, Exogenous Testosterone, hCG(00:35:26) Sponsor: AG1(00:36:57) Tool: Lifestyle Factors & Sperm Quality, Alcohol(00:43:27) Sperm Quality, Recreational & Over-the-Counter Drugs, Cannabis(00:46:56) High-Impact Sports, Traumatic Brain Injury (TBI), Pituitary & Testosterone(00:49:55) Bicycling, Numbness & Sexual Dysfunction; Walking & Testosterone(00:55:39) Exogenous Testosterone Therapy & Cancer(00:58:39) Sponsor: LMNT(00:59:57) Sexual & Urinary Health, Nighttime Urination(01:03:12) Sleep & Semen Quality; Overall Health(01:09:19) Tool: Sperm Analysis & Overall Health; Sperm Banking(01:13:21) Paternal Age & Puberty Trends; Older Fathers & Child Health Risk(01:26:42) Tool: Prostate Health, Urination; Tadalafil (Cialis)(01:33:02) Urinary Tract Infections (UTIs); Erectile Dysfunction Causes(01:38:21) Blood Flow & Erectile Dysfunction, Medication; Cardiovascular Health(01:44:30) Mechanical Erectile Dysfunction Treatments; Peptides; Delayed Ejaculation(01:52:36) Pelvic Floor Health, Urology & Physical Therapy; Split-Stream Urination(01:59:03) Penile Length & Trends; Dihydrotestosterone (DHT), Puberty(02:09:01) Hair Loss, Dutasteride, Finasteride & Sexual Health; Post-Finasteride Syndrome(02:16:11) Clomiphene, Testosterone & Estrogen Signaling(02:19:31) Follicle-Stimulating Hormone (FSH) Therapy; Prolactin, Estrogen(02:24:15) Varicocele; Peyronieâs Disease(02:27:26) Testis & Cancer Risk; Insurance, Blood Profiles & Semen Analysis(02:35:03) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network NewsletterTitle Card Photo Credit: Mike BlabacDisclaimer
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Welcome to a preview of the 12th Ask Me Anything (AMA) episode, part of Huberman Lab Premium.
The Huberman Lab Premium subscription was launched for two main reasons. First, it was launched in order to raise support for the standard Huberman Lab podcast channel — which will continue to come out every Monday at zero-cost. Second, it was launched as a means to raise funds for important scientific research. A significant portion of proceeds from the Huberman Lab Premium subscription will fund human research (not animal models) selected by Dr. Huberman, with a dollar-for-dollar match from the Tiny Foundation.
If you're an existing Premium member, you can login to access the full episode.
If you're not a member, you can join Huberman Lab Premium to enjoy exclusive content, including monthly Ask Me Anything (AMA) episodes, AMA transcripts, podcast episode transcripts, early access to live events and help advance human scientific research.
Timestamps
(00:00:00) Introduction
(00:01:46) Resveratrol and Longevity Supplements
(00:26:49) Huberman Lab Premium
In the full AMA episode, we discuss:
What Is Working Memory and How to Improve It
Title Card Photo Credit: Mike Blabac
Disclaimer -
In this episode, I provide science-based tools and protocols to improve mood and mental health. These tools represent key takeaways from several recently published research studies, as well as from former Huberman Lab guests Lisa Feldman Barrett, Ph.D., an expert in the science of emotions, and Paul Conti, M.D., a psychiatrist with vast clinical expertise in helping people overcome mental health challenges. I explain the first principles of self-care, which include the âBig 6â core pillars for mood and mental health. Those ensure our physiology is primed for our overall feelings of well-being. Then, I explain science-based tools to directly increase confidence, build a stronger concept of self, better understand our unconscious mind, manage stress and improve our emotional tone and processing. I also explain ways to better process negative emotions and traumas. This episode ought to be of interest to anyone wishing to improve their relationship with themselves and others, elevate their mood and mental health, and better contribute to the world in meaningful ways.For show notes, including referenced articles and additional resources, please visit hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanPlunge: https://plunge.com/hubermanEight Sleep: https://eightsleep.com/hubermanWaking Up: https://wakingup.com/hubermanInsideTracker: https://insidetracker.com/hubermanMomentous: https://www.livemomentous.com/hubermanTimestamps(00:00:00) Mood & Mental Health Toolkit(00:03:10) Sponsors: Plunge, Eight Sleep & Waking Up(00:05:35) First Principles of Self-Care & 6 Pillars of Mental Health(00:13:58) Pillar #1: Sleep & Sleep Routine(00:18:00) Pillar #2: Light, Sunlight(00:24:38) Tool: Nighttime Environment & Darkness(00:28:33) Pillar #3: Movement; Pillar #4: Nutrition(00:33:18) Sponsor: AG1(00:34:51) Pillar #5: Social Connection(00:40:00) Pillar #6: Stress Control; Physiological Sigh(00:45:40) Tool: Raise Stress Threshold, Deliberate Cold Exposure(00:50:00) 6 Pillars & Brain Predictability, Affect & Emotion(00:57:58) Pharmacology, Psychedelics, Supplements & Neuroplasticity(01:06:25) Sponsor: InsideTracker(01:07:26) Tool: Emotional Granularity(01:14:39) Tool: Heart Rate Variability & Emotional Graduality; Physiological Sigh(01:23:49) Tool: Unconscious Mind(01:26:54) Tool: Self-Concept, Self-Narrative Exercise(01:34:34) Tool: Unconscious Mind & Dream Analysis; Liminal States(01:42:52) Tool: Journaling; Generative Drive(01:52:43) Tool: Processing Trauma(02:00:43) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network NewsletterTitle Card Photo Credit: Mike BlabacDisclaimer
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In this episode, my guests are Mark Zuckerberg, CEO of Meta (formerly Facebook, Inc.), and his wife, Dr. Priscilla Chan, M.D., co-founder and co-CEO of the Chan Zuckerberg Initiative (CZI). We discuss how CZI plans to cure all human diseases by the end of this century by funding transformative projects and technologies at the intersection of biology, engineering, and artificial intelligence (AI). They describe their funding and development of Biohubs and the progress already underway to accelerate the understanding of cell function, pathways, and disease. Then, Mark discusses social media, its impact on mental health, and new tools for online experiences. We also discuss Metaâs virtual reality (VR), augmented and mixed reality tech, and how AI will soon completely transform our online and physical life experiences. This episode ought to interest anyone curious about biology, medicine, mental health, AI, and the future of technology and humanity.For the full show notes, including the episode transcript (available exclusively to Huberman Lab Premium members), please visit hubermanlab.com.The Brain Body ContractTickets: https://www.hubermanlab.com/eventsPre-sale password: HUBERMANThank you to our sponsorsAG1: https://drinkag1.com/hubermanEight Sleep: https://eightsleep.com/hubermanLMNT: https://drinklmnt.com/hubermanInsideTracker: https://insidetracker.com/hubermanMomentous: https://livemomentous.com/hubermanThe Brain Body ContractTickets: https://www.hubermanlab.com/eventsTimestamps(00:00:00) Mark Zuckerberg & Dr. Priscilla Chan(00:02:15) Sponsors: Eight Sleep & LMNT; The Brain Body Contract(00:05:35) Chan Zuckerberg Initiative (CZI) & Human Disease Research(00:08:51) Innovation & Discovery, Science & Engineering(00:12:53) Funding, Building Tools & Imaging(00:17:57) Healthy vs. Diseased Cells, Human Cell Atlas & AI, Virtual Cells(00:21:59) Single Cell Methods & Disease; CELLxGENE Tool (00:28:22) Sponsor: AG1(00:29:53) AI & Hypothesis Generation; Long-term Projects & Collaboration(00:35:14) Large Language Models (LLMs), In Silico Experiments(00:42:11) CZI Biohubs, Chicago, New York(00:50:52) Universities & Biohubs; Therapeutics & Rare Diseases(00:57:23) Optimism; Children & Families(01:06:21) Sponsor: InsideTracker(01:07:25) Technology & Health, Positive & Negative Interactions(01:13:17) Algorithms, Clickbait News, Individual Experience(01:19:17) Parental Controls, Meta Social Media Tools & Tailoring Experience(01:24:51) Time, Usage & Technology, Parental Tools(01:28:55) Virtual Reality (VR), Mixed Reality Experiences & Smart Glasses(01:36:09) Physical Exercise & Virtual Product Development(01:44:19) Virtual Futures for Creativity & Social Interactions(01:49:31) Ray-Ban Meta Smart Glasses: Potential, Privacy & Risks(02:00:20) Visual System & Smart Glasses, Augmented Reality(02:06:42) AI Assistants & Creators, Identity Protection(02:13:26) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network NewsletterTitle Card Photo Credit: Mike BlabacDisclaimer
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In this episode, my guest is Dr. Lisa Feldman Barrett, Ph.D., a Distinguished Professor of Psychology at Northeastern University who is a world expert in the science of emotions. She explains what emotions are and how the brain represents and integrates signals from our body and the environment around us to create our unique emotional states. We discuss the relationship between emotions and language, how our specificity of language impacts our emotional processing, the role of facial expressions in emotions, and how emotions relate to sleep, movement, nutrition and the building and reinforcement of social bonds. We also discuss actionable tools for how to regulate feelings of uncertainty and tools to better understand the emotional states of others. This episode ought to be of interest to anyone curious about the neuroscience and psychology underlying emotions and for those who seek to better understand themselves and relate to others and the world in richer, more adaptive ways.For show notes, including referenced articles and additional resources, please visit hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanEight Sleep: https://eightsleep.com/hubermanLevels: https://levels.link/hubermanInsideTracker: https://insidetracker.com/hubermanMomentous: https://livemomentous.com/hubermanTimestamps(00:00:00) Dr. Lisa Feldman Barrett(00:03:01) Sponsors: Eight Sleep & Levels(00:05:46) Core Components of Emotions(00:10:42) Facial Movement & Interpretation, Emotion(00:19:33) Facial Expressions & Emotion, Individualization(00:31:03) Emotion Categories, Culture & Child Development(00:36:53) Sponsor: AG1(00:37:50) Legal System, âUniversalâ Emotions & Caution(00:41:07) Language Descriptions, Differences & Emotion(00:48:18) Questions & Assumptions; Language, Emotions & Nervous System(00:53:40) Brain, Uncertainty & Categories(01:02:51) Sponsor: InsideTracker(01:03:57) Brain & Summaries; Emotions as âMultimodal Summariesâ(01:14:45) Emotional Granularity, Library Analogy(01:19:40) Brain & Compression, Planning(01:29:04) Labels & Generalization(01:34:29) Movement, Sensation, Prediction & Learning(01:42:44) Feelings of Discomfort & Action(01:50:32) Tool: Feelings of Uncertainty, Emotion, âAffectâ(02:01:18) Tool: Experience Dimensions & Attention; Individualization(02:08:36) Affect, Allostasis & Body Budget Analogy(02:15:41) Depression, âEmotional Fluâ(02:20:20) Tool: Positively Shift Affect; Alcohol & Drugs; SSRIs(02:27:40) Relationships: Savings or Taxes, Kindness(02:36:50) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network NewsletterTitle Card Photo Credit: Mike BlabacDisclaimer
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In this episode, I discuss neuroscience and psychology studies that address the basis of willpower and tenacity, how they differ from motivation and how we can all increase our levels of willpower and tenacity. I discuss whether willpower is a limited resource, the controversial âego depletionâ theory of willpower and the role that beliefs play in determining our tenacity and willpower. Then, I discuss the neural basis of willpower in the brain and body and how tenacity and willpower relate to sleep, stress, focus, and possibly lifespan. Then, I provide a series of science-supported tools and protocols to increase your level of tenacity and willpower.For show notes, including referenced articles and additional resources, please visit hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanMaui Nui Venison: https://mauinuivenison.com/huberman Helix Sleep: https://helixsleep.com/huberman LMNT: https://drinklmnt.com/huberman Momentous: https://livemomentous.com/hubermanTimestamps(00:00:00) Tenacity & Willpower(00:01:19) Sponsors: Maui Nui & Helix Sleep(00:03:49) Tenacity & Willpower vs. Habit Execution; Apathy, Depression & Motivation (00:10:40) Ego Depletion & Willpower as a Limited Resource; Controversy (00:19:14) Tool: Autonomic Function, Tenacity & Willpower; Sleep & Stress (00:28:02) Sponsor: AG1(00:28:58) Willpower as a Limited Resource (Theory)(00:35:36) Willpower & Glucose, Brain Energetics(00:42:44) Beliefs about Willpower & Glucose; Multiple Challenges(00:52:43) Sponsor: LMNT(00:54:01) Willpower Brain âHubâ; Anorexia Nervosa, Super-Agers(01:07:15) Anterior Midcingulate Cortex & Brain/Body Communication (01:14:54) Allostasis, Anterior Midcingulate Cortex Function(01:25:19) Anterior Mid-Cingulate Cortex (aMCC), Difficult Tasks & Neuroplasticity(01:29:30) Tool: Novel Physical Exercise & Brain; Cognitive Exercise(01:43:43) Tool: âMicro-sucksâ, Increase Tenacity/Willpower(01:50:58) Impossible Tasks, Super-Agers & Learning, Will to Live(01:57:23) Tool: Rewards & Improving Tenacity/Willpower(02:01:07) Tenacity & Willpower Recap(02:05:55) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network NewsletterTitle Card Photo Credit: Mike BlabacDisclaimer
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In this episode, my guest is Chris Voss, a former Federal Bureau of Investigation (FBI) agent who was the lead negotiator in many high-risk, high-consequence cases. Chris has taught negotiation courses at Harvard and Georgetown Universities and is the author of the book âNever Split the Difference.â We discuss how to navigate difficult conversations of all kinds, including in business, romance and romantic breakups, job firings and tense conversations with family and friends. Chris explains how to navigate online, in person and in written negotiations, the red flags to watch out for and how to read body and voice cues in face-to-face and phone conversations. He explains how to use empathy, certain key questions, proactive listening, emotional processing and more to ensure you reach the best possible outcome in any hard conversation. This episode ought to be of interest to anyone looking to improve their interpersonal abilities and communication skills and for those who want to be able to keep a level head in heated discussions. For show notes, including referenced articles and additional resources, please visit hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanPlunge: https://plunge.com/hubermanROKA: https://roka.com/hubermanInsideTracker: https://insidetracker.com/hubermanInsideTracker Giveaway: https://info.insidetracker.com/hydrowMomentous: https://livemomentous.com/hubermanTimestamps(00:00:00) Chris Voss(00:02:18) Sponsors: Plunge & ROKA(00:04:59) Negotiation Mindset, Playfulness(00:11:41) Calm Voice, Emotional Shift, Music(00:18:59) âWin-Winâ?, Benevolent Negotiations, Hypothesis Testing(00:28:38) Generosity(00:32:46) Sponsor: AG1(00:33:44) Hostile Negotiations, Internal Collaboration(00:39:40) Patterns & Specificity; Internet Scams, âDouble-Dipâ(00:48:15) Urgency, Cons, Asking Questions(00:54:46) Negotiations, Fair Questions, Exhausting Adversaries(01:01:09) Sponsor: InsideTracker(01:02:18) âVision Drives Decisionâ, Human Nature & Investigation(01:07:47) Lying & Body, âGut Senseâ(01:15:42) Face-to-Face Negotiation, â738â & Affective Cues (01:20:39) Online/Text Communication; âStraight Shootersâ(01:26:47) Break-ups (Romantic & Professional), Firing, Resilience(01:32:16) Ego Depletion, Negotiation Outcomes(01:37:35) Readiness & âSmall Space Practiceâ, Labeling(01:45:17) Venting, Emotions & Listening; Meditation & Spirituality(01:51:41) Physical Fitness, Self-Care(01:57:01) Long Negotiations & Recharging(02:02:40) Hostages, Humanization & Names(02:08:50) Tactical Empathy, Compassion(02:15:27) Tool: Mirroring Technique(02:22:20) Tool: Proactive Listening(02:29:48) Family Members & Negotiations(02:35:21) Self Restoration, Humor (02:39:01) Fireside, Communication Courses; Rapport; Writing Projects(02:47:45) âSounds LikeâŠâ Perspective(02:50:54) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network NewsletterTitle Card Photo Credit: Mike BlabacDisclaimer
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Welcome to a preview of the 11th Ask Me Anything (AMA) episode, part of Huberman Lab Premium.
The Huberman Lab Premium subscription was launched for two main reasons. First, it was launched in order to raise support for the standard Huberman Lab podcast channel — which will continue to come out every Monday at zero-cost. Second, it was launched as a means to raise funds for important scientific research. A significant portion of proceeds from the Huberman Lab Premium subscription will fund human research (not animal models) selected by Dr. Huberman, with a dollar-for-dollar match from the Tiny Foundation.
Subscribe to Huberman Lab Premium at www.hubermanlab.com/premium.
Timestamps
(00:00:00) Introduction
(00:01:46) Is There a Way to Get Better at Task Switching?
(00:32:17) Huberman Lab Premium
In the full AMA episode, we discuss:
What Can I Do in Order to Avoid Getting Brain Fog?
Title Card Photo Credit: Mike Blabac
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This is episode 4 of a 4-part special series on mental health with Stanford and Harvard-trained psychiatrist Dr. Paul Conti, M.D. Dr. Conti explains what true self-care is and how our mental health benefits from specific self-care and introspection practices â much in the same way that our physical health benefits from certain exercise and nutrition habits. He describes how the foundation of mental health is an understanding of oneâs own mind and the specific questions to ask in order to explore the conscious and unconscious parts of ourselves. He describes how this process can be done either on our own, through journaling, meditation and structured thought, or in therapy with the help of a licensed professional. He also explains how unprocessed trauma can short-circuit the process and how to prevent that, and the role of friendships and other relational support systems in the journey of self-exploration for mental health. People of all ages and those with and without self-introspection and therapy experience ought to benefit from the information in this episode.For show notes and additional resources, please visit hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanBetterHelp: https://betterhelp.com/hubermanWaking Up: https://wakingup.com/hubermanMomentous: https://livemomentous.com/hubermanTimestamps(00:00:00) Self Care(00:02:37) Sponsors: BetterHelp & Waking Up(00:05:34) What is Self-Care?, Foundation, Self-Understanding(00:13:18) Life Narratives(00:15:24) Journaling, Self-Inquiry & Therapy(00:24:41) Unconscious Mind, Salience & Journaling; Panic Attacks(00:28:20) Self-Inquiry; Grief & Death(00:33:23) Sponsor: AG1(00:34:39) Self-Harm, Hopelessness & Therapy(00:37:27) Apprehension of Unconscious Mind Exploration(00:42:34) Mental Health Map: Cupboards, Agency & Gratitude, Generative Drive(00:54:18) Structure of Self, Unconscious Mind, Abscess Analogy(01:01:57) Exploring the Unconscious Mind, Curiosity, âQuestion the Givensâ(01:10:48) Conscious Mind Exploration; Self Curiosity, Busyness(01:19:20) Exploring Defense Mechanisms, Character Structure(01:24:54) Self & Character Structure, âTending the Gardenâ(01:32:45) Function of Self Cupboards(01:35:50) Self-Awareness Exploration, Mirror Meditation(01:38:34) Defense Mechanisms in Action & Self-Inquiry, Patterns(01:47:15) Salience Exploration, Grounding Meditation(01:52:37) Behavior & Self-Reflection; Phantom Driver Analogy(02:00:14) Self & Strivings; Empowerment & Humility(02:09:07) Challenges in Certain Life Domains(02:17:49) Friendships & Support, Social Media(02:23:50) Anger & Self-Care(02:34:18) Self-Care & Challenges(02:38:43) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Social Media, Momentous, Neural Network NewsletterTitle Card Photo Credit: Mike BlabacDisclaimer
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In this episode, my guest is Dr. Vivek Murthy, M.D., the acting U.S. Surgeon General who earned his undergraduate degree from Harvard and his M.D. from Yale School of Medicine. We discuss nutrition, food additives, social media and mental health, public health initiatives to combat the crisis of social isolation, the obesity crisis, addiction and other pressing issues in public health. Dr. Murthy explains the role of the U.S. government in promoting specific public health issues and the steps needed to rebuild public trust in scientific and medical information. We also discuss health care accessibility, insurance barriers and individual versus team-based medical care. We also discuss topics gleaned from listener questions, such as the facts and myths about âBig Pharmaâ and âBig Foodâ industries, scientific research and public health policies.For show notes, including referenced articles and additional resources, please visit hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanMaui Nui Venison: https://mauinuivenison.com/hubermanROKA: https://roka.com/hubermanLMNT: https://drinklmnt.com/hubermanMomentous: https://livemomentous.com/hubermanTimestamps(00:00:00) Dr. Vivek Murthy(00:01:53) Sponsors: Maui Nui & ROKA(00:04:35) Surgeon General Roles(00:07:44) Illness Framework, Enhancing Wellbeing(00:12:42) Priorities as Surgeon General(00:19:50) Public Health Message Distribution(00:28:24) Diagnosis vs. Optimizing Health(00:33:04) Sponsor: AG1(00:34:01) Food Additives, Highly Processed Foods, Food Availability(00:39:11) Difficulties Addressing Health Issues & Highly Processed Foods(00:49:53) Retribution, Integrity & Public Trust(00:54:41) Company Opposition(00:58:32) Sponsor: LMNT(00:59:50) Public Health Communication, Masks & COVID-19, Public Trust(01:07:01) Masks, Humility; Building Public Trust(01:10:45) Rebuilding Relationship to Public, Vaccines(01:17:41) Community Core & Diversity; Federal Funding(01:24:55) Big Pharma, âPill for Every Problemâ Society (01:31:48) Interdisciplinary Medical Teams, Individualized & Value-Based Medical Models(01:38:44) Insurance Barriers, Mental Health Care, Drug Prices(01:44:40) Isolation Crisis, Social Disconnection, Health Risks (01:49:15) Community Organizations & Modern Life, Social Media(01:56:36) Youth & Social Media, Parents, Policy Change(02:06:45) Real Life vs. Social Media, Kids & Playtime(02:11:56) Social Media Advice for Parents(02:20:43) Society & Disconnection, Human Connection & Service(02:31:20) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network NewsletterTitle Card Photo Credit: Mike BlabacDisclaimer
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This is episode 3 of a 4-part special series on mental health with Dr. Paul Conti, M.D., a psychiatrist who did his medical training at Stanford School of Medicine and residency at Harvard Medical School. He is the author of the book, âTrauma: The Invisible Epidemic.â Dr. Conti explains how to find, develop and strengthen healthy relationships â including romantic relationships, work and colleague relationships, and friendships. He explains a roadmap of the conscious and unconscious mind that can allow anyone to navigate conflicts better and set healthy boundaries in relationships. We also discuss common features of unhealthy relationships and clinically supported tools for dealing with relationship insecurity, excessive anxiety, past traumas, manipulation and abuse. Dr. Conti explains how, in healthy relationships, there emerges a dynamic of the mutually generative âusâ and how to continually improve that dynamic. The next episode in this special series explores true self-care, which can be cultivated through a process of building self-awareness along with other important practices. For the full show notes, visit hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanBetterHelp: https://betterhelp.com/hubermanWaking Up: https://wakingup.com/hubermanEight Sleep: https://eightsleep.com/hubermanMomentous: https://livemomentous.com/hubermanTimestamps(00:00:00) Build Healthy Relationships(00:02:04) Sponsors: BetterHelp & Waking Up(00:05:01) Healthiest Self in Relationships(00:10:51) Structure & Function of Self(00:15:44) Relationships, Levels of Emergence(00:22:48) Generative Drive in Relationships(00:35:00) Sponsor: AG1(00:36:26) Generative Drive, Aggressive Drive, Pleasure Drive(00:45:16) Romantic Relationships & Matched Generative Drives, Trauma Bonds(00:53:05) Generative Drive Expression, Libido, Giving & Taking(01:04:29) Sponsor: Eight Sleep(01:05:50) Generative Drive in Partnerships(01:11:16) Libido, Avoidance & Working through Barriers(01:18:02) Repeating Bad Relationship Patterns, Repetition Compulsion(01:29:23) Narcissism, Dependence, Attachment Insecurity(01:34:10) Abusive Relationships, Demoralization(01:39:37) Oppressors, Darkness, Hope & Change(01:48:08) Work Relationships, Oppression & Accountability(01:53:53) Jealousy vs. Envy, Narcissism(01:59:13) Power Dynamics in Relationships(02:05:54) Giving vs. Taking in Relationships(02:09:39) Transactions & Relationships; Family & Generative Drive; Flexibility(02:19:47) Relationships & Kindergarten(02:23:04) Anxiety in Relationships, Communication(02:31:32) The âMagic Bridge of the Usâ(02:37:09) Mentalization, Getting into Anotherâs Mindset; Navigating Conflict(02:46:51) Healthy Boundaries(02:52:08) Self-Awareness, Mentalization(02:55:28) âBroken Compassâ & Self Inquiry, âMapâ Analogy(03:02:25) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Social Media, Momentous, Neural Network NewsletterTitle Card Photo Credit: Mike BlabacDisclaimer
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In this episode, I describe how your brain and body are fundamentally wired to perceive and respond to music and how those responses can be leveraged to improve your mood, allow for processing sad emotions and enhance learning and performance. I explain the data showing how music can increase motivation for cognitive or physical work, what specific music has been shown to enhance cognitive performance, and whether silence or music is more effective in enhancing focus while studying. I also discuss how specific musical pieces can rapidly reduce anxiety, as well as certain prescription medications. I explain how listening to certain types of music can improve various health metrics (e.g., heart rate). Finally, I discuss how music helps to enhance neuroplasticity (rewiring of brain connections), thereby improving learning and memory. Whether you sing, play an instrument or enjoy listening to music, this episode provides numerous science-informed tools for using music to enhance productivity, mood, emotional states, and overall enjoyment of life.For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Transcripts are available exclusively for Huberman Lab Premium members.The Brain Body ContractTickets: https://hubermanlab.com/tourCode: "Huberman"Thank you to our sponsorsAG1: https://drinkag1.com/hubermanEight Sleep: https://eightsleep.com/hubermanROKA: https://roka.com/hubermanInsideTracker: https://insidetracker.com/hubermanMomentous: https://livemomentous.com/hubermanTimestamps(00:00:00) Music & Your Brain(00:03:32) The Brain Body Contract(00:04:12) Sponsors: Eight Sleep & ROKA(00:07:09) Music & Emotions; Brain & Body Interpretation(00:13:03) Music & Intent; Babies, Music & Movement(00:19:19) Tool: Health Metrics & Music, Breathing & Heart Rate(00:29:54) Sponsor: AG1(00:30:50) Music, Brain & Predictions(00:38:07) Music & Brain: Novelty, Arousal, Memories(00:44:22) Tool: Movement; Motivation & Faster Music(00:50:49) Tool: Cognitive Work & Binaural Beats(00:54:11) Silence or Music for Studying?, White Noise, Binaural Beats(00:58:47) Tool: Retain Information & Internal Dialogue(01:00:53) Tool: Focus, Work Breaks & Music(01:04:11) Physical Exercise, Performance & Music(01:07:37) Sponsor: InsideTracker(01:08:43) Music & Shifting Mood(01:14:41) âHappyâ vs. âSadâ Music, âOne-Hit Wondersâ & Artificial Intelligence(01:19:30) âBass Faceâ; Music, Movement & Facial Expressions(01:22:46) Tools: Shift to Happy Mood with Music; Sad Mood Catharsis(01:27:30) Tool: Music & Reducing Anxiety, âWeightlessâ(01:31:16) Playing Instruments, Singing & Brain Connectivity(01:39:58) Music & the Brain(01:42:14) Zero-Cost Support, Spotify & Apple Reviews, Sponsors, YouTube Feedback, Momentous, Social Media, Neural Network NewsletterTitle Card Photo Credit: Mike BlabacDisclaimer
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This is episode 2 of a 4-part special series on mental health with Dr. Paul Conti, M.D., a Stanford and Harvard-trained psychiatrist currently running a clinical practice, the Pacific Premiere Group. Dr. Conti explains specific tools for how to overcome lifeâs challenges using a framework of self-inquiry that explores all the key elements of self, including defense mechanisms, behaviors, self-awareness and attention. We also discuss our internal driving forces, how to align them and ultimately, how to cultivate a powerful âgenerative driveâ of positive, aspirational pursuits. Dr. Conti also explains how to adjust your internal narratives, reduce self-limiting concepts, overcome intrusive thoughts, and how certain defense mechanisms, such as âacting outâ or narcissism, show up in ourselves and others. The next episode in this special series explores how to build healthy relationships with others.For the full show notes, including articles, books, and other resources, visit hubermanlab.com.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanBetterHelp: https://betterhelp.com/hubermanWaking Up: https://wakingup.com/hubermanEight Sleep: https://eightsleep.com/hubermanMomentous: https://livemomentous.com/hubermanTimestamps(00:00:00) Improve Mental Health(00:02:19) Sponsors: BetterHelp & Waking Up App(00:05:26) Structure & Function of Healthy Self (00:16:25) Agency & Gratitude(00:21:14) Aggressive Drive, Pleasure Drive, Generative Drive(00:30:00) Physical & Mental Health Similarities, Verb States(00:37:05) Sponsor: AG1(00:38:32) Lack of Motivation, Drives(00:43:06) Video Games/Social Media & Distraction, Generative Drive(00:51:46) Asking Better Questions, Psychiatric Medicine, Physical Health Parallels(00:59:10) Sponsor: Eight Sleep(01:00:30) Self-Reflection & Structure of Self âCupboardsâ, Trauma & Agency(01:08:53) Feeling Stuck, Defense Mechanisms & Sublimation, Character(01:13:58) Self-Reflection & Function of Self âCupboardsâ, Self-Awareness(01:19:24) Defense Mechanisms & âActing Outâ(01:26:43) Salience, Intrusive Thoughts(01:31:24) Self-Reflection, Behaviors & Strivings; Roadmap Forward(01:38:25) Internal Narratives, Childhood(01:44:44) Internal Narratives: Self-Scrutiny & Overcoming; Trauma(01:55:18) Time Required for Change, Understanding Intrusive Thoughts(02:03:13) Self-Reflection on Internal Drives; Envy(02:09:56) Generative Drive; Strong Aggressive Drive & Envy(02:21:50) High Aggressive Drive & Social Relationships, Narcissism(02:28:43) Narcissism, Destruction, Envy(02:37:18) Narcissism & Childhood, Change(02:41:26) Engaging with Narcissists, Disengagement(02:44:47) Demoralization, Learned Helplessness(02:49:34) Self-Inventory of Drives, Optimization(02:56:09) Social Media & Salience, Generative Drive(03:03:21) Rational Aspiration(03:13:16) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Social Media, Momentous, Neural Network NewsletterTitle Card Photo Credit: Mike BlabacDisclaimer
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In this journal club episode, my guest is Stanford and Johns Hopkins-trained physician, Dr. Peter Attia, M.D., who is also the host of The Drive podcast and the author of the bestselling book "Outlive: The Science & Art of Longevity."We each present a scientific paper and discuss the findings' strengths, weaknesses and actionable takeaways.First, we discuss an article that addresses whether taking the drug metformin can enhance longevity. Then, we discuss an article on belief effects (similar to placebo effects), showing how the effects of a drug on the brain and cognition depend on one's belief about the dose of the drug taken, not the actual dose.Our conversation also highlights how to read, interpret and critique scientific studies. This episode ought to be of interest to those curious about health and longevity, medicine and psychology and for anyone seeking to better understand how to read and digest scientific findings.For show notes, including referenced articles and additional resources, please visit hubermanlab.com. Transcripts are available exclusively for Huberman Lab Premium members.Thank you to our sponsorsAG1: https://drinkag1.com/hubermanHelix Sleep: https://helixsleep.com/hubermanLevels: https://levels.link/hubermanInsideTracker: https://insidetracker.com/hubermanMomentous: https://livemomentous.com/hubermanTimestamps00:00:00 Dr. Peter Attia, Journal Club00:03:27 Sponsors: Helix Sleep & Levels00:06:11 Dreams00:12:36 Article #1, Metformin, Mitochondria, Blood Glucose00:19:47 Type 2 Diabetes & Causes, Insulin Resistance00:25:30 Type 2 Diabetes Medications, Metformin, Geroprotection, Bannister Study00:36:19 Sponsor: AG100:37:15 TAME Trial; Demographics, Twin Cohort00:44:27 Metformin & Mortality Rate00:51:28 Kaplan-Meier Mortality Curve, Error Bars & Significance, Statistical Power01:01:17 Sponsor: InsideTracker01:02:23 Hazard Ratios, Censoring01:09:00 Metformin Advantage?, Variables, Interventions Testing Program01:16:02 Berberine, Acarbose, SGLT2 Inhibitors01:23:48 Blood Glucose & Energy Balance; Caloric Restriction, Aging Biomarkers01:32:22 Tool: Reading Journal Articles, 4 Questions, Supplemental Information01:38:10 Article #2, Belief Effects vs. Placebo Effect01:45:22 Nicotine Effects01:51:07 Nicotine Doses & Belief Effects, fMRI Scan02:00:07 Biological Effects, Dose-Dependent Response & Belief Effects02:05:14 Biology & Beliefs, Significance, Dopamine Response, Non-Smokers02:10:57 Dose-Dependence & Beliefs, Side Effects, Nocebo Effect02:19:06 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social MediaTitle Card Photo Credit: Mike BlabacDisclaimer
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